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안면부에 재발되는 환상 홍반을 보인 Sjogren 증후군
강진문 ( Jin Moon Kang ),윤경한 ( Kyeong Han Yoon ),한승경 ( Seung Kyung Hann ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5
Sjogren's syndrome has been considered to be an autoimmune disease affecting various organs including salivary and lacrimal glands. It occurs most commonly in middle-aged women, and less than 20 cases with primary Sjogren's syndrome have been reported in children. An 11-yim-old boy presented with recurrent annular erythema on the face that had been present for 2 years. A schirmers test showed a positive result. ANA was detected at a dilution of 1:640. Anti-Ro/SSA and anti-La/SSB antibodies were also detected. On histological examination, lymphocytes were infiltrated in the periappendegeal areas as well as the papillary and reticular dernis. The skin findimg is uncommon in children, but has become a characteristic feature of childhood Sjogrens syndrome with anti-Ro and/or anti-La antibodies. (Korean J Dermatol 1998;36(S): 910-913)
강진문 ( Jin Moon Kang ),조한경 ( Han Kyoung Cho ),이광훈 ( Kwang Hoon Lee ),이정복 ( Jung Bock Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.6
Background : Trichloroacetic acid(TCA) chemical peel has been used for variable skin lesions. However, the effect of TCA chemical peel on acne scars has not been studied. Objective : The object of this study is to evaluate the effect of TCA chemical peel on atrop hic acne scars. Method: Twenty three patients with atrophic acne scars, who were treated with TCA chemical peel were included. The patieits were interviewed for evaluation of the therapeutic efficacy of TCA chemical peel regarding the number of treatment and satisfaction rates. Results : Those who received treatment for more than 6 times with good or excellent results were 13 out of 15 patients, whereas, those who received treatment for 4 times with good or excellent results were 4 out of 7 patients. Thus, chemical peel on acne scars showed that the more often the treatment was carried out, the better the therapeutic effect. There was no significant complication. Conclusion : TCA chemical peel is safe and effective for the treatment of atrophic acne scars. (Kor J Dermatol 1996;34(6): S19-923)
Desferrioxamine이 사람 간암 세포주의 DNA 합성에 미치는 영향
강진경(Jin Kyung Kang),김원호(Won Ho Kim),송시영(Si Young Song),김도영(Doe Young Kim),문일환(Il Hwan Moon),윤견일(Kyun Il Yoon) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
N/A Desferrioxamine (DFO), an iron chelator, has been sbown to have antiproliferative activity in a variety of malignant cells including hepatocellular carcinoma. The antiproliferative effect of DFO's known to be caused by decreased activity of ribonucleotide reductase, a key enzyme in DNA synthesis. This study was conducted to investigate the effect Of DFO on the DNA synthesis of cultured hepatoma cells. The proliferation of hepatocellular carcinoma (Hep 3B) as well as hepatoblastoma (Hep G2) cells was measured by trypan blue dye exclusion method and the DNA synthesis was measured by [3H] thymidine incorporation. The results obtained were as follows: The proliferation of hepatoma cells was slightly inhibited by 2 ug/ml and markedly inhibited by 6 ug/ml of DFO. This antiproliferative effect was not enhanced any more by higher dose of DFO. The percent viability of Hep 3B and Hep G2 cells was above 90%. after 96 hours of incubation with 60 ug/ml of DFO and that of Hep 3B and Hep G2 cells was 88.0% and 89.6% respectively after l6 hours of culture with 120 ug/ml of DFO. DNA synthesis of hepatoma ceils was decreased by DFO in a dose dependent manner up to 20 ug/ ml. The decrease of DNA synthesis was not enhanced any more by higher dose of DFO. In conclusion, the antiproliferative effect of DFO on cultured human hepatoma cell lines was caused by the inhibition of DNA synthesis rather than by direct cytocidal effect.
강진형(Jin Hyoung Kang),문찬수(Chan Soo Moon),김훈교(Hoon Kyo Kim),이경식(Kyung Shik Lee),김동집(Dong Jip Kim),윤세철(Sei Chul Yoon),조승호(Seung Ho Cho),서병도(Byung Do Suh) 대한두경부종양학회 1992 대한두경부 종양학회지 Vol.8 No.1
The causes of treatment failure in head and neck cancer are locoregional recurrence, distant metastasis and second primary cancer. The favorite sites of second primary cancer are head and neck, lung and esophagus. But, the incidence of stomach cancer in Korea is the highest of all, high incidence of stomach cancer is expected in head and neck cancer patients. We experienced 2 cases of stomach cancer after successful treatment of primary head and neck cancer at Kang Nam St. Mary's hospital. The first case was a 60-year-old male with nasopharyngeal non-keratinizing carcinoma(stage III, T1N1M0). He received three cycles of induction chemotherapy including cisplatin and 5-fluorouracil followed by radiotherapy which resulted in complete response. Five months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. He received one cycle of FAM chemotherapy and died 4 months after diagnosis of stomach cancer. The second case was a 50-year-old male with pyriform sinus squamous cell carcinoma(stage II, T2N0M0). He received curative partial pharyngolaryngectomy followed by radiotherapy which result in free of disease. Four months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. Bypass gastrojejunostomy was performed. The screening test for stomach cancer including upper gastrointestinal X-xay series and/or endoscope of the stomach should be performed periodically for the patients with head and neck cancer in Korea.
윤형규(Hyung Gue Yoon),강진형(Jin Hyung Kang),문한림(Han Lim Moon),채장성(Jang Seong Chae),김훈교(Hoon Kyo Kim),이경식(Kyung Shik Lee),김동집(Dong Jip Kim),이광수(Kwang Soo Lee),윤세철(Sei Chul Yoon),조승호(Seung Ho Cho),서병도(Byung 대한두경부종양학회 1993 대한두경부 종양학회지 Vol.9 No.1
저자들은 극소진행형 비인강암(제 4기, N₄N₂(c)) 환자에서 종양으로 인한 경동맥동 과민증후군과 관련되어 실신이 발생하였으며 방사선치료후 호전된 환자 1예를 경험하였다. The syndrome of carotid sinus hypersensitivity is cardovascular symptom complex including lightheadedness, transient loss of consciousness, perspiration, pallor, weakness of lower extremities, transient hypotension, bradycardia and seizure, which occurs from firing of hyperactive carotid sinus reflex. Most cases are idiopathic, but maliganant tumors involving parapharyngeal space have been occasionally implicated. We present a case of carotid sinus hypersensitivity due to nasopharyngeal carcinoma invading the parapharyngeal space with bilateral cervical lymphnode metastases(stage IV, T₄N₂M(0)). The patient experienced several episodes of severe syncope proceeded by blurring of vision, dizziness and nausea, which were used to occur while he was working in erect position. The tumors were markedly regressed by external radiation therapy with successful resolution of syncope.
김용주(Young Joo Kim),문한림(Han Lim Moon),김병욱(Byung Wook Kim),김희열(Hee Yeol Kim),방승호(Seung Ho Bang),안중현(Joong Hyun Ahn),한상국(Sang Kook Han),강진형(Jin Hyung Kang),홍영선(Young Seon Hong),김훈교(Hoon Kyo Kim),이경식(Kyun 대한내과학회 1995 대한내과학회지 Vol.48 No.5
N/A Acute leukemia after chemotherapy and/or radio- therapy for malignant disorder is called secondary acute leukemia(SAL) or therapy related leukemia. Typically, SAL is preceded by a prodrome phase or myelodysplastic syndrome (MDS) resulting in trilineage dysplasia manifested by pancytopenia, associated with cytogenetic abnormalities involving chromosome 5 and 7, and carries a poor prognosis. Although FAB M3 type(acute promyelocytic leukemia) of SAL had been rarely reported, recently there was a report on 16 cases of therapy-related acute promyelocytic leukemia. We hereby report a case of secondary acute promyelocytic leukemia after treatment of advanced breast cancer. A 62-year-old woman was admitted because of pancytopenia, purpura of legs and gingival bleeding. Since six years before admission when she was diagnosed as infiltrating ductal carcinoma of breast with metastases to lung, She had received CMF(cyclophosphamide, methotrexate, 5-fluorouracil) chemotherapy and radiotherapy, and underwent modified radical mastectomy after complete disappearance of pulmonary nodules, She had received further chemotherapy with cumulative doses of chemotherapeutic agents as following; 21g of cyclophosphamide, 410mg of doxorubicin, 21g of 5-fluorouracil, and 600 mg of methotrexate. Radiation doses to chest wall, axilla and supraclavicular area were 2880 to 3400cGy. The examination of bone marrow aspiration and biopsy showed acute promylocytic leukemia(FAR M3). Cytogenetic analysis of peripheral blood demonstrated 46XX[1]/46XX, t(7; 11) (p15; p15) [12]. The patient did not achieved a complete remission despite retinoic acid therapy and intensive chemotherapy with Ara-C and AMSA, and died 10 months after diagnosis of acute promyelocytic leukemia.