Interleukin-17이 배양된 류마티스관절염 활막세포에서 vascular endothelial growth factor 생성에 미치는 영향

곽임수 ( Ihm Soo Kwak ),남태수 ( Tae Soo Nam ),나하연 ( Ha Yeon Rha ),서정탁 ( Jeung Tak Suh ),김유선 ( Yoo Sun Kim ),김성일 ( Sung Il Kim ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.3

Objective: To investigate the the effects of interleukin-17 (IL-17) on the production of vascular endothelial growth factor (VEGF) from cultured rheumatoid arthritis synoviocytes. Methods: Fibroblast-like synovial cells(FLS) were prepared from the synovial tissues of rheumatoid arthritis patients and cultured in the presence of IL-17, IL-17 with or without transforming growth factor-β(TGF-β), tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β). VEGF levels were determined in the culture supernatants by sandwitch ELISA. Results: Stimulation of FLS by serial concentration of IL-17, TGF-β, TNF-α, IL-1β increased the production of VEGF by 2.1-2.7, 2.2-3.0, 2.0-2.9, 2.3-3.1 fold over the constitutive levels of unstimulated FLS. Stimulation of FLS by IL-17 with TGF-β or TNF-α or IL-1β also increased the production of VEGF according to culture periods by 1.6-1.8, 1.1-1.9, 1.5-1.7 fold over the levels stimulated with TGF-β or TNF-α or IL-1β, respectively. This results indicated that IL-17 increased the effect of TGF-β, TNF-α, IL-1β on FLS, leading synergistic enhancement of VEGF production. Conclusion: IL-17 may be involved in the neovascularization in rheumatoid synovitis by enhancing the production of VEGF.

신기능 저하 환자에서 99mTc - DMSA 신장 스캔을 이용한 신 섭취율과 사구체 여과율의 상관성

이수봉(Soo Bong Lee),정현철(Hyun Chul Jung),곽임수(Ihm Soo Kwak),나하연(Ha Yeon Rha),안승재(Seoung Jae An),정유석(Yoo Suck Jung) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.4

배 경 : 신기능 저하 환자에서 신기능을 정확히 평가하는 것은 중요하고, 다양한 방법으로 사구체 여과율(GFR)을 구하고 있다. 임상에서 흔히 ^99mTc-DTPA 신장 스캔과 99mTc-DMSA 신장 스캔이 개별 신기능의 평가에 많이 이용되고 있다. 본 연구에서는 99mTc-DMSA 신장 스캔을 이용하여 신피질 영상을 위한 1시간 상대적 신 섭취율과 사구체 여과율 사이의 상관성을 검토하고자 하였다. 방 법: 1998년 1월부터 2001년 3월까지 부산대학교병원 신장내과에 내원한 환자들 중 ^99mTc-DMSA 신장 스캔, ^99mTc-DTPA 신장 스캔, 혈청 크레아티닌, 24시간 요 중 크레아티닌을 검사한 65명의 환자들 중에서, 중증 및 중등도 신기능 저하 환자 42명을 대상으로 하였다. ^99mTc-DTPA 신장 스캔을 이용한 사구체 여과율(DTPA-GFR)에 따라 중증 신기능 저하군(A)과 중 등도 신기능 저하군(B)으로 나누었다(A군 : ≤20 mL/min/1.73㎡, n=20명, B군 : 20-50 mL/min/1.73㎡, n=22명). 99mTc-DMSA 신장 스캔을 이용하여 1시간 상대적 신 섭취율(DMSA-%uptake, TRUR)을 구하고, 이것을 99mTc-DTPA 신장 스캔을 이용한 사구체 여과율(DTPAGFR), 내인성 크레아티닌 청소율(Ccr), Cockcroft와 Gault가 고안한 추정 크레아티닌 청소율(C & G Ccr)과 Spearman rank correlation test를 이용하여 상관성을 비교하였다. 결 과 : 전체 42명의 대상 환자들 중에서 15명은 남자였고, 27명은 여자였다. 평균 나이는 54 세(28-80세)였다. 두 군에서 평균 DTPA-GFR과 평균 TRUR은 각각 통계적으로 유의한 차이 를 보였다(14.8±4.7 vs 34.9±8.4 mL/min/1.73㎡, p<0.05; 8.9±3.7 vs 16.3±7.4%, p< 0.05). 그러나 TRUR의 DTPA-GFR에 대한 상관성을 보았을 때, A군에서는 유의한 상관관계는 없었으나, B군에서는 유의한 상관관계를 보였다(0.263, p>0.05 vs 0.731, p<0.01). 또한 TRUR의 혈청 크레아티닌, Ccr, C & G Ccr에 대한 상관성을 보았을 때, 두 군 모두에서 통계적으로 유의한 상관관계를 보였다. 결 론 : ^99mTc-DMSA 신장 스캔에서 신피질 영상으로 사용되는 1시간 상대적 신 섭취율은 실제 사구체 여과율을 정확하게 측정할 수는 없지만, 신기능이 중증이하로 감소되지 않은 경우에는 사구체 여과율을 간접적으로 반영하였다. Background : Glomerular filtration rate(GFR) is an important parameter for the evaluation and monitoring of renal function. The aim of this study was to investigate the correlation between the relative 1 hour uptake of 99mTc-DMSA renal scan(DMSA-%uptake, TRUR) and GFR which was estimated by 99mTc-DTPA, serum creatinine and 24 hour-urinary creatinine excretion. Methods : Between January 1998 and March 2001, 65 patients had undergone ^99mTc-DMSA renal scan, ^99mTc-DTPA renal scan, serum creatinine and 24 hour-urinary creatinine excretion. Of them, 42 patients had moderately or severely reduced renal function(DTPA-GFR ≤50 mL/min/1.73㎡). According to the DTPA-GFR level, patients were divided into two groups : Group A(n=20) with DTPA-GFR ≤20 mL/min/1.73㎡(mean±S.D. 14.8±4.7), Group B(n=22) with DTPA-GFR 20-50 mL/min/1.73㎡(mean±S.D. 34.9±8.4). Between the TRUR and other methods to estimate renal function such as DTPA-GFR, 24 hour-urinary creatinine clearance(Ccr) and Cockcroft & Gault`s formula(C & G Ccr), the correlation coefficient was measured by Spearman rank correlation test. Results : Of 42 patients, 15 were men and 27 were women(mean age 54 years; range 28-80 years). there were significant differences between mean DTPA-GFR and mean TRUR in both groups(14.8±4.7 vs 34.9±8.4 mL/min/1.73㎡, p<0.05; 8.9±3.7 vs 16.3±7.4%, p<0.05). In group A, TRUR(mean±S.D. 8.9±3.7%) was not significantly correlated with DTPA-GFR(r=0.263, p>0.05). In group B, TRUR (mean±S.D. 16.3±7.4%) was significantly correlated with DTPA-GFR(r=0.731, p<0.01). In both group, serum creatinine, Ccr and C & G Ccr were significantly correlated with TRUR. Conclusion : Although the relative 1 hour uptake of the ^99mTc-DMSA renal scan, as a method of renal cortical image could not estimate the true GFR, it showed a good correlation with GFR in patients with moderately reduced renal function. 99mTc-DMSA renal scan seems to be helpful to evaluate the renal function in patients with moderately reduced renal function.

사구체 신염 환자에서 Gallium-67 신티그램의 임상적 유용성

이수봉(Soo Bong Lee),이우철(Woo Chul Lee),정현철(Hyun Chul Jung),송상헌(Sang Heun Song),곽임수(Ihm Soo Kwak),나하연(Ha Yeon Rha) 대한내과학회 1999 대한내과학회지 Vol.56 No.4

N/A Objectives : Gallium 67(Ga-67) scintigraphy has been used to diagnose inflammatory and neoplastic diseases. We undertook a study to determine the clinical value of Ga- 67 renal scan in patients with various glomerular diseases. Methods : Ga-67 scintigraphy was performed in 48 patients with various biopsy proven forms of renal diseases. Renal uptake in 48 patients images was graded as follow: Grade 0 = not visualization at 48 hours : 1 = faintly visualize : 2 = equal to uptake in spine : 3 = greater than over the spine : 4 = greater than activity over the liver. Results : 1) Of the 48 patients, 31 were male, and mean age was 32 years. 11 patients had hypertension and 29 patients had hematuria. 2) Positive scintigram were seen in 40 of 48(83%) cases. In results of renal biopsy, IgA nephropathy(IgAN) was 15 patients, minimal change disease(MCD) was 14, focal segmental glomerulosclerosis (FSGS) was 8, membranoproliferative glomerulonephritis (MPGN) was 3, lupus nephritis(LN) was 3, poststreptococcal glomerulo- nephritis(PSGN) was 3 and membranous glomerulonephritis(MGN) was 2. 3) In 26 patients (54%) with nephrotic-range proteinuria, Grade 2 or higher renal uptake was observed in 9 (75%) of MCD, 5(100%) of FSGS, 2(100%) of LN and 3(75%) of IgAN. 4) In comparision nephrotics with non-nephrotics at biopsy, renal Ga-67 uptake in who patients had nephrotic- range proteinuria was correlated with clinical severity determined by serum albumin, serum total cholesterol and 24 hours urine protein excretion. Conclusions : Renal Ga-67 scintigraphy may be able to be a predictor in the assessment for severity of nephrotic syndrome.

IgA 신병증에서 혈중 Vascular Endothelial Growth Factor 농도의 임상적 의의

이수봉(Soo Bong Lee),이동원(Dong Won Lee),김용범(Yong Bum Kim),정현철(Hyun Chul Jung),곽임수(Ihm Soo Kwak),나하연(Ha Yeon Rha) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.4

목 적: Vascular Endothelial Growth Factor(VEGF)는 혈관 내피 세포의 증식과 혈관 신생, 혈관 투과도의 증가 등을 유발하는 특이한 성장인자로서 신장에서도 생성된다고 하나 아직 완전한 기능은 밝혀지지 않은 상태이다. 이에 저자들은 원발성 사구체 질환 중에서 가장 흔한 IgA 신병증 환자를 대상으로 질병의 중증도와 관련된 여러 인자들과 혈청 VEGF 농도 사이의 상관관계를 알아보기 위해 본 연구를 시행하였다. 방 법 : 부산대학교병원 신장내과에 입원하여 신생검 시행결과 IgA 신병증으로 진단된 21명의 환자를 대상으로 혈청 VEGF를 Sandwich ELISA 방법으로 정량 하였으며 조직학적 소견을 포함한 질환의 중증도를 반영하는 인자들과 혈청 VEGF 농도와의 상관관계를 조사하였다. 결 과: 조직학적 중증도, 조직 표본중의 반월(crescent)의 비율, 혈청 중의 크레아티닌, 알부민, IgA들의 각각의 농도와 24시간 요단백 배설량, 크레아티닌 청소율을 구하여 이들과 혈청 VEGF 농도와의 상관관계를 분석한 결과 조직학적 등급(r=0.471, p<0.05), 세포성 반월의 비율 (r=0.485, p<0.05), 간질 섬유화의 정도(r=0.562, p<0.01), 24시간 요단백 배설량(r=0.439, p<0.05), 그리고 혈청 알부민 농도(r=-0.594, p<0.01)가 각각 의미 있는 상관관계를 보였다. 반월이 관찰되지 않았던 17명을 대상으로 한 조사에서는 혈청 알부민 농도만이 혈청 VEGF 농도와 의미 있는 상관관계를 보였다. 7명의 조직학적 등급 IV, V인 환자를 대상으로 혈청 VEGF의 농도를 조사한 결과 반월의 존재 여부에 따라 유의한 차이를 보였다. 결 론: IgA 신병증에서 혈중 VEGF 농도는 조직학적 소견에서 사구체 경화와 같은 만성적인 변화보다는 급성 신손상을 반영하는 세포성 반월(cellular crescent)의 형성과 의미 있는 양(positive)의 상관 관계를 보인다. 따라서 혈청 VEGF 농도는 IgA 신병증 환자에서 급성 신 손상의 정도, 그 중에서도 특히 세포성 반월 형성을 반영하는 좋은 표지자로 판단된다. Background : Vascular endothelial growth factor (VEGF) is a potent enhancer of microvascular permeability and a selective endothelial cell growth factor. In human kidney, VEGF is expressed mainly in glomerular visceral epithelial cells. We investigated the relationship between serum levels of VEGF and factors reflecting the severity of disease including histological patterns in order to elucidate the relevance of VEGF in the pathogenesis of IgA nephropathy. Methods : Serum VEGF was studied using a sandwich ELISA from 21 patients with IgA nephropathy. Histological patterns are classified to 5 grades by WHO classification and frequencies of crescent and glomerular sclerosis, degree of interstitial fibrosis were recorded. Serum concentrations of creatinine, albumin, IgA, amounts of 24 hour urine protein excretion, and creatinine clearances are also evaluated. Results : Serum VEGF levels were significantly correlated with histological grade(r=0.471, p<0.05), frequency of cellular crescent(r=0.485, p<0.05), degree of interstitial fibrosis(r=0.562, p<0.01), and 24 hour urine protein excretion(r=0.439, p<0.05), and inversely with serum albumin concentration(r=-0.594, p<0.01). Studies in 17 patients without crescent formation revealed that only serum albumin concentration showed significant correlation with serum VEGF level. Conclusion : Serum VEGF concentration is mainly correlated with cellular crescent formation reflecting activity of the disease rather than chronic structural changes such as glomerular sclerosis or interstitial fibrosis. Elevated serum VEGF concentration seems to be due to the release of relatively large amounts of stored VEGF from damaged visceral epithelial cells. Serum VEGF concentration may be a useful marker to evaluate the degree of acute renal injury, especially cellular crescent formation.

균혈증 및 패혈증의 임상 양상 및 예후 인자에 대한 고찰

이수봉(Soo Bong Lee),이우철(Woo Chul Lee),정현철(Hyun Chul Jung),송상헌(Sang Heun Song),이동원(Dong Won Lee),김용범(Yong Bum Kim),정주섭(Joo Seop Chung),곽임수(Ihm Soo Kwak),조군제(Goon Jae Cho),나하연(Ha Youn Rha),장철훈(Chul Hun Ch 대한내과학회 1999 대한내과학회지 Vol.56 No.3

N/A Objectives : In spite of the improvement in therapeutic strategy, the mortality rate from sepsis is still high. The purpose of this study was to examine the clinical characteristics and prognostic factors of sepsis to get help in treatment and estimation of prognosis of sepsis. Methods : We analyzed the clinical and bacteriologic data of 313 admitted patients with bacteremia at Pusan National University Hospital from Jan., 1996 to Dec., 1997 retrospectively and all patients were categorized into 4 groups (bacteremia, sepsis, severe sepsis, septic shock) by the definition from American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference, 1992. Results : 1) Male to female ratio was 1.22 : 1 and mean age was 52 years. 2) The overall mortality rate was 32.3% and the mortality rates of bacteremia, sepsis, severe sepsis and septic shock were 14.9%, 22.8%, 52.0%, and 95.2%, respectively. 3) Underlying diseases predisposing to bacteremia were diabetes mellitus(14.4%), solid cancer (13.1%), hematologic malignancy(10.2%) and liver cirrhosis(9.9%), but the most common was no underlying disease. 4) Among the total 80 species of isolated microorganisms, gram-positive organisms were responsible in 169 cases, gram-negative organisms in 218 cases. E. coli was isolated most frequently, followed by S. aureus, S. epidermidis, K. pneumoniae, Enterococcus spp., Enterobacter spp., Str. viridans group, CNS, P. aeruginosa and S. typhi. 5) Although the source of bacteremia could not be identified in 28.8% of the patients, the others had the primary site of infections ; skin(17.9%), gastrointestinal tract(16.9%), respiratory tract(12.5%), urinary tract(9.9%) and biliary tract(7.3%). 6) The mortality rate in patients with gram-positive bacteremia was 39.4%, with gram-negative bacteremia was 20.9% and with polymicrobial bacteremia was 33.3%. MRSA sepsis showed the highest mortality rate(58.8%), followed by Enterococcus spp.(50.0%), K. pneumoniae (35.0%), P. aeruginosa(27.3%) and E. coli(18.8%). 7) There was significant relation between etiologic organisms of bacteremia and the primary site of infections. 8) Using logistic regression analysis, mortality was predicted by disseminated intravascular coagulation, severity of sepsis and severity of underlying diseases. Conclusion : Sepsis occurred in 16 patients among 1,000 adult admitted patients and overall mortality rate was 32.3%, still high. The mortality rate had positive correlation with the severity of sepsis. Among 16 evaluated risk factors of mortality, mortality was predicted by disseminated intravascular coagulation, severity of sepsis and severity of underlying disease.

간질환에 있어서 LDH isozyme 에 관한 연구

박규현,황순철,곽임수,김홍범,문한규 ( Kyu Hyun Park,Soon Chun Hwang,Ihm Soo Kwak,Hong Bum Kim,Han Kyu Moon ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.1

The activities of LDH isozymes, transaminases and alkaline phosphatase were studied on 71 cases of liver diseases, among them hepatoma were 27 cases, liver cirrhosis 18 cases and hepatitis 26 cases. The results were as follow: ]. The total activity of LDH in normal control was 171.48+66.37 unit and the fractions of LDH isozymes from LDH-1 to LDH-5 were 30. 655. 81%, 35. 67+3. 73%, 25. 13+3. 83o, 4. 61W3. 08% and 4, 03 2. 73% respectively. 2. The total activity of serum LDH was significantly increased in the cases of liver diseases to compare with those of normal control group. 3, The fractions of LDH-4, LDH-5 and the ratios of LDH-5/LDH-I, LDH-5/LDH-4 and LDH-4+5/LDH-1+2 were significantly increased and LDH-2 and LDH-3 were decreased in the cases of liver diseases to compare with those of normal control. 4. LDH-4+5/LDH-I+2, GOT and alkaline phosphatase were significantly increased in hepatoma than in liver cirrhosis, the fractions of LDEI-5/LDH-1, LDH-5/LDH-4, LDH-4+5/ LDH-I+2 and GOT, GPT were increased in hepatitis than in liver cirrhosis. Nevertheless, there was no significant difference between hepatoma and hepatitis.

신이식 후 호전을 보인 Nephrogenic Fibrosing Dermopathy

김훈수 ( Hoon Soo Kim ),김수한 ( Su Han Kim ),고현창 ( Hyun Chang Ko ),김문범 ( Moon Bum Kim ),송상헌 ( Sang Heon Song ),김정섭 ( Jung Sup Kim ),곽임수 ( Ihm Soo Kwak ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.2

Nephrogenic fibrosing dermopathy (NFD) is a rare cutaneous fibrosing disorder that primarily affects patients with a history of renal disease. NFD manifests with induration, thickening and hardening of the skin with brawny hyperpigmentation. Lesions are typically symmetrical and usually develop on the limbs and trunk. Flexion contractures of the joints may be a feature of the disease. Histopathological features of NFD include proliferation of dermal fibroblasts and dendritic cells, thickened collagen bundles, increased elastic fibers and focal mucin deposition. Although the pathogenesis remains largely unknown, some of the factors implicated in the pathogenesis include renal dysfunction, circulating fibrocytes, vascular injury, and gadolinium which is a contrast material used in magnetic resonance imaging. Currently, no definitive or uniformly effective therapies are available for the treatment of NFD. We herein describe the case of a 44-year-old female NFD patient who undergoes significant improvement of skin lesions and associated joint contracture after renal transplantation. (Korean J Dermatol 2010;48(2):143∼147)

만성 콩팥병 환자에서 추정 사구체 여과율에 따른 25-Hydroxyvitamin D의 특성

고정희 ( Jung Hee Koh ),곽임수 ( Ihm Soo Kwak ),송상헌 ( Sang Heon Song ),이수봉 ( Soo Bong Lee ),이하린 ( Harin Rhee ),성은영 ( Eun Young Seong ),박창준 ( Chang Jun Park ),김태균 ( Tae Kyun Kim ),오상보 ( Sang Bo Oh ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6

Background/Aims: Accumulating data suggest that vitamin D deficiency is prevalent in patients with chronic kidney disease (CKD). However, comprehensive data are lacking for Koreans. The aim of this study was to survey vitamin D deficiency among patients with CKD in Korea and to identify the relationships among various factors. Methods: We conducted a retrospective cohort study of 444 patients who were divided into four subgroups by estimated glomerular filtration rate (eGFR) for comparisons of mean 25-hydroxyvitamin D [25(OH)D] level and other parameters. In addition, non-dialyzed patients were categorized into four groups based on 25(OH)D levels (<10, 10-19, 20-29, and ≥ 30 ng/mL), and risk factors for severe vitamin D deficiency (<10 ng/mL) were investigated. Results: Of patients with an eGFR ≥ 60 mL/min/1.73 m2, 43% (34/79) showed severe 25(OH)D deficiency, and the mean 25(OH)D level was 11.7±5.3 ng/mL. In CKD3 group, 53.2% (41/77) showed severe 25(OH)D deficiency, with a mean level of 11.3±7.2 ng/mL. In CKD4 group, 53.3% (49/92) had severe 25(OH)D deficiency, with a mean level of 11.0±6.2 ng/mL. Approximately 71% (139/196) of patients in CKD5 group showed severe deficiency, and the mean level was 9.2±5.9 ng/mL. Severe 25(OH)D deficiency was affected by winter season, renal function, diabetes, and low-density lipoprotein cholesterol. The serum parathyroid hormone level was inversely correlated with the 25(OH)D level, such that 25(OH)D < 20 ng/mL were associated with a steep increase in parathyroid hormone. Conclusions: Vitamin D deficiency is highly prevalent in the Korean population. Few patients met a sufficient 25(OH)D concentration, even in the early stages of CKD. Our data suggest that 25(OH)D level of 20 ng/mL is a threshold for a rapid increase in parathyroid hormone levels. (Korean J Med 2012;83:740-751)

패혈증에 의한 급성 신부전의 예견인자로서의 APACHE III prognostic system과 Liano system의 유용성

신호진(Ho Jin Shin),이수봉(Soo Bong Lee),곽임수(Ihm Soo Kwak),나하연(Ha Yeon Rha),송상헌(Sang Heun Song),정현철(Hyun Chul Jung),배우형(Woo Hyung Bae),안승재(Seung Jae Ahn) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.2

N/A Uncontrolled infection quite often 1eads to systemic inflammatory response syndrome and multi-organ dysfunction syndrome. Despite advances in medical knowledge and technology, the mortality of patient with sepsis is still 35-60%, and even reach up to 50-90% in septic patients having acute renal failure. The purpose of this study was to examine the characteristics and predictive factors of progression to acute renal failure(ARF) in sepsis. We analyzed the bacteriologic and laboratory data of 54 admitted patients with SIRS(systemic inflam-matory response syndrome) at Pusan National University Hospital from July 1997 to July 1999(ARF 23 vs non-ARF 31). Multiple factor which may influence mortality and progression to AEK in sepsis, were evaluated and measured on admission day. The following of results, 1) Of the 54 patients, 23 were ARF group and 31 were non-ARF group. Mean age were,52 years and 51 years. The mortality of ARF group and non-ARF group were 78% and 23%, Urine output, albumin, cholesterol, mean arterial blood pressure and evidence of underlying disease were not statistically different in each group. 2) Although the sources of sepsis could not identified in 9%(ARF), 23%(non-ARF), the others had the primary site of infections ' gastrointestinal tract(35% vs 29%), lung(30% vs 19%), genitourinary tract(9% vs 13%), skin(17% vs 16%). 3) Although statistically not different, gram-posi-tive bacterial infection was more common in ARF group(mainly staphylococcus aureus). Culture negative results were 4 patients(ARF), 1 patient(non- ARF). 4) APACHE III score in ARF group was higher than non-ARF group(48.1±16.5 vs 30.2±15.6). Liafio score in ARF group was higher than non-ARF group(39.1±13.0 vs 28.9±8.3). 5) APACHE III score and Liailo score in non- survivors were higher than survivors(APACHE III score:48.6±15.3 vs 28.1±14.0, Liaho score:37.9±12.0 vs 29.4±9.2) 6) APACHE lII system was positively correlated with Liaho system(r=0.512, p=0.001). In conclusion, APACHE III system and Liaho system were significant predictors of progression to ARF and mortality in sepsis. In the future, prospec-tive and multicenter studies are required to improve the method of treatment and the prognosis in sepsis.

내과 입원환자에서의 심한 저칼륨혈증

정현철 ( Hyun Chul Jung ),이수봉 ( Soo Bong Lee ),곽임수 ( Ihm Soo Kwak ),나하연 ( Ha Yeon Rha ) 대한내과학회 2003 대한내과학회지 Vol.64 No.3

목적 : 혈청 칼륨 측정 검사는 임상에서 흔히 시행되는 검사이며, 심한 저칼륨혈증은 사망률이 높고, 즉각적인 칼륨의 보충이 필요한 위험한 전해질 장애이지만 내과 입원환자에서 이에 대한 유용한 정보는 부족한 실정이다. 본 연구는 내과 입원 환자에서 저칼륨혈증의 빈도와 심한 저칼륨혈증 환자의 임상적 특징을 알아보고자 하였다. 방법 : 1999년 12월 2000년 6월까지 부산대학교 병원 내과에 입원하여 전해질 검사를 시행한 환자 3,124명 중 입원 기간 Background: Serum potassium level asses nt is one of the commonly requested laboratory tests, Hypokalemia is defined as a serum potassium level of less 3.5mEq/L, It can be potentially life-threatening when severe, due to its association with cardiac arrhy