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참치( Katsuwonus pelamis ) 자숙액 농축물의 마우스 대식세포 및 비장세포에 대한 면역증강활성
강보경 ( Bo Kyeong Kang ),김꽃봉우리 ( Koth Bong Woo Ri ),안나경 ( Na Kyong Ahn ),최연욱 ( Yeon Uk Choi ),김민지 ( Min Ji Kim ),박시우 ( Si Woo Bark ),박원민 ( Bark Won Min ),김보람 ( Bo Ram Kim ),박지혜 ( Ji Hye Park ),배난영 ( Nan 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6
Tuna cooking juice concentrate (TCJC) is by-produced during the canning processing of skipjack tuna Katsuwonus pelamis and it is well known that TCJC contains various nutritional components. Therefore, the immuno-stimulating activity of TCJC was investigated using macrophage RAW 264.7 cell line and the spleen cell isolated from BALB/c mice. The TCJC increased the production of IL-6, TNF-α, and IL-1β in a dose-dependent manner compared to the control in RAW 264.7 cells without any toxicity. In particular, the production of TNF-α was increased over 300-fold. The production of both Th1 cytokine (such as IFN-γ, TNF-α, IL-2, and IL-12) and Th2 cytokine (IL-4, IL-6, IL-10) was also increased by TCJC treatment in splenocytes. Moreover, the TCJC increased the splenocyte proliferation in a concentration-dependent manner compared to control. These results indicate that TCJC may enhance immune function by promoting various cytokine production.
한약재 및 해조류 추출물에 의한 고등어 육중의 Histamine 생성 억제 효과
정슬아(Seul-A Jung),김동현(Dong-Hyun Kim),김꽃봉우리(Koth-Bong-Woo-Ri Kim),김현지(Hyun-Jee Kim),정다현(Da-Hyun Jeong),강보경(Bo-Kyong Kang),박시우(Si-Woo Bark),박원민(Won-Min Pak),김보람(Bo-Ram Kim),변명우(Myoung-Woo Byun),안동현(Dong- 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.8
한약재 및 해조류 추출물에 대한 Photobacterium phosphoreum의 항균력을 측정한 결과, 오미자 열수 및 에탄올 추출물과 감태 및 비틀대 모자반 에탄올 추출물이 항균력을 나타내었으며 비틀대 모자반과 감태 에탄올 추출물이 각각 0.015625 mg/mL, 0.125 mg/mL의 최소저해농도를 나타내었다. P. phosphoreum 유래 HDC의 저해 효과를 측정한 결과, 감태와 대황 에탄올 추출물이 1 mg/mL에서 각각 32%, 25%의 높은 저해활성을 나타내었다. P. phosphoreum에 대해 항균력과 HDC 저해 효과를 나타낸 천연물을 고등어육에 첨가한 후 균주를 접종하여 생균수 및 histamine 생성량을 측정한 결과, 저장일차가 증가함에 따라 처리구에서 균수가 크게 감소하였다. Histamine의 함량도 다소 감소하였지만 주로 항균활성에 의해 histamine이 저해된 것으로 나타났다. This study was conducted in order to investigate the inhibitory effects of natural materials on histamine production in mackerel. Antimicrobial activities on Photobacterium phosphoreum of medicinal herbs and seaweeds were investigated using the paper disc assay and MIC (minimum inhibitory concentration) test. According to the results, Sargassum sagamianum and Ecklonia cava ethanol extracts exhibited antibacterial activity. In particular, Sargassum sagamianum ethanol extract showed excellent antibacterial activity at 0.015625 mg/mL by the MIC test. Anti-histamine release activities of natural materials were further investigated by examining their inhibitory effects on histidine decarboxylase (HDC) activity in the crude enzyme preparation from Photobacterium phosphoreum. The ethanol extracts of Ecklonia cava and Eisenia bicyclis exhibited the strongest HDC inhibitory activity, with 32% and 22%, at a concentration of 1 mg/mL, respectively. Therefore, natural materials may reduce histamine poisoning through decrease of histamine production in mackerel.