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국내 유통 한약재 중 Aristolochic Acid 분석
강숙경(Sook-Kyung Kang),송경빈(Kyung Bin Song) 한국식품영양과학회 2003 한국식품영양과학회지 Vol.32 No.7
국내 유통 중인 한약재에 발암물질로 알려진 aristolochic acid 함유 여부를 검사하고자 방기, 목통, 목향, 마두령, 세신, 청목향 등을 대상으로 aristolochic acid 검출 유무 및 정량분석을 수행하였다. 시료에 대한 TLC와 C_(18) column을 이용한 HPLC의 aristolochic acid 최적 분석 조건을 수립하였고 aristolochic acid 정량분석 결과 방기 type II에는 3.9 mg/g, 마두령에는 2.3 mg/g이 함유되어 있는 것으로 나타났다. 그외 목향, 목통, 세신, 청목향 등 시료에서는 aristolochic acid가 검출되지 않았다. Aristolochic acid has been known to be a carcinogenic compound and to cause Chinese herbs nephrophathy (CHN). To determine the content of aristolochic acid in various medicinal herbs marketed domestically, samples of Aristolochia fangchi, Aristolochia fructus, Aristolochia radix, Asiasari radix, Saussureae radix, and Akebia caulis were analyzed using TLC and HPLC. The optimal conditions for TLC and HPLC using C18 column were established for the quantitative analysis of aristolochic acid. This study showed that Aristolochia fangchi and Aristolochia fructus examined in this study contain aristolochic acid of 3.9 and 2.3 mg/g sample, respectively. In contrast, aristolochic acid was not detected in the other samples.
HBsAg 과 Anti - HBs 동시 검출예의 임상적 의의
강숙경(Sook Kyung Kang),서동진(Dong Jin Suh) 대한내과학회 1988 대한내과학회지 Vol.35 No.2
N/A To evaluate the clinical significance of concurrent HBsAg and anti-HBs, we studied the underlying liver disease, HBeAg/anti-HBe status, titer of HBsAg and anti-HBs, subtypes and the follow-up change in 220 patients with both HBsAg and anti-HBs. The results were as follows; 1) Concurrent HBsAg and anti-HBs was more frequent in patients with chronic HBV infection (chronic hepatitis 39%, asymptomatic carrier 25.5%, liver cirrhosis 23.2% and hepatoma 7.3) than acute type 8 hepatitis(5%). 2) Hepatitis R e antigen was detected in 123(78.3%) of 157 patients with concurrence. 3) The serum level of antibody was less than 100 RIA unit in 117 patients(53%), but more than 500 RIA unit in 35 patients(16%), Higher titer was found more common- ly in patients with chronic infection. 4) In 5 patients in whom subtyping was possible, HBsAg was adr and concurrent anti-HBs was anti-y, 5) Anti-HBs persisted with HBsAg in 909o of 30 patients with chronic HBV infection who were followed over 1 year, It was not related to clinical course. We conclude that concurrent HBsAg and anti-HBs is a common phenomenon in HBV infection, with little clinical or prognostic significance.
만성 B 형 활동성 간염에서 간조직내 항원 검출의 임상적 의의
강숙경(Sook Kyung Kang),서동진(Dong Jin Suh) 대한내과학회 1988 대한내과학회지 Vol.35 No.3
N/A In order to evaluate the clinical significance of HBV antigens in the liver in chronic HBV infection, HBsAg and HBcAg were detected in the liver tissue of 156 patients with HBsAg-positive chronic active hepatitis by the ABC immunoperoxidase method. The correlation of tissue antigens with serologic markers of HBV and the underlying liver histology were analyzed. The results were as follows: 1) Of 156 patients with chronic active hepatitis, HBsAg was detected in the liver in 57 patients (36.5%), both HBsAg and HBcAg in 58 patients (37.2%), and HEkAg in 12 patients (7.7%). 2) While tissue HBsAg was commonly found irrespective of HBeAg or anti-HBe, HBcAg was more frequently found in HBeAg-positive patients (47%) than in anti-HBe-positive patients (21.4%). 3) The presence of tissue HBcAg was more commonly associated with positive serum HBV-DNA and IgM anti-HBc. 4) There was no relationship between the presence of HBcAg and the severity of chronic active hepatitis. It is suggested that in chronic active hepatitis, HBcAg in the liver is often associated with serum HBeAg, HRV -DNA and IgM anti-HBc and can be used as a marker of active viral replication.
동종골수이식을 한 환자에서 발생한 물방울양 건선 1 예
강숙경(Sook Kyoung Kang),노경현(Kyung Hyun Roh),고재경(Jai Kyoung Koh),문기찬(Kee Chan Moon),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.5
In many student it has been demonstrated that donor-derived cells would eventually replace the hematopoietic and immune system of the recipient after allogeneie bone marrow transplantation (B.M.T). And there are siveral case reports desering resolution or development of autommune deseases after BMT. Psoriasis is considered to be an autoimmune disease of abnormal keratinocyte proliteration induced by T lymphocytes. Herein we describe a 17-year-old woman presenting with guttate psoriasis, who suffered from acute lymphocytic leukcmia and underwent allogencie BMT 6 months ago This is the First case of gultate psoriasis possibly associated with BMT in thee Korean literature.
강숙경(Sook Kyoung Kang),이미우(Mi Woo Lee),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.12
The case of an unusual desmoplastic variant of trichilemmoma arising in the face of a 72-year-old man is reported. Desmoplastic trichilemmoma is characterized by the presence of a densely sclerotic stroma, surrounded by lobules of epithelial cells with features of outer root sheath differentiation, including glycogen-rich, clear cytoplasms and peripheral palisading. In the central part of the tumor, irregular cords and nests of epithelial cells entrapped in the desmoplastic stroma are found. The pathological appearance can mimic trichilemmal carcinoma, morpheic basal cell carcinoma, and squamous cell carcinoma. Recognition of this benign neoplasm as such will prevent misdiagnosis and unnecessary aggressive treatment. (Korean J Dermatol 2001;39(12):1407~1410)
강숙경 ( Sook Kyoung Kang ),김은성 ( Eun Sung Kim ),이미우 ( Mi Woo Lee ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.4
Syphilis and human immunodeficiency virus(HIV) disease may coexist, and syphilis is often the presenting infection of patients with concurrent HIV infection, because syphilis may accelerate development of immunodeficiency in HIV-infected persons, and conversely HIV infection causes reactivation of dormant syphilis. Cutaneous secondary syphilis in HIV-infected patients is often associated with unusual and s clinical features. We report a 44- year old man in that syphilis reactivated by HIV infection, and a 23-year-old m in that syphilis was a presenting sign of HIV infection.
강숙경(Sook Kyoung Kang),장경애(Kyoung Ae Jang),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.7
Survival from malignant melanoma has improved, and as a consequence, the possibility of raised risk of second primary cancers needs to be taken into account in clinical management. We report two cases of second primary cancers in patients with cutaneous malignant melanoma. One is a 61-year-old man suffered from head and neck squamous cell carcinoma with acral lentiginous melanoma, the other is a 65-year-old woman who suffered from malignant lymphoma with superficial spreading melanoma. (Korean J Dermatol 2001;39 (7) 798-802)
반복적으로 혈청 α - Fetoprotein 의 심한 상승을 보인 간경변증환자
김연수(Yun Soo Kim),강숙경(Sook Kyung Kang),서동진(Dong Jin Suh) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2
The serum concentration of AFP can be rnildly elevated in non-neoplastic liver disease, and it reflects the regeneration after hepatocellular necrosis. The authors report a 48 year old male with HBeAg-positive liver cirrhosis who showed markd elevation of serum AFP recurrently. During 2 years follow-up, recurrent elevation of AFP occurred 3 times with coincident exacerbation of serum ALT and reappearance of HBeAg. AFP was elevated to 3113, 1370 and 104 ng/ml respectively. No evidence of tumor was found by ultrasonography, CT scan and celiac angiography, and biopsy of the liver revealed micronodular cirrhosis.