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Dae-Kwang Kim(김대광) 대한체질인류학회 2008 해부·생물인류학 (Anat Biol Anthropol) Vol.21 No.4
ABCCII 유전자는 ATP결합 카세트 유전자군의 일종이다. ABCCII 유전자에는 귀에지형을 결정하는 단일염기서열다형성(SNP)이 존재한다. 이 연구의 목적은 귀에지 관련 유전자의 대립유전자의 빈도를 한국인에서 조사하고자 한다. 총 619명의 대상자에서 Dde I 제한효소를 이용하여 제한단편길이다형성 (RFLPs)을 분석하였다. 정상 대조군에서 건성/건성 유전자형이 99%(99/100); 정신분열증의 경우 98.1%(207/211); 유방암의 경우 99%(99/100); 자궁근종의 경우 96%(48/50); 비만인의 경우 98.3%(59/60); 위암의 경우 100%(43/43) 그러고 주위력결핍과다활동장애(ADHD)의 경우 98.2%(54/55)로 나타났다. 습성/습성 유전자형은 나타나지 않았으며, 대조군과 실험군과의 유전자형의 분포에는 유의성이 없었다. 이상의 결과에서 한국인에서 대부분의 경우 건성 귀에지를 가지며, 귀에지를 결정하는 SNP는 한국인에서 나타나는 여러 질병과 병적인 신체 조건의 경우에서 유전적 연관성을 연구하는데 적합하지 않는 것으로 생각된다. The ABCCII gene is a member of the ATP-binding cassette gene family. A single nucleotide polymorphism (SNP) in the ABCCII gene is associated with the determination of human earwax type. The purpose of this research is to evaluate the allelic frequencies of this gene in Korean population samples. A total of 619 individuals were analyzed by Dde I restriction fragment length polymorphisms (RFLPs). The genotype frequency of dry earwax in Koreans was very high. The proportions of dry/dry genotype found were 99%(99/100) in normal controls; 98.1% (207/211) in patients with schizophrenia; 99%(99/100) in patients with breast cancer; 96%(48/50) patients with uterine myoma; 98.3%(59/60) in obesity subjects; 100%(43/43) in patients with stomach cancer, and 98.2%(54/55) in attention deficit hyperactivity disorder (ADHD) patients. The wet/wet genotype was not found. There were no significant differences in the distribution of earwax genotypes between controls and experimental groups. These results suggest that the frequency of dry earwax are very high, and therefore the SNP determining earwax type will not be useful in genetic studies of the process involved in various diseases or pathologic conditions in Korean populations.
김대광 ( Kim Dae-kwang ),현일환 ( Hyun Il-hwan ) 대한운동사협회 2003 대한운동사협회 운동사대회자료집 Vol.2003 No.-
In a society based on knowledge, it is primarily dependent on the level of quality of childhood education to educate students creatively. Although one hundred years has been passed since the education of children in kindergarten began, the policy on childhood education has not been treated seriously at a national level, but changed according to the administrational opportunism and political interests. Educationally advanced countries already established public educational system of childhood education, and has been managing human resource through normal childhood education as early as possible. In spite of that, Korea, is still inferior to educationally advanced nations in many areas of childhood education including public finance, educational system, educational contents, method and so on. Physical education can reduce the national hygienics and social welfare cost and it has high economical worth because of it's high efficiency with low cost. Futhermore, vitality of life with each individuals health and physical fitness is not only the foundation of. individual's potential but also directly related with the soundness of society. Therefor, American and European advanced countries came to regard, physical education and it's infra structure which provide human resources, health and hygienics of people, as the social overhead capital (SOC) since 1990's. Especially, even though the area of child physical education has unlimited possibility of development in it's marketability and industrial aspect it is still paltry for insufficiency of policy, finance, facilities, program, and educators. Today it is needed to produce systematic, professional and future- oriented Educators Under these circumstances, there is only a few mid term and long term plans for the development of child physical education, guide books for child physical educators, programs which reflect characteristics of child physical education and child development. literatures about effect and success of child physical education related with family, kindergarten and community, and researchs about child physical education. As a result, I suggest that much effort should be made to support child physical education at a national level, to lead active participation of citizens by active media campaign and providing various programs, to produce quality physical educators in cooperation of child education and child physical education.