봉독(蜂毒) 약침(藥鍼)이 구안와사에 미치는 영향에 대한 임상적 고찰

김민수,김현중,박영재,김이화,이은용,Kim, Min-soo,Kim, Hyun-joong,Park, Young-jae,Kim, Ee-hwa,Lee, Eun-yong 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4

Objective: Ths research was to investigate the efficacy of bee venom theraphy on peripheral facial paralysis. Methods: Thirty patients were deyided into two groups with fifteen patients each. Group A and B were both treated with basic oriental medicine treatment, and also group A was treated with bee venom aqua-acupunture additionaly. The groups were evaluated by Yanagihara's unweighted grading system before treatment, and at every one week till four weeks after treatment. Results: The Yanagihara's scores of group B were higher than those of group A before treatment, after one week and two weeks, but not statistically significant. After three and four weeks, the Yanagihara's scores of group A were higher than those of group B, but not statistically significant. The improvement indexes of group A were higher than those of group B from the first week and statistically significant after three and four weeks. Conclusion: Combinding bee venom aqua-acupunture theraphy on peripheral facial paralysis was more efficacious than the only use of basic oriental medicine treatment.

면역결핍 모델에서 β-1,3/1,6-glucan과 유산균을 이용한 in vivo 면역 활성 조절 효과

김민수,김중수,류민정,김기홍,황권택,Kim, Min-Soo,Kim, JoongSu,Ryu, Min Jung,Kim, Ki hong,Hwang, Kwontack 한국식품저장유통학회 2017 한국식품저장유통학회지 Vol.24 No.8

본 연구에서는 LP-BM5 murine AIDS virus에 감염된 면역 결핍동물 모델을 이용하여 실험기간 10주 동안 ${\beta}$-1,3/1,6-glucan, 유산균 및 ${\beta}$-1,3/1,6-glucan+유산균의 식이가 면역활성에 미치는 영향을 조사하였다. 그 결과 LP-BM5 murine AIDS virus에 감염으로 면역능이 떨어진 T세포 증식능은 홍삼대조군과 비교하여도 유의적으로 감소된 T 세포증식능을 증가시키는 것으로 나타났고, B 세포 증식능은 감염 대조군에 비하여 유의적으로 증가된 B 세포 증식능을 감소되었다. cytokine 생성능에서는 Th1 type cytokine중에서 IL-2, IL-12, IL-15는 감염대조군에 비하여 분비량을 증가시키는 것을 확인할 수 있었고, IFN-${\gamma}$는 유산균과 ${\beta}$-1,3/1,6-glucan을 각각 처리군이 혼합처리군보다 증식능이 증가하였다. TNF-${\alpha}$는 감염대조군에 비하여 유의적으로 감소하였다. Th2 cytokine 들의 분비량 측정에서 IL-4, IL-6, IL-10 측정 결과 감염대조군에서 유의적으로 억제되어 Th1/Th2 type cytokine 발현을 조절하여 면역항상성을 유지하는 것으로 보였다. 면역글로블린 분비량측정에서 IgE, IgA, IgG 모두 감염대조군에 비하여 유의적으로 떨어지는 것으로 나타났다. 이로서LP-BM5 murine AIDS virus에 감염된 면역 결핍동물 모델에 ${\beta}$-1,3/1,6-glucan+유산균군을 혼합처리로 면역조절의 효능이 있음을 확인할 수 있었다. In this study, ${\beta}$-1,3/1,6-glucan, lactic acid bacteria, and ${\beta}$-1,3/1,6-glucan+lactic acid bacteria were tested for 10 weeks using an immunodeficient animal model infected with LP-BM5 murine AIDS virus On the immune activity. Cytokines production, plasma immunoglobulin concentration, T cell and B cell proliferation were measured. As a result, the T cell proliferative capacity which was weakened by immunization with LP-BM5 murine AIDS virus increased significantly T cell proliferative capacity compared with the red ginseng control group. B cell proliferative capacity was significantly higher than the infected control group. Increased B cell proliferation was reduced. In the cytokine production, IL-2, IL-12 and IL-15 in the Th1-type cytokine increased the secretion of IL-2, IL-12 and IL-15 compared to the infected control. The proliferative capacity of the treated group was higher than that of the mixed treatment group. TNF-${\alpha}$ was significantly decreased compared with the infected control group. The IL-4, IL-6 and IL-10 levels were significantly inhibited in the infected control group and the Th1/Th2 type cytokine expression was regulated by immunohistochemistry. IgE, IgA, and IgG levels were significantly lower in the immunoglobulin secretion assay than in the control. As a result, the immunomodulatory effect of ${\beta}$-1,3/1,6-glucan+lactic acid bacteria was confirmed by mixing with LP-BM5 murine AIDS virus-infected immunodeficient animal model.

김치에서 분리한 Lactococcus lactis W-44에 의한 감귤발효물의 양식 넙치 성장에 미치는 영향

김민수,문상욱,이영돈,김세재,김영진,이준원,이정희,이정숙,김보연,안종석,안순철,Kim, Min-Soo,Moon, Sang-Wook,Lee, Young-Don,Kim, Se-Jae,Kim, Yeong-Jin,Lee, Jun-Won,Lee, Jeong-Hee,Lee, Jung-Sook,Kim, Bo-Yeon,Ahn, Jong-Seog,Ahn, Soon-Cheo 한국미생물학회 2007 미생물학회지 Vol.43 No.2

젖산균을 접종하여 감귤 분쇄액을 발효시켜 얻은 감귤발효물의 어류양식 사료 첨가제로의 가능성을 넙치(Paralichthys olivaceus) 양식에서 검토하였다. 김치에서 항균활성이 우수한 젖산균 W-44를 분리한 후 16S rDNA 염기서열 분식을 통하여 Lactococcus lactis W-44로 동정하였다. L. lactis W-44를 이용하여 감귤 분쇄액 발효를 수행한 결과, 생리활성이 우수한 무배당체 flavonoids인 naringenin, hesperitin의 함량이 각각 약 10과 6배 증가함을 확인하였다. L. lactis W-44를 이용하여 발효된 감귤발효액을 양식넙치의 사료첨가제로 투여한 결과, 감귤발효액을 투여하지 않은 대조구의 평균 전장 및 체중 증가율과 현격한 차이가 있었다. 또한 0.2% (v/v)의 감귤발효액을 투여한 실험군에서 넙치의 성장이 가장 우수한 것으로 나타났다. 이러한 결과로부터 젖산균의 감귤발효산물을 넙치 양식에서 기능성 사료첨가제로 사용할 수 있는 가능성을 확인하였다. We evaluated the use of citrus fruit fermented by lactic acid bacteria, as a feed supplement for flounder (Paralichthys olivaceus) cultivation. For the fermentation, a lactic acid bacterial strain W-44 showing antibacterial activity was isolated from kimchi. From the phylogenetic analysis based on, 16S rDNA sequence, the strain W-44 was identified as Lactococcus lactis. After the fermentation of citrus fruit with L. lactis W-44, the contents of naringenin and hesperetin, bioactive flavonoid aglycones, were increased about ten-fold and six-fold, respectively. The effects of fermented citrus fruit-based feed additives (CFBFA) were tested on the growth of flounder, Paralichthys olivaceus. There were significant differences in average total length and body weight between the experimental and control group. The growth rate of the experimental group fed with the 0.2% CFBFA-supplemented diet was increased 4.5% and 20.9% more than the control group in total length and body weight, respectively. These results suggest that the fermented citrus fruit could be used as a functional feed additive for flounder cultivation.

상황버섯 균사체 추출물의 숙취해소 효과에 관한 연구

김민수,안유진,이재철,박가령,박동수,전남근,이영재,한창훈,Kim, Min-Su,An, Yoo-Jin,Lee, Jae-Chul,Park, Ga-Ryoung,Park, Dong Soo,Jeon, Nam Gen,Lee, Youngjae,Han, Chang-Hoon 대한수의학회 2016 大韓獸醫學會誌 Vol.56 No.4

This study was conducted to evaluate the hangover relieving effect of Sanghwang mushroom mycelium extract (SME). The extract showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging effect in a concentration-dependent manner and high antioxidant capacity ($56.67{\pm}1.77%$) when administered at $120{\mu}g/mL$. In addition, SME significantly increased (p < 0.005) the aldehyde dehydronase (ALDH) activity ($126.03{\pm}9.11%$) when applied at 8 or $16{\mu}L/mL$. A locomotor activity test showed that the alcohol-water treated group showed significantly decreased motor activity at 90 min post-administration. However, the alcohol-SME treated group showed a 20-fold higher motor activity than that observed in the alcohol-water treated group at 90 min post-administration. Blood was harvested from each mouse at 90 min post-administration, and both alcohol and aldehyde concentrations were measured. The alcohol-SME treated group showed significantly lower (p < 0.5) alcohol ($120.13{\pm}12.83{\mu}g/mL$) and aldehyde ($7.26{\pm}1.22{\mu}g/mL$) concentrations than the values observed in the alcohol-water treated group. These results suggest that the hangover relieving effect of SME results from increased ALDH activity, which reduces the aldehyde concentration in the blood.

수종의 광중합기를 이용한 교정용 광중합형 글라스 아이오노머 시멘트의 전단 결합 강도에 관한 연구

김민수,유승훈,김종수,Kim, Min-Soo,You, Seoung-Hoon,Kim, Jong-Soo 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.1

본 연구에서는 세 가지 서로 다른 광원(할로겐 램프 :. Elipar Trilight ; 3M ESPE, Seefeld, Germany, Light Emitting Diode (LED) ; Elipar Freelight2 ; 3M ESPE, Seefeld, Germany, 플라즈마 광 : Flipo ; LOKKI, France)을 사용하여 브라켓과 광원사이의 거리에 따른 광중합형 글라스 아이오노머 시멘트(Fuji ORTHO LC : GC, Japan)의 전단 결합 강도를 알아보고자 하였다. 1. 광중합기에 따른 전단 결합 강도는 광중합기로부터 브라켓까지의 거리가 0mm일 때 3가지 광원에 유의할 만한 차이는 보이지 않았고 광중합기로부터 브라켓까지의 거리가 3mm, 6mm일 때, 할로겐 광과 플라즈마 광 사이에는 유의할 만한 차이가 없었으나 LED 광은 유의성 있게 낮은 전단 결합 강도를 나타냈다. 2. 할로겐 광과 플라즈마 광으로 광중합시 거리에 따른 전단 결합 강도에 유의한 차 없었고 LED광을 사용하여 광중합시에는 거리가 증가할수록 전단 결합 강도가 감소하였다. 특히 0mm에서 3mm로 거리가 증가시 유의할 만한 감소를 나타내었다. The purpose of this study was to assess the effect of light-tip distance on the shear bond strength of a visible light-cured glass ionomer cement(Fuji Ortho LC ; GC, Japan) cured with three different light curing units : a halogen light(Elipar Trilight ; 3M ESPE, Seefeld, Germany), a Light Emitting Diode (LED, Elipar Freelight2 ; 3M ESPE, Seefeld, Germany) and a plasma arc light (Flipo ; LOKKI, France). 1. When used at a distance of 0mm from the bracket, the three light curing units showed no statistically different shear bond strengths. At distance of 3 and 6mm, no significant differences were found between the halogen and plasma arc lights, but both had significantly higher shear bond strengths than the LED light. 2. The halogen light and plasma arc light showed that no significant differences in bond strength were found among the three distances. Using the LED light, a greater light-tip distance produced significantly lower shear bond strengths.

매개변수 종속 최적화에서 최대치형 목적함수 처리에 관한 연구

김민수,최동훈,Kim, Min-Soo,Choi, Dong-Hoon 대한기계학회 1997 大韓機械學會論文集A Vol.21 No.10

This study explores the treatment of the max-value cost function over a parameter interval in parametric optimization. To avoid the computational burden of the transformation treatment using an artificial variable, a direct treatment of the original max-value cost function is proposed. It is theoretically shown that the transformation treatment results in demanding an additional equality constraint of dual variables as a part of the Kuhn-Tucker necessary conditions. Also, it is demonstrated that the usability and feasibility conditions on the search direction of the transformation treatment retard convergence rate. To investigate numerical performances of both treatments, typical optimization algorithms in ADS are employed to solve a min-max steady-state response optimization. All the algorithm tested reveal that the suggested direct treatment is more efficient and stable than the transformation treatment. Also, the better performing of the direct treatment over the transformation treatment is clearly shown by constrasting the convergence paths in the design space of the sample problem. Six min-max transient response optimization problems are also solved by using both treatments, and the comparisons of the results confirm that the performances of the direct treatment is better than those of the tranformation treatment.

부산지역 파킨슨병 재활서비스의 현황 및 분석

김민수,허준호,정대윤,김민지,김도연,전호현,김경민,박수빈,김희영,Kim, Min-Soo,Heo, Jun-Ho,Jung, Dae-Youn,Kim, Min-Ji,Kim, Do-Yeon,Jeon, Ho-Hyeon,Kim, Kyung-Min,Park, Su-Bin,Kim, Hee-Young 대한고유수용성신경근촉진법학회 2020 PNF and Movement Vol.18 No.1

Purpose: This study aimed to investigate the current and future status of Parkinson's disease rehabilitation service in Busan. Methods: A literature search of domestic journals was conducted using the keywords "Parkinson's", "exercise", "rehabilitation", and "physical therapy". The chosen databases were Research Information Sharing Service (RISS), e-articles, and Korean studies Information Service System (KISS). International literature was searched in PubMed, Pedro, DOI, Publisher, CINAHL (EBSCOhost), and PsycINFO using the same combination of keywords. Results: The results of this study showed that 33 medical institutions provide Parkinson's disease rehabilitation service and five do not. Regarding the composition of Parkinson's disease rehabilitation teams, 15 medical institutions provide physical therapy, occupational therapy, and speech therapy as their rehabilitation program, 15 medical institutions provide physical therapy and occupational therapy, and three provide only physical therapy. The study found that muscle-strengthening, flexibility, endurance, and balance exercises were commonly provided in all 33 medical institutions for Parkinson's disease. Additional exercises were provided in only three medical institutions. The frequency was five times a week in 20 medical institutions. Conclusion: Medical institutions located in Busan provide a variety of Parkinson's disease rehabilitation services, not only in general hospitals but also in multiple medical institutions, although the composition of their Parkinson's disease rehabilitation teams and the frequency of treatment vary.

인쇄체 문자 인식기의 성능 평가에 관한 연구

김민수,강은영,김우성,한선화,김진형,Kim, Min-Soo,Kang, Eun-Young,Kim, Eun-Young,Han, Sun-Hwa,Kim, Jin-Hyung 한국정보처리학회 2000 정보처리논문지 Vol.7 No.11

본 논문에서는 국내의 대표적인 상용인식기들의 성능을 평가하기 위한 평가 방법과 평가 기준을 제안한다. 제안한 평가 기준으로 상용화된 오프라인 문자인식기들과 실험실 인식기를 비교해본 후 각각의 특성을 분석해 보았다. 인식에 필요한 대상 문서는 400 DPI로 스캔한 1000여개의 문서영상과 수작업으로 작성한 원문이 존재하는 KT 테스트 컬렉션을 사용하였다. 본 논문에서 인식기의 성능을 평가하기 위해 문자단위 인식률 측정 방법을 제안하였다. 비교를 위한 문서의 유형을 제안하여, 단일 특성을 가지는 문서, 복합 특성을 가지는 문서 등으로 비교·분석하였다. In this paper we propose measure for performance evaluationof character recognition, We used three commercial character recognizers and one laboratory character recognizer for test. The characteristics of each recognizer is compared by proposed evaluation standrd, and analyzed characteristrics For the input test data, KT test collection are used. KT test collection is composed of 1000 document images about and complete source text. In this paper we propose method for measuring recognition rage in character unit for evaluation of character recogrition, The recogrition rates are compared and analyzed by single feature characteristic or mixed feature characteristic.

스핀코팅 방법으로 제작된 ZnO 나노 섬유질 박막의 전구체 농도에 따른 표면 및 광학적 특성

김민수,김군식,임광국,조민영,전수민,최현영,이동율,김진수,김종수,이주인,임재영,Kim, Min-Su,Kim, Ghun-Sik,Yim, Kwang-Gug,Cho, Min-Young,Jeon, Su-Min,Choi, Hyun-Young,Lee, Dong-Yul,Kim, Jin-Soo,Kim, Jong-Su,Lee, Joo-In,Leem, Jae-Young 한국진공학회 2010 Applied Science and Convergence Technology Vol.19 No.6

ZnO nano-fibrous thin films with various precursor concentrations ranging from 0.2 to 1.0 mol (M) were grown by spin-coating method and effects of the precursor concentration on surface and optical properties of the ZnO nano-ribrous thin films were investigated by using scanning electron microscopy (SEM) and photoluminescence (PL). ZnO nuclei were formed at the precursor concentration below 0.4 M and the ZnO nano-fibrous thin films were grown at the precursor concentration above 0.6 M. Further increase in the precursor concentration, the thickness of the ZnO nano-fibrous thin films is gradually increased. The intensity and the full-width at half-maximum (FWHM) of the near-band-edge emission (NBE) is increased as the precursor concentration is increased. The deep-level emission (DLE) is red-shifted as the precursor concentration is increased. 스핀코팅 방법을 이용하여 다양한 농도의 전구체로 ZnO 나노 섬유질 박막(ZnO nano-fibrous thin films)을 성장하였고, 그에 따른 표면 및 광학적 특성 변화를 scanning electron microscopy (SEM)와 photoluminescence (PL)을 이용하여 측정하였다. 전구체 농도가 0.4 mol (M) 이하 일 때는 성장률이 낮아 ZnO 핵생성만이 되었고, 0.6 M 이상일 때 ZnO 박막은 나노섬유질 구조가 되었다. 전구체 농도가 더욱 증가함에 따라 ZnO 나노 섬유질의 굵기가 굵어졌고 ZnO 박막의 두께도 단계적으로 두꺼워졌다. 전구체 농도가 증가함에 따라 ZnO 나노 섬유질 박막의 photoluminescence (PL)의 근밴드가장자리 광방출(near-band-edge emission) 피크 세기와 full-width at half-maximu (FWHM)이 증가하였고, 깊은 준위 광방출(deep-level mission) 피크는 적색편이(red-shift)하였다.

피부 병변에 대한 VMAT 치료 시 열가소성 bolus의 유용성 평가: case review

김민수,김주호,신현경,조민석,박가연,Kim, Min Soo,Kim, Joo Ho,Shin, Hyun Kyung,Cho, Min Seok,Park, Ga Yeon 대한방사선치료학회 2020 대한방사선치료학회지 Vol.32 No.-

목 적: 열가소성(thermoplastic) bolus가 가지는 이점을 알아보고자 이를 사용하여 치료한 두 건의 case를 선량과 위치 재현성 측면으로 나누어 피부 병변 VMAT 치료에서의 열가소성 bolus의 유용성을 평가하였다. 대상 및 방법: 좌측 유방 피부 병변 치료 환자 두 명을 대상으로 열가소성 Bolus를 사용하여 simulation 하였고 2 arc VMAT으로 계획하였다. 각 치료 계획은 처방선량(Prescription dose)이 표적 체적의 95% 이상 조사되도록 설계하였다. CBCT(Cone Beam CT) 영상에서 air gap의 길이를 측정하여 bolus 위치의 재현성을 평가하였다. 선량의 재현성을 평가하기 위해 Plan에서의 선량 분포와 CBCT에서의 선량 분포를 비교하였고 환자 2에 대해 in vivo 측정을 하였다. 결 과: 환자 1의 치료계획용 CT에서의 air gap과 CBCT image에서 10회 치료 동안 생긴 평균 air gap(M1)의 차이는 -0.42±1.24mm였다. 환자 2에서 14회 치료 동안 생긴 skin과 bolus 사이의 평균 air gap(M2)과 치료계획용 CT의 air gap의 차이는 -1.08±1.3mm, 두 bolus 사이의 air gap(M3)과의 차이는 0.49±1.16으로 나타났다. 치료계획용 CT와 CBCT의 선량 분포 차이는 환자 1에서 PTV1 D95가 -1.38%, Skin(max)가 0.39%의 차이를 보였고 환자 2에서 PTV1 D95가 0.63%, SKIN(max)가 -0.53%의 차이를 나타내었다. in vivo 측정 결과 계획된 선량과 -1.47% 차이를 보였다. 결 론: 열가소성 Bolus는 3D printer로 제작한 것과 비교하여 제작 과정이 단순하고 소요 시간이 길지 않으며, set up 측면에서 재현성 있는 결과를 보였고 선량 측면에서도 안정적인 결과를 나타내어 불규칙한 표면의 피부 병변 치료에서 그 유용성이 높은 것으로 사료된다. Purpose: To find out the advantages of thermoplastic bolus compared to conventional bolus, which is mainly used in clinical practice, We evaluated Two cases in terms of dose and location reproducibility to assess Usability of thermoplastic Bolus for skin VMAT radiotherapy. Materials and Methods: Two patient's treated with left breast skin lesion were simulated using thermoplastic Bolus and planned with 2arc VMAT. the prescription dose was irradiated to 95% or more of the target volume. We evaluated The reproducibility of the bolus position by measuring the length of the air gap in the CBCT (Cone Beam CT) image. to evaluate dose reproducibility, we compared The dose distribution in the plan and CBCT and measured in vivo for patient 2. Results: The difference between the air gap in patient 1's simulation CT and the mean air gap (M1) during 10 treatments in the CBCT image was -0.42±1.24mm. In patient 2, the difference between the average air gap between the skin and the bolus (M2) during 14 treatments was -1.08±1.3mm, and the air gap between the bolus (M3) was 0.49±1.16. The difference in the dose distribution between Plan CT and CBCT was -1.38% for PTV1 D95 and 0.39% for SKIN (max) in patient 1. In patient 2, PTV1 D95 showed a difference of 0.63% and SKIN (max) -0.53%. The in vivo measurement showed a difference of -1.47% from the planned dose. Conclusion: thermoplastic Bolus is simpler and takes less time to manufacture compared to those produced by 3D printer. Also compared to conventional bolus, it has high reproducibility in the set-up side and stable results in terms of dose delivery.