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      • SCOPUSSCIEKCI등재

        전측두엽 절제술시 해마체 절제 범위와 경련 예후

        이완수,이정교,이상암,강중구,고태성,Lee, Wan Su,Lee, Jung Kyo,Lee, Sang Am,Kang, Jung Ku,Ko, Tae Seong 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.12

        Objective : Little consensus exists concerning which temporal lobe structures need to be resected or how much resection should be done during hippocampal resection. The purpose of this study is to identify whether the extent of hippocampal resection influences seizure after anterior temporal lobectomy. Materials and Methods : The extent of hippocampal resection was assessed in 96 patients who underwent temporal lobectomy for medically intractable complex partial seizures originating from a unilateral seizure focus in the anteromesial temporal lobe. Patients who had structural lesion were excluded from the study. Postoperative magnetic resonance imaging in the coronal and saggital planes were used to quantify the extent of the hippocampal and lateral cortical resection. The patients were divided into two groups. Patients who underwent hippocampal resection to the level of the cerebral peduncle were included in the partial resection group, and those who had resection to the level of the colliculus were assigned to total resection group. Seizure outcomes were defined according to the Engel classification and compared between the two groups. Neuropsychologic outcomes in the selected cases were reviewed. Results : The over-all seizure-free outcome(Engel classification 1) was accomplished in 75%(72/96) of the patients (mean duration of follow-up, 36.8 months). The total hippocampectomy group had a statistically superior seizure outcome than the partial hippocampectomy group(87.3% versus 58.5% seizure-free, p-value=0.001). Also, younger patients had a more favorable outcome. Other variables such as laterality, the extent of lateral cortical resection, age at onset and gender were not significant. The pre- and postoperative memory functions were evaluated in 24 patients. A worse postoperative memory outcome was associated with partial hippocampectomy. However this was not acceptable due to a former bias. Conclusion : The result of this study conforms that aggressive hippocampectomy resulted in a better seizure outcome.

      • SCOPUSSCIEKCI등재

        난치성 간질에 대한 기능적 대뇌반구 절제술 및 Peri-insular 대뇌반구 절제술의 효과

        이동걸,이완수,이정교,김정호,고태성,이상암,Lee, Dong Kul,Lee, Wan Su,Lee, Jung Kyo,Kim, Chung Ho,Ko, Tae Seong,Lee, Sang Am 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.9

        Objective : To confirm the efficacy of functional hemispherectomy and peri-insular hemispherotomy on treatment of intractable epilepsy. Materials & Methods : From April 1997 to February 1999, we performed 1 functional hemispherectomy and 6 peri-insular hemispherotomy in 7 consecutive patients. These procedures result in completely disconnected hemisphere while maintaining the disconnected portion of the hemisphere intact within the surgical cavity. The indications were hemimegalencephaly in 2 cases, infarction with encephalomalacia in 2, Sturge-Weber syndrome in 1, hemiconvulsion hemiplegia epilepsy syndrome in 1, cortical dysplasia with leptomeningeal cyst in 1. Mean follow-up is 15.8 months(range 8-28 months). Results : Among 7 patients, 1 patient died immediately after peri-insular hemispherotomy. Five patients became seizure free with reduced doses of medications. One patient developed rare disabling seizure with medication. In 6 patients, there were improvements in the function of the hemiparetic limbs in the postoperative phase. A 3-year-old boy with infarction and encephalomalacia died few hours after surgery due to postoperative hypothermia. Two patients required shunt after surgery. Two patients developed postoperative brain swelling but were successfully managed with conservative care. Conclusion : In conclusion, functional hemispherectomy and peri-insular hemispherotomy may provide substantial seizure control in selected cases of young hemiplegic patients with intractable epilepsy.

      • KCI등재후보

        부신백질이영양증의 임상적, 생화학적 소견 및 뇌자기공명영상 소견

        유지숙(Jee Suk Yu),김기중(Ki Joong Kim),고태성(Tae Seong Ko),이백희(Baeck Hee Lee),황세희(Se Hee Hwang),황용승(Yong Seung Hwang),김인원(Kim In One),지제근(Je Geun Chi) 대한소아신경학회 1993 대한소아신경학회지 Vol.1 No.1

        Seven cases of adrenoleukodystrophy who were diagnosed in the Department of Pediatrics, Seoul National University Hospital from January 1985 to April 1993 were reviewed. The results were as follows: 1) All of the patients were male and the onset of symptoms was between 5 and 13 years of age. They were all classified as X-liked childhood adrenoleukodystrophy. 2) The initial symptoms were behavior change, visual disturbance, skin pigmentation poor school perfomance and gait disturbance. 3) Skin pigmentation was noticed in 3 cases which showed elevated plasma ACTH level on ACTH stimulation test, the cortisol levels were not stimulated. One case out of 4 cases having no hypoadrenal symptoms showed no response to ACTH stimulation test. 4) Elevated CSF IgG and protein levels were noticed in 4 cases of 7(57%) and 4 cases out of 6(67%), respectively. 5) There is no correlation between the evoked potentials and the subjective visual and auditory disturbance. 6) There is correlation between the involved sites on brain MRI and the clinical manifestations. 7) Brain MRI showed typically bilateral, symmetrical hyperintense areas in the periventricular white matter of parieto-occipital areas in 5 cases out of 7 cases, One case showed frontal lobe involvement only without occipital lobe and another case showed multiple patch involvement in the internal capsules and thalamus. 8) Management was including restriction of saturated VLCFA in diet, steroid therapy, physiotherapy, IV globulin, and Lorenzo oil. Clinical courses were not reversed. In conclusion, we could confirm adrenoleukodystrophy using plasma VLCFA assay without brain biopsy, and earlier diagnostic approach was possible owing to brain MIR.

      • KCI등재

        신경역동법과 역학적 인터페이스의 중재가 요통과 연관된 하지통 환자에게 미치는 영향

        유정희(Yu Jeong-Hee),허진강(Hur Jin-Gang),고태성(Ko Tae-Seong) 대한치료과학회 2013 대한치료과학회지 Vol.5 No.1

        Objective: The objective of this research is to conduct a 4 week study of low back related leg pain. Management of neurodynamic and mechanical interface, the results on the patients' pain and function, centralization of phenomenon. Method: This research was conducted on 3 low back related leg pain patients undergoing physiotherapy at W hospital from January, 2013 until March, 2013. In the evaluation, pain level with Numeric Pain Rating Scale(NPRS), pain location scale(PLS), korean oswestry disability index(KODI). All measurement of each subject were measure at pre-treatment and post-treatment(after 4weeks). The physical therapy program designed of SPSS 18.0 program was used to compile result. The difference between was compared pre-test and post-test using paired t test. Results: The pain and function, centralization of phenomenon were significantly difference between pre-treatment and post treatment(after 4weeks)(p<.05) Conclusion: This study suggest that management of mechanical interface with neural mobilization technique improved ROM, Disability and decrease pain score.

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