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김문진,김은종,박수남,Kim, Moon Jin,Kim, Eun Jong,Park, Soo Nam 한국응용과학기술학회 2014 한국응용과학기술학회지 Vol.31 No.4
니아울리 잎 추출물의 항산화 효능과 성분 분석에 관한 연구를 시행하였다. 실험에 사용한 시료는 건조된 니아울리 잎의 50% 에탄올 추출물, 에틸아세테이트 분획 및 아글리콘 분획을 이용하였다. 자유라디칼(1,1-phenyl-2-picrylhydrazyl, DPPH) 소거활성($FSC_{50}$)은 에틸아세테이트 분획이 $10.05{\mu}g/mL$로, 지용성 항산화제로 알려진 (+)-${\alpha}$-tocopherol ($8.89{\mu}g/mL$)과 유사한 효과를 나타내었다. 루미놀 발광법을 이용한 $Fe^{3+}-EDTA/H_2O_2$ 계에서 생성된 활성산소종(reactive oxygen species, ROS)에 대한 니아울리 잎 추출물의 총 항산화능($OSC_{50}$)에서 에틸아세테이트 분획은 $1.61{\mu}g/mL$, 아글리콘 분획은 $1.07{\mu}g/mL$를 나타냈다. 에틸아세테이트 분획과 아글리콘 분획 모두 항산화 활성이 매우 큰 비교 물질인 L-ascorbic acid ($1.50{\mu}g/mL$)와 비슷한 활성산소 소거활성을 나타내었다. Rose-bengal로 광증감된 $^1O_2$에 의한 세포손상에 대한 세포보호능 측정에서 추출물 및 분획 모두 농도 의존적($5{\sim}50{\mu}g/mL$)으로 세포보호 활성을 나타내었다. 특히 아글리콘 분획과 50% 에탄올 추출물의 ${\tau}_{50}$은 $10{\mu}g/mL$에서 각각 158.80 min, 50.1 min으로 지용성 항산화제로 알려진 (+)-${\alpha}$-tocopherol (38.0 min)보다 더 큰 세포 보호 효과를 나타내었다. TLC와 HPLC를 이용하여 니아울리 잎 추출물의 에틸아세테이트 분획으로부터 avicularin과 quercitrin이 존재함을 처음 확인하였다. 이상의 결과들은 니아울리 잎 추출물 또는 분획이 항산화 원료로서 화장품에 응용 가능함을 시사한다. The antioxidative effects and component analysis of the Melaleuca quinquenervia leaf extracts were investigated. All experiments were performed with 50% ethanol extract, ethyl acetate fraction and aglycone fraction obtained from dried M. quinquenervia leaves. The DPPH (1,1-phenyl-2-picrylhydrazyl) scavenging activity ($FSC_{50}$) of ethyl acetate fraction ($10.05{\mu}g/mL$) of M. quinquenervia leaf extracts was similar to (+)-${\alpha}$-tocopherol($8.89{\mu}g/mL$) known as a typical antioxidant. Reactive oxygen species (ROS) scavenging activities ($OSC_{50}$) of the ethyl acetate fraction ($1.61{\mu}g/mL$) and aglycone fraction ($1.07{\mu}g/mL$) of leaf extracts of M. quinquenervia on ROS generated in $Fe^{3+}-EDTA/H_2O_2$ system using the luminol-dependent chemiluminescence assay were similar to that of L-ascorbic acid ($1.50{\mu}g/mL$). The cellular protective effect of the extracts on the rose bengal sensitized photohemolysis of human erythrocytes was increased in a concentration dependant manner ($1{\sim}50{\mu}g/mL$). Especially, the cellular protective effects of Aglycone fraction (${\tau}_{50}=158.80min$) and 50% Ethanol extract (${\tau}_{50}=50.1{\pm}0.2min$) on the $^1O_2$-induced cellular damage of human cells were exhibited the higher than (+)-${\alpha}$-tocopherol (${\tau}_{50}=38.0min$). TLC and HPLC were used to analyse active components in the ethylacetate fraction of the extracts. Results showed that avicularin and quercetrin were active components of the extracts. These findings suggest that the M. quinquenervia leaf extracts can be applied to new cosmetics products as an effective antioxidant ingradient.
극소 저출생 체중아에서 SMOFlipid의 투여가 미숙아 질환 예방에 미치는 영향: Cholestasis 예방 중심으로
김문진 ( Moon Jin Kim ),배혜정 ( Hye Jung Bae ),조윤숙 ( Yoon Sook Cho ),김귀숙 ( Kwi Suk Kim ),김향숙 ( Hyang Suk Kim ),이혜숙 ( Hye Suk Lee ),이주영 ( Ju Young Lee ),김이경 ( Ee Kyung Kim ),김한석 ( Han Suk Kim ) 한국정맥경장영양학회 2013 한국정맥경장영양학회지 Vol.5 No.2
Purpose: Very low birth weight infants (VLBWI) are found to have a higher incidence of cholestasis due to long-term total parenteral nutrition (TPN). Although there have been some studies on relationships between omega-3 fatty acids and reduced incidence of cholestasis, the advantages that the fatty acids provide for premature infant diseases have not yet been fully understood. The aim of this study was to evaluate the advantages of SMOFlipid, a lipid emulsion product that contains omega-3 over other lipid emulsion products that do not. Methods: The medical records of 182 newborn (127 boys and 55 girls) were reviewed retrospectively between April 2010 and August 2012. These infants were born with a birth weight of <1,500 g and administered either of lipid emulsions (Intra MCT 20% or SMOFlipid) from birth to a full-feeding condition at our neonatal intensive care unit. Cholestasis is defined as serum direct bilirubin (DB) >1.0 mg/dL when total bilirubin (TB) is <5 mg/dL or DB/TB ratio is >20% when TB >5 mg/dL. Results: The incidence of cholestasis was found to be lower in the SMOFlipid group than in the medium-chain triglyceride/long chain triglyceride (MCT/LCT) group (7.3% [4/55] versus 18.9% [24/127], P=0.046). At the start of lipid emulsion administration (day 0), the baseline bilirubin level showed no significant difference between the two groups. However, the maximum value of DB on days 7∼ 14 was lower in the SMOFlipid group than in the MCT/ LCT group (0.8 [0.3∼2.2] versus 1.1 [0.3∼2.8] mg/dL, P= 0.030). The DB/TB ratio was also lower in the SMOFlipid group than in the MCT/LCT group (10.2% [4.9%∼40.0%] versus 24.1% [5.1%∼62.5%], P=0.002). Conclusion: This study concluded that SMOFlipid was effective in the prevention of cholestasis in VLBWI. Therefore, omega-3-containing lipid emulsion can be highly recommended in premature babies, especially in VLBWI who require TPN support. (JKSPEN 2013;5(2):67-75)
증례 : 알레르기 ; Visipaque(R) 조영제 사용 후 발생한 후기 부작용 1예
김차영 ( Cha Young Kim ),김희진 ( Hee Jin Kim ),김문진 ( Moon Jin Kim ),강여진 ( Yeo Jin Kang ),김현정 ( Hyun Jung Kim ),장세호 ( Se Ho Chang ),박동준 ( Dong Jun Park ) 대한내과학회 2011 대한내과학회지 Vol.81 No.1
저자들은 신 증후군 환자에서 Visipaque(R) 사용 후 발생한 후기 지연 부작용을 경험하였고, 이를 문헌고찰과 함께 보고 하는 바이다. Late adverse reactions to iodinated contrast medium are defined as reactions occurring 1 hour to 1 week after contrast medium injection. The majority of late adverse reactions are cutaneous reactions, and include itching, maculopapular rash, urticaria, erythematous patches, and angioedema. We report a patient with an iodixanol (Visipaque(R))-induced late adverse reaction. She was admitted for evaluation of nephrotic range proteinuria and edema. Abdomen and chest enhanced computed tomography was performed as a malignancy work-up. Sixteen hours after radiocontrast exposure, her entire body felt itchy. A maculopapular rash was first detected on her back and abdomen 24 hours after exposure, and spread over her entire body, including her face. Her skin lesions resolved completely in 5 days after administering steroid and antihistamine. We should consider late adverse reactions of iodinated contrast medium when we detect skin lesions late after radiocontrast use. (Korean J Med 2011;81:130-134)
한국연안의 푸른바다거북(Chelonia mydas ) 인공위성표지방류
문대연 ( Dae Yeon Moon ),안용락 ( Yong Rock An ),정민민 ( Min Min Jung ),김삼연 ( Sam Yeon Kim ),최석관 ( Seok Kwon Choi ),이해영 ( Hae Young Lee ),유준택 ( Jun Taek Yoo ),김문진 ( Moon Jin Kim ) 한국수산과학회(구 한국수산학회) 2011 한국수산과학회지 Vol.44 No.6
To investigate the distribution and migrations of sea turtles occurring in Korean waters, an adult female green sea turtle Chelonia mydas was tagged with a satellite transmitter and released at Busan in October 2009. The confirmation was made for the first time that the released green sea turtle migrated back to Korea after visiting Jeju Island and Japan for approximately 9 months. The green sea turtle spent the winter in Jeju and Japan because of low water temperatures in the East Sea and South Sea during winter months, which were not suitable for turtle survival. Compared with an immature green sea turtle that was released at Jeju Island, the adult green showed a markedly different migration pattern, suggesting that juvenile and adult greens move differently because of their peculiar life cycle and their stage of maturity, in addition to responses to temperature changes. Additional satellite tracking with increased representation of species, sexes and sizes of turtles, and regions is required to gather information on the distribution and movements of sea turtles in Korean waters.
쿼세틴과 루틴을 담지한 양이온 리포좀의 특성조사 및 UVA에 대한 세포 보호 효과
구현아 ( Hyun A Gu ),김문진 ( Moon Jin Kim ),김해수 ( Hae Soo Kim ),하지훈 ( Ji Hoon Ha ),유은령 ( Eun Ryung Yu ),박수남 ( Soo Nam Park ) 한국공업화학회 2015 공업화학 Vol.26 No.2
Quercetin and its glycoside, rutin, are flavonoids, which are well known as natural antioxidants. In this study, cationic liposomes loaded with flavonoids (quercetin or rutin) were investigated for their effects on cell and skin permeability, and protective effects against UVA. The particle size of the empty cationic liposomes was in the range of 100∼130 nm, and the zeta potential was + 33.05 mV. The entrapment efficiency of 0.5R/CL was higher than that of 0.5 Q/CL. The cellular uptake of the cationic liposomes was five-fold higher than that of liposomes. The skin permeability of quercetin and rutin was investigated using Franz diffusion cells. Compared to the initial loading dose, the amount of quercetin or rutin delivered to the skin by cationic liposomes was higher than that delivered by conventional liposomes or phosphate-buffered saline. From the protective effect of cationic liposomes against UVA (25 J/cm2), we found that the cell viability in cationic liposomes containing flavonoids was higher than that of using UVA irradiation only. These results indicate that cationic liposomes provide enhanced delivery of flavonoids (quercetin and rutin) into the skin and may be used for antiaging and antioxidant cosmetics.
구현아 ( Hyun A Gu ),김해수 ( Hae Soo Kim ),김문진 ( Moon Jin Kim ),유은령 ( Eun Ryeong Yu ),조기정 ( Gi Jung Joe ),장진동 ( Jin Dong Jang ),김보현 ( Bo Hyeon Kim ),박수남 ( Soo Nam Park ) 한국공업화학회 2013 공업화학 Vol.24 No.6
In this study, ethosomes loaded with Eucommia ulmoides extracts that have anti-inflammatory and anti-aging activities on the skin were prepared as cosmetic materials. The particle size, physical property, and entrapment efficiency of ethosomes to identify their stabilities during 4 weeks were measured. Ethosomes containing 0.01∼0.05% E. ulmoides extracts did not show either precipitation or separation. The mean particle size of these ethosomes was 136.4 nm, and monodisperse. The particle size of ethosome containing 0.05% E. ulmoides extracts was 151.15 nm and the entrapment efficiency was 81.79%. Therefore, in vitro skin permeation experiment was performed with ethosome containing 0.05% E. ulmoides extracts that showed the high loading efficiency and stability during 4 weeks. The order of skin permeation of E. ulmoides extracts was ethosome (77.16%) > liposome (62.80%) > ethanolic solutoin (41.59%). These results suggest that ethosomes containing 0.05% E. ulmoides extracts are effective for the skin permeation and may be used as a cosmetic formulation containing plant extracts.
수온 및 광조건에 따른 대왕바리 Epinephelus lanceolatus의 산소소비 특성
정민환 ( Min Hwan Jeong ),김상덕 ( Sang Duck Kim ),임한규 ( Han Kyu Lim ),김문진 ( Moon Jin Kim ),김봉석 ( Bong Seok Kim ) 한국어류학회 2014 韓國魚類學會誌 Vol.26 No.4
본 연구에서는 수온 및 광조건에 따른 대왕바리 Epinephelus lanceolatus의 산소소비 특성을 조사하였다. 수온 17, 22,27 및 32.C에서 대왕바리의 산소소비량은 각각 61.7±0.4,72.2±0.6, 102.9±0.8 및 141.7±1.0 mg O2/kg/h으로 수온상승과 비례하여 증가하였다. 광조건은 명기 (06:00~18:00h)와 암기(18:00~06:00 h)는 각각 12시간씩 주었으며, 수온 17.C에서 명기와 암기의 산소소비량은 각각 62.7±0.4,62.5±0.3 mg O2/kg/h로 유의한 차이를 보이지 않았다(P¤0.05). 수온 22.C에서 명기와 암기의 산소소비량은 각각74.8±0.7, 69.6±0.6 mg O2/kg/h, 수온 27.C에서는 107±1.2, 98.0±0.7 mg O2/kg/h, 그리고 수온 32.C에서는 147.6±1.1, 135.8±0.8 mg O2/kg/h로 암기보다 명기에 산소소비가 많은 경향을 보였다. This study investigated the effe℃ts of water temperature and photoperiod on oxygen ℃onsumption (O℃) in the giant grouper Epinephelus lan℃eolatus. O℃ rate in the giant grouper at 17, 22, 27 and 32℃ were 61.7±0.4, 72.2±0.6, 102.9±0.8 and 141.7±1.0 mg O2/kg/h, respe℃tively, indi℃ating a linear in℃rease in O℃ with water temperature. Photoperiod was regulated in a℃℃ordan℃e with the light (06:00~18:00 h, L) and dark (18:00~06:00 h, D) phases of the diel ℃y℃le (12L/12D), with a water temperature of at 17, 22, 27 and 32℃. O℃ rates during the light and dark phases were 62.7±0.4, 62.5 ±0.3 mg O2/kg/h, respe℃tively, at 17℃. No signifi℃ant differen℃es were observed between the light and dark phases (P¤0.05). O℃ raters during the light and dark phases were 74.8±0.7, 69.6±0.6 mg O2/kg/h at 22℃, 107±1.2, 98.0±0.7 mg O2/kg/h at 27℃ and 147.6±1.1, 135.8±0.8 mg O2/kg/h at 32℃, respe℃tively, indi℃ating that O℃ is higher during daylight than nighttime. Giant grouper is thought to be a diurnal fish spe℃ies, be℃ause the level of oxygen ℃onsumption during light period was higher than that during dark period.