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강은비,이정은,정지훈,이기백,인인식,박성영 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.33 No.-
We report that combining diagnostic bioimaging fluorescence and photothermal therapeutic (PTT)within a single nano-platform can be used to simultaneously and accurately diagnose and ablate tumors. The integrated pH with thermo-responsive poly(dimethylaminoethyl methacrylate-co-N-isopropyla-cylamide) sulfobetaine (PDNS) backbone carrier retained optical bioimaging from boron dipyrro-methane (BODIPY) and sufficient photothermal generation is ensured by integrating IR825 within thissame theranostic system. BODIPY (fluorescence dye) with IR825 (NIR dye) quaternized zwitterionicPDNS (IR825/BOD-PDNS) showed pH and temperature-dependent fluorescence emissions and NIRirradiated in vitro photothermal toxicity to cancer cells. This fluorescence platform maximizes theantitumor response, monitors treatment condition, and successfully ablates tumors with thermalenergy.
고등학생의 성격요인과 학업지연의 관계에서 스트레스 대처방식의 조절효과 : 성실성과 신경증을 중심으로
강은비,김동일,김명찬 한국청소년상담복지개발원 2013 청소년상담연구 Vol.21 No.2
본 연구에서는 성격 5요인 중 성실성과 신경증, 스트레스 대처방식, 학업지연 간의 관계 를 살펴보고 스트레스 대처방식이 성실성, 신경증과 학업지연 간의 관계를 조절할 것이 라는 가설을 검증하고자 하였다. 본 연구를 수행하기 위해 경기도 지역의6 개 고등학교 에 재학 중인 학생 315명을 대상으로 성격, 스트레스 대처방식, 학업지연에 관한 설문조 사를 실시하였다. 분석결과로 첫째, 성실성과 학업지연 간의 관계에서 문제중심적 대처 의 조절효과가 확인되었다. 즉, 성실성이 높을수록 학업지연 수준은 낮아지는데, 문제중 심적 대처를 할수록 학업지연 수준이 더욱 낮아지는 것으로 나타났다. 둘째, 신경증과 학업지연 간의 관계에서도 문제중심적 대처의 조절효과가 확인되었다. 신경증이 높을수 록 학업지연 수준은 높아지는데, 문제중심적 대처를 할수록 학업지연 수준이 더욱 높아 지는 것으로 나타났다. 선행연구에서는 적극적 대처의 하위 유형으로서 문제중심적 대 처를 일관되게 기능적, 적응적으로 보아왔지만 본 연구에서는 성격에 따라 스트레스 대 처방식의 효용성이 달라질 수 있음을 확인하였다. 따라서 본 연구의 결과는 개인의 성 격 특성에 따라 지연행동 개입 방향이 달라져야 한다는 점을 시사한다. 마지막으로 본 연구의 제한점과 향후 연구 방향에 대해 제언하였다 The current study is to verify the moderating effect of coping strategy on the relation of personality and academic procrastination. 300 highschool students in Gyeonggi participated in the study. Based on the result, hierarchial regression analysis were conducted to analyze the moderating effect of coping strategy. The outcomes of this study were shown as follows. First, there was the meaningful moderating effect of problem-focused coping between conscientiousness and academic procrastination. In other words, conscientious students who use problem-focused coping did less academic procrastination. Also, the problem-focused coping style negatively moderated the relationship between neuroticism and academic procrastination. That is, neurotic students who use problem-focused coping did more academic procrastination. Findings suggest that effectiveness of coping strategies differ as to personality.
강은비,박성영,이기백 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
We report a combined diagnostic fluorescence for bioimaging and therapeutic fluorescence for photothermal therapy (PTT) within an integrate hybrid nanoparticles can simultaneously and accurately diagnosis and ablates the tumor. This new class triggered photothermal therapeutic agents for pH responsive cancer cells target bio-imaging constructed using near-infrared dye (NIR) IR825, polymer conjugated anchored reduced graphene oxide (rGO) hybrid nanoparticles. Using hybrid nanoparticles administered PTT agents, the time-dependent in vivo tumor accumulated hybrid nanoparticles generated require photothermal heat, which caused dominant suppression of tumor growth. The ability to maximize tumor therapy and to monitor treatment condition in target area explores an appealing interest for the successful application of photothermal therapy. This was supported by Korea National University of Transportation in 2015.
강은비,Shazid Md. Sharker,인인식,박성영 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.43 No.-
Fluorescent carbon nanoparticles based target drug delivery with bio-imaging systems offer tremendousscope for future. We described Pluronic mimickingfluorescent nanoparticles (Plu-FNPs) surfacedecorated doxorubicin (DOX) via acid-cleavable hydrazone linkages with tumor target folic acid (FA)[Plu-FNPs-FA-DOX]. The acid labile of hydrazine linkage to DOX can easily break off by controlled pHinducing release of conjugated DOX at site of over-expressed folate receptors (FR). This nanoparticlesystem can deliver DOX to the target FR and trace the delivery pathway of cancer cells. The approachingplatform demonstrates the selectivity and sensitivity of molecular targets, thereby able to maximize thetherapeutic efficiency.
강은비,인인식,이강대,박성영 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.55 No.-
We report mitochondria-targeted photothermal nanoparticles with the blocker 3-bromopyruvate (BP), delocalized lipophilic triphenylphosphonium (TPP) cations to target them to the mitochondrial membrane, and folic acid (FA) to target cancer cells. The carbonized polyethylene glycol grafted poly (dimethyl aminoethyl methacrylate)-q-catechol (F-PEG-g-PDMA-CCDP) was crosslinked with boronic acid-grafted polyethylene glycol-g-poly (dimethyl aminoethyl methacrylate) conjugated with IR825 as a near-infrared (NIR) responsive fluorescent agent, FA, TPP, BP (PEG-g-PDMA-FA/IR/TPP/BP). The F-PEG-g- PDMA-CCDP@PEG-g-PDMA-FA/IR/TPP/BP (F-FNP) showed in vitro anticancer activity to normal and cancer cell under NIR light treatments. The blocking of metabolic activity in mitochondria with a photothermal system might represent a new pathway for cancer therapy.