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12주간 유산소 및 저항운동이 비만 중학생의 신체구성, 염증유발지표 및 인슐린저항성에 미치는 영향
강동하(Dong Ha Kang),정소봉(So Bong Jeong),홍세정(Sai Jeong Hong),김윤미(Yun Mi Kim),고성경(Seong Kyeong Ko) 한국사회체육학회 2011 한국사회체육학회지 Vol.0 No.44
To determine the effects of the aerobic and resistance training on body composition, inflammatory markers and insulin resistance in obese middle school boys, 12.5-14.9 year old, who were classified into three groups (aerobic group (AG) n=13, resistance group (RG) n=13, non-exercise obese group (NE) n=8). Obesity was defined by BMI>25.0 kg/㎡. Aerobic training was performed for 40 min/day at 50-85%HRR with three times and the exercise modes were rope jumping, running, cycling exercise. Resistance training was performed 2-3 sets of 10-15 repetitions with 40-75% RM with seven exercises. After 12 weeks of training, %fat, waist circumstance, RMR, V·O2max, TNF-α, IL-6, insulin and HOMA-IR had a significant main effect on exercise period. Therefore when compared between pre and post in same groups, %fat and waist circumstance and HOMA-IR of AG and RG were significantly decreased after training. And TNF-α and IL-6 of AG were significantly decreased, but V·O2max of AG and RG were significantly increased after training. Additionally, IL-6 and HOMA-IR had a significant interaction effect on exercise period and type. Although the amounts of changes of inflammatory markers and insulin resistance index were not much in RG, physical training programs with aerobic and resistance exercise seemed to be beneficial decreasing the risks of cardiovascular and metabolic diseases in obese boys.
대장선암에서 Metallothionein과 p53의 표출
강동하,양승하 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3
Colonic adnocarcinoma is common malignant tumor in Korea. Many oncogenes have been found in malignant tumor cells. Among these oncogenes, MT has high affinity for metals such as copper and zinc. The fuction of MT is metabolism and detoxification of copper and zinc. The relation between the expression of MT and prognosis of patients in various cancers are reported but is controversial. p53 is a regulator of cellular proliferation, and the over expression of p53 relates to malignant trasformation and prognosis. To evaluate the expression of MT and p53 according to histopathologic features in colonic adenocarcinoma, we have performed immune staining, using mouse anti-MT and mouse anti-p53. The results were as follow; 1) The expression rates of MT in hyperplastic polyp, adenoma, and adenocarcinoma of colon were 100%, 64.1%, and 46.6%, p53 were 0%, 64.1%, and 48.9%, respectively. 2) MT and p53 in colonic adnoma showed increased espressionrat according to severity of dysplasia 3) MT incolonic adenoarcinoma showed statisfically significant higher expressionrates in female9P=0.04), in cases showing lymph node metastasis(P=0.012), and in stage C(P=0.0001), but there is no significant difference according to age, site, differentiation, and invasion depth. 4) p53 in colinic adenocarcinoma showed statisfically significant higher expression rates rates in cases showing lymph node metastasis(P=0.047), but there is no statisfically significant difference in age, sex, site, invasion depth, stage. 5) In colonic adenocarcinomas expressing MT(+)p53(+) there is more many cases in carcinomas within the wall, in carcinoma showing lymph node metastasis, and stage C, but no statisfically significant difference. 6) Correlation between MT and p53 in colonic adenocarcinoma were not seen.
강동하,김대중,김창진,김의한,양승하 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
Gastric adenocarcinoma is the most common malignant tumor in Korea. Many oncogens have been found in malignant tumor cells. E-cadherin located in cell membrane is important for progression and metastasis of tumor. To evaluate the expression of E-cadherin according to histopathologic features and the relation between E-cadherin and prognosis on gastric adenocarcinoma, we have performed immune staining, using mouse HECD-1 for 97 cases. The results were as follows; 1) Gastric adenocacinoma showed the loss or marked reduction of the expression of E-cadherin in 30.9% of 97 cases, and early carcinoma 34.2% and advanced 28.8%. 2) According to differentiation of gastric adenocarcinoma, cases showing the loss or marked reduction of the expression of E-cadherin was well differentiated form 16.1%, moderately 35.7%, poorly 31.9% and mucinous carcinoma 100%. 3) According to the degree of invasion in early carcinoma, cases showing the loss or marked reduction of the expression of E-cadherin was carcinoma within mucosa 41.2% and carcinoma invaded to submucosa 28.6%, but there is no significant difference according to types. 4) According to absence or presence of lymph node metastasis in advanced carcinoma, cases showing the loss or marked reduction of the expression of E-cadherin was 17.6% in non-metastatic cases and 33.3% in metastatic cases, but there is no significant difference according to degree of invasion. Above results indicated that the loss or marked reduction of the expression of E-cadherin in gastric adenocarcinoma may be related to prognosis of the patients.
대퇴골 과상부 골절에 대한 관절경 감시하 과상부 금속정 고정법(예비 보고)
황태성,강동하,윤석웅,안정일 대한골절학회 1998 대한골절학회지 Vol.11 No.4
Supracondylar nailing is one of the treatment methods for supracondylar fractures of the femur but it needs arthrotomy. We introduce a new technique of supracondylar nailing under the arthroscopy without arthrotomy. It is closed reduction and intramedullary supracondylar nailing under the arthroscopic control. The potential benefits of this method are decreased unnecessary soft tissue dissection, excellent intraarticular visualization and reduction, decreased blood loss and shortened operative time and postoperative recovery. We performed this new teehnique on 4 cases of supracondylar fractures of the femur. The average follow up period was 14(12-18)months. The results were as follows; l. Among the 4 case., 3 cases were AO type A and 1 case was AO type C. 2. All cases showed bony union and average range of knee motion was 110 degrees. 3. The operation time ranged from 60 minutes to 170 minutes and averaging 110 minutes.