두경부암 환자에 병발된 위암 2예

강진형(Jin Hyoung Kang),문찬수(Chan Soo Moon),김훈교(Hoon Kyo Kim),이경식(Kyung Shik Lee),김동집(Dong Jip Kim),윤세철(Sei Chul Yoon),조승호(Seung Ho Cho),서병도(Byung Do Suh) 대한두경부종양학회 1992 대한두경부 종양학회지 Vol.8 No.1

The causes of treatment failure in head and neck cancer are locoregional recurrence, distant metastasis and second primary cancer. The favorite sites of second primary cancer are head and neck, lung and esophagus. But, the incidence of stomach cancer in Korea is the highest of all, high incidence of stomach cancer is expected in head and neck cancer patients. We experienced 2 cases of stomach cancer after successful treatment of primary head and neck cancer at Kang Nam St. Mary's hospital. The first case was a 60-year-old male with nasopharyngeal non-keratinizing carcinoma(stage III, T1N1M0). He received three cycles of induction chemotherapy including cisplatin and 5-fluorouracil followed by radiotherapy which resulted in complete response. Five months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. He received one cycle of FAM chemotherapy and died 4 months after diagnosis of stomach cancer. The second case was a 50-year-old male with pyriform sinus squamous cell carcinoma(stage II, T2N0M0). He received curative partial pharyngolaryngectomy followed by radiotherapy which result in free of disease. Four months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. Bypass gastrojejunostomy was performed. The screening test for stomach cancer including upper gastrointestinal X-xay series and/or endoscope of the stomach should be performed periodically for the patients with head and neck cancer in Korea.

몇가지 관해유도요법제에 의한 급성임파구성 백혈병의 관해율

강진형(Jin Hyoung Kang),진종률(Jong Youl Jin),홍영선(Young Seon Hong),한치화(Chi Wha Han),박종원(Jong Won Park),김춘추(Choon Choo Kim),김동집(Dong Jip Kim),김학기(Hack Ki Kim) 대한내과학회 1987 대한내과학회지 Vol.32 No.5

N/A The case analysis of 74 patients, who were admitted to St. Mary's hospital from Jan, 1982 to Dec. 1986, and had a diagnosis as acute lymphocytic leukemia by bone marrow aspiration and biopsy was conducted. Of all the patients, the number of patients who were treated with VP regimens were 7, VPM regimens 6, VP, L-asp. regimens 4, L2, regimens 28, Modified L, regimens 15, miscellaneous regimens 3 for induction of complete remission. All of them were 63. We could find several interesting informations about the CR rate, duration of CR, survival rate between several prognostic factors. The CR rate in VP regimens was 42.9%, VP. L-asp. regimens 60.7%, L, regimens 67.9%, Modified L, regimen 93.3% According to the FAB classification, there were no difference in CR rate. (L1 76.2%, L2 70.3%, L3 80%) In patients who had CHOP regimen as consolidation, median, duration of CR was longer (6.6 months) than that in patients without CHOP (3.8 months). In the comparison of duration of survival between the immunologic classification, median duration of survival in C-ALL was 12 months and T-ALL was 4.5 months. We might come to conclusion as follows; 1) Modified L2 regimen is superior to other regimens to bring CR. 2) Early consolidation therapy give us more longterm disease free survival. 3) The survival rate of C-ALL is better than that of T-ALL.

증례 : 혈액종양 ; 비인두암 환자 중 동시항암화학방사선요법 후 발생한 단순 헤르페스 뇌염

최혜진 ( Hye Jin Choi ),이지은 ( Ji Eun Lee ),홍숙희 ( Suk Hee Hong ),전은경 ( Eun Kyung Jeon ),이시원 ( Sea Won Lee ),김연실 ( Yeon Shil Kim ),강진형 ( Jin Hyoung Kang ) 대한내과학회 2015 대한내과학회지 Vol.88 No.5

동시항암화학방사선요법 또는 전뇌방사선 치료 등을 시행하는 환자의 경우 면역 반응의 저하로 인하여 HSE가 발병할 확률이 증가하며 임상증상 및 검사 소견이 비특이적이다. 따라서 발열 및 의식 변화가 나타나는 환자에서는 HSE를 감별진단 중 하나로 고려해야 한다. 본 증례에서는 즉각적인 항바이러스 치료에 좋은 반응을 보였으며 비교적 양호한 임상경과를 보인, 동시항암화학방사선요법 시행 중에 병발한 HSE를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다. Herpes simplex encephalitis (HSE) is a rare viral encephalitis in adults. A high (70%) mortality rate with serious complications has been reported even after active, appropriate management. The association between HSE and immune suppression is unclear, but there are case reports of cancer patients in which HSE concomitantly developed after whole brain radiation or high-dose steroid treatment. The clinical manifestations and laboratory findings of these patients are atypical compared to the general population. Although brain magnetic resonance images reveal typical HSE findings, cerebrospinal fluid (CSF) analysis might be normal in cancer patients. We report a case of HSE in a 48-year-old male diagnosed with nasopharyngeal cancer and treated with concurrent chemoradiation. This patient had a normal cell count in CSF, but HSE was finally diagnosed from positive polymerase chain reaction test results. After administration of acyclovir and systemic steroid treatment, the patient had a good clinical course with few neurologic sequelae. (Korean J Med 2015;88:602-607)

조경용 투수성 블록 포장의 열환경 특성

한승호,류남형,강진형,Han Seung-Ho,Ryu Nam-Hyong,Kang Jin-Hyoung 한국조경학회 2006 韓國造景學會誌 Vol.34 No.2

This study aims to measure and to analyze the thermal environment characteristics of the various permeable pavement materials such as grass pavement (GREEN BLOCK PARK), stone and grass pavement (GREEN BLOCK STEP), stone pavement (GREEN BLOCK MOSAIC) and wood pavement (WOOD BLOCK) under the summer outdoor environment. The thermal environment characteristics measured in the study includes the changes of surface temperature during the day, changes of the temperature on each pavement layer, and long and short wave radiation of each pavement surface. The experimental condition is based on the data on the hottest temperature (August 5, 2005, $34.0^{\circ}C$) of the you. Some of main findings are: 1) The heat environment was worse on the wood pavements than on the stone pavement. This is mainly due to the low albedo of the wood pavements (0.37) while the albedo value of stone pavements is 0.41. Small heat capacity of the wood pavements also contributes to this difference. 2) The heat environment was worse on the stone pavements than on the turf pavements. This was mainly due to the evapotranspiration of the plant growth layer of the turf pavements. 3) The peak surface temperature was the highest on the wood pavements ($56.1^{\circ}C$). The peak surface temperatures on the stone pavements, the stone-grass pavements and the grass pavements were $43.1^{\circ}C,\;40.1^{\circ}C\;and\;37.9^{\circ}C$, respectively. 4) To improve the thermal environments in the urban area, it is recommended to raise the albedo of the pavements by brightening the surface color of the pavement materials. Further studies on the pavement materials and the construction methods which can enhance the continuous evapotranspiration from the pavements surface are needed.

투수성 잔디블록 포장 하부 토양의 물리성

한승호,김원태,강진형,Han, Seung-Ho,Kim, Won-Tae,Kang, Jin-Hyoung 한국조경학회 2006 韓國造景學會誌 Vol.34 No.4

Impervious pavement is primary contributor to the malfunctioning of the urban water circulation system. The aim of this research is to provide basic information and data for new pavement materials and paving technology which could enhance the urban water circulation system. For the study purposes, physical properties of soils sampled from 16 stations were analyzed. The sampling spots were paved with grass block porous pavement material. The findings from the analysis are as follows. The hardness of soils under the pavement was $17{\sim}22mm$ for thoroughfare and $6{\sim}32mm$ for parking areas. The bulk density was $1.42{\sim}1.81g/cm^{3}$ for thoroughfare and $1.38{\sim}1.75g/cm^{3}$ for parking area. The solid phase ration was $46.9{\sim}62.5m^{3}/m^{3}$ for thoroughfare and $45.6{\sim}61.3m^{3}/m^{3}$ for parking area. The porosity was $37.5{\sim}53.1m^{3}/m^{3}$ for thoroughfare and $38.7{\sim}54.4m^{3}/m^{3}$ for parking area. The saturated hydraulic conductivity was $8{\sim}164mm/hr$ for thoroughfare and $14{\sim}201mm/hr$ for parking area. The saturated hydraulic conductivity of the H sample area (the area was completed three months ago) and that of the other area were compared. There was up to 80% decreases of the saturated hydraulic conductivity within one year after the completion of pavement. After the first year, decrease in the saturated hydraulic conductivity was modest. Also there are changes in both surface and under soil physical properties of the grass block porous pavement depending on compaction. The extent of change depends on the degree of compaction. All these factors are combined to influence the permeability of the soil under the pavements. The results of this suggest that it is required to develop a new pavement technology which ensures both the durability and porosity of the pavement to improve the water circulation system by applying Ecological Area Rate.

잔디주차장 시공을 위한 잔디블록 활용방안

한승호 ( Seung Ho Han ),강진형 ( Jin Hyoung Kang ),최준수 ( Joon Soo Choi ),양근모 ( Geun Mo Yang ),윤용한 ( Yong Han Yoon ),구태익 ( Tae Ik Ku ),김원태 ( Won Tae Kim ) 한국환경과학회 2009 한국환경과학회지 Vol.18 No.9

저수형 잔디블록 저수조 내 충진재료에 따른 저수량 및 초종별 증발산량

한승호,최준수,양근모,양병이,강진형,김원태,Han, Seung-Ho,Choi, Joon-Soo,Yang, Geun-Mo,Yang, Byoung-E,Kang, Jin-Hyoung,Kim, Won-Tae 한국조경학회 2006 韓國造景學會誌 Vol.34 No.5

The purpose of this study was to investigate the performance of porous grass block. For the investigation, Festuca arundinacea and Zoysia japonica 'Zenith' were planted, and the volume of evapotranspiration and remains were examined based on different materials in the water tank in the experiment of Festuca arundinacea, the volume of water storage of treatment with perlite ($10.84{\iota}/m^2$) was higher than that with drainage ($7l/m^2$). The difference between the two was $3.84/m^2$. The drainage treatment without water storage capacity showed the higher degree of dryness in turf grass. The volume of evapo-transpiration of treatment with perlite was the highest (21.57mm/week). The volume of evapotranspiration of treatment with sand was 19.57mm/week, and with treatment with drainage was 18.24mm/week. Based on the measured volume of daily evapotranspiration of $2.60{\sim}3.08mm\;d^{-1}$, it was determined that the unit with water storage capacity would store water of one to two days usage compared to unite without such storage capacity. In the experiment of Zoysia japonica 'Zenith', the volume of water storage of treatment with perlite was $10.77l/m^2$ which was similar to the former experiment. The volume of evapotranspiration of treatment with perlite and sand were 21.64mm/week and 20.64mm/week, respectively. In case of airtight water tank, the volume was measured as 22.06mm/week. Each treatment has no notable difference in the volume of evapotranspiration. In conclusion, from the investigation in this study, porous grass block with water tank was found to be effective in plant growth under low irrigation. As the ecological area ratio and vegetated porous pavement have became more emphasized, additional study of rain infiltration and reservoir effect are needed in the future.

증 례 : EGFR 돌연변이와 ALK 재배열 공존하는 폐선암 환자 1예

김민아 ( Min Ah Kim ),강진형 ( Jin Hyoung Kang ),김인호 ( In Ho Kim ),김태정 ( Tae Jung Kim ),김승준 ( Seung Joon Kim ),성숙환 ( Sook Whan Sung ),허솔미 ( Sol Mi Huo ) 대한내과학회 2016 대한내과학회지 Vol.90 No.1

A 58 year-old woman was diagnosed with lung adenocarcinoma (cT3N1M0). We detected a point mutation in epidermal growth factor receptor (EGFR) exon 21 (L858R) and an echinoderm microtubule-associated protein-like 4- anaplastic lymphoma kinase (ALK) rearrangement. The patient was treated with preoperative neoadjuvant chemotherapy and underwent a left lower lobectomy with mediastinal lymph node dissection. However, we could not detect any mutation in EGFR or the ALK rearrangement from the tumor tissue removed. Then, 70 days after completion of adjuvant chemotherapy, she visited our outpatient clinic with diminished visual accuracy and tinnitus. A single brain metastatic lesion was seen on brain magnetic resonance imaging. She underwent surgical removal of the brain mass, which showed a mutation of EGFR, exon 21, but no ALK rearrangement. We report this unusual case of lung adenocarcinoma with a coexisting EGFR mutation and ALK rearrangement, and identify gene alterations before chemotherapy, after chemotherapy, and at recurrence. (Korean J Med 2016;90:72-77)

두경부암에서 정밀의료

박혜성(Hye-sung Park),강진형(Jin-Hyoung Kang) 대한두경부종양학회 2023 대한두경부 종양학회지 Vol.39 No.1

Technological advancement in human genome analysis and ICT (information & communication technologies) brought ‘precision medicine’ into our clinical practice. Precision medicine is a novel medical approach that provides personalized treatments tailored to each individual by precisely segmenting patient populations, based on robust data including a person’s genetic information, disease information, lifestyle information, etc. Precision medicine has a potential to be applied to treating a range of tumors, in addition to non-small cell lung cancer, in which precision oncology has been actively practiced. In this article, we are reviewing precision medicine in head and neck cancer (HNC) with focus on tumor agnostic biomarkers and treatments such as NTRK, MSI-H/dMMR, TMB-H and BRAF V600E, all of which were recently approved by U.S. Food and Drug Administration (FDA).

충청지역에서 발생한 Rickettsia 감염 40 예에 대한 임상적고찰

이종민(Jong Min Lee),강진형(Jin Hyoung Kang),박석영(Suk Young Park),김석영(Suk Young Kim),박준철(Jun Chul Park),임계순(Kae Soon Im),백남종(Nam Jong Baeg),김영우(Young Woo Kim),정희영(Hee Young Chung),주용구(Young Kyu Chu),이호왕(Ho W 대한내과학회 1988 대한내과학회지 Vol.34 No.5

N/A In Korea, there has been an increasing concern on rickettsiosis as a possible cause of unknown febrile illness since Tsutsugamushi disease among Koreans were first reported m 1986. We experienced 40cases of rickettsiosis occuring in Choong-chung-do area during the period October-November, 1986. 30cases were confirmed as Tsutsugmushi disease by indirect immunofluorescent antibody test. 10cases were positive to Weil-Felix test but negative to indirect immunofluorescent antibody test. The clinical illness was chracferized by abrupt onset of fever, chill and skin rash. Lymphadenopathy, headache and myalgia were not uncommon. Eschar was also detected in several cases and intersitial pneumonitis, pulmonary edema were appeared in 3cases, In our study, Tsutsugamushi disease was an mild to moderate febrile illness of 2 to 3 weeks duration.