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흰쥐 공여심장 획득후 보존용액에 첨가한 Fructose-1.6-Diphosphate가 이식심장의 심근내 미세구조물에 미치는 영향에 관한 연구
권우석,김형묵 고려대학교 의과대학 1992 고려대 의대 잡지 Vol.29 No.1
A rat heart transplantation model is used in an experimental study whether myocardial protection is enhanced when FDP is added to preservation solution (St. Thomas hospital solution). The effect of cardiac preservation solution on cardiac function and ultra-structure was studied in intraperitoneal heterotopic cardiac transplantation model of Sprague-Dawley rat. Preservation solution was cold (0-4℃) St. Thomas hospital solution. The degree of damage of donor myocardium during preservation was quantified by means of electron-microscopic (EM) examination. In control group (N=10), donor hearts were preserved in cold St. Thomas' hospital solution for 4 hours. In experimental group (N=10), hearts were preserved in cold St. Thomas hospital solution containing FDP for 4 hours prior to transplantation. EM studies of the left ventricle of transplanted heart revealed that Flameng's scores for mitochondria1 damage were significantly lower in experimental group than control (cotrol : 1.82. experimental : 1.16) (p<0.01). Cardiac beating score was not significant (p>0.05). In conclusion, it is suggested that adding FDP to preservation solution improve myocardial protection for transplantation.