수종의 한약재 열수추출물이 멜라토닌 수용체 발현에 미치는 영향

김보라미 ( Bo Ra Mi Kim ),양동호 ( Dong Ho Yang ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2007 동의신경정신과학회지 Vol.18 No.1

Objective : This study was to investigate the effects of several herbs on the levels of MT1 and MT2 melatonin receptorsMethods : For this study, we carried out dementia assessment examination of 34 patients with memory disturbance who have come to Cheongju oriental hospital of Daejeon university from April 2005 to February 2006. This study classified the patients as none-dementia(ND), questionable dementia(QD), and dementia(DA) groups and analyzed the result of examination. Results : 1. The water extracts of Dimocarpus long (WEDL) induced the levels of MT2 melatonin receptor expression in a concentration-dependent manner without altering the levels of MT1 melatonin receptor expression. 2. The treatment with the water extract of Zizyphus vulgaris (WEZV) induced the levels of MT1 melatonin receptor expression and the levels of MT2 melatonin receptor expression was not affected. 3. The levels of MT1 as well as MT2 melatonin receptor expression were markedly up-regulated in the water extract of Fossilia ossis (WEFO) and the water extract of Ostreae caro (WEOC)-treated C6 cells. 4. The combination treatment with WEDL and WEZV induced not only the levels of MT1 melatonin receptor expression but also MT2 melatonin receptor expression, but the synergic effects of the combination treatment with WEFO and WEOC were not detected in C6 cells. Conclusion : The study provides important new insights into the possible mechanisms on the regulation of melatonin receptor synthesis by WEDL, WEZV, WEFO and WEOC.

특급 호텔 조리 식음료 종사자의 위생 관리 인지도 및 수행도에 관한 연구

김보라미(Bo-Ra-Mi Kim),이라래(Ra-Rae Lee),이미호(Mi-Ho Lee),이성재(Sung-Jae Lee),조유진(Yu-Jin Cho),윤현주(Hyun-Joo Yoon),윤기선(Ki-Sun Yoon) 동아시아식생활학회 2007 동아시아식생활학회지 Vol.17 No.6

해초 Biochar를 이용한 Cr⁶⁺과 As³⁺ 흡착 특성

김보라,신우석,김영기,Kim, Bo-Ra,Shin, Woo-Seok,Kim, Young-Kee 한국공업화학회 2015 공업화학 Vol.26 No.4

본 연구에서는 제주도에서 채집한 Hizikia fusiformis biochar를 이용하여 수용액 상에서 $Cr^{6+}$과 $As^{3+}$ 중금속의 흡착 특성을 평가하였다. $Cr^{6+}$과 $As^{3+}$ 흡착에 있어서 최적 pH는 각각 pH 2와 pH 6이었다. 동역학적 실험 결과, 대부분의 중금속이 처음 100 min 동안 흡착이 되었으며, 300 min 이후 평형에 도달하였다. 또한, 해초 biochar의 $Cr^{6+}$과 $As^{3+}$ 중금속 흡착은 유사 1차 모델과 2차 모델에서 모두 잘 부합하고 있는 것으로 나타났다. 평형 흡착 실험 결과는 Langmuir 모델에 잘 부합했고, $Cr^{6+}$ (25.91 mg/g)이 $As^{3+}$ (16.54 mg/g)보다 흡착량이 높았다. 본 연구 결과를 통해, 오염된 환경에서 해초 biochar는 $Cr^{6+}$ 및 $As^{3+}$ 중금속의 효과적인 흡착제임을 보였다. This study examined the adsorption characteristics of $Cr^{6+}$ and $As^{3+}$ in the aqueous solution by Hizikia susiformis biochar which was collected from Jeju Island. The optimal pH for $Cr^{6+}$ and $As^{3+}$ adsorption were 2 and pH 6, respectively. Kinetic data showed that the adsorption occurred during the first 100 min, and the most of heavy metals were bound to biochars within 300 min. Moreover, the kinetic data presented that the course of adsorption follows the Pseudo first and second order models. The equilibrium data were well fitted by the Langmuir model and the $Cr^{6+}$ adsorption capacity (25.91 mg/g) was higher than that of $As^{3+}$ (16.54 mg/g). From these results, the seaweed biochar was shown to be a efficient adsorbent for $Cr^{6+}$ and $As^{3+}$ metals in a contaminated environment.

디지털 방사선에서 조사선량과 관전압조절에 의한 원본영상과 처리영상 분석

김보라,류신영,석진영,최준구,Kim, Bo-Ra,Ryu, Sin-Young,Seok, Jin-Young,Choi, Jun-Gu 대한디지털의료영상학회 2011 대한디지털의료영상학회논문지 Vol.13 No.1

Dynamic range on the digital detector can be a representation to the ratio of maximum and minimum of pixel value. Wide dynamic range and post processing ability of the digital detector made difficult to recognize visually to high or low dose images. We were evaluated a change of mean pixel value on the original and processed image, when we controlled the kVp, mA, exposure time on the digital detector. On the kVp of a constant condition, we were acquired an original and processed image by changes of mA, exposure time. According to the thickness of the subject under the same conditions, to determine a relation of pixel value and X-ray intensity, we used an aluminum step wedge. When mA and exposure times were changed under the kVp of a constant condition, the X-ray intensity was decreased by the reduction of the mean pixel value. In addition when kVp was increased in a constant condition of mAs, the mean pixel value was increased according to the increment of the X-ray intensity. Therefore, low kVp, high mA and short exposure time were a way to reduce a patient dose.

기혼 중년 남성의 갱년기 증상이 자살 사고에 미치는 영향에서 주관적 행복감의 매개효과

김보라,성경미,Kim, Bo Ra,Sung, Kyung Mi 한국디지털정책학회 2021 디지털융복합연구 Vol.19 No.4

본 연구는 기혼 중년 남성의 갱년기 증상이 자살 사고에 미치는 영향에서 주관적 행복감의 매개효과를 파악한 연구이다. 자료수집은 2020년 12월부터 2021년 1월까지 실시하였으며 인터넷 커뮤니티를 통해서 설문 응답에 자발적으로 참여한 기혼 중년 남성을 대상으로 하였다. 최종 연구 대상자는 갱년기 증상이 있는 199명의 기혼 중년 남성이었다. 기혼 중년 남성의 갱년기 증상, 자살 사고 및 주관적 행복감은 유의한 상관관계가 있었으며, 갱년기 증상과 자살 사고의 관계에서 주관적 행복감은 매개효과가 있는 것으로 나타났다. 본 연구의 결과로 갱년기 남성의 주관적 행복감을 향상시키는 것이 자살 사고를 예방하는데 도움이 될 수 있음을 확인하였다. 따라서 연구자는 본 연구 결과를 토대로 추후 갱년기 남성의 자살 사고를 예방하는 간호중재 방안을 마련하여 그 효과를 확인해 볼 것을 제언한다. This study was to investigate the mediating effect of subjective happiness on the effect of andropause symptoms on suicidal Ideation in married middle-aged men. Final Participants were 199 married middle-aged men with andropause symptoms. Andropause symptoms, suicidal ideation, and subjective happiness of middle-aged men showed significant correlations. The mediating effect of subjective happiness on the relationship between andropause symptoms and suicidal ideation was verified. The findings revealed that an improving subjective happiness of men with andropause symptoms can be helpful for the prevention of suicidal ideation. Therefore, the researchers suggest that future researchers develop nursing interventions for the prevention of suicide ideation of men with andropause symptoms based on the results of the study, and evaluate its' effects.

코팅 피치의 물성제어를 통한 흑연 음극재의 전기화학 성능 향상 연구

김보라,김지홍,강석창,임지선,Kim, Bo Ra,Kim, Ji Hong,Kang, Seok Chang,Im, Ji Sun 한국공업화학회 2022 공업화학 Vol.33 No.5

A pitch coating method was proposed for the purpose of improving the electrochemical properties of natural graphite. The synthesis conditions of pitch coating were optimized via measuring electrochemical properties of pitch-coated graphite anodes. As the synthesis temperature increased, the thermal stability was improved in addition to an increase in the softening point and residual carbon weight. However, the synthesis temperature of 430 ℃ resulted in the synthesis of a large amount of NI (NMP Insoluble) due to excessive condensation reaction. As the surface uniformity and coating thickness increased due to high thermal stability, the initial coulombic efficiency and rate capability of the pitch-coated graphite were improved. However, the graphite coated with the pitch containing excessive NI showed lower electrochemical properties than the uncoated graphite. NI had low dispersibility and formed spheres after heat treatment, so it formed the heterogeneous and thicker SEI layer. The optimum conditions for forming a uniform surface and an appropriate coating layer were investigated.

전광(癲狂) 유사 증상을 나타낸 화병(火病) 환자 치험 1례

양동호 ( Dong Ho Yang ),김보라미 ( Bo Ra Mi Kim ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.3

Hwa-byung is said as a Korean folk syndrome in DSM-Ⅳ,and that is translated into ``Anger syndrome``. In Oriental Medicine, Hwa-Byung is related with clonic emotional-stress, and include symptoms having the character of ``fire``.In this case, the patient had symptoms similar with schizophreniform disorder. We treated the patient with Sihoukan-tang, Ssanghwa-tang and Ziunkoron. And her condition was improved through these oriental medical treatment.

증례 : 류마티스 ; 류마티스 관절염에서 발생한 급성 횡단척수염 치료 1예

김보라 ( Bo Ra Kim ),권혁이 ( Hyucki Kwon ),김지현 ( Ji Hyun Kim ),박성현 ( Sung Hyun Park ),정재훈 ( Jae Hoon Jeong ),정진선 ( Jin Seon Jeong ),문기원 ( Ki Won Moon ) 대한내과학회 2015 대한내과학회지 Vol.89 No.5

본 증례는 류마티스 관절염 환자에서 발생한 급성 횡단 척추염을 면역글로불린 정주로 성공적으로 치료하였기에 문헌고찰과 함께 보고하는 바이다. Acute transverse myelitis (ATM) is a heterogeneous syndrome characterized by acute spinal cord dysfunction resulting in paresis and sensory and autonomic impairment below the level of the lesion. The etiology of ATM includes parainfectious, paraneoplastic, drug-induced, systemic autoimmune disorders, and acquired demyelinating diseases. ATM is very rare in patients with rheumatoid arthritis (RA). A 79-year-old woman with RA, a recurring peptic ulcer, and congestive heart failure presented with acute weakness of both upper and lower extremities. She was diagnosed with ATM based on the results of laboratory and radiological tests. ATM is usually treated with high-dose glucocorticoid. However, we treated her with intravenous immunoglobulin (IVIG) considering the adverse events of high-dose glucocorticoid, and she improved. We report a case of ATM in a patient with RA successfully treated with IVIG. (Korean J Med 2015,89:604-608)

장소이미지를 제고한 경험 디자인에 관한 연구 - 서울 도시 갤러리 프로젝트를 중심으로 -

김보라(Kim, Bo-Ra), 문정민(Moon, jung-min) 조선대학교 조형미술연구소 2012 조형미술논문집 Vol.12 No.1

이용자들마다 다르게 받아들이는 주관적인 성격을 가진 장소 이미지는 물리적 공간 안에 사람과 환경간의 상호작용 속에서 형성되는 문화, 상징, 감정 등의 복합적인 요소들로 하여금 장소의 고유한 정체성을 가지며 장소의 이미지 또한 제고될 수 있다. 장소의 형성의 중요성을 인식하여 사업화한 서울 도시 갤러리 프로젝트는 지역주민들의 삶과 예술작품이 조화를 이루는 도시환경을 만들고자한 사례로 이러한 공간의 정체성을 표현하고 장소의 이미지를 만들어내는데 있어 공간에 대한 인지를 높이기 위한 프로젝트 중 이용자들의 경험을 고려한 디자인으로 장소의 가치를 높이고 도시공간을 활성화한 사례를 조사하여 경험 디자인의 요소들의 영향을 분석하여 앞으로 장소 이미지를 제고하기 위해 시행될 작업들이 참고 할 수 있는 결과물을 얻어내는데 본 연구의 목적이다. 첫째, 장소의 특성과 맥락을 고려하여 이용자들에게 이용자들만의 감성을 느끼고 장소를 기억하게 하는 방식을 활용하며 다양한 방식으로 도시의 장소 이미지를 만들고 있다. 둘째, 경험 디자인의 적용 방법 중 이용자들의 기억, 연상을 유도하여 이용자들에게 다양한 경험과 체험의 기회를 주며 그에 따른 감성을 자극하는 방식이 많이 활용되고 있으며 셋째, 기억 구조인 연상 작용에 의해서 이용자들의 기억된 경험을 불러일으켜 기억되는 장소로 인식되어 장소의 이미지를 제고 시킬 것이다. Keywords : 경험디자인, 장소 이미지 Experience Design, Place Image

광주와 서울의 교통 시설물의 설치 현황과 가이드라인 반영 분석 - 국제 행사장 지역 중심으로 -

김보라(Kim, Bo - Ra), 문정민(Moon, Jeong - Min) 조선대학교 조형미술연구소 2011 조형미술논문집 Vol.11 No.1

As street space is composed of many facilities, behaviors of users should be carefully considered. Most of the past urban facilities were confusing, focusing on economic and functional aspects, but present urban space has actively been engaged to express urban elements considering aesthetic design. At this point when guidelines on public facility installation and standard design have been announced by each local government, it is necessary to evaluate present public facilities.Therefore, this study analysed whether present public facilities which were installed through the past deliberation are suitable for standard guidelines and present public facilities reflect guidelines properly and the results are presented as follows: First, facilities in Gwanju and Jeonnam which have been reorganized based on organized and systematic guidelines have similar shapes, colors and textures, which seems that the degree recommended standards are reflected is low. Second, it is suggested that present guidelines need specific recommendations considering structures, shapes and characteristics of streets targeting hierarchical goals and integrated strategies of public facilities and space. Third, partial replacement and revision of the recommended installation guidelines of each local government are needed for reorganization of public space. Keywords : 교통시설물, 국제행사장, 가이드라인