Open, randomized and comparative study for the efficacy of oral finasteride and the efficacy of the combination therapy of oral finasteride and 5% topical minoxidil

계영철 ( Young Chul Kye ) 대한피부과학회 2008 초록집 Vol.46 No.20

Pityrosporum orbiculare에 대한 수종약물의 최저억제농도에 관한 연구

계영철(Young Chul Kye),진용우(Yong Woo Cinn),김수남(Soo Nam Kim) 대한피부과학회 1983 大韓皮膚科學會誌 Vol.21 No.2

The bacteria as well as the fungi can build up resistance against different kinds of drugs or can decrease in sensitivity to these drugs. Therefore it is necessary that we use the MIC test for acertain period of time to determine the right concentration of drug to use in therapy. The culturing of P. orbiculare was successful in 1951. Up until that time, there were few drugs available to use in the MIC test. So, treatment for Tinea versicolor was dependent upon ones previous experience in determining the drug's effective concentration. Therefore, we performed the MIC test of clotrimazole, sodium thiosulfate, selenium sulfide, propylene glycol against P. orbiculare. The diagnos is for Tinea versicolor in the patient was confirmed by using KOH smear and by the clinical manifeststion. The fungi were then isolated in a culture from an olive oil rich media Mixture of isolated fungus and olive oil was applied to the lateral side of a healthy male's right upper extremity. After one week, P. orbiculare was confirmed by wood lamp examination, KOH smear and culture. After confirmation of P. orbiculare, a variety of concentrated drugs were used. Then media, containing propylene glycol, sodium thiosulfate, selenium sulfide and clotrimazole with a small amount of olive oil was used in inoculations of 10 viable unit/ml of P.orbiculare in attempt to estblish the MIC test. Test results are as follows: l) Propylene glycol MIC Range; 12. 5mg/ml~7. 5mg/ml. 2) Sodium thiosulfate MIC Range; 500mg/ml~7. 5mg/ml. 3) Selenium sulfide MIC Range; l. 25mg/ml~0. 04mg/ml. 4) Clotrimazole MIC Range; 0. 5mg/ml~ 0. 0005mg/ml.

피부질환에 대한 레이저 치료

계영철 ( Young Chul Kye ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.1

피부 및 피부 부속기에서의 HBsAg 발현에 관한 면역조직화학적 연구

계영철(Young Chul Kye),안철현(Chul Hyun Ahn),김한겸(Han Kyeom Kim),오칠환(Chil Hwan Oh),김수남(Soo Nam Kim) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.1

The present study was carried out to investigate the HHsAg in the normal skin, dis- eased skin and skin specimens of window period of HBsAg positive patients in their serum with normal liver function. This study was done by immunoperoxidase techniques using the monoclonal antibody to hepatitis E3 surface antigen and by electron microscopy. Immunoperoxidase staining was dane on twenty specimeris of normal skin Group .D twenty specimens of diseased skin (15 cases of dermographism, 2 cases of purpura, 1 case of follicuht,is and 1 cases of morbilliform eruption) (Ciroup II ) and three specimens of normal skin af window period (Group III ) of HBsAp positive patients in their serum. Twelve cases of Group I, eleven cases of Group IL (1(J cases of dremographism and 1 rase of purpura) and two cases of Group II were stained positively for HBsAg. Positive sites were keratinocyte of epidermis, sweat gland, blood vessel and hair follicle. Electron microscopy failed to reveal viral particle, The above resuts suggest the possibility of transmission of viral hepatitis B thraugh the skin and skin appendages. (Kor J Dermatol 29(1): 18 25, 1991)

좌족에 발생한 Clear Cell Sarcoma

계영철(Young Chul Kye),김용상(Yong Sang Kim),홍승민(Seung Min Hong),진용우(Yong Woo Cinn),김수남(Soo Nam Kim) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.3

Clear cell sarcoma of tendon and aponeuroses is slow growing and painless. It occur chiefIy in young adults, predominates in women and is most common in the region of the foot and knee. It is intimately bound to tendons or aponeuroses and is composed of srnall nest or aggregates of round or fusiform, pale staining cells showing prominent nucleoli. And it is tend to recur and to resuIt in eventual development of metastatic growth after a protracted clinical ccurs. Herein, we report a case of clear cell sarcorna of tendon anu aponeuross of metatarsophalangeal joint area between 2nd and 3rd light of left foot. The patient, 50-year-old female had a slow groving, asymptomatic, slightly eevated, emooth surfaced and normal skin colored mass for 2 years. Histopatholcigic tindings in dermis revealed nests of atypical polygonal or monotonous cells. Each cell had vesicular or hyperchrornatic nucleus with prominent nucleoli, occcasionally mitotic figure and abundant eosinophilic cytoplasm. For. treatment, transmetatarsal amputation was done.

Recurrent Infantile Digital Fibroma

최현철(Hyun Chul Choi),계영철(Young Chul Kye),오칠환(Chil Whan Oh) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5

Recurrent infantile digital fibroma is a peculiar fibrous tumiir that may be single or multiple on fingers and toes of infants and children. We report a 5-year-old gril with recurrent infantile digital fiber oma which was recurrent on the left 5th toe. The lesion had noted at the age of 6 months. and was excised surgically when the child was 3 year old. 2 years after operation, the lesion was recurred in operation site. Microscopically, nodular fibrous mass is attached to flattened,pidermis. The underlying nodule is composed of proliferating fibroblasts surrounded by derse collagenous tissue. We could find eosinophilic inclusion bodies in the cytoplasm of fibro ilast. It was stained pink with H&E, bright red with Massons trichrome and purple with PTAH. (Kor J Derrnatol 1992;30(5):743-746)

아토피성 질환에서의 피부단자시험 성적 및 혈청 IgE , RAST에 관한 연구

최현철(Hyun Chul Choi),계영철(Young Chul Kye),문기찬(Kee Chan Moon),김수남(Soo Nam Kim) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5

This study was done for the evaluation of correlation among skin test reactivity, total serum IgE and RAST level in 202 atopic disease patients, who weie composed of 165 patients with allergic rhinitis, 22 patients with bronchial asthma, 11 patients with urticaria and 4 patients with atopic dermetitis. The results were as follows: 1. The sex ratio of male to female of 202 pat,ients with atopic disease was 1.3:1(114:88) and patients with age grciup of 2nd and 3rd decades occupied 64.9%. 2. The positive reactivity of the skin scratch test in general was 62.9%. The positive ratio was highest in 2nd and 3rd decades, 76.5% and 63.8% respectirely. The positive ratio was decreased as the age of patients increased. 3. The individual allergens which showed higher positive reaction in skin scratch test were D. farinae, house dust, cat hair, cockroach and Trichophyton ii descending order. In group allergens, the house dust groups consisted 45.5% of positiv. reaction of total number of the positive allergens. The positive ratio of aeroallergen was 84.5% whereas that of foods was only 11.5%. 4. The positive ratio of house dust group was 45.0% of total patients. 5. 41.1% of patients showed positive reactivity to two or more allegens while 21.8% was positive to single allergen. The most frequent combinations were 2 to 4 allergens(95.2%). 6. The mean of total serum IgE level in 63 patients who were poitiie skin scratch test was 470.5 IU/ml. 81.0% of these patients showed high serum IgE level. 7. As the positive reactivity of skin scratch test was increased, the mean level of total serum IgE was elevated(r=0.919). 8. A highly significant correlation was existed between the mear size of D. farinae scratch test reactions and the level of specific IgE to D. farinae(r=0.977). (Kor J Dermatol 1992;30(5):633-643)

건선으로 진단된 병소의 조직병리학적 관찰

조호연,계영철,김수남 (Ho Youn Jo,Young Chul Kye,Soo Nam Kim) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.4

Background: Psoriasis is a dynamic process, both clinically and histopathologically. There is wide spectrum of histological change recognizable in psoriatic lesions. Objective : We attempted to clarify the histological features in psoriasis by quantitative studies. Methods : We reviewed the clinical charts, photographs and skin biopsy slides of 106 patients who were diagnosed as psoriasis clinically or histopathologically between March, 1990 and August, 1994 at the Department of Dermatology, Korea University Hospital. The 12 histopathologic fea tures of psoriasis were listed and examined whether these features were seen or not. in each section. And if seen, then the features were scored 0 to 1. The sum of score in ear,h section could range from 0 to 12. Results : 1. 72 of 106 patients were psoriasis vulgaris. In other patients, the clinical forms of psoriasis wer e guttate psoriasis, pustulosis palmoplantaris, and generalized pustular psoriasis. 2. The average score of histopathologic features seen in each section were 8.11 -2.11. 3. Sections commonly showed club shaped rete ridges, elongation and ederna of the dermal papil- lae, perivascular mononuclear infiltrate in the upper dermis, absent granular layer, parakeratosis, suprapapillary plate thinning, mitosis above basal cell layer, and dilated tortuous blood vessels. The observed frequency of Munro microabscess, spongiform pustule, and dilated tortuous blood vessels were significantly lower in psoriasis vulgaris than in other clinical forms(p<0.05). Conclusion : This study showed that the histologic picture of psoriasis varied with the clinical forms. In each section seen, the observed frequncy of Munro microabscess and spongiform pustule was relatively low. (Kor J Dermatol 1996;34(4): 580-584)

성장 호르몬 치료와 관련되어 발생한 건선 2예

허영수 ( Young Soo Heo ),정세영 ( Se Yeong Jeong ),최재은 ( Jae Eun Choi ),서수홍 ( Soo Hong Seo ),안효현 ( Hyo Hyun Ahn ),계영철 ( Young Chul Kye ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6

Growth hormone (GH) has been available for more than 4 decades for the treatment of GH deficiency. But mass production of recombinant DNA growth hormone has made GH therapy widely available for children with no GH deficiency. The use of GH therapy in children has resulted in adverse effects ranging from minor disturbances such as edema and injection site reactions to more significant, but rare events such as benign intracranial hypertension and slipped capital femoral epiphysis. Yet there has been no report in the dermatological field on skin adverse effects associated with GH therapy. We report here on 2 cases of psoriasis following GH therapy in children. (Korean J Dermatol 2009;47(6):714∼717)

Erbium YAG 레이저 조사 후 Guinea Pig 피부에서 관찰된 조직학적 변화

양재석,계영철,김수남 ( Jae Seok Yang,Young Chul Kye,Soo Nam Kim ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.4

Background: Laser resurfacing has beneficial effects in the treatment of several skin problems such as acne and chicken pox scars. Recently pulsed erbium YAG laser has been used for skin resurfacing, but not enough is known about the scientific basis of such treatment. Objectiye : The purpose of the study was to assess the macroscopic and microscopie changes after irradiation with the pulsed Er-YAG laser. Methods : We did two tests on guinea pig skin, First, the laser was used to irradiate the skin of a guinea pig with the intensity of 500 mJ, 5 watt until pinpoint bleeding began. Skin biopsies were performed immediately, one, two and four weeks after the irradiation. Second, the laser was used to irradiate the skin of a guinea pig with the intensity of 300mJ(3watt), 500mJ(5watt), 700mJ(7watt) until pinpoint bleeding began, Skin biopsies were examined immediately, one, two and four weeks after the irradiation. Results : 1. Histological changes to the dermis over time after laser irradiation with 500 mJ, 5 watt are as follows: After one week, complete reepithelization and proliferation of the blood vessels within the dermis occured. A reaction of th dermis which consisted of newly formed collagen and was distinguisbed from the lower dermis was also examined. The reaction was rnost active after two weeks and lasted up to four weeks. 2. Histological changes to the dermis over time after laser irradiations with different intensities of 300 mJ(3watt), 500 mJ(5watt), and 700 mJ(7watt) are as follows : In all the cases of laser irradiation with different intensities, edema, neovascularization and fine collagen fiber in the upper dermis were observed. At higher intensities, the dermal reactions were stronger and were sustained for a longer time. Conclusion : Pulsed erbium YAG laser had effects on the epidermis and dermis. Therefore, pulsed erbium YAG laser can be used for skin resurfacing effectively and safely. (Kor J Dermatol 1997;35(4): 851-659)