Langerhans세포 조직구증의 세침흡인 세포학적 소견 - 1 예 보고 -

곽정자,진소영,이동화,Kwak, Jeong-Ja,Jin, So-Young,Lee, Dong-Wha 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2

Langerhans cell histiocytosis or histiocytosis X is a disease of unknown etiology characterized by proliferation of mature histiocytes. While a few descriptions of the cytologic features of eosinophilic granuloma ocurring in the bone have been published, reports of cytologic findings of lymph node-based Langerhans cell histiocytosis are very rare. We report the cytologic findings of a case of Langerhans cell histiocytosis diagnosed by fine needle aspiration cytology from the left supraclavicular and right inguinal lymph nodes in a 65-year-old male. Cytologic smears showed characteristic reticuloendothelial cells which have elongated, folded, grooved nuclei and abundant pale cytoplasms. Particularly, nuclei were highly irregular and multilobated. A few mitotic figures were present. The cytologic diagnosis was confirmed by tissue biopsies from the left supraclavicular and right inguinal lymph nodes. Proliferation of histiocytes were also present in the skin. Immunohistochemistry for S-100 protein, vimentin, $\alpha1-antichymotrypsin$ and lysozyme showed positive staining. Electron microscopy disclosed Birbeck granules.

Ki-1양성 대세포림프종의 세침흡인 세포학적 소견 - 1예 보고 -

권계현,곽정자,진소영,이동화,Kwon, Kye-Hyun,Kwak, Jeong-Ja,Jin, So-Young,Lee, Dong-Wha 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2

Ki-1 lymphoma is a sort of high grade large cell lymphoma and defined on the basis of the reactivity of the tumor cells with monoclonal antibody Ki-1. On fine needle aspiration cytology, the reported case is rare and the differential diagnosis is not easy, especially from undifferentiated carcinoma and Hodgkin's lymphoma. We experienced a case of fine needle aspiration cytology of Ki-1 positive large cell lymphoma in a 61-year old male patient. Fine needle aspiration cytology from the cervical lymph node disclosed hypercellular smears with large single cells on polymorphous lymphoid background. The tumor cells had abundant dense cytoplasm and large nuclei with Irregular profiles. Although most cells were mononuclear binucleated and multilobed/multinucleated cells were also seen Immunohistochemistry was done and revealed strong positive staining for Ki-1 antigen.

이하선에 발생한 기저세포선종의 치험례

이주철,박은수,곽정자,Lee, Joo Chul,Park, Eun Soo,Kwak, Jeong Ja 대한두개안면성형외과학회 2012 Archives of Craniofacial Surgery Vol.13 No.2

Purpose: Basal cell adenoma of the salivary gland is an uncommon type of monomorphic adenoma. The most frequent location is parotid gland. It usually appears as a firm, mobile and slow-growing mass. Originally the term "basal cell adenoma" is described as a benign salivary gland tumor comprised of uniform appearing basaloid cells which are arranged in solid, trabecular, tubular, and membranous patterns. But the myxoid and chondroid mesenchymal like component as seen in pleomorphic adenoma is lacking in basal cell adenoma. We report a case of basal cell adenoma of parotid gland with review of the literatures. Methods: The 59-year-old female patient was referred to our department with a painless palpable mass in the left preauricular region for about 1 year. Movable and nontender subcutaneous mass was palpable. There was no evidence of cervical metastasis in computed tomography and ultrasonography. On fine needle aspiration cytology, pleomorphic adenoma was suspected. Under general anesthesia, superficial parotidectomy including tumor was performed. The biopsy result was basal cell adenoma. Results: Long-term follow-up for 54 months showed favorable result without evidence of recurrence except for temporary facial nerve weakness right after the surgery. Conclusion: Basal cell adenoma is the third most frequent benign tumor of the salivary gland, following pleomorphic adenoma and Warthin's tumor, although the incidence is low. The typical clinical feature of the basal cell adenoma is slowly growing, asymptomatic, and freely movable parotid mass. Basal cell adenoma should be also considered as a differential diagnosis of the parotid gland benign tumor.

유방의 아포크린 암종의 세침흡인 세포학적 소견 - 2예 보고 -

진소영,이동화,곽정자,Jin, So-Young,Lee, Dong-Wha,Kwak, Jeong-Ja 대한세포병리학회 1992 대한세포병리학회지 Vol.3 No.2

Apocrine carcinoma is a rare form of breast malignancy and is composed of entirely or predominantly of apocrine type epithelial cells. Apocrine metaplastic cells are frequently noted in fine needle aspiration cytology(FNAC) of breast lesions, especially fibrocystic disease. These apocrine cells may occasionally be atypical, to make a diagnostic difficulty. Two cases of apocrine carcinoma of the breast diagnosed by FNAC are described, and differential cytologic points between apocrine metaplasia and apocrine carcinoma are discussed. The first case is a right breast mass of a 37-year-old woman for 20 days. The smears show many single or sheets of large cells on bloody background. Each cell has a large vesicular nuclei with multiple macronucleoli and abundant eosinophilic granular cytoplasm. The second case is a left breast mass of a 35-year-old woman for one month. The smears show similar findings as seen in the first one. Histopathologic findings of both cases are typical of apocrine carcinoma. Electron microscopy demonstrates variable numbers of large osmiophilic granules in diameter of $200\sim600nm$ in both cases.

증 례 : 내시경 점막하 터널 절제술로 제거한 위 분문의 고유근층 기원 근종

정은수 ( Eun Soo Jeong ),홍수진 ( Su Jin Hong ),한재필 ( Jae Pil Han ),곽정자 ( Jeong Ja Kwak ) 대한소화기학회 2015 대한소화기학회지 Vol.66 No.6

While endoscopic submucosal dissection (ESD) is widely used to treat gastrointestinal tumors, it is rarely used for subepithelial tumors (SETs) originating from the muscularis propria of the esophagus and gastric cardia because of the risk of perforation and problems with inadequate space and field of view during procedures. Submucosal tunneling endoscopic resection (STER) is a new therapeutic method for treating SETs in specific locations in the esophagus and stomach. This technique is highly skill-dependent, using a mucosal flap that covers a deeper part of the gut wall, but is safe and minimally invasive compared with conventional endoscopic approaches such as ESD in SETs originating from the muscularis propria.We report a patient who underwent STER to remove a SET located at the gastric cardia. The patient recovered without any complications. We believe that our case shows the efficacy and safety of the STER technique for patients with a SET originating from the muscularis propria.(Korean J Gastroenterol 2015;66:340-344)

12세 여아에게서 활동성 폐결핵에 동반된 장결핵 1례

박가영,박재영,김창휘,곽정자,박재옥,Park, Ga Young,Park, Jae Young,Kim, Chang Hwi,Kwak, Jeong Ja,Park, Jae Ock 대한소아감염학회 2013 Pediatric Infection and Vaccine Vol.20 No.3

결핵은 다양한 임상양상을 보이는 감염병으로 과거에 비해 많이 감소하였고 소아 결핵도 점차 줄어들고 있으나 여전히 중요한 감염병이다. 소아의 결핵은 성인과는 다른 임상적 특징을 가지며 폐외 결핵의 빈도가 성인보다 높고, 청소년의 결핵은 결핵균 감염에서 실제 질병으로 발전될 위험이 크다. 폐외 결핵 중 장결핵은 증상이 비특이적이고 다양하여 진단이 늦어질 경우 사망률 및 이환율이 높아질 수 있다. 크론병 또는 만성적인 소화기 질환과의 감별이 중요하며, 최근 대장 내시경의 발달로 감별 진단이 용이해지고 있다. 저자들은 6개월간 지속된 설사와 복통, 체중 감소와 간헐적이고 반복적인 $37.5-38^{\circ}C$의 발열로 내원한 12세 여아에게서 대장 내시경 검사를 하여 시행한 생검 조직의 PCR 검사와 조직학적 소견으로 장결핵을 진단하였고, 연이어 촬영한 흉부 방사선 상 활동성 폐결핵으로 진단되어 11개월간의 항결핵제 치료로 완치된 증례를 경험하였다. Intestinal tuberculosis (TB) is presented with nonspecific and variable clinical manifestations such as abdominal pain, diarrhea, fever and weight loss. Diagnosis of tuberculous enteritis may be missed or confused with many other chronic gastrointestinal disorders such as the Crohn disease and intestinal neoplasms. The diagnosis should be based on careful clinical evaluations, such as extra-intestinal signs and colonoscopic and histologic findings. Newer techniques such as PCR tests from the specimens through colonoscopic biopsy may be helpful to confirm diagnosis of tuberculous enteritis. The treatment regimens for pulmonary tuberculosis are generally effective for tuberculous enteritis as well. If not treated early, the prognosis of intestinal tuberculosis is poor. We report a case of tuberculous enteritis diagnosed by colonoscopic biopsy and TB PCR which was presented with diarrhea, abdominal pain, intermittent fever and weight loss in a 12-year-old girl with active pulmonary tuberculosis. The patient was treated successfully with antituberculosis agents for 11 months without any complications.

폐경 호르몬 치료를 받지 않은 폐경여성에서 자궁내막증: 2예 보고

김태희 ( Tae Hee Kim ),이해혁 ( Hae Hyeog Lee ),정수호 ( Soo Ho Chung ),곽정자 ( Jeong Ja Kwak ),박황신 ( Hwang Shin Park ) 대한폐경학회 2010 대한폐경학회지 Vol.16 No.3

자궁내막증은 여성호르몬과 관계가 있어 가임기 여성에서 호발하는 질환이며, 만성 염증성부인과 질환의 하나이다. 자궁내막증은 생리통과 성교통, 불임과 연관성이 높으며, 폐경 후에 자궁내막증은 드물다. 또한 부인암과의 연관성도 적다고 알려져 있다. 호르몬 치료를 받지 않은 폐경 후 여성에서 수술 후 자궁내막증으로 판명된 두 명의 환자를 대상으로 의무 기록을 바탕으로 하여, 이와 관련된 문헌 고찰을 통하여 보고하는 바이다. Endometriosis is an estrogen dependent disease in reproductive age. Endometriosis is a chronic inflammatory gynecologic disease. Problems associated with endometriosis include dysmenorrhea, dyspareunia, and infertility. Postmenopausal endometriosis is rare; however, postmenopausal endometriosis is infrequently associated with cancer, thus management is most important for gynecologists. We present two cases of endometriosis associated with postmenopausal women who were not receiving menopausal hormone therapy with a retrospective review of the medical records and a brief review of the literature. (J Korean Soc Menopause 2010;16:176-180)

폐경 후 발생한 자궁내막증에서 기원한 장액성 난소암

김태희 ( Tae Hee Kim ),이해혁 ( Hae Hyeog Lee ),정수호 ( Soo Ho Chung ),곽정자 ( Jeong Ja Kwak ),이병익 ( Byoung Ick Lee ),홍연표 ( Yeon Pyo Hong ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.4

Endometriosis is estrogen dependent disease in reproductive age. Endometriosis is a chronic inflammatory gynecologic disease. Problems associated with endometriosis include dysmenorrhea, dyspareunia, and infertility. Postmenopausal endometriosis is rare. Also, malignant transformation in endometriosis is rare. There is no report in Korea about serous adenocarcinoma arising from endometriosis after menopause. The authors present a case of serous adenocarcinoma arising from endometriosis after menopause with brief review of the literature.

바르톨린샘 농양으로 오인된 외음부 스파르가눔증

김태희 ( Tae Hee Kim ),이해혁 ( Hae Hyeog Lee ),정수호 ( Soo Ho Chung ),이범하 ( Boem Ha Yi ),곽정자 ( Jeong Ja Kwak ),남해선 ( Hae Seon Nam ),차상헌 ( Sang Heon Cha ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.8

Sparganosis is a parasitic infection caused by the plerocercoid larvae of diphyllobothroid tapeworms belonging to the genus Spirometra, as first described by Manson in 1882. The infection is transmitted by ingestion of contaminated water, frogs, and snakes, and contact between a second intermediate host and an open wound or mucus membranes. Humans are accidental hosts in the life cycle, but dogs, cats, and other mammals are definitive hosts. Once a human becomes infected, the plerocercoid larvae migrate to a subcutaneous location, where they typically develop into a painful nodule. We misdiagnosed vulva sparganosis as a Bartholin`s gland abscess. The patient was a green consumer, so she may have been infected by consuming health foods. Sparganosis should be considered as a cause of soft tissue masses especially among patients who have ingested health foods.

만성 콩팥병 3기 환자의 부갑상선암 1예

김진국 ( Jin Kuk Kim ),박무용 ( Moo Yong Park ),박정미 ( Jung Mi Park ),조윤희 ( Youn Hee Cho ),최수정 ( Soo Jeong Choi ),황승덕 ( Seung Duk Hwang ),곽정자 ( Jeong Ja Kwak ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6

Parathyroid carcinoma is a rare disease in patients with primary hyperparathyroidism. We experienced a case of parathyroid carcinoma presenting with hyperparathyroidism. A 62-year-old male patient had hypercalcemia, chronic kidney disease, and an elevated parathyroid hormone level for at least 3 months. An ultrasonogram and parathyroid scan did not show parathyroid neoplasm. He underwent left hemithyroidectomy and parathyroidectomy. Biopsy revealed a parathyroid carcinoma. His azotemia and hypercalcemia improved after surgery. (Korean J Med 2012;83:796-801)