오미자(五味子) 전탕액(煎湯液)의 투여(投與)가 흰쥐의 혈청(血淸) cholesterol 대사(代射)에 미치는 영향(影響)

한상환,Han, Sang-Hwan 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1

It was investigated effect of Fructure schizandra chinesis Water extract on the white rat which was induced hypercholesterolemia by fatty diet. The results obtained were summarized as follows; Neutral lipid level in blood lipid was greatly decreased on the group being fed animal fat diet and Fructure schizandra chinesis Water extract, total cholesterol was decreased on the group being fed vegetative fat diet, HDL-cholesterol was shown that the group being fed vegetative fat diet and Fructure schizandra chinesis Water extract at a time more increased HDL-cholesterol in a little than the other group, and normal fat diet group show to highest figure,38.5mg/dl. Animal fat diet group is 20.75 mg/dl. but, the group being fed Fructure schizandra chinesis Water extract was increased to 31.00mg/dl. LDL-cholesterol had no difference between fat diet group and the group being fed Fructure schizandra chinesis Water extract.

크롬 폭로가 자매염색분체교환 빈도 및 8-hydroxydeoxyguanosine 농도에 미치는 영향

한상환,조수헌,김헌,하미나,주영수,박수민,권호장,김용대,정명희,Han, Sang-Hwan,Cho, Soo-Hun,Kim, Heon,Ha, Mi-Na,Joo, Young-Soo,Park, Soo-Min,Kwon, Ho-Jang,Kim, Yong-Dae,Chung, Myung-Hee 대한예방의학회 1995 예방의학회지 Vol.28 No.2

크롬염 안료제조공장 근로자를 대상으로 크롬 폭로와 말초혈액 림프구의 8-OH-dG 농도의 상관성을 직접 관찰함으로써 크롬의 암 발생기전에 산소유리기(oxygen free radical)가 관여하는지 여부와 크롬폭로에 따라 자매염색분체교환 빈도가 증가하는지를 밝힐 목적으로 본 연구를 수행하였다. 안료공장에 1년 이상 근무한 근로자 38명을 대상으로 설문지를 통하여 근무기간, 연령, 성, 크롬 폭로와 관련된 자각적 증상 등을 조사하였으며, 이들의 크롬 폭로 수준을 평가할 수 있는 생물학적 지표로서 혈중 및 크레아티닌 보정 요중 크롬 농도를 측정하였다. 크롬에 의한 생물학적 영향지표로서 말초혈액 림프구로 부터 dG에 대한 8-OH-dG의 몰 농도비를 측정하였으며, 분열 중기의 세포 30개를 관찰하여 세포당 자매염색분체교환 빈도를 계수하여 염색체 46개당 평균 자매 염색분체교환 빈도로 환산하였다. 분석결과 현재 크롬 폭로 수준을 판단하는 생물학적지표로 가장 많이 사용되는 크레아티닌 보정 요중 크롬 농도와 림프구에서의 dG에 대한 8-OH-dG의 물 농도비는 유의한 상관관계(r=0.47, p<0.01)를 보이는 것으로 분석되었으며, 현재의 흡연수준을 보정하고 분석한 결과에서는 상관계수가 증가하는 결과(r=0.62, p<0.05)를 나타내었다. 한편 자매염색분체교환 빈도와 크롬 폭로수준간에는 유의한 상관관계가 관찰되지 않았다. 이러한 결과는 크롬의 발암성에 DNA 부가체(adduct)의 형성이 중요한 기전일 수 있다는 기존의 연구결과와 일치하며, 따라서 8-OH-dG는 크롬에 의한 발암성을 예측할 수 있는 생물학적 영향지표로서 활용될 수 있음을 시사한다고 할 수 있다. To elucidate some DNA adducts as a biological marker for workers of chromate pigment, the effects of chromium exposure on the formation of 8-hydroxydeoxyguanosine(8-OH-dG) and sister chromatid exchanges(SCEs) frequency in 38 workers of a pigment plant in Bucheon which utilized lead chromates, were examined. The chromium contents of venous blood and urine were measured as working environmental exposure level. The concentrations of 8-OH-dG in DNA isolated from lymphocytes were determined with high performance liquid chromatography and electrochemical detector and denoted as a molar ratio of 8-OH-dG to deoxyguanosine(dG). The SCEs frequency were analyzed in DNA isolated from lymphocytes. A significant correlation was found between creatinine adjusted urine chromium concentration and the molar ratio of 8-OH-dG to dG(r=0.47, p<0.01). After adjusting the current smoking habit, the correlation coefficient was increased(r=0.62, p<0.05). However, there was no significant correlation between the SCE frequency and chromium exposure. This significant results between molar ratio of 8-OH-dG to dG and chromium exposure are in good agreement with in vitro studies that support the importance of DNA adduct formation for the carcinogenic effect of chromium.

군용 항공기 이륙소음이 청력, 혈압, 스트레스 및 주관적 인지도에 미치는 영향

한상환,조수헌,고경심,권호장,하미나,주영수,신명희,Han, Sang-Hwan,Cho, Soo-Hun,Koh, Kyung-Shim,Kwon, Ho-Jang,Ha, Mi-Na,Ju, Yeong-Su,Shin, Myung-Hee 대한예방의학회 1997 예방의학회지 Vol.30 No.2

In effort to determine whether aircraft noise can have health effects such as hearing loss, hypertension and psychological stress, a total of 111 male professors and administrative officers working a college near a military airport in Korea(exposed group) and a total of 168 males and 112 females matched by age groups(control groups) were analyzed. Personal noise exposure and indoor and outdoor sound level of jet aircraft noise were measured at the exposed are3. And pure tone, air conduction test and measurement of blood pressure were given to the exposed(males) and matched control groups (males and females). BEPSI(Brief Encounter Psychological Instrument) and psychological response to aircraft noise were examined for the exposed group. The noise dosimetry results revealed time-weighted averages(TWAs) that ranged from 61 to 68 dBA. However the levels encountered during taking off jet airplanes reached 126 dBA for two half minutes time period. Th, audiometric, test showed that mean values of HTL(hearing threshold level) in exposed group at every frequency(500, 1,000, 2,000, 4,000, and 8,000 Hz were much lower than them of male and female control groups. And in old age groups, interaction of age and noise was observed at 8,000 Hz in both ears(p<0.05). Conclusively, aircraft noise does not appear to induce hearing loss directly in high frequency, but may decreased hearing threshold level by interaction of aging process and noise exposure. However, difference of mean values of exposed and control groups on blood pressure was not significantly. In psychological test, annoyance was the most severe psychological response to noise in exposed group, but mean value of BEPSI was not correlated with job duration in exposed group.

두충(杜沖) 전탕액(煎湯液)이 흰쥐의 혈청(血淸) 지질(脂質) 대사(代謝)에 미치는 영향(影響)

한상환,Han, Sang-Hwan 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3

The effects of 3% Cortex Eucommiae extracts on serum lipid contents were evaluated in rats. Forty-two male Sprague-Dawley rats weighing $100{\pm}10g$ were divided into seven groups and fed different fat diets for four weeks. Each group was administered with following group: Control, basal fat diet, saturated fat diet and unsaturated fat diet respectively was fed 1% cholesterol, Cortex Eucommiae extracts 3%. The contents of serum lipid contents triglyceride in the basal fat diet group were higher than those of control group. The contents of total-cholesterol in serum of the saturated fat diet group was significantly higher than other group. The contents of HDL-cholesterol in serum of the 3% Cortex Eucommiae extract group were higher than those other fat diet group. The contents of LDL-cholesterol in serum of the 3% Cortex Eucommiae ex1ract group was lower than other fat diet groups. These results suggest that 3% Cortex Eucommiae extract group may reduced elevated levels of serum lipid contents in rats different fed fat diet.

구조방정식을 활용한 업무관련 근골격계 증상의 경로 분석

한상환 ( Sang Hwan Han ),김지영 ( Ji Young Kim ) 대한보건협회 2009 대한보건연구 Vol.35 No.2

모바일 융복합 학사종합 콘텐츠 구현 및 개발

한상환(Sang-Hwan Han),이종서(Jong-seo Lee),이혜림(Hye-Rim Lee),오찬(Chan Oh),문일영(Il-Young Moon) 한국정보기술학회 2007 Proceedings of KIIT Conference Vol.2007 No.-

대학생활을 하면서 혹시 휴강인줄 모르고 수업을 들어간 적이 있을 것이다. 또 대학생이라면 누구나 수강신청 전쟁에 지쳤을 것이다. 이러한 문제를 해결하기 위해 핸드폰을 선택하였다. 현재 우리나라는 1인 1핸드폰 시대를 맞이하였다. 핸드폰을 이용하면 시간과 장소에 구애 받지 않을 수 있다. 이러한 추세에 맞추어 M(mobile)-Campus를 이용하여 학교와 학생간의 1:1 서비스를 가능하게 하고자 한다. Sometimes every one would take lessons without knowing no lecture in campus life. And, If you are a university student, you become tired. Because you register for a cource in a crowded. For solving this problem, we choose the cellular phone. Nowadays peoples have one cellular phone to one person in korea. Using cellular phone, you have to use cellular phone anywhere any time. We walk in step with this trend, According to use M Campus, universitys and students use one to one service.

요골두 금속 치환물의 국내 사용

한상환(Sang-Hwan Han),문준규(Jun-Gyu Moon),박종웅(Jong-Wong Park),장기모(Ki-Mo Jang) 대한견주관절의학회 2007 대한견주관절의학회지 Vol.10 No.1

묶음 대각철근을 갖는 세장한 철근콘크리트 연결보의 이력거동

한상환(Sang-Whan Han),유경환(Kyoung-Hwan Yoo),이기학(Ki-Hak Lee),신명수(Myoung-Su Shin) 한국콘크리트학회 2015 콘크리트학회논문집 Vol.27 No.6

대퇴 골두 괴사에서 시행한 Sugioka 경전자 절골술의 결과

천성광(Sung-Kwang Chun),홍재영(Jae-Young Hong),한상환(Sang-Hwan Han),문준규(Jun-Kyu Moon),허창룡(Chang-Young Hur),손원용(Won-Yong Shon) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.2

목적: 대퇴 골두 무혈성 괴사에서 Sugioka 절골술의 결과에 대해서는 논란이 많다. 일본에서 시행된 연구 결과들은 비교적 만족스러운 결과를 보고하는 반면, 특히 미주에서 발표되는 연구들에서는 실망스러운 결과들을 주로 보고하였다. 저자들은 젊고, 범위가 넓은 대퇴 골두 무혈성 괴사에 시행하였던 Sugioka 절골술 45예를 경험하고, 결과를 보고하고자 한다. 대상 및 방법: 1994년 4월부터 2004년 5월까지 젊은 연령에서 발생한 대퇴 골두 무혈성 괴사에 대해 Sugioka 경전자 절골술을 시행한 49예(46명) 중, 시행 후 2년 이상 추시가 가능했던 45예(43명)를 대상으로 하였다. 수술 당시의 연령은 평균 31세(21-46세)였다. 대퇴 골두 무혈성 괴사의 원인은 알콜성인 경우가 33예로 가장 많았으며, 술 전 방사선학적 검사에서 Ficat-Arlet stage IIa는 6예, IIb는 17예, Ⅲ는 22예이었으며 남자는 39예 여자는 6예였다. 평균 추시 기간은 52개월(24-132개월)이었다. 결과: 성예 중 33예(74%)에서 마지막 추시 기간까지 대퇴 골두를 보존하였으며, 33예의 임상적인 결과는 우수 15예, 양호 12예, 보통 6예로 평균 83점(75점-96점)이었다. 수술 후 12예에서 합병증[과도한 내반 변형 7예(15%), 경부 골절 3예(6%), 감염 2예(4%)]이 발생하였고, 이중 7예(15%)와 절골술후 골두 붕괴 진행된 5예(11%)에서 고관절 전 치환술을 시행하였다. 결론: 젊은 환자에서 비교적 광범위하게 침범된 대퇴 골두 괴사의 치료로 Sugioka 경전자 회전 절골술은 시도해볼만한 수술이지만 합병증 발생률이 높으므로 조심스럽게 시행되어야 한다. Purpose: The results of Sugioka's transtrochanteric rotational osteotomy are controversial. While many Japanese studies have reported favorable results, European and American studies have been disappointing. We present the results of Sugioka's rotational osteotomy for extensive osteonecrosis of the femoral head in young patients. Methods and Materials: Between April. 1994 and May. 2004, Sugioka's osteotomy was performed for osteonecrosis involving a large part of the weight bearing area on 49 hips (46 patients). Of these 49 hips, 45 (43 patients) were available for follow-up. The patients were followed up for at least 2 years with an average of 52 months (range: 24-132 months). The major causes of osteonecrosis were chronic alcohol abuse in 33 hips. The mean age of the patients at the time of surgery was 31 years (range: 21-46), and the male to female ratio was 39:6. Six, 17 and 22 hips were classified as stage IIA, IIb and Ⅲ using the Ficat and Alert classification, respectively. Results: Thirty three of the 45 hips (74%) survived clinically and radiologically. Of these, the clinical results were excellent, good and fair in 15, 12 and 6 hips, respectively. Major complications were encountered in 12 hips [Progressive severe varus deformity in 7 hips (15%)], femur neck fracture in 3 hips (6%) and deep infection in 2 hips (4%). Among these 12 hips, seven hips (15%) required secondary THA. Five other hips (11%) were also subsequently converted to THA due to progressive collapse of the femoral head after the transtrochanteric osteotomy. Conclusion: Transtrochanteric osteotomy can be used to treat osteonecrosis of the femoral head in young patients with extensive necrotic lesions of the femoral head. However, Sugioka osteotomy should be used with caution due to its high incidence of complications.

한수(寒嗽) 및 열수(熱嗽)에 대(對)한 문헌적(文獻的) 비교(比較) 고찰(考察)

이순호,한상환,Lee, Sun-Ho,Han, Sang-Hwan 대한한방내과학회 1993 大韓韓方內科學會誌 Vol.14 No.2