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강정완 ( Jung Wan Kang ),임백인 ( Baik In Im ) 대한내과학회 1971 대한내과학회지 Vol.14 No.12
This is the first paper of collective study of syringomyelia published in Korea although we heard that there was a report of operated cases of syringomyelia at the annual conference of the Korean neurosurgical society in October 1971. Seven patients with t
반복적인 가래 기침을 주소로 내원한 9세 여아에서 발견된 낭성섬유증 1례: CFTR 유전자 변이 D339Y, Q220X
김민정 ( Min Jung Kim ),강정완 ( Jung Wan Kang ),이지현 ( Ji Hyun Lee ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),이민구 ( Min Goo Lee ),김명준 ( Myung Joon Kim ),김규언 ( Kyu Earn Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.1
낭성섬유증은 막전도 조절 유전자의 변이에 의해 나타나는 상염색체 열성질환으로 국가와 인종에 따라 발병률에 차이를 보이며 우리나라에서는 매우 드문 질환이다. 연령 및 침범한 기관에 따라 다양한 증상 및 경과를 보여 반복되는 기침이나 만성 부비동염, 소화불량 또는 성장 부전. 남성 불임까지 유발할 수 있으며, 점차 말단 장기로 진행하여 만성호흡기 질환 및 췌장 기능부전 등의 치명적인 결과를 초래 하기도 한다. 이미 미국이나 유럽에서는 신생아 선별검사를 통한 조기 진단 및 정기적인 추적 관찰, 유전 연구 등으로 진단 및 예후에 큰 변화를 보였으나 국내의 경우 몇몇 증례 보고만 있었다. 저자들은 반복적인 가래 기침을 주소로 내원했던 9세 여아에서 특징적인 임상 경과 및 땀 염소농도 검사 양성을 보이며 2개의 CFTR 변이 유전자(Q220X, D993Y)가 확인된 낭성섬유증 1례를 경험하였기에 보고하는 바이다. Cystic fibrosis is the most common autosomal recessive disease in Caucasian. Cystic fibrosis is caused by cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations that lead to dysfunction of chloride ion channel regulations in the epithelium. Cystic fibrosis can affect multiple organ functions, resulting in various signs and symptoms. Typically, chronic airway infection, maldigestion, failure to thrive, and male infertility can occur. There are approximately 1800 CFTR gene mutations which have been identified thus far. However, there are only a few types of mutations reported in Korea because the prevalence of the disease is different among ethnicitiess and nations. Despite its rarity, reports of CFTR mutations or diagnosed patients on the rise. Therefore, we have to detect better outcomes as early as possible based on a precise understanding of the disease entity. We report a 9-year-old girl carrying D339Y and Q220X gene mutations, as the first case report of a D339Y mutation in Korea. [Pediatr Allergy Respir Dis(Korea) 2011;21:61-66]
선행적 진통 요법의 효과성에 대한 연구 -발치 전과 후 진통 요법의 효과 비교-
정영수,김문기,박형식,이의웅,강정완,Jung, Young-Soo,Kim, Moon-Key,Park, Hyung-Sik,Lee, Eui-Wung,Kang, Jeong-Wan 대한치과마취과학회 2003 Journal of Dental Anesthesia and Pain Medicine Vol.3 No.1
Background: Studies on the pain have been dealing with many different ways for last several centuries. Especially, preemptive analgesia is being used as a method to control the postoperative pain. Many studies on its efficacy have been processed in different ways about various drugs, administration methods and times for various operations. And the value of preemptive analgesia are still controversial regarding the results of other clinical studies. The authors performed a clinical study on efficacy of preemptive analgesia using an non-steroidal anti-inflammatory drug (NSAID) for the surgical extraction of impacted third molar teeth and present the more effective pain treatment after oral surgery with literature review. Methods: Using a randomized double blind test design, this study compared the analgesic efficacies of an NSAID, Talniflumate 370 mg. This drug administrated first either 1 hour preoperatively (experimental group) or when the pain developed moderately to severely over 5 scale of verbal rating scales (0-10) to respective 30 patients undergoing the removal of impacted third molars. Pain intensity and the time from the end of surgery were assessed postoperatively whenever the patients demanded additional drug over 5 scale for forty eight hours using same verbal rating scales. Results: The sex distribution, the age of the patients. and the time required for surgery in two groups were similar. The average first time for demanding additional drug after surgery was 163.9 minutes in experimental group and 191.5 minutes in control group. At this time, the average pain intensity was 5.8 in experimental group and 6.1 in control group. And the average second time for demanding additional drug was 365.5 minutes in experimental group and 351.8 minutes in control group. At this time. the average pain intensities were 6.6 in experimental group and 6.2 in control group. No statistically significant difference was found between the average first times and second times, and the average pain intensities at first and second times in two groups. Conclusions: From these results the efficacy of preemptive analgesia used in this study was not appeared. This clinical study indicates that many NSAIDs administrated preoperatively in present practices have weak efficacy of preemptive analgesia for postoperative pain, thus the authors recommend that only postoperative analgesics are adequate without preoperative use of analgesics.
곽영길,최민수,배재훈,전인평,황광연,양주열,김도헌,강정완,Kwag Young-Kil,Choi Min-Su,Bae Jae-Hoon,Jeon In-Pyung,Hwang Kwang-Yun,Yang Joo-Yoel,Kim Do-Heon,Kang Jung-Wan 한국전자파학회 2006 한국전자파학회논문지 Vol.17 No.8
비행체 탑재 레이다는 민군 겸용으로 기상에 관계없이 전천후로 비행체의 안전 항행, 임무 감시, 사격 통제, 충돌 회피, 이착륙 등 비행에 필수적인 항공 전자 장치이다. 본 논문에서는 헬기 탑재 다중 모드 X-밴드 펄스 도플러 레이다 시험 모델의 설계, 제작 및 비행 시험 결과를 제시한다. 레이다 시스템은 안테나부, 송수신부, 신호처리부와 전시부의 4개의 LRU로 구성되며, 개발 기술은 평판 슬롯 배열 안테나, TWTA 송신기, coherent I/Q detector, 디지털 펄스 압축, MTI, DSP 기반 도플러 FFT 필터, 적응 CFAR, 도플러 추정보상 기법, 비행 안정화 및 TWS 추적 처리기를 포함한다. 개발된 레이다 시스템의 설계 성능은 다양한 지상 고정 및 이동 시험과 헬기 탑재 비행 시험을 통하여 이동 비행체 이동 클러터 보상과 MTD 성능을 확인하였다. An airborne radar is an essential aviation electronic system for the aircraft to perform various civil and/or military missions in all weather environments. This paper presents the design, development, and test results of the multi-mode X-band pulsed Doppler radar system test model for helicopter-borne flight test. This radar system consists of 4 LRUs(Line-Replacement Unit), which include antenna unit, transmitter and receiver unit, radar signal & data processing unit and display Unit. The developed core technologies include the planar array antenna, TWTA transmitter, coherent I/Q detector, digital pulse compression, MTI, DSP based Doppler FFT filter, adaptive CFAR, moving clutter compensation, platform motion stabilizer, and tracking capability. The design performance of the developed radar system is verified through various ground fixed and moving vehicle test as well as helicopter-borne field tests including MTD(Moving Target Detector) capability for the Doppler compensation due to the moving platform motion.
비스테로이드성 항염진통제의 투여시기가 구강외과 술 후 통증에 미치는 효과에 대한 연구
정영수,김문기,엄유정,박형식,이의웅,강정완,Jung, Young-Soo,Kim, Moon-Key,Um, Yoo-Jung,Park, Hyung-Sik,Lee, Eui-Wung,Kang, Jeong-Wan 대한치과마취과학회 2004 Journal of Dental Anesthesia and Pain Medicine Vol.4 No.2
Background: Many studies on efficacy of preemptive analgesia have been processed in different ways. But the value of preemptive analgesia is still controversial. The goal of this study was to compare analgesic effect of an NSAID according to three different administration times for oral surgical pain. Patients and Methods: Using a randomized, parallel-group, single-center, and active-controlled test design, this study was conducted to healthy 80 patients undergoing a surgical removal of an impacted mandibular third molar requiring bone removal. The oral NSAID was first administered 1 hour preoperatively, or 1 hour postoperatively, or no scheduled administration in pre or postsurgery. Whenever patients felt at least moderate pain (score ${\ge}$ 5 on a 10-point scale) after surgery, they were instructed to take the same drug. Pain intensities and times to the first and second onset of postoperative pain from end of surgery were assessed for 24 hours. Results: Of the enrolled eighty subjects in this study, 25 patients were assigned to preemptive, 26 to post-treatment and 29 to no treatment group. The demographic distribution and duration of surgery in the three groups were statistically similar. The mean time to first onset of postoperative pain was significantly prolonged in post-treatment group (277.2 minutes, p < 0.05) compared to preemptive (158.4 minutes) and no treatment group (196.5 minutes). The mean time to second onset of postoperative pain was not significantly different among the three groups. No significant statistical difference was found among the mean pain intensities at the first and second onset of postoperative pain in the three groups. Conclusions: In this small selected group of subjects and limited study design, the analgesic effects of NSAID administered preoperatively were no longer effective for postoperative pain. The results in this population imply that scheduled postoperative analgesics before pain development are adequate for postoperative analgesia without preoperative administration.