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강주형 ( Joo Hyung Kang ),조문균 ( Moon Kyun Cho ),최보라 ( Bo Ra Choi ),황규왕 ( Kyu Yang Whang ),노영석 ( Young Suck ),이창우 ( Chang Woo Lee ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Background: Heat shock proteins (HSP), especially the HSP 70 family, may play certain roles in the immunophysiology of some skin diseases such as psoriasis, pemphigus, and lichen planus. HSPs generally induce down-regulation of the process of apoptosis that is considered to be one of the acantholysis-producing pathways in pemphigus. Objective: We planned to examine possible roles of HSPs 70/105 in the blistering process in pemphigus vulgaris (PV) and pemphigus foliaceus (PF), in connection with the detection results of apoptosis in local tissue specimens. Methods: Immunohistochemical stainings and Western blot analysis were performed for the detection and semiquantitation of HSPs 70/105 in skin specimens from lesional, nonlesional, and normal control sites. Hoechst 33342 staining was simultaneously carried out to examine features of apoptosis in lesional skin specimens. Results: The findings on expression of HSP were as follows. In PV, the expression of HSP 70 was minimum or negative; however, in PF, the expression was obvious and recognizable in lesional and perilesional normal skin. In contrast, HSP 105 was not detected in all cases of PV and PF. The features of apoptosis were evident at the lesional skin of all cases of pemphigus with acantholytic changes. Conclusion: PV and PF had different relative intensities of HSPs in lesional tissue stainings, especially in cases with HSP 70. This suggests that there may be subtle differences in the mechanisms causing acantholysis between PV and PF. (Korean J Dermatol 2008;46(8):1003~1010)
급성 감염후 사구체 신염이 동반된 성인 Henoch-Schonlein 자반증 1례
문경민 ( Kyoung Min Moon ),강주형 ( Joo Hyung Kang ),김동규 ( Dong Gyu Kim ),이웅철 ( Woong Chul Lee ),문유리 ( Yu Ri Moon ),주종은 ( Jong Eun Joo ),김용일 ( Yong Il Kim ),양승오 ( Seoung Oh Yang ),이영숙 ( Young Sook Lee ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.4
Henoch-Schonlein purpura (HSP) is a small-vessel vasculitis that are predominantly observed in children, affecting their skin, joints, gut and kidneys. The renal prognosis of HS nephritis is known to be worse in adults than in children. It is defined by tissue deposition of IgA. In most HSP patients, serum complement levels are usually normal. However, some authors reported abnormalities of serum complement levels in children-onset HSP. The authors report here a rare adult-onset case of HSP combined with post-infectious glomerulonephritis, especially hypocomplementemia and subepithelial `hump`-like electron dense deposits.
강주형,박정환,김정수,노영석 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.2
Vcrrucous cyst is a rare form of epidermal cyst showing verrucous changes of their stratified squamous epithelial lining, characterized by papillomatosis, acanthosis, and hypergranulosis with large, irregular keratohyaline granules. In addition, vacuolated keratinocytes, parakeratosis, and squamous cddies are often present. Herein, we describe a 45-year-old woman with a verrucous cyst, which occurred on left axilla three months ago, showing the above-mentioned characteristic histologic features. Both the immunohistochemical stain and polymcrase chain reaction for the common antigen for human papillomavirus and DNA chip study for human papillomavirus were negative. (Korean J Dermatol 2004;42(2):232~235)