지방육종의 치료에서 술후 방사선 치료의 역할

강용구,박원종,송석환,김형민,이승구,우영균,김정만,문명상,인용,Kang, Yong-Koo,Bahk, Won-Jong,Song, Seok-Whan,Kim, Hyoung-Min,Rhee, Seung-Koo,Woo, Young-Kyun,Kim, Jung-Man,Moon, Myung-Sang,In, Yong 대한근골격종양학회 1995 대한골관절종양학회지 Vol.1 No.2

To evaluate the role of post-operative irradiation in reducing local recurrence after surgical treatment of liposarcoma, 19 patients who were treated between July 1988 and June 1994 at Department of Orthopedic Surgery, Catholic University were studied retrospectively. The average follow up was 31 months. 1. There were 14 males and 5 females and an average age was 51 years old. 2. Thirteen cases were in extremities and buttock, 3 in neck, 2 in retroperitoneum and 1 in back. 3. Histologic types were 16 cases of myxoid type and 3 cases of well differentiated type. 4. Ten cases were achieved with wide margin and 9 with inadequate(intralesional or marginal) margin. 5. There were no local recurrence in 10 cases with wide margin, whereas 6(67%) local recurrences in 9 cases with inadequate margin. 6. Among 6 cases of local recurrence, 5 cases had been treated with post-operative irradiation. In conclusion, post-operative irradiation for inadequate margin(intralesional or marginal margin) was not sufficient to reducing local recurrence.

Stage II B형 골육종에 대한 술전 항암화학요법 및 수술적 치료 결과

강용구,김형민,이승구,우영균,김정만,김훈교,Kang, Yong-Koo,Kim, Hyung-Min,Rhee, Seung-Koo,Woo, Young-Kyun,Kim, Jung-Man,Kim, Hoon-Kyo 대한근골격종양학회 1996 대한골관절종양학회지 Vol.2 No.1

Recent advances in imaging techniques, surgery and combination anti-cancer chemotherapy have brought high survival rates in osteosarcoma. To investigate the survival rate, local recurrence and complications in treatment, we analysed 25 osteosarcoma cases who had been treated with preoperative neo-adjuvant chemotherapy, surgery and post operative chemotherapy at Department of Orthopedic Surgery, Catholic University. From May 1988 to April 1995, 42 cases of stage IIB osteosarcoma were admitted in Department of Orthopedic Surgery. Among them, 17 cases who didn't follow our treatment guidance were excluded in this study. The average age were 19 years. There were 21 males and 4 females. The involved sites were 4 humerus, 10 femur, 10 tibia and 1 talus. Eleven cases had received intraarterial cisplatin and intravenous adriamycin chemotherapy, and 7 T-10 protocol and 7 intravenous ifosfamide, ADR, methotrexate, cisplatin. Twenty-three cases were treated with limb salvage surgery, and 2 amputation. The average follow-up was 35 months(3~82). There were 14 cases of continuous disease free, 9 cases of died of disease, 1 case of alive with disease, and 1 case of no evidence of disease at final follow-up. There were three cases of local recurrence at 6,8 and 12 months after operation. The estimated Kaplan-Meier's 5 year survival rates for all, ADR-cisplatin group, T-10 protocol group, and ifosfamide regimen group were 6%, 73%, 44% and 72%, respectively.

척추 거대세포종의 수술적 치료

강용구,유기원,이승구,박원종,정양국,박창구,Kang, Yong-Koo,Rhyu, Kee-Won,Rhee, Seung-Koo,Bahk, Won-Jong,Chung, Yang-Guk,Park, Chang-Goo 대한근골격종양학회 2009 대한골관절종양학회지 Vol.15 No.2

목적: 척추 거대세포종은 매우 드문 질환으로, 종양이 추체 내에 확산이 될 때까지는 증상이 나타나지 않아, 진단이 늦어지는 경우가 대부분으로 치료가 매우 힘든 질환으로 알려지고 있다. 최근 척추수술 술기의 발전과 진단기기의 발달로 척추종양을 척추 전절제술(total spondylectomy)로 치료하여 좋은 치료결과를 보고하고 있는바, 전절제술로 치료한 증례와 소파술로 치료한 증례를 분석하여, 척추 전절제술의 효용성을 알아보기 위하여 본 연구를 하였다. 대상 및 방법: 1987년 4월부터 2006년 3월까지 척추의 거대세포종에 대한 수술적 치료를 받은 환자 중에서 3년 이상 추시가 된 10례를 분석하였다. 남자 3명, 여자 7명이었으며, 평균나이는 32세(25-44세)이었다. 경추 2례, 흉추 4례, 요추 2례, 천추 2례이었다. 전례에서 동통이 주소이었으며 7례는 신경학적 증상도 동반되었다. 4례는 전후방 도달에 따른 척추 전절제술, 1례는 후방도달에 따른 천추전절제술 수술을 시술받았으며, 경추 2례를 포함한 5례에서는 소파술 및 전방추체유합술로 치료를 받았다. 결과: 수술적 치료 후 9례에서 동통과 신경학적 증상의 호전이 있었다. 그러나 4례(40%)에서 국소재발이 합병하였는데 2례가 경추에서, 흉추와 천추에서 각 1례가 발생하였다. 국소재발은 소파술로 치료한 3례와 전절제술로 치료 받은 1례이었다. 결론: 거대세포종은 수술적인 치료 후에도 국소재발이 많이 합병하는 바, 초기 치료에서 척추에 대한 전후방 도달법을 이용한 전절제술과 같은 완전 절제술이 필수적임을 알 수 있었다. Purpose: Giant cell tumor of the spine is very rare, and the treatment is very difficult. However, surgical techniques and diagnostic modalities are developed, and postoperative functional results are improved. To evaluate the efficacy of total spondylectomy for giant cell tumor of the spine, the clinical results of the surgical treatments for the giant cell tumor of the spine with intralesional curettage or total spondylectomy were evaluated. Materials and Methods: From April 1987 to March 2006, 10 patients who were underwent surgical treatments using total spondylectomy or intralesional curettage were studied. There were 3 men and 7 women. The mean age of the patients was 32 years (range, 25~44 years). The mean duration of follow-up was 8 years (range, 3~15 years). Locations of the tumor were 2 cervical spines, 4 thoracic spines, 2 lumbar spines and 2 sacrum. Initial main symptom of 10 patients was pain, and 7 patients had neurologic impairments too. Four patients were treated with total spodylectomy using anterior and posterior combined approach, 1 patient was treated with total sacrectomy using posterior approach only, and 5 patients were treated with intralesional curettage using anterior approach. Results: Nine patients improved pain and neurologic impairments. Local recurrences developed in 4(40%) patients (2 cervical spines, 1 thoracic spine, 1 sacrum). While a local recurrence developed from 5 total spondylectomy, 3 local recurrences developed from 5 intralesional curettage. Conclusion: Local recurrence rate after surgical treatment with intralesional curettage for the giant cell tumor of the spine was very high. Total spondylectomy using anterior and posterior approach is advisable to prevent the local recurrence after surgical treatment.

대퇴골에 발생한 방골성 지방종 - 1례 보고 -

강용구,이한용,고해석,유기원,송주현,장일석,Kang, Yong-Koo,Lee, Han-Yong,Koh, Hae-Seok,Rhyu, Kee-Won,Song, Joo-Hyoun,Jang, Il-Suck 대한근골격종양학회 1999 대한골관절종양학회지 Vol.5 No.1

A parosteal lipoma is a benign tumor containing mature adipose tissue and is intimately related to the adjacent periosteum. We experienced a very rare case of parosteal lipoma arising from the shaft of femur. A 46 years old lady visited the hospital with complaining of slowly growing mass in her thigh for 7 month. Initially, it was difficult to differentiate from osteochondroma, parosteal osteosarcoma or liposarcoma. Based on the assessment of plain radiogram and magnetic resonance imaging, it was suspected the parosteal lipoma or osteosarcoma. Marginal excision was performed, and it was confirmed to parosteal lipoma histologically. We present the case with review of literatures.

슬관절 주위 골연골종과 슬내장의 동반 발생

강용구,송주현,이한용,라기항,Kang, Yong-Koo,Song, Joo-Hyoun,Lee, Han-Yong,Ra, Ki-Hang 대한근골격종양학회 2005 대한골관절종양학회지 Vol.11 No.2

목적: 슬관절 주위 골연골종 환자의 병리적 증상과 슬내장이 동반되는 빈도 및 임상적 중요성을 알아보고자 하였다. 대상 및 방법: 1995년부터 2004년 사이에 슬관절 주위에 골연골종이 있어 제거술을 시행 받았던 20세 미만의 45예를 대상으로 후향적 연구를 하였다. 연령, 성별, 과거 병력, 가족력, 골연골종의 다발성 여부와 병리적 증상 및 슬내장의 원인 등을 조사하였다. 결과: 총 45예 중 슬내장은 9예(20%)에서 확인되었다. 다발성 골연골종은 4예이었으며, 1예에서 슬내장이 동반되었다. 병리적 증상 중 무통성 종괴가 39예로 가장 많았고, 이 중 9예는 슬내장으로 슬관절에 동통이 있었다. 슬내장의 원인은 반월상 연골판 파열이 7예, 병적 추벽 증후군이 2예이었고, 반월상 연골판 파열 중 4예는 원판형 연골이었다. 결론: 슬관절 주위 골연골종과 슬내장의 동반 발생에 대한 연관성은 부합적으로 사료되지 만, 그 빈도는 낮지 않은 것으로 판단되므로, 반드시 자기공명영상 등 특수 검사와 세심한 관찰을 해야 할 것이다. Purpose: To find out the pathologic symptoms, and the incidence and clinical significance of the coexistence of internal derangement of knee(IDOK) in osteochondroma around the knee. Materials and Methods: We retrospectively reviewed forty-five patients under 20 years of age treated with the excision of the osteochondroma around the knee between 1995 and 2004. We analyzed age, gender, past history, family history, solitary or multiple osteochondroma, presenting pathologic symptoms, and causes of IDOK. Results: IDOK was confirmed in nine(20%) among the 45 cases. There were four cases of multiple osteochondromatosis, and IDOK was coexisted in one case among them. The most common presenting pathologic symptoms were painless mass of 38 cases, however 9 cases among them had joint pain for IDOK. There were 7 cases of meniscal tears and 2 of pathologic plica. Discoid meniscus was found in 4 cases among the 7 cases of meniscal tears. Conclusion: Coexistence of osteochondroma around knee and IDOK in this study probably represents a coincidence rather than a real association. However the incidence might be not low, special study and close observation should be done.

척추에 발생한 거대세포종의 수술적 치료

강용구,이인주,장한,권순용,유기원,이상훈,Kang, Yong-Koo,Lee, In-Ju,Chang, Han,Kwon, Soon-Yong,Rhyu, Kee-Won,Yi, Sang-Hoon 대한근골격종양학회 1998 대한골관절종양학회지 Vol.4 No.1

Between 1992 and 1996, 5 patients with the giant-cell tumor of the spine were treated. Four were female and one was male. The mean age was 34 years old, and the mean follow-up time was 36 months. The locations of the lesions were the cervical spine in 1, the thoracic spine in 3, and the lumbar spine in 1. Pain was the predominant presenting symptom in all cases and four had a neurological deficit. A combined anterior and posterior surgical approach wds as performed in all cases, which were also treated with AIF(anterior interbody fusion) and anterior and/or posterior instrumentation. Adjuvant radiation therapy was performed in 1 case of cervical spine. At the final follow-up, the pain and neurologic symptoms were improved. Radiologic examination showed no evidence of local recurrence and no failure of instrumentation of the spine.

Retraction to: 백하수오와속단추출물의뼈골격성장과 IGF-I 생성촉진효과

강용구,홍상근,Kang, Yong Koo,Hong, Sang Keun 한국미생물 · 생명공학회 2015 한국미생물·생명공학회지 Vol.43 No.2

연부조직육종의 수술후 방사선 치료결과

김연실(Yeon Shil Kim),장홍석(Hong Seok Jang),윤세철(Sei Chul Yoon),유미령(Mi Ryeong Ryu),강기문(Ki Moon Kang),정수미(Su Mi Chung),김훈교(Hoon Kyo Kim),강용구(Yong Koo Kang) 대한방사선종양학회 1998 Radiation Oncology Journal Vol.16 No.4

목 적 : 최근들어 연부 조직 육종의 치료방법이 광범위 구획절제에서 사지기능을 보존하는 제한적 수술과 방사선/항암화학요법의 다병용치료로 변환되고 있으며 광범위 수술과 유사한 치료성적을 거두고 있다. 저자들은 수술후 방사선 치료를 시행한 연부 조직 육종 환자를 대상으로 치료 결과 및 실패 양상을 알아보고 관련된 예후 인자를 분석하여 수술 후 방사선치료의 역할을 알아보고자 하였다. 대상 및 방법 : 대상환자는 1983년부터 1994년까지 치료한 60명이었고 모두 추적관찰이 가능했으며 평균 추적기간은 50개월이었다. 원발병소는 상·하지가 35례(58%)로 가장 많았고 체간 12례(20%), 두경부 7례(12%)였으며 병리학적 유형에 따른 구분은 악성섬유구종 14례(23%),지방육종이 10례(17%), 악성신경섬유종 7례(12%) 등 이었다. 전체환자중 6례를 제외하고는 조직학적등급의 분석이 가능했고 grade I, II, III가 각각 27례(45%), 3례(5%), 24례(40%)였다. 수술적 절제는 19례(32%)에서 광범위절제, 36례(60%)에서 변연절제, 5례(8%)에서 국소절제를 시행하였다. 방사선치료선량은 28.8- 80Gy였고 25례에서 방사선치료와 함께 항암화학 요법을 병용하였다. 결 과 : 최종분석 시 실패 양상은 국소재발이 20례(25%), 원격전이 7례(12%), 국소재발과 원격전이를 동반한 경우가 14례(23%)였다. 원격전이한 환자는 구제치료와 상관 없이 모두 사망하였고 국소재발한 환자중 5명이 구제치료에 성공하여 무병생존하였다. 전체환자의 2년 및 5년 국소제어률은 68.0%와 48.7%로 비교적 저조한 결과를 보였다. 국소제어율에 영향을 미친 예후인자는 조직학적 유형, AJCC 병기, 조직학적 등급, 수술의 범위, 수술절연 침범 유무 및 잔존종양 정도, 림프절 전이 유무(p <0.05)였다. 전체 환자의 5년 생존률과 5년 무병생존률은 각각 60.4%, 36.6%였고 평균 생존기간은 89개월이었다. 단변량 분석에 의한 생존률에 영향을 미친 예후인자로는 조직학적 유형, AJCC 병기, 림프절 전이 유무, 조직학적 등급, 수술절연 침범 유무와 잔존 종양 정도 였다. 결 론 : 결론적으로 본 연구 결과 연부 조직 육종에서 제한적 수술과 수술 후 방사선치료로 비록 저조한 국소제어률을 보였으나 사지 절단 혹은 광범위 구획절제와 비교시 유사한 생존률을 얻었다. Purpose : The major goal of the therapy in the soft tissue sarcoma is to control both local and distant tumor. However, the technique of obtaining local control has changed significantly over the past few decades from more aggressive surgery to combined therapy including conservative surgery and radiation and/or chemotherapy. We retrospectively analyzed the treatment results of the postoperative radiation therapy of soft tissue sarcoma and its prognostic factor. Materials and Methods : Between March 1983 and June 1994, 60 patients with soft tissue sarcoma were treated with surgery and postoperative radiation therapy at Kang-Nam St. Mary's hospital. Complete follow up was possible for all patints with median follow up duration 50 months (range 6 - 162 months). There were 28 male and 32 female patients. Their age ranged from 6 to 83 with a median of 44 years. Extremity (58%) was the most frequent site of occurrence followed by trunk (20%) and head and neck (12%). Histologically malignant fibrous histiocytoma (23%), liposarcoma (17%), malignant schwannoma (12%) constitute 52% of the patients. Daily radiation therapy designed to treat all areas at a risk for tumor spread upto dose of 4500-5000 cGy. A shrinking field technique was then used and total 55-65 Gy was delivered to tumor bed. Twenty-five patients (42%) received chemotherapy with various regimen in the postoperative period. Results : Total 4 1 patients failed either with local recurrence or with distant metastasis. There were 29 patients(48%) of local recurrence. Four patients (7%) developed simultaneous local recurrence and distant metastasis and 8 patients (13%) developed only distant metastasis. Local recurrence rate was rather higher than of other reported series. This study included patients of gross residual, recurrent cases after previous operation, trunk and head and neck prima ry. This feature is like ly explanation for the decreased loca l control rate . Five of 29 patients who fa iled only loca lly were salvaged by re- excis ion and/or re- irradiation and rema ined free of disease . Factors affecting loca l control include histologic type , grade, stage , extent of operation and surgica l ma rgin involvement, lymph node metastas is (p <0.05). All 21 patients who fa iled distantly are dead with progress ive disease at the time of this report. Our overall survival results are similar to those of larger series . Actuarial 5 year overall survival and disease fresurvival were 60.4 %, 36.6% respectively. Grade, stage (being close association with grade), residual disease (negative ma rgin, microscopic, gross) were significant as a predictor of survival in our series (p <0.05). Conclusion : Combined surgery and postoperative radiation therapy obtained 5 year survival rate comparable to that of radical surgery.

카포시 수두양 환자에서 면역억제제 사용에 의해 이차적으로 발생한 내피각막염 1예

강용구(Yong Koo Kang),김명준(Myung Jun Kim),김홍균(Hong Kyun Kim) 대한안과학회 2016 대한안과학회지 Vol.57 No.10

목적: 카포시 수두양 발진의 치료로 면역억제제를 사용한 환자에게서 단순포진바이러스의 재활성화로 인하여 이차적으로 발생한 내피각막염을 경험하였고, 이를 치료하였기에 보고하고자 한다. 증례요약: 23세 여자 환자가 우안 충혈, 눈물흘림, 통증 및 시력저하를 주소로 내원하였다. 아토피 피부염의 병력이 있는 환자로 얼굴의 카포시 수두양 발진을 진단 받고 피부과에서 면역억제제를 사용 중이었다. 세극등현미경검사상 우안의 각막부종으로 장기간의 콘택트렌즈 착용에 의한 각막염을 의심하여 콘택트렌즈를 제거하고 예방적 목적으로 항바이러스제를 사용하였다. 치료 4일 후 세극등 현미경검사상 우안 각막 중심부 기질의 웨슬리면역고리를 포함한 부종 및 전방 염증이 발생하여 단순포진바이러스의 재활성화로 인한 내피각막염을 진단하였고, 5% NaCl 점안액과 스테로이드 점안제와 조절마비제를 추가로 사용하였다. 치료 2주 후 각막부종은 감소하였고 1개월 후 전방 염증은 감소하여 점안제를 서서히 감량하였으며, 이후 각막염의 재발은 관찰되지 않았다. 결론: 카포시 수두양 발진 환자에서 면역억제제를 사용할 경우 단순포진바이러스에 의한 안구 침범의 가능성 확인을 위해 안과적인 검사가 필요하며, 발생한 각막염은 점안제를 통한 적절한 치료가 필요할 것으로 보인다. <대한안과학회지 2016;57(10):1640-1644> Purpose: To report a case of endothelial keratitis occurred after reactivation of herpes simplex virus following immunosuppressant therapy for Kaposi’s varicelliform eruption. Case summary: A 23-year-old female was referred for ocular pain and blurred vision. She had atopic dermatitis and was diagnosed with Kaposi’s varicelliform eruption on her face after using an immunosuppressant. Slit lamp examination revealed central corneal edema in the right eye. She was initially diagnosed with contact lens-induced keratitis. Subsequently, the contact lens was removed and topical antiviral agent used for prevention of ocular involvement. Four days after treatment, Wesseley immune ring of deep stromal haze and cells in the anterior chamber were present. She was diagnosed with endothelial keratitis caused by reactivation of herpes simplex virus after using an immunosuppressant. Topical steroid, hypertonic saline eye drops and cycloplegic eye drops were added to the treatment for the progression of endothelial keratitis. Corneal edema was decreased 2 weeks after treatment and anterior chamber cells decreased 1 month after treatment. There was no recurrence during the follow- up period. Conclusions: Patients diagnosed with Kaposi’s varicelliform eruption after using immunosuppressants should have an ophthalmic examination to confirm ocular involvement; use of appropriate eye drops is necessary for the treatment of corneal involvement. J Korean Ophthalmol Soc 2016;57(10):1640-1644

흉추결핵 치료후 후만곡변형에 합병한 지연마비

강용구(Yong-Koo Kang),정인설(In-Seol Chung),임성원(Sung-Wan Lim),김성철(Sung-Cheol Kim) 대한정형외과학회 1991 대한정형외과학회지 Vol.26 No.5