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화소값의 통계적 분석을 이용한 신속 망막혈관검출기법 연구
남현성(Hyung-Sung Nam),강욱(Uk Kang),서종모(Jong-Mo Seo),이해영(Hae-Young Lee),篠田啓(Kei Shinoda),곽상인(Sang-In Kwarg) 대한검안학회 2012 Annals of optometry and contact lens Vol.11 No.1
목적: 디지털 안저사진에서 망막혈관의 직경을 신속히 측정하기 위하여, 화소값을 통계적으로 분석하여 망막 혈관을 검출하여 보았다. 대상과 방법: 정상인 디지털 안저사진에서 적색 화소값을 이용한 영상 전처리를 통해 시신경유두를 분획하였다. 이후 이 정보를 활용하여 녹색 화소값에 대하여 시신경유두중심으로부터 시신경유두직경의 2배에서 3배 사이를 관심영역으로 정한 후, 5화소 간격의 동심원을 그리고 동심원상에서의 화소값을 얻었다. 평편화와 3차 스플라인 곡선 추정으로 혈관을 제외한 망막영역의 화소 추세를 구하고, 원래 화소값과의 차이를 구하여 최종적인 화소값 분포를 얻었다. 이것으로부터 평균과 표준편차를 구하고, 84%, 95%, 97.5%의 화소를 포함하는 역치에서 혈관이 구분되는지를 전문가의 판독과 비교하여 보았다. 결과: 97.5% 역치에서는 망막 정맥을, 95% 역치에서는 망막 정맥과 중심반사가 명확한 동맥을, 84%역치에서는 모세혈관 이상의 망막 혈관들을 대부분 검출할 수가 있었다. 망막정맥직경은 97.5% 역치에서, 망막동맥직경은 84% 역치에서 구한 것이 전문가의 판독과 잘 일치하였다. 결론: 기존의 복잡한 혈관추적 기법 대신 단순 통계 기법을 활용하여도 매우 의미있는 결과를 빠르게 얻을 수 있었다. Purpose: In fundus photographs, pixel data were statistically analyzed in order to detect retinal vessel rapidly. Methods: Red channel data was used to detect the optic nerve head (ONH) and make the region of interest (ROI). ROI was established between the circle of radius 2RONH and the circle of radius 3RONH when ONH has radius RONH. After that, intensity profiles along each concentric circle can be obtained in the ROI by using green channel data. Each concentric circle has radius from 2RONH to 3RONH at 5 pixel intervals. Local maximum data were derived from each intensity profile, and data smoothing and cubic spline interpolation were utilized to acquire trend lines. Using these intensity profiles and trend lines, the pixel distribution information was derived by subtracting each intensity profile from the corresponding trend line. Mean and standard deviation (SD) values were calculated for each new intensity profile, and three threshold values (1.96, 1.65 and 1.00 SD from the mean) were used. Segmentation results were analyzed by two retina specialists. Results: Several venules were detected at the threshold 97.5%, venules and clear arterioles were detected at the the threshold 95%, and most venules & arterioles were detected at the threshold 84%. The diameters of the retinal vessels were corresponded with physician s interpretation for venules at the threshold 97.5%, and for arterioles at the threshold 84%. Conclusions: Meaningful result was derived with the fast and simple statistical method which is different from existing complicated vessel tracking algorithms. It would be possible to measure the blood vessel diameter more accurately with the arteriole/venule classification and the compensation of vascular direction.
裵秀眞(Soo-Jin Bae),姜旭(Uk Kang) 대한전기학회 2007 전기학회논문지 Vol.56 No.9
This study suggests a new fluorescence microscope to observe micro-samples within fluorophore in a variety of biomedical fields including the fluorescence analysis of a biochip, such as a DNA micro-array. A fluorescence microscope is a device for irradiating light onto a micro-object, executing an excitation and fluorescence emission process. In this study, it adopts a total internal reflection fluorescence(TIRF) method to excite a whole micro-sample substrate different from an existing way which uses an evanescent wave resulting from a total internal reflection on the micro-sample surface. Suggested TIRF microscope can reduce optical noise and obtain images with higher sensitivity thus obtain precise information about the density, quantity, location, etc. of a flurophore, and can simultaneously process separate images even when plurality of fluorophores having different excitation and fluorescent wavelength ranges is distributed, thus easily obtain information about the fluorophores.
裵秀眞(Soo-Jin Bae),姜旭(Uk Kang) 대한전기학회 2007 전기학회논문지 Vol.56 No.1
We suggest the fluorescence endoscope system that has light source apparatus providing selectable white or excitation light. White light source generates normal color images and is easily switched over to excitation light with the wide spectrum range from 380 ㎚ to 580 ㎚. 5-ALA is deposited selectively in the abnormal tissue like cancer and causes fluorescence in the red spectrum range when excited by blue spectrum range. In addition, the others of excitation light make the color background image by reflected light to allow accurate orientation and visualization of the abnormal tissue and around. According to clinical studies, the fluorescence intensity contrast that defines the fluorescence intensity of lesion over the fluorescence intensity of around has more than 2 in tumour. Proposed system is useful and objective way in early diagnosis. Furthermore, it can be used in the biopsy for tumour classification at the highest fluorescence intensity point.
이승엽(Seung Yup Lee),배수진(Soojin Bae),강욱(Uk Kang),임근희(Geun Hie Rim),강지명(Jimyung Kang) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7
현재 전 세계적으로 건강의 측면뿐만 아니라 미용의 측면에서도 피부에 대한 관심이 증가하고 있다. 또한 다양한 통신 네트워크를 통한 원격 진료 시스템들이 개발되고 있다. 본 연구에서는 전력선 통신(PLC, Power Line Communication)을 이용하여 형광 피부 진단 장비를 통해 획득한 고화질 형광 컬러 영상을 원격지로 전송하는 원격 피부진단 시스템을 구축하였다. 이를 통하여 피부과 영역에서의 원격 진료의 가능성과 U-healthcare 시스템 구축에 있어서 전력선 통신망의 적용 가능성을 보였다.
여드름 환자에서 휴대용 디지털 피부형광 진단기기의 임상적 유용성에 관한 연구
김영훈 ( Young Hoon Kim ),최태열 ( Tae Yul Choi ),배수진 ( Soo Jin Bae ),강욱 ( Uk Kang ),노영석 ( Young Suck Ro ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.7
Background: Propionibacterium acnes (P. acnes) is a gram positive anaerobic bacteria which plays a key role in the development of acne. Therefore, culture of P. acnes from the acne lesion can serve as an important clinical tool for selecting antibiotics and judging the therapeutic response. However the conventional cultural method is not easy to perform in clinical settings. Objective: The aim of this study was to investigate the clinical application of portable digital skin fluorescence imaging equipment in patients with acne. Methods: Total of 60 objects (33 males and 27 females) with facial acne were recruited. To estimate fluorescence color and size according to the acne lesion, digital fluorescence images were taken and analyzed with image analysis program. Also, we examined the species and the quantification of bacteria aerobically and anaerobically isolated from each kind of acne lesion. Results: Among the bacteria cultured, coagulase negative staphylococci (CNS) was the most common (57.7%), followed by P. acnes (46.1%). Noninflammatory lesions (comedones) showed statistically significant correlation with red fluorescence and inflammatory lesions (papules and pustules) with green fluorescence (p=0.004). The density of CNS and P. acnes were also significantly associated with fluorescence size (p=0.014, p=0.005). However, there was no statistical association between the strains of bacteria and the color of fluorescence (p=0.192). Conclusion: Since the size of fluorescence correlates well with P. acnes levels, we found the noninvasive technique of portable digital skin fluorescence imaging equipment to be useful in choosing adequate antibiotics and monitoring antibiotic therapy in acne vulgaris. (Korean J Dermatol 2008;46(7):889~895)