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고효율 LED 방열효과 증대를 위한 융합형 Heat Sink 장치 방열 해석
강창수(Chang Soo Kang),강기성(Ki Sung Kang) 대한전자공학회 2011 電子工學會論文誌 IE (Industry electronics) Vol.48 No.2
본 논문은 조명용 LED 모듈과 히트싱크 장치의 방열 특성을 확인하기 위한 수치 시뮬레이션을 하였다. 해석 케이스는 200 W급의 가로등 또는 보안등용 조명장치이며 용도에 따라 장치의 자세가 달라짐을 고려하여 발광면이 정상부를 향하는 경우와 정하부를 향하는 경우로 나누어서 해석이 진행되었고, 또한 발열소자의 체적이 큰 경우와 작은 경우로 나누어 해석하였다. 해석 결과 현재의 히트싱크 형상으로 충분히 LED의 발열량을 외부로 배출시킬 수 있음을 확인하였고, 장치의 자세와 발열소자의 크기에 따라 방열 성능의 차이가 나타남을 조사하였다. In this paper, did numerical simulation to confirm LED module for lighting and protection against heat special quality of heat sink device. Analysis was gone dividing on case that emitting light side turns normalcy department considering that eat of device according to usage and case that turn down looking being street lamp of 200 W or security appointment lighting device analysis case, and also, volume of thermal element divides on big case and small case and analyzed.Confirmed that can do so that may discharge LED's thermal value to outside enough in analysis wave and current heat sink shape, and investigated that difference of protection against heat performance according to position of device and size of thermal element appears.
황종현,김승만,황귀서,전찬용,강기성,Hwang, Jong-hyun,Kim, Seung-man,Hwang, Gwi-seo,Jeon, Chan-yong,Kang, Ki-sung 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4
Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of a water extract of Acanthopanax senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231). Methods: The MTT assay was used to assess cell proliferation. The expression of apoptosis-related genes was assessed by quantitative real-time PCR. Results: ASF treatment caused a dose-dependent inhibition of cell growth in both estrogen-independent MDA-MB-231 and estrogen-dependent MCF-7 breast cancer cells. ASF decreased mRNA expression of the apoptotic suppressor gene Bcl-xL, and increased mRNA expression of proapoptotic genes. ASF increased the mRNA expression of p21 and RIP-1 in both cell types. ASF decreased the mRNA expression of survivin in the MCF-7 cell line. Conclusions: ASF exhibits anti-cancer activity involving apoptotic cell death.
LPS로 유도된 RAW 264.7 대식세포에서 닭발, 오가피, 두충 혼합 추출물의 항염증 활성
백지윤(Ji Yun Baek),강기성(Ki Sung Kang),이아영(Ah Young Lee),김현영(Hyun Young Kim) 한국생물공학회 2020 KSBB Journal Vol.35 No.4
This study was to investigate the anti-inflammatory effect of chicken-feet, Acathopanax, and Eucommia ulmoides Oliver mixture (CAEM) extract against lipopolysaccharide (LPS) in RAW 264.7 macrophage cells. We examined cytotoxicity of CAEM extract on RAW 264.7 cells, and their anti-inflammatory properties by measuring nitric oxide (NO) and pro-inflammatory cytokine production. In addition, inflammation-related gene expression was analyzed by real time-PCR in LPS-stimulated RAW 264.7 macrophage cells. Treatment of CAEM extract at concentrations of 0.31-2.5 mg/mL did not have any cytotoxic effect in RAW 264.7 cells. Treatment of LPS significantly increased the NO production, whereas CAEM extract (1.25, 2.5mg/mL) significantly decreased the levels of NO, compared to only LPS-treated cells. Furthermore, treatment with CAEM extract significantly suppressed the LPS-induced interleukin (IL)-6 and tumor necrosis factor-α (TNF-α) production. In order to confirm whether CAEM extract regulates inflammation-related gene expression, we analyzed the mRNA levels of IL-6, TNF-α, IL-1β, and inducible NO synthase (iNOS) by real time-PCR. Exposure of RAW 264.7 cells on LPS upregulated the mRNA levels of IL-6, TNF-α, IL-1β, and iNOS, compared to control group. However, those of expression were downregulated by treatment with CAEM extract. These findings suggest that CAEM extract may contribute to the prevention and treatment of inflammatory-related diseases.
Kamut (Triticum turgidum spp.) 식빵 급여가 고지방식이 유도 비만 C57BL/6 마우스에 미치는 효과
정현기(Hyun Gi Jung),백지윤(Ji Yun Baek),최예정(Ye Jung Choi),강기성(Ki Sung Kang),김현영(Hyun Young Kim),김지현(Ji Hyun Kim),최진상(Jine Shang Choi) 한방비만학회 2021 한방비만학회지 Vol.21 No.2
Objectives: The purpose of this study was to investigate the effect of white pan bread added with Kamut (Triticum turgidum spp.) on high fat diet (HFD)-induced obese C57BL/6 mice. Methods: The white pan bread or white pan bread with Kamut (BK) were administered for 8 weeks in HFD-induced obese C57BL/6 mice. To evaluate the effect and its mechanisms of BK on obese mice, we measured body weight change, serum lipid profiles, histopathological analysis, and protein expression of CCAAT/enhancer binding protein-α (C/EBPα) in the liver. Results: Administration of BK significantly decreased body weight in HFD-induced obese mice. In addition, BK-administered group significantly reduced serum total cholesterol, glucose, and high-density lipoprotein cholesterol levels compared with the HFD-induced control group. The HFD-induced mice had damaged liver tissue and increased the size of adipose tissue, but BK-administered group attenuated liver damage and decreased the size of adipocyte. Furthermore, administration of BK significantly down-regulated C/EBPα in the liver compared with HFD-fed mice. In particular, BK-administered group has higher inhibited body weight, serum lipid profiles, and C/EBPα expressions than white pan bread-administered group. Conclusions: This study demonstrated that administration of BK attenuated HFD-induced obesity by regulation of C/EBPα than consumption of white pan bread. Therefore, BK could be developed as a bread for prevention of obesity.