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한국인 대장암 환자에서 serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 발현
김진휘(Jin-Whi Kim),박도심(Do-Sim Park),박원철(Won-Cheol Park),안소라(Sora Ahn),강동백(Dong-Back Kang),김근영(Keun-Young Kim),김용(Yong Kim) 대한종양외과학회 2016 Korean Journal of Clinical Oncology Vol.12 No.2
Purpose: Splicing factors play important roles in tumorigenesis. Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 proteins, the members of SR family proteins, are dysregulated in various cancers. However, their protein expression levels and diagnostic values are unclear in colorectal cancer. Methods: We quantified the protein levels of SRSF2, SRSF4, and previously known colon cancer markers (heterogeneous nuclear ribonucleoprotein A1 [HNRNPA1] and carcinoembryonic antigen [CEA]) in tumor compared with adjacent normal-looking areas (non-tumor) of the colon in Korean patients with colon cancer using immunoblot analysis. Results: The protein levels of HNRNPA1 and CEA were remarkably increased in tumor compared to non-tumor tissue and up-regulated in all of the tumor samples. However, the protein levels of SRSF2 and SRSF4 in tumor tissue were reduced in contrast with those of non-tumor tissue. Conclusion: None of the SRSF proteins were significantly different between the low (≤II) and high (>II) stages.