http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
강혜심 ( Hye Sim Kang ),임은선 ( Eun Seon Im ),최승아 ( Seung Ah Choi ),전혜원 ( Hye Won Jun ),이택상 ( Taek Sang Lee ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.2
Benign metastasizing leiomyoma (BML) is a rare entity, defined as a muscle tumor in association with one or more smooth muscle tumor of the uterus and without evidence of any extra uterine primary site. The lung is the most common site of involvement,2 and the etiology of BML remains unknown. We experienced a case of BML arising in pelvic and para-aortic lymph nodes and report with a brief review of literature.
속발성 무월경 외 비정상 표현형이 없는 Trisomy 8 Mosaicism의 증례 보고
강혜심(Hye Sim Kang),손영수(Young Soo Son),김성엽(Sung Yob Kim),박철민(Chul Min Park),심순섭(Soon Sup Shim) 대한의학유전학회 2011 대한의학유전학회지 Vol.8 No.1
체질성 8삼염색체 모자이시즘은 비교적 드문 염색체 이상으로 특이한 두개안면 모양 (변형 두개골, 돌출된 이마, 낮거나 변형된 귀), 골격계 기형, 심장 기형, 신장 기형, 잠복고환, 다양한 정도의 발달지체 등의 특징적인 표현형을 갖는다. 그 표현형과 세포유전학적 표현의 다양성 때문에 특정 질환이 생기기 전까지 진단이 늦어지기도 한다. 전형적인 표현형 없이 속발성 무월경을 동반한 28세 여성에서 발견된 체질성 8삼염색체 모자이시즘(47,XX,+8[9]/46,XX[41])을 보고한다. Constitutional trisomy 8 mosaicism (CT8M) is a relatively rare aneuploidy in humans with characteristic phenotypes including typical craniofacial feature (such as deformed skull, prominent forehead, low-set and/or dysplastic ears), skeletal malformation, cardiac anomaly, renal malformation, cryptochidism, varying degree of developemental delay. Due to the extremely variable phenotypic and cytogenetic expression, CT8M has gone undiagnosed in certain patients. We report a 28-year-old women with secondary amenorreha without characteristic CT8M phenotype. Chromosomal analysis showed a CT8M (47,XX,+8[9]/46,XX[41]).
자궁강내 인공수정 후 단각자궁 비소통 흔적 자궁에 임신돤 환자의 자궁 파열 및 태아 생존
심순섭 ( Soon Sup Shim ),강혜심 ( Hye Sim Kang ) 대한주산의학회 2013 Perinatology Vol.24 No.2
Rudimentary horn is a rare uterine anomaly and pregnancy in the rudimentary horn is an extremely rare condition. We report a case of live birth in a non-communicating rudimentary horn pregnancy and rupture. The pregnancy was successfully delivered by cesarean section, with neonatal and maternal survival.
박정우 ( Jeong Woo Park ),강혜심 ( Hye Sim Kang ),오경준 ( Kyung Joon Oh ),박찬욱 ( Chan Wook Park ),안현숙 ( Hyun Sook Ahn ),박중신 ( Joong Shin Park ),전종관 ( Jong Kwan Jun ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.12
We present two fetuses who were prenatally diagnosed by amniocentesis as having chromosomal mosaicism but who had a normal karyotype in the fetal blood by cordocentesis. One of the both fetuses had Turner and the other had trisomy 20 mosaicism. The prognosis for Turner mosaicism and trisomy 20 mosaicism diagnosed prenatally has yet to be established. The pregnancy with 45,X/46,XX mosaicism was terminated at 23+3 weeks` gestation. Autopsy findings showed no features of Turner`s syndrome. Postnatal cytogenetic analysis revealed 45,X[4]/46,XX[52] mosaicism in skin and 46,XX in the lung tissue. The other fetus had amniocytes with trisomy 20 mosaicism and fetal cord blood cells with a normal karyotype. The baby was delivered at 38+2 weeks` gestation. At birth and 3 months after birth, no apparent abnormal findings were found. These cases with chromosomal discrepancy among various fetal tissues are rare. Two cases were discussed with the review of literature.
제대혈 내 Matrix Metalloproteinase-9 농도와 제대염의 연관성
심순섭 ( Soon Sup Shim ),강혜심 ( Hye Sim Kang ),맹영희 ( Young Hee Maeng ),김영돈 ( Young Don Kim ) 대한주산의학회 2015 Perinatology Vol.26 No.1
Objective: Intrauterine inflammation (IUI) is a leading cause of preterm delivery. Although matrix metalloproteinase8 (MMP8) and intercellular adhesion molecule1 (ICAM1) are known to be related with IUI, it has not been fully elucidated whether MMP9 or ICAM3 is associated with IUI. We performed this study to determine whether the levels of tumor necrosis factoralpha (TNFα), MMP9 and ICAM3 in umbilical cord blood of preterm infants are associated with chorioamnionitis, funisitis or bronchopulmonary dysplasia. Methods: Eightytwo pairs of pregnant women and their preterm newborns <35 weeks gestation were enrolled. Levels of TNFα, MMP9 and ICAM3 in umbilical cord blood were measured using immunoassays and compared with results of histological examination of placenta and clinical data of the study participants. Results: The level of MMP9 in umbilical cord blood was significantly associated with the presence of funisitis (P=0.007). The level of TNFα in umbilical cord blood was significantly associated with the development of bronchopulmonary dysplasia ( P=0.030). However, presence of chorioamnionitis or funisitis was not associated with development of bronchopulmonary dysplasia. With the establishment of receiver operating characteristic (ROC) curve, the best cutoff value for umbilical blood MMP9 was 99.42 pg/mL in identification of funisitis. The area under a constructed ROC curve for prediction of funisitis was 0.847 (standard error, 0.112; 95% confidence interval, 0.7500.917). Conclusion: Measurement of MMP9 concentration in umbilical cord blood may be an alternative way to predict whether a preterm infant has been exposed to IUI. Further study with larger numbers of subjects will be necessary to elucidate the association between the presence of IUI and neonatal adverse outcome.