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권강주,박양춘,김병탁,김동희 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.1
To evaluate the effect of Younghyoeum(YHE) on allergy and chronic lung disease, studies were done experimentally. YHE significantly inhibited the histamine release from mast cell induced by compound 48/80(10㎕/㎖). It inhibited the IgE production from spleen lymphocyte induced by Con A(2.5㎕/㎖) and LPS(10㎕/㎖) as a function of concentration. It also inhibited IgE gene expression of IC-2 mast cells induced by PMA, ionomycin. It significantly prevented the growth reaction of IC-2 mast cell. It upregulated expression of IL-4 and downregulated expression of IL-1 β , IL-5, IL-6, IL-13, GM-CSF, TNF- α .It inhibited Fc □ RI gene expression of IC-2 mast cells. It significantly decreased the values of Lung TBA. These results indicated YHE had anti-allergic activity and still needed additional study on its mechanism. Key word : allergy, cytokine, Younghyoeum