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젊은 여자에서 발병한 간질성 신염 포도막염 증후군 1예
김수민 ( Soo Min Kim ),송재욱 ( Jae Uk Song ),최이령 ( E Ryoung Choi ),최희정 ( Hee Joung Choi ),이정은 ( Jung Eun Lee ),권기영 ( Ghee Young Kwon ),허우성 ( Woo Seong Huh ),김윤구 ( Yoon Goo Kim ),김대중 ( Dae Joong Kim ),오하영 ( 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.5
We report a case of adult-onset tubulointerstitial nephritis and uveitis syndrome with Fanconi syndrome. A 31-year-woman presented with fever, anorexia, nausea, general weakness and weight loss for two months. Her initial laboratory findings showed anemia, high serum creatinine, hypouricemia, hypophosphatemia, hypokalemia, glucosuria, and proteinuria. She was diagnosed as having acute tubulointerstitial nephritis by renal biopsy. The etiology of tubulointerstitial nephritis was unclear. She was treated with systemic corticosteroid. Six months later and while the patient was still on systemic corticosteroid (Deflazacort 36 mg), bilateral uveitis developed. Renal function was recovered by systemic corticosteroid and mycophenolic acid. But ocular symptoms relapsed twice despite systemic corticosteroid treatment. The ocular symptoms improved after topical ophthalmic steroid drops and injection. Tubulointerstitial nephritis and uveitis syndrome should be considered in the differential diagnosis of the unexplained tubulointerstitial nephritis. And the need of the steroid treatment also should be considered in the case of adult-onset.
한국산 발아 벼 추출물의 여러 가지 암세포주에 대한 증식 억제 효과 비교
김현영(Hyun Young Kim),황인국(In Guk Hwang),정은미(Eun Mi Joung),김태명(Tae Myoung Kim),김대중(Dae Joong Kim),박동식(Dong Sik Park),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.3
한국산 벼 6종(일품벼, 백진주벼, 설갱벼, 고아미2호, 거대배아벼 및 흑광벼)의 발아 및 무발아 에탄올 추출물에 대한 암세포주 증식 억제효과를 위암세포주(MKN45), 대장암세포(HCT116) 및 폐암세포(NCI-H460)에 대하여 살펴 본 결과 일부 품종의 경우 발아 후에 1 ㎎/mL 농도에서 암세포증식 억제효과가 증가하였다. 대장암세포주에 대한 성장억제 효과가 가장 좋았던 품종은 흑광벼로 발아 에탄올 추출물 18.89%의 생존율을 보였으며, 폐암세포주에 대해서는 일품, 고아미2호, 백진주 및 설갱벼 발아 에탄올 추출물은 5~10%의 생존율을 보였다. 위암세포에 대해서는 일품, 고아미2호, 백진주 및 설갱벼에 대하여 5~10%의 생존율을 보여 대조군에 비해 암세포주 증식 억제효과가 있는 것으로 나타났다. 본 연구결과 벼를 발아시킬 경우 항암활성이 증가함을 알 수 있었으며, 발아 후 벼의 성분분석 및 추후 항암실험의 다양한 지표를 활용하여 항암활성을 입증하는 연구가 수행 되어야 할 것으로 판단된다. This study was conducted to investigate the effects of 70% ethanol extracts of various germinated-rough rice cultivars: (‘Ilpum’, ‘Goami2’, ‘Keunnun’, ‘Sulgaeng’, ‘Baegjinju’, and ‘Heugkwang’) on proliferation of human cancer cell lines (MKN-45, HCT116 and NCI-H460). Antiproliferation effects of rough rice on different cancer cell lines were higher in after germination than before germination. The viability of HCT-116 colon cancer cells was lowest at 18.89% in after germination of ‘Heugkwang’ at 1.0 ㎎/mL. The cell viability of MKN-45lung cancer cells and MKN-45 stomach cancer cells were in the range of 5~10% in after germination of ‘Ilpum’, ‘Goami2’, ‘Baegjinju’, and ‘Sulgaeng’, and ‘Heugkwang’ at 1.0 mg/mL. These results suggest that germinated rough rice might have a potential preventive effect on human cancer cells.
고속 종합 검측 시스템 도시철도 적용시 시스템 전원 공급 방안 연구
정연포(Yeon-Po Jung),김진영(Jin-Young Kim),송동호(Dong-Ho Song),김대중(Dae-Joung Kim),강주희(Ju-Hee Kang),유근규(Kun-Kyu Yo),강봉완(Bong-Wan Kang) 한국철도학회 2016 한국철도학회 학술발표대회논문집 Vol.2016 No.5
철도의 안전한 승객 수송을 위해 전차선, 궤도, 신호분야 등 각 시설물들을 확인하기 위해 중요한 시설물은 검측차를 사용해 정기적으로 검사하고 있다. 국내 검측차는 100% 외산으로 고장시 장기간 운행중단 및 고가의 부품으로 유지보수에 애로사항이 많아왔다. 본 논문에서는 현재 국가 R&D 과제로 수행중인 고속 종합 검측 시스템의 도시철도 적용을 위한 시스템 부하 사용량 및 도시철도 차량 전원공급 여유도를 검토하여 고속 검측 시스템 탑재시 원활하고 최적화된 시스템 전원공급 방안을 제시하고자 한다. The company conducts regularly inspection for the safe transport of passengers such as catenary, track and signal sector in the railway company. Measuring and inspection vehicles imported 100% remain difficult maintenance in KOREA due to the fact that the vehicle was operating stop for a long time because of heavy broken and expensive components. In this paper, we propose power supply way of urban railway when equipped with high-speed inspection system in national R&D project. Furthermore, we researched the optimized power supply of the system due to the fact that we reviewed for load usage of measuring and inspection system and urban rail vehicle power supply margin.
위부분절제술 후 발생하는 담도 확장 및 담석증의 임상적 의의
정석 ( Seok Jeong ),윤해리 ( Ha Rry Yoon ),권창일 ( Chang Il Kwon ),이태훈 ( Tae Hoon Lee ),한정호 ( Joung Ho Han ),송태준 ( Tae Jun Song ),황재철 ( Jae Chul Hwang ),김대중 ( Dae Jung Kim ) 대한소화기학회 2015 대한소화기학회지 Vol.66 No.1
Background/Aims: The well-organized study to support that increased cholelithiasis and bile duct dilatation can occur after gastrectomy has not been reported. The aim of this study was to determine the incidence of cholelithiasis and the degree of common bile duct (CBD) dilatation in patients undergoing subtotal gastrectomy, compared to those undergoing endoscopic treatment for gastric cancer. Methods: Patients who diagnosed with gastric cancer and received treatment at six academic referral centers were investigated for the incidence and time of cholelithiasis and the degree of CBD dilatation after treatment by analysis of 5-year follow-up CTs. The operation group underwent subtotal gastrectomy without vagotomy, while in the control group endoscopic treatmentwas administered for gastric cancer. Results: A total of 802 patients were enrolled in 5-year analysis (735 patients in the operation group and 67 patients in the control group). Cholelithiasis occurred in 47 patients (6.39%) in the operation group and 3 patients (4.48%) in the control group (p=0.7909). The incidences of cholelithiasis were 4.28% in Billoth-I and 7.89% in Billoth-II (p=0.0487). The diameter of proximal CBD and distal CBD increased by 1.11 mm and 1.41 mm, respectively, in the operation group, compared to 0.4 mm and 0.38 mm, respectively, in the control group (p<0.05). Patients with increased CBD dilatation more than 5 mm showed statistically significant increases in alkaline phosphatase and gamma-glutamyltransferase. Conclusions: The incidence of cholelithiasis was not increased due to subtotal gastrectomy without vagotomy, but the incidence was higher after Billoth-II compared to Billoth-I. In addition, significant change in the CBD diameter was observed after subtotal gastrectomy. (Korean J Gastroenterol 2015;66:33-40)