구안와사 환자의 삶의 질에 대한 연구

문효,박민철,홍석훈,윤인환,이동효,이충호,김남권,Moon, Hyo,Park, Min-Cheol,Hong, Seok-Hoon,Youn, In-Hwan,Lee, Dong-Hyo,Lee, Chung-Ho,Kim, Nam-Kwon 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.1

Objective : The face is very important for human communication. So facial palsy patients experience not only physical disturbances but also serious emotional stress. Therefore the focus of treatment must be to not only aid the recovery of objective symptoms but also the improvement of subjective quality of life. However there has not been enough Oriental Medical study in this field until now. Thus this study was begun to suggest a useful index for the treatment of facial palsy. Methods : Grade of paralysis, sequelas, and quality of life were used for evaluation. To evaluate Grade of paralysis, House-Brackman Grade was used as the Gross scale and Kim's Grade was used as the Regional scale. Sequelas were evaluated by muscle contraction, synkinesis, NA, and grade of philtrum tilt. Quality of life was evaluated by SF-36v2, Facial Disability Index, and Vas. Results & Conclusion : 1. The change of grade of paralysis between the early and the present time reveals remarkable improvement statistically. 2. There was a remarkable improvement in all parts of quality of life except several areas of SF-36(RP, RE, MH, VT) 3. In only PF(Physical Function) of FDI, quality of life increased remarkably according to the improvement of grade of paralysis. 4. There is the positive relationship among Kim's grade, HB grade and Synkinesis 2. 5. Synkinesis among sequelas has the greatest effect on quality of life. And muscle contraction, change of NA, and grade of philtrum tilt also affect quality to some extent. 6. There was no remarkable relationship between the period of illness and change of quality of life. 7. Change of NA is shown after 3 months of illness and synkinesis becomes worse after 6 months of illness.

국내 한의학계에 보고된 흑색종 관련 실험적 연구들의 비교 고찰

권강,김남권,김선영,이동진,김철윤,서형식,Kwon, Kang,Kim, Nam-Kwen,Kim, Sung-Young,Lee, Dong-Jin,Kim, Chul-Yun,Seo, Hyung-Sik 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.3

Objective : Melanoma is a very critical and devastating disease. Although many people have depended on surgical operation in melanoma treatment, they have placed importance on non-invasive methods constantly. So we planned to establish a research methodology by analysing existing articles containing conservative melanoma treatments in Journals of Korean Medicine published in Korea.Methods : Using search words of anti-cancer, B16, cancer, lung metastasis, melanoma, metastasis, S-100, SK-MEL, tumor, tyrosinase, we collected 26 articles by searching internet portal sites as following;Using search words of anti-cancer, B16, cancer, lung metastasis, melanoma, metastasis, S-100, SK-MEL, tumor, tyrosinase, we collected 26 articles by searching internet portal sites as following<uri>http://oasis.kiom.re.kr</uri>,<uri>http://www.koreantk.com</uri>,<uri>http://www.riss.kr</uri>,<uri>http://www.dbpia.co.kr</uri>,<uri>http://www.ndsl.kr</uri>,<uri>http://kiss.kstudy.com</uri>,<uri>http://www.naver.com</uri>,<uri>http://www.google.com</uri>.Result : The number of articles is 26 and in the year of 2003, 2004 is ranked the highest number in publication. The journal of acupuncture & moxibustion society ranked the highest(30.8%). 2 and 4 authors ranked the highest(26.9%) in number of authors. T-test ranked the highest(58.1%) in statistics methods. P.O. med indicated in 11 articles and Pharmacopuncture in 15 articles. B16 murine melanoma cell was indicated in 25 articles by cancer-induced methods. In measurement, T cell activity was indicated in 14 articles, NK activity in 4 articles, IL-2 in 6 articles, apoptosis in 1 article, lung metastasis in 14 articles.Conclusion : Considering overall results, it is necessary to diversify cancer-induced methods and measurement methods in experimental melanoma research.

안이비인후과목, 피부외과목의 전공만족 및 전공 몰입경험 척도의 신뢰도와 타당도 연구

김철윤,김남권,권강,서형식,Kim, Chul-Yun,Kim, Nam-Kwen,Kwon, Kang,Seo, Hyung-Sik 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.2

Objective : This Study was conducted in order to develop the Learning Satisfaction (LS)and Learning Flow Scale(LFS) for Korean Medical Ophthalmology & Otolaryngology & Dermatology and to investigate the reliability and validity. Methods : LF and LFS were administered to 44 students and 20 resident physicians . We examined the test-retest reliability, internal consistency and perfomed factor analysis. Result : 1. Test-retest reliability were reliable on LS and LFS for Korean Medical Ophathalmology & Otolaryngology.2. Test-retest reliability were unreliable comparatively on LS and LFS for Korean Medical Dermatology.3. internal consistency were all reliable in LS and LFS Korean Medical Ophthalmology & Otolaryngology & Dermatology.4. factor analysis were reliable only LS of Korean Medical Dermatology. Conclusions : LS and LFS has reliability to measure learning satisfaction and learning flow of Korean Medical students. But there is no evidence about validity of LS and LFS for Korean Medical Ophthalmology & Otolaryngology & Dermatology.

한방안이비인후피부과학회지에 게재된 임상실험연구에 대한 고찰

김철윤,서형식,김남권,이동진,권강,Kim, Chul-Yun,Seo, Hyung-Sik,Kim, Nam-Kwen,Lee, Dong-Jin,Kwon, Kang 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.4

Objective : This study was carried out to analyze the quality and quantity of Clinical Trials that have been published in the journal of korean medical ophthalmology, otolaryngology, dermatology(JKOOD). Methods : We analyzed 25 clinical trials that published in JKOOD from 1988 to 2014. We excluded case reports, protocol and retrospective studies and classified searched papers into three categories; Randomized Clinical Trials(RCT), Non Randomized Clinical Trials(NRCT), Before After Study(BAS) by using study Design Algorithm for Medical literature of Intervention(DMAI). All articles were analyzed according to diagnosis, statistics program and intervention period. The bias of RCTs were evaluated by Cochrane Risk of Bias(RoB). Result : 1. The number of searched journals is 25 papers; 13 RCT, 2 NRCT, 10 BAS 2. Distribution of clinical trial; 'Atopic dermatitis' ranked the highest(44%) in disease, 'External application' raked the highest(71%) in treatment method. 3. 'allocation sequence' and 'prevention of allocated intervent to patients and therapists' are graded 'Low' but 'incomplete outcome date' and 'selective outcome' are graded 'Uncertain'. Conclusions : It is necessary to study more RCT. It will be helpful to study systematic reviews and meta analysis in JKOOD.

고지방식이가 생쥐 지방조직에서의 포도당수송체-2의 유전자 발현에 미치는 영향

김태두 ( Tae Doo Kim ),김남권 ( Nam Kwon Kim ),김진일 ( Jin Il Kim ),이용호 ( Yong Ho Lee ) 대구가톨릭대학교 자연과학연구소 2013 자연과학연구논문집 Vol.11 No.1

포도당흡수의 주요조직 중 하나인 지방조직에서의 포도당수송체 -2 (GLUT2) 의 mRNA 발현 여부를 조사하고 고지방식이, 비만화, 인슐린저항성 및 노령화가 GLUT2 의 발현 양상에 미치는 영 향을 조사하고자 하였다. 4주령부터 일반식이 (ND) 또는 고지방식이 (HFD) 로 16, 26, 36, 47, 77 주령까지 키웠다. 각 그룹당 6~10 마리의 생쥐들이 본 실험에 이용되었으며, 이들 생쥐로부터 혈장과 복부피하지방조직을 적출하여 혈장 인슐린 농도를 ELISA 법으로 측정하였으며 지방조직에서 RNA 를 추출하고 cDNA를 합성 하여 Real Time PCR 롤 포도당수송체 2(GLUT2) 의 mRNA 발현량을 조사하였다, 실험결과 낮은 농도이지만 생쥐의 지방조직에서도 GLUT2 mRNA가 발현되고 있음을 확인하였고 26, 36 및 77주령의 HFD 생쥐 그룹은 비교군인 같은 주령의 ND생쥐 그룹보다 통계적으로 유의하게 높은 GLUT2 mRNA 발현량을 나타내었다. 각 주령의 ND생쥐 그룹간의 GLUT2 mRNA 발현 변화는 나타나지 않았으나, HFD 생쥐 그룹 중에 서 는 77주령의 HFD 생쥐 그룹에 서 가장 높은 GLUT2 mRNA 발현이 나타났으며 다른 HFD 생쥐 그룹이나 모든 ND생쥐 그룹들 보다 유의하게 높은 발현이 확인되었다. 생쥐 그룹들간의 발현의 차이에 영향을 미치는 요인을 분석한 결과 혈장인슐린 농도가 통계적으로 매우 유의하게 연관되어 있음이 확인되었다(p<0.0001). 지방조직에서의 GLUT2 mRNA의 발현과 HFD 생쥐 그룹에서의 증가된 발현 양상은 높아진 혈장 인슐린 농도가 직접적인 요인이며 또한 고지방식이에 의한 비만화가 유도한 인슐린저항성에 의한 낮아진 GLUT4의 포도당 수송 활동을 보상하는 기작으로 추측되며 추가적인 확인이 필요하겠다. The aim of this study was to see whether adipose tissue expresses glucose transporter 2 (GLUT2) and to investigate the effects of long term consumption of a high fat diet (HFD), obesity, and aging on GLUT2 gene expression in mouse adipose tissue. C57BL/6 mice were fed on either normal diet (ND) or HFD after starting at 6 weeks of age. Gene expression levels of GLUT2 and normalizing gene, GAPDH, were examined by real time PCR in subcutaneous abdominal adipose tissue (SubQ) from ND or HFD male mice at 16, 26, 36, 47, and 77 weeks of age. In addition, plasma insulin levels were measured by ELISA. The results demonstrated that GLUT2 mRNA was expressed in mouse adipose tissue with high Ct values in Real Time PCR. Adipose tissue from HFD mice of 26, 36, and 77 weeks of age expressed significantly increased GLUT2 mRNA compared to age matched ND control mice. While GLUT2 mRNA was not changed by aging among ND mice groups, GLUT2 mRNA expression was highest in the HFD mice at 77 weeks of age and significantly higher than all of other HFD or ND mice groups. Plasma insulin levels were very significantly correlated with GLUT2 mRNA expression in SubQ adipose tissue (p<0.0001).Increased expression of adipose tissue GLUT2 in HFD mice was likely directly induced by increased plasma insulin levels and seems to be a compensation for reduced activity of GLUT4 in insulin resistant obese mice induced by HFD consumption, which needs to be elucidated further.

화병환자의 불면증상에 대한 침치료 유효성 평가연구: 환자-평가자 눈가림, 무작위배정, 일반대조군 임상시험

이고은 ( Go Eun Lee ),김남권 ( Nam Kwon Kim ),김향이 ( Hang Yi Kim ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2012 동의신경정신과학회지 Vol.23 No.1

Objectives: The purpose of this research is to examine the effects of acupuncture treatment on Hwa-byung patient`s insomnia. Methods: The study was performed through a patient-assessor blind, randomized, placebo-controlled trial in which the volunteers, data collectors and analysts were unaware of individuals who were receiving the treatment. A total of thirty-seven volunteers were divided into 2 groups. 18 subjects were placed into a trial group and 19 subjects into a control group by a randomization table. The trial group was treated on bilateral Shigu, Ahnmyun, B62 (Shinmaek), and K6 (Chohae), while the control group was not given any other treatment. The ISI(Insomnia Severity Scale) was measured as the 1st evaluative instrument, and then a comparative analysis was conducted by comparing the results with those measured by a Likert scale for major symptoms of Hwa-byung, PSQI, Hwa-byung scale, BDI, STAI, and STAXI. Results: In the ISI, PSQI, and the Likert scale regarding major symptoms of Hwa-byung, Hwa-byung scale, BDI, and STAI, more significant decreases were found in those concerning the trial group compared to those of the control group from a statistical perspective. However, in the STAXI, regarding the trial group, there was no significant decrease compared to the control group. Conclusions: The results suggest that acupuncture treatment is effective in the treatment regarding Hwa-byung patients who suffer from insomnia.

더덕 분획별 抽出液이 멜라닌 生成에 미치는 影響

오한철,홍철희,이수형,황충연,김남권,Oh, Han-Cheol,Hong, Chul-Hee,Lee, Soo-Hyeong,Hwang, Chung-Yeon,Kim, Nam-Kwon 대한한의진단학회 2004 大韓韓醫診斷學會誌 Vol.17 No.2

Melanin pigmentation has an essential role in protecting human skin against the damaging effects of ultra violet radiation, infection, environmental factor, etc. However abnormal melanin pigmentation can directly cause a number of congenital and acquired pigmentary skin disease. This study conducted to evaluate the effects of various partition extracts of Codonopsis lanceolata on the melanogenesis in the B 16 melanoma cells. The cells were treated for 3 days with various partition extracts of Codonopsis lanceolata. While treatment with the BuOH partition extract of Codonopsis lanceolata increased significantly the tyrosinase activity and melanin content, the n-Hexane or ethyl acetate partition extract dose-dependently suppressed them compared with untreated control. But ethyl acetate partition significantly decreased the cell viability. The H2O partiton extract at various concentrations did not exhibit any significant change on the melanogenesis. These results indicate that treatment with the n-Hexane partition extract inhibits the melanogenesis in B16 melanoma cells, and raise the possibility that this extract may be effective in the abnormal melanin pigmentation as well as the whitening agent for the skin.

이드반응이 동반된 족부백선 환자 치험 1례

권강,김철윤,이동진,김남권,서형식,Kwon, Kang,Kim, Chul-Yun,Lee, Dong-Jin,Kim, Nam-Kwen,Seo, Hyung-Sik 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.1

Objective : This study was carried out to find out the effect of Korean medical treatments on tinea pedis with id reaction. Method : We treated a 33-year-old man was afflicted with tinea pedis complicating id reaction with herbal medicine, acupuncture, ointment, wet-dressing and steam treatment. After treatments, we measured the status of scales, fissures and the degree of pruritus. We followed up symptom changes by taking pictures and compared before and after. Result & Conclusion : Three days after admission, erythema occurred at upper and lower limbs and the degree of pruritus increased by id reaction. As tinea pedis improved, id reaction decreased, too. Consequently, both sites of primary lesions of tinea pedis and secondary id reactions were significantly improved, and accompanied symptoms were resolved simultaneously.

Lipopolysaccharide에 의해 유발된 발열에 있어서 升麻의 해열효과

권일호(Il-Ho Kwon),김남권(Nam-Kwon Kim),강학천(Hsueh-Chuan Chiang),임홍진(Hong-Jin Lim),김진만(Jin-Man Kim) 대한한의학회 2002 대한한의학회지 Vol.23 No.4

Behçet 患者의 單球細胞에서 溫淸飮의 cytokine 分泌抑制 효과

임홍진(Hong Jin Lim),황충연(Choong Yeon Hwang),강학천(Hsueh Chuan Chiang),김남권(Nam Kwon Kim),권일호(Il Ho Kwon) 한의병리학회 2002 동의생리병리학회지 Vol.16 No.4