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베체트병 환자에서 발생한 Azathioprine에 의한 재발성 급성 췌장염
김상현 ( Sang Hyon Kim ),이승환 ( Seung Hwan Lee ),고윤석 ( Yoon Seok Koh ),김성동 ( Sung Dong Kim ),김해림 ( Hae Rim Kim ),윤종현 ( Chong Hyun Yoon ),이상헌 ( Sang Heon Lee ),박성환 ( Sung Hwan Park ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.1
Acute pancreatitis is a serious disease with a fatality rate of up to 15%. Drugs are considered a rare cause of acute pancreatitis and azathioprine has been linked to subsequent acute pancreatitis in several case reports. We present a 48-year-old female who developed abdominal pain and elevation of serum amylase and lipase levels following azathioprine treatment for Behcet`s disease. Abdominal CT scan reveals diffuse enlarged pancreas and large amount of fluid collection at peritoneal cavity. She was recovered with conventional therapy for acute pancreatitis and withdrawal of azathioprine. When the patient erroneously took the drug once again, acute pancreatitis was more rapidly developed than initial attack.
베체트병 환자에서 혈청 대식세포 유주 억제 인자 (Macrophage Migration Inhibitory Factor, MIF)의 상승
김성동 ( Sung Dong Kim ),김상현 ( Sang Hyon Kim ),김해림 ( Hae Rim Kim ),박미경 ( Mi Kyung Park ),윤종현 ( Chong Hyeon Yoon ),김완욱 ( Wan Uk Kim ),이상헌 ( Sang Heon Lee ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.3
Objective: Macrophage migration inhibitory factor (MIF) has emerged recently as an important regulator of inflammatory and immune responses. This work was undertaken to evaluate serum levels of MIF and in vitro MIF production by whole blood cells in patients with Behcet`s disease and investigate the relationship between serum levels of MIF and clinical manifestations. Methods: Sixty-five patients with Behcet`s disease and forty-eight healthy controls were studied to evaluate serum levels of MIF. Six patients with Behcet`s disease and Five healthy controls were studied for evaluating the production of MIF by whole blood cells. Serum and culture supernatant levels of MIF were measured by enzyme-linked immuno-sorbent assay (ELISA). The production of MIF by whole blood cells was investigated by culturing peripheral blood cells in the absence or presence of Concanavalin A (Con A). Results: Serum levels of MIF were higher in patients with Behcet`s disease than in healthy controls. Serum levels of MIF were changed in each patient with Behcet`s disease according to clinical disease activity (higher at active state). The MIF production by Con A-stimulated peripheral blood cell culture was higher in patients with Behcet`s disease than in healthy controls. Conclusion: Circulating levels of MIF are higher in patients with Behcet`s disease than in healthy controls and the levels of MIF may be associated with clinical disease activity. MIF may play an important role as a mediator of inflammation in Behcet`s disease and provide opportunity for the development of anti-MIF strategy for the treatment of patients with Behcet`s disease.
루푸스 신염의 치료에 있어 Mycophenolate Mofetil의 효과와 안전성
김해림 ( Hae Rim Kim ),김상현 ( Sang Hyon Kim ),김성동 ( Sung Dong Kim ),박경수 ( Kyung Soo Park ),윤종현 ( Chong Hyeon Yoon ),김완욱 ( Wan Uk Kim ),홍연식 ( Youn Sik Hong ),이상헌 ( Sang Heon Lee ),박성환 ( Sung Hwan Park ),조철 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.3
Objective: To determine the therapeutic effect of mycophenolate mofetil (MMF) and the adverse effects associated with MMF in patients with lupus nephritis. Methods: We studied 51 patients with lupus nephritis, who had received MMF for more than 3 months. The efficacy was assessed as renal profiles, SLE disease activity index (SLEDAI), serum cytokine levels and oral corticosteroid dose. The adverse effects were evaluated by medical records and interview of each patient. Serum cytokine levels of IL-10, IFN-α and IFN-γ were determined by sandwich ELISA at starting MMF and at 12 months after MMF therapy. Results: MMF treatment resulted in complete remission 52.9%, partial remission 25.5% and treatment failure 21.6%. There was no difference of MMF efficacy between WHO class IV and V in 32 patients with biopsy-proven nephritis. The renal profiles and parameters for disease activity were improved, as assessed by increased serum albumin and C3 level, decreased proteinuria, cyturia, ESR, SLEDAI and oral corticosteroid doses. Serum IL-10 decreased after MMF therapy in class IV group, but not in class V group. Serum IFN-α, IFN-γ level and IFN-γ/IL-10 ratio also tended to decrease after MMF therapy. GI troubles including dyspepsia, nausea, vomiting and diarrhea were the most common adverse effects of MMF as 54.9%, followed by hair loss, leukopenia, anemia, infection, but there was no serious adverse effect. Conclusion: MMF is an effective and well tolerable immunosuppressant for both class IV and V lupus nephritis, even not responding or intolerable to conventional immunosuppressive therapy.
로터리 압축기용 Short-Cycle 신뢰성 시험장치 제안
이태구(Tae-Gu Lee),이상재(Sang-Jae Lee),김현우(Hyun-Woo Kim),김상현(Sang-Hyun Kim),이재헌(Jae-Heon Lee),유호선(Hoseon Yoo) 대한설비공학회 2006 대한설비공학회 학술발표대회논문집 Vol.2006 No.6
In this paper, a test apparatus for reliability evaluation of a rotary compressor has been suggested with a short-cycle concept. CO₂ refrigerant is adopted for this cycle to avoid phase change during cycle operation. Evaporator is not necessary in short-cycle. Utilizing a short-cycle, the test apparatus was built on the purpose of evaluating the reliability of each rotary compressor on the conveyer belt of the factory. The primary validation of the test apparatus is discussed by analyzing the experimental heat balance data. Additional validation was performed through the overload continuous operation test where the wear rate of the CO₂ short-cycle was found to similar to that of the R22 normal-cycle. The reliability evaluation test apparatus with a short-cycle in present investigation was found simple and efficient in the view of reducing sample numbers, costs, and test time in analyzing the reliability of rotary compressors.