한강에서 분리한 장구균의 항생제 내성과 분자생물학적 분석

권오민,김말남,Kwon, Oh-Min,Kim, Mal-Nam 한국미생물학회 2012 미생물학회지 Vol.48 No.2

2008년 3월, 서울의 상수원으로 이용되는 한강에서 분리된 Enterococcus 76주를 동정하고 이 균주들에 대한 항생제 감수성과 항생제 내성유전자 구조분석, 교차접합, PFGE 및 MLST를 실시하였다. 분리 균주 중 E. casseliflavus는 25주이었으며, E. faecalis 및 E. hirae가 각각 4주 및 1주이었다. 항생제 감수성을 조사한 결과 15주가 vancomycin에 대해 내성을 나타내었으며 E. faecium 11주와 E. casseliflavus 4주가 VRE인 것을 알 수 있었다. VRE를 대상으로 vanA 유전자 검출을 통해 6주의 E. faecium가 vanA를 가지는 VREF임을 밝혔으며, vanA가 포함된 transposon인 Tn1546 구조를 분석한 결과 Km36과 Km37은 Tn1 type, Km20과 Km38은 Tn2 type 그리고 Km 39와 Km40은 Tn3 type으로 나타났다. PFGE 결과 6주의 VREF 중 Km36과 Km37은 동일한 subtype을 나타내었으며, 나머지 4주는 각기 다른 subtype을 나타냈다. VREF 6주를 대상으로 MLST를 실시한 결과 3주는 ST78, 나머지 3주는 각각 ST18, ST192 및 ST230로 나타났다. 이들의 clonal complex는 모두 병원에서 분리되는 CC17로부터 파생된 것으로 파악되었으며 4주는 CC78에, 나머지 2주는 각각 CC18과 CC192에 포함된 것을 확인할 수 있었다. Identification was performed in March 2008 for the 76 Enterococcus strains isolated from the Han-river, which is used as water supply for Seoul citizens. The antibiotic susceptibility, antibiotic resistant structural analysis, trans-conjugation, pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST) were also carried out for the isolated strains. Among the isolated strains, 25 strains were E. casseliflavus, 4 strains were E. faecalis and 1 strain was E. hirae. Investigation of antibiotic susceptibility indicated that 15 strains demonstrated tolerance against vancomycin, and that 11 strains of E. faecium and 4 strains of E. casseliflavus were VRE. The vanA gene detection of the VRE strains revealed that 6 E. faecium strains were vancomycin-resistant Enterococcus faecium (VREF) possessing vanA. Analyses of transposon Tn1546 structure containing vanA demonstrated that Km36 and Km37 belonged to Tn1 type, Km20 and Km38 was Tn2 type, and Km39 and Km40 was Tn3 type. PFGE disclosed that among the 6 VREF strains, Km36 and Km37 exhibited equivalent subtype, while the rest 4 strains showed subtypes different to each other. MLST for the 6 VREF strains disclosed that 3 strains were ST78, while the rest 3 strains were ST18, ST192 and ST230, respectively. All these clonal complexes were derived from CC17 which has been isolated from clinical sources. 4 strains belonged to CC78, while the rest 2 strains were CC18 and CC192, respectively.

이규준(李圭晙)의 심기철학(心氣哲學)과 부양론(扶陽論)의 연관성 연구 -"석곡심서(石谷心書)"와 부양론(扶陽論)을 중심으로-

권오민,Kwon, Oh-Min 한국한의학연구원 2004 한국한의학연구원논문집 Vol.10 No.1

This paper is the research on the relationship between Lee Kyujoon(李圭晙)'s Shimqi(心氣) Philosophy and medical theory of Buyang(扶陽). Lee Kyujoon is the philosopher and medical doctor in the late Chosun Dynasty. His philosophical hypothesis is that the cosmos constitutes of the only entity, Qi(氣) and Medically, human body is also made of the only one entity, or Qi. The Qi of the body comes from Shim (心:heart). So, Encouraging the Qi(扶陽) of heart is the most critical in maintaining life. He is favorably used to prescribe the medications full of the herbs boosting the ShimYang(心陽) of body. In conclusion, his Shimqi(心氣) Philosophy and Buyang(扶陽) theory is the twins of one Shimqi(心氣) monism.

일반논문 : 원효교학과 아비달마 -화쟁론을 중심으로

권오민 ( Oh Min Kwon ) 동아시아불교문화학회 2015 동아시아불교문화 Vol.0 No.21

본고는, 원효는 ‘한국사상가’이기에 앞서 불교사상가이며, 아비달마-중관-유식-여래장-천태·화엄 등의 동아시아 性宗과 원효로 이어지는 불교학은 正理(혹은 道理, yukti, nyaya).法性(dharmata)을 궁극의 가치로 삼는다는 점에서 모종의 연속성을 갖는다는 전제 하에 초기불전에서의 ‘滅諍(혹은 止諍, adhikaranasamatha)’과 ‘和合(samagra, samagga)’의 전후사정을 통해 그의 화쟁론을 살펴본 것이다. 초기불전에서의 ‘화합’은 성질이 다른 물과 젖의 화합처럼 異執 異部의 존재를 인정하여 서로 다투지 않는 것으로, 이들은 界(sima)를 달리하여 포살.갈마를 시행함으로써 새로운 개별 승가로 출현할 수 있었다. 원효의 ‘화쟁’ 역시 하나로의 통일이 아니라 서로 다른 주장의 이해소통을 통한 다툼의 종식을 의미한다. 그럴 경우 사상(성격과 내용)을 달리하는, 혹은 다른 학파에서 전승한 경전의 이해소통(會通)은 필수적으로--‘會通’은 아비달마 논서에 의하면 ‘안내하다(guide)’ ‘인도하다(lead away)’는 뜻의 어원 √ni에서 파생한 niyate의 譯語이다--, “正理法性에 어긋나지 않으면 佛說”이라는 개방적인 성전관, 경전의 말씀(能詮, *abhidhana)보다 배경이나 맥락에 따른 의미(所詮, abhidheya)를 중시할 수밖에 없는데, 이러한 사유는 기본적으로 설일체유부 아비달마에서 정립된 것이었다. 즉 유부 毘婆沙師(Vaibhasika)는 “[누가 설한 것이든] 法性에 어긋나지 않으면 佛說”이라는 불설정의를 확립하였을 뿐만 아니라 그들에 있어 衆經의 了義/眞實義는 경에서 설하고 있는 그대로의 뜻(yatharutartha: 如說義)이 아니라 경설 이면의 별도의 意趣(abhipraya)로, 이를 드러낸 것이 아비달마였고, 이것이 진실의 佛說이었다. 원효의 화쟁론은 이에 기초한 것이었다.: “[경에서] 말한 대로 취(이해)할 경우 [異說은] 모두 인정되지 않지만, 뜻(意趣, 意旨)을 얻어(밝혀) 말한다면 인정하지 못할 것이 없다.” This thesis is researched on Wonhyo`s Theory of Harmonization through context of ‘Cease of struggle(滅諍 or 止諍, adhikaranasamatha)’ and ‘Harmony(和合, samagra)’ in early Buddhist scripture. This research is based on two premises, 1) Wonhyo is Buddhist thinker before Korean thinker, 2) Buddhology, followed by Abhidharma-Madhyamika-Yogacara-Tathagatagarbha-EastAsian Buddhism like T`ien-T`ai(天台)/Huayan(華嚴) and Wonhyo, has some kind of continuity on that it takes Logic(道理, *yukti, nyaya) and Truth(法性, dharmata) as ultimate values. In early Buddhist scripture, ‘Harmony’ means acknowledging different views and other schools and do not struggle each other like a harmony of different matters, water and milk. Wonhyo`s ‘Harmony’ means the cease of struggle through understanding and communication(會通) between different views, not the unification into one. For that, understanding and communication with other schools` scripture with different views are necessary - by Abhidharma text, it is the translation of niyate, derived from the root ni, which means ‘guide’ or ‘lead away’ -, and having to emphasize on open view of scripture that it is Buddha`s Words(佛說) if it`s not contradiction with the Truth or Logics, and on meaning(所詮, abhidheya) rather than Words(能詮, *abhidhana), these thoughts are basically established by Sarvastivadin`s Abhidharmavibhasa.

Synchronization of Chaotic Secure Communication Systems with Interval Time-varying Delays

권오민(Oh-Min Kwon),박주현(Ju-Hyun Park),이상문(Sang-Moon Lee),박명진(Myeong-Jin Park) 대한전기학회 2009 전기학회논문지 Vol.58 No.6

In this paper, a method of designing a controller which ensures the synchronization between the transmission and the reception ends of chaotic secure communication systems with interval time-varying delays is proposed. To increase communication security, the transmitted message is encrypted with the techniques of N-shift cipher and public key. And to reduce the conservatism of the stabilization criterion for error dynamic system obtained from the transmitter and receiver, a new Lyapunov-functional and bounding technique are proposed. Through a numerical example, the effectiveness of the proposed method is shown in the chaotic secure communication system.

New Delay-dependent Stability Criteria for Uncertain Stochastic Systems with Time-varying Delays

권오민(Oh-Min Kwon),박주현(Ju-Hyun Park),이상문(Sang-Moon Lee) 대한전기학회 2009 전기학회논문지 Vol.58 No.11

In this paper, the problem of delay-dependent stability of uncertain stochastic systems with time-varying delay is considered. The uncertainties are assumed to be norm-bounded. Based on the Lyapunov stability theory, new delay-dependent stability criteria for the system are derived in terms of LMI(linear matrix inequality). Two numerical examples are given to show the effectiveness of proposed method.

A New Augmented Lyapunov Functional Approach to Robust Delay-dependent Stability Analysis for Neutral Time-delay Systems

권오민(Oh-Min Kwon) 대한전기학회 2011 전기학회논문지 Vol.60 No.3

This paper propose a new delay-dependent stability criterion of neutral time-delay systems. By employing double-integral terms in augmented states and constructing a new Lyapunov-Krasovskii's functional, a delay-dependent stability criterion is established in terms of Linear Matrix Inequality. Through numerical examples, the validity and improvement results obtained by applying the proposed stability criterion will be shown.

소승불교 一考

권오민(Kwon. Oh-Min) 새한철학회 2003 哲學論叢 Vol.31 No.1

서구의 비지배적 의학이한의학의 전략 선택에 주는 시사점

권오민(Oh-min Kwon),안상우(Ahn Sang Woo) 한국의사학회 2008 한국의사학회지 Vol.21 No.1

The professionalization of unauthoritative medical service has been progressed over time, transforming based on the motive, strategy and the social environment of the medical society. Osteopathology and Chiropractic have been professionalized in totally different steps, even though their basic philosophy and the theory are very much the same. The historical suggestions of these osteolopathology and chiropractic in England and United States is that the economical conditions and the point of view that society has on the relationship between human and medicines affect decisively on the social transformation of the community. Observations through these examples will provide many informations as a source on political measures for a medical society to decide for its future direction.

Delay-dependent Robust Stability of Uncertain Dynamic Systems with Time-varying Delays

權五珉(Oh-Min Kwon),朴柱炫(Ju-Hyun Park) 대한전기학회 2009 전기학회논문지 Vol.58 No.1

In this paper, the stability analysis for uncertain dynamic systems with time-varying delays is considered. By constructing a new Lyapunov functional, a novel stability criterion is established in terms of linear matrix inequalities (LMIs). Two numerical examples are carried out to support the effectiveness of the proposed method.

Non-fragile Guaranteed Cost Controller Design for Uncertain Time-delay Systems via Delayed Feedback

權五珉(Oh-Min Kwon),朴柱炫(Ju-Hyun Park) 대한전기학회 2008 전기학회논문지 Vol.57 No.3

In this paper, we propose a non-fragile guaranteed cost controller design method for uncertain linear systems with constant delyas in state. The norm bounded and time-varying uncertainties are subjected to system and controller design matrices. A quadratic cost function is considered as the performance measure for the system. Based on the Lyapunov method, an LMI(Linear Matrix Inequality) optimization problem is established to design the controller which uses information of delayed state and minimizes the upper bound of the quadratic cost function for all admissible system uncertainties and controller gain variations. Numerical examples show the effectiveness of the proposed method.