산업안전보건법상 관리대상 유해물질 선정기준 마련에 관한 연구

박은우 ( Eun Woo Park ),박준호 ( Jun Ho Park ),이권섭 ( Kwon Seob Lee ),홍문기 ( Mun Ki Hong ),안병준 ( Byung Jun Ahn ),이은정 ( Eun Jung Lee ) 한국산업보건학회 2014 한국산업보건학회지 Vol.24 No.4

Objectives: This study was performed in order to establish reliable and relative selection criteria for hazardous substances requiring management(HSRM) in the Occupational Safety and Health Act in Korea. Methods: To determine the relative criteria and weight of evidence for HSRM, we analyzed the difference between the selection method of priority substances in studies by KOSHA(Korea Occupational Safety and Health Agency) and the European Union Risk Ranking Method(EURAM). In addition, 597 hazardous substances with exposure limit valueswereanalyzed and the posted health hazards classification by MOEL(Ministry of Employee and Labor), MOE(Ministry of Environment), and EU CLP(Classification, Labelling and Packaging regulation) were compared based on GHS(Globally Harmonized System of classification and labelling of chemicals) criteria. The existing HSRM(167 substances) were evaluated for suitability by the proposed criteria in this study. Results: As a result of this study, the criteria and procedures for selecting HSRM in the Occupational Safety and Health Act were arranged utilizing GHS health hazard classification results, occupational disease cases and domestic use situations. Conclusions: The applicability of the proposed criteria was proved via the evaluation of existing HSRM(167 substances). Most HSRM (161 substances) were found to correspond to a significant health effect or substantial health effect. The question of whether to include the six substances that have been found to have general health effects as HSRM would be require further research.

아세클로페낙 ( 100 mg ) 제재인 세나펜 정과 에어탈 정의 생물학적동등성 평가

박은우(Eun Woo Park),송우헌(Woo Heon Song),차영주(Young Joo Cha),최영욱(Young Wook Choi) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.4

Aceclofenac is an orally effective non-steroidal anti-inflammatory agent of the phenylacetic acid derivative. Bioequivalence study of two aceclofenac preparations, the test drug (Senafen^R: Daewon Pharmaceutical Company) and the reference drug (Airtal^R:Daewoong Pharmaceutical Company), was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen healthy male volunteers, 24 ±4 years old and 63.9 ±6.9 kg of body weight in average, were divided randomly into two groups and administered the drug orally at the dose of 100 mg as aceclofenac in a 2 x 2 crossover study. Plasma concentrations of aceclofenac were monitored by HPLC method for 12 hr after administration. AUC_(0-12h) (area under the plasma concentration-time curve from initial to 12 hr) was calculated by the linear trapezoidal method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach C_(max)) were compiled directly from the plasma drug concentration-time data. Student`s t-test indicated no significant differences between the formulations in these parameters. Analysis of variance (ANOVA) revealed that there are no differences in AUC_(0-12h), C_(max) and T_(max) between the formulations. The apparent differences between the formulations were far less than 20% (e.g., 0.25, 0.01 and 7.32 for AUC_(0-12h), C_(max) and T_(max), respectively). Minimum detectable differences (%) between the formulations at α=0.05 and 1-β=0.8 were less than 20% (e.g., 14.65, 12.47 and 15.46 for AUC_(0-12h) C_(max) and T_(max) respectively). The 90% confidence intervals for these parameters were also within ±20% (e.g., -10.19∼10.68, -8.87∼8.89 and -3.69∼18.33 for AUC_(0-12h), C_(max) and T_(max), respectively). These results satisfy the bioequivalence criteria of KFDA guidelines, indicating that two formulations of aceclofenac are bioequivalent.

2009개정 고등학교 과학교과서의 탐구활동 분석

박은우(Park, Eun Woo),이영희(Lee, Young Hee) 학습자중심교과교육학회 2016 학습자중심교과교육연구 Vol.16 No.8

본 연구는 2009 개정 교육과정의 고등학교 과학교과서를 대상으로 미국 국립연구 회(NRC, 2012)의 차세대 과학기준(NGSS)에서 제시하는 과학적 실천요소를 조사하였다. 이를 위해 현 고등학교 과학교과서 5종을 임의 선정하여 본문에 포함된 탐구 활동 및 과학적 실천 요소의 분포수와 탐구활동에 포함된 8가지 과학적 실천요소의 강조 양상을 교과서별/단원별로 분석하였다. 연구 결과는 다음과 같다. 첫째, 5종의 고등학교 과학교과서는 각 교과서별로 포함된 탐구활동과 과학적 실천요소의 수가 큰 차이를 보이면서 탐구에 대한 강조 정도가 다양한 것으로 조사되었다. 둘째, 고등 학교 과학교과서의 탐구활동 속에 포함된 과학적 실천 요소는 8개의 요소 중에서 주로 4. 자료 분석하고 해석하기와 8. 정보를 얻고, 평가하고, 소통하기가 전체의 약 70% 이상을 차지하면서 강조되었다. 반면 1. 질문하고 문제 규정하기는 전혀 포함되지 않았고 다른 실천 요소들도 매우 제한적으로 제시되고 있었다. 셋째, 고등학교과 학교과서는 교과서별로 탐구활동에 대한 강조 정도는 달랐지만 교과서별/단원별로 포함되고 제시되는 과학적 실천 요소의 분포 양상은 유사하였다. 결론적으로 고등학 교과학교과서는 전반적으로 유사하고 제한된 탐구활동을 제시하면서 학생들에게 다양한 탐구의 본질에 대한 이해 및 역량 배양에 한계를 줄 수 있다고 판단된다. The purpose of this study was to analyze inquiry activities in high school science textbooks on the revised 2009 science curriculum using the components of scientific practices from the Next Generation Science Standards(NRC, 2012). The results in this study as follows: First, the extent of emphasis of science inquiry varies in the high school science textbooks by devoting the different numbers of inquiry activities and the scientific practices. Second, the inquiry activities in the textbooks hevily emphasized the two of eight types of scientific practices including “Analyzing and interpreting data” and “Collecting, Evaluating, and Communicating with the Information” devoting more than 70% of the contents while other components of scientific practices were appeared slightly in the science inquiry activities. Significantly, the component of “Asking questions and defining the Problem” was not shown at all in science inquiry activities. Third, even though the extent of emphasis of science inquiry is different from the high school science textbooks, the pattern of emphasis of the scientific practices in science inquiry activities is similar across the different publishing companies as well as the chapters of the textbooks. Overall findings indicate that high school science textbooks included limited scientific practices in science inquiry activities and were not relevant for high school students to learn the authentic scientific inquiry.

코지산을 함유한 폴록사머 겔 제제의 약물방출 및 피부자극성

박은우(Eun Woo Park),조성완(Seong Wan Cho),김동섭(Dong Sup Kim),최기환(Ki Hwan Choi),최영욱(Young Wook Choi) 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.3

N/A Low toxicity, reverse thermal gelation and high drug loading capabilities suggest that poloxamer 407 gels have great potential as a topical drug delivery system. Kojic acid (KA) is an antimelanogenic agent which has been widely used in cosmetics to whiten the skin color. However, it has the drawbacks of skin irritancy due to its acidic pH. Poloxamer gels of different polymer contents were formulated to overcome the problem and compared to the cream type formulations of either w/o/w multiple emulsion cream or o/w type emulsion cream. Using Franz diffusion cells mounted with a synthetic cellulose membrane (MWCO 12.000), drug release characteristics of the formulations were evaluated by the HPLC assay of KA concentration in the receptor compartment of pH 7.4 phosphate buffered saline solutions. Drug release from w/o/w multiple emulsion cream was controlled by oil membrane, showing the apparent zero order release kinetics. The KA release from the poloxamer gels was also controlled by the gel matrix, showing that drug release increased linearly as KA contents increase, but decreased exponentially as the polymer contents increase. In the skin irritancy test, the primary irritancy index(PII) of poloxamer gel base was lower than those of multiple emulsion cream base and o/w cream. Depending on KA contents or polymer contents in the gel, PII values in poloxamer gels were ranged from 1.3 to 2.0, which are interpreted as low or negligible irritation on skin. There was a good correlation between the log value of flux in drug release and PII value in skin irritation. It was possible to conclude that the poloxamer gels containing KA might be a good candidate for an antimelanogenic topical delivery system by virtue of the controlled release of the drug and the reduced skin irritancy.

서울대학교 농림기상학전공 대학원협동과정: 회고와 기대

박은우 ( Eun Woo Park ) 한국농림기상학회 2021 한국농림기상학회지 Vol.23 No.4

농림기상학은 농업생명과학을 구성하는 세부 학문 분야를 포괄할 수 있고, 생태-사회시스템을 구성하는 다양한 하부 시스템 간의 관계를 구명할 수 있는 학제간(interdisciplinary) 더 나아가서 모든 이해관계자가 함께 참여하는 초학문(transdisciplinary) 과학이다. 시대적 필요성에 따라 서울대에서는 2012년에 공식적인 대학원 교육 조직으로서 농림기상학전공 협동과정을 설치하였다. 지난 10년 동안 성과도 있었지만 향후 발전을 위해 개선해야 할 점도 있다. 이 글에서는 이 협동과정 설립 10주년을 맞이하여 내가 농림기상학에 대해 관심을 갖게 된 계기를 만들어준 세 분의 과학자를 소개하고, 협동과정 설립을 주도했던 사람으로서 초기의 생각과 상황을 정리하고, 향후 발전을 위한 기대를 공유하고자 한다.

잿빛곰팡이병균 ( Botrytis cinerea ) 형태형 간의 생리적 다양성

김병섭,박은우,노성환,조광연 ( Byung Sup Kim,Eun Woo Park,Seong Hwan Roh,Kwang Yun Cho ) 한국균학회 1997 韓國菌學會誌 Vol.25 No.4

우리나라 골프장 잔디에서 분리한 Pythium spp.

김진원,박은우 ( Jin Won Kim,Eun Woo Park ) 한국균학회 1997 韓國菌學會誌 Vol.25 No.4

Bipolaris coicis 의 완전세대인 Cochliobolus nisikadoi 의 배양기내 형성

김성기,김기우,박은우,강위수,양장석 ( Sung Kee Kim,Ki Woo Kim,Eun Woo Park,Wee Soo Kang,Jang Souck Yang ) 한국균학회 1998 韓國菌學會誌 Vol.26 No.2

외용겔 및 다중유제크림의 코지산 방출특성과 피부자극성

유성운(Sung Un Yu),박은우(Eun Woo Park),최영욱(Young Wook Choi) 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.2

N/A Kojic arid (KA) is an antimelanogenic agent which has been widely used in cosmetics to whiten the skin color. However, it has the drawbacks of the skin irritancy and the instability against the pH, temperature, and light. In order to overcome these problems, various topical gels and multiple emulsion creams which can control the release of active ingredient. KA, were formulated employing cream bases of mineral oil with caprylic capric triglyceride and hydrophilic polymers such as chitosan, carbopol, and pluronics. Using Franz diffusion cells mounted with a synthetic cellulose membrane (MWCO 12,000), drug release characteristics of the formulations were evaluated by the HPLC assay of KA concentration in the receptor compartment of pH 7.4 phosphate buffered saline solution. Drug release from chitosan-based gels (ChitoGel) obeyed to the first order kinetics with at rapid release especially in the initial period. However, pluronic-based gels (PluGel) and carbopol-based gels (CarboGel) revealed controlled release of drug to some extent, followed by the square root-time kinetics. Moreover, the release of KA was further controlled with the W/O/W multiple emulsion creams (MultiCream), showing the apparent zero order release kinetics by virtue of dynamic rate-controlling membrane of the oil layer. The flux (J. ㎍/㎠/hr) of ChitoGel, CarboGel, PluGel, and MultiCream in the initial period of 6hr were 73.30, 28.67, 29.04 and 7.72, respectively. On the other hand, the skin irritancy score of ChitoGel and MultiCream were observed as 2.5 and 2.3 respectively, in the rabbit skin irritation test. Although there were insignificant, differences at p<0.05 between those formulations, it was possible to conclude that the W/O/W multiple emulsion creams containing KA might be a good candidate for an antirnelanogenic drug delivery system due to the controlled release of acidic drug molecules.

Rural Systems Visioneering: Paradigm Shift from Flux Measurement to Sustainability Science

김준,강민석,타이칸 오끼,박은우,카즈히토 이치이,요하나 마리아 인드라와티,조성식,문지현,유완철,이지영,이협승,카롤리 은자우,안성훈,Kim, Joon,Kang, Minseok,Oki, Taikan,Park, Eun Woo,Ichii, Kazuhito,Indrawati, Yohana Maria,Cho, Sungsik,Moon, Jihyun,Yoo, Wan Ch Korean Society of Agricultural and Forest Meteorol 2018 한국농림기상학회지 Vol.20 No.1

지속가능성과학은 다양한 학문 배경과 관심을 가진 과학자, 전문직 종사자 및 이해당사자들 간의 소통과 협력뿐 아니라 결정론적 환원주의적 접근에서 오래전 기본으로의 패러다임 전환이 요구되는 떠오르는 초학문적 연구다. 생태-사회시스템은 많은 구성성분(또는 행위자)들로 이루어져 이들의 국지 규모의 무작위 상호작용이 자연스럽게 시스템 전체 규모의 질서를 만들어내는 공진화하는 복잡계다. 여기서, 시스템과 주변환경 간의 에너지와 물질과 정보의 흐름이 중요한 역할을 한다. 본 통신에서는 이렇게 계속 변화하는 역동적 시스템, 즉 '자기-조직화하는 계층구조의 열린 시스템(SOHOs)'의 개념적 틀을 소개한다. 먼저 SOHOs의 구조와 기능성을 이해하기 위해 물리학의 두 기본 법칙을 다시 논의한다. 두 법칙의 재해석을 통해 시스템의 운명과 지속가능성을 향한 보다 나은 경로, 또한 생태계의 온전함과 사회의 비전/가치 추구를 어떻게 조화시킬 것인가에 대한 이해를 돕고자한다. 그 다음에 소위 '비저니어링(V)'이라는 틀을 되먹임/전방급전(feedback/feedforward) 루프로 SOHOs 틀에 통합시켜서, '슬쩍 찌르는(nudged) 자기-조직화'가 시스템을 구성하는 행위자들이 합력하여 지속가능한 생태-사회 시스템을 이루어 가도록 유도한다. 마지막으로, SOHOs-V의 적용사례로서, 현재 탄자니아의 농촌마을에서 진행되고 있는 미래지구의 지속가능발전목표 연구실(SDG Lab)인 '농촌시스템 비저니어링(Rural Systems Visioneering)'을 예로 제시하였다. Sustainability science is an emerging transdisciplinary research which necessitates not only the communication and collaboration of scientists, practitioners and stakeholders from different disciplines and interests, but also the paradigm shift from deterministic and reductionist approaches to the old basic. Ecological-societal systems (ESS) are co-evolving complex systems having many interacting parts (or agents) whose random interactions at local scale give rise to spontaneous emerging order at global scale (i.e., self-organization). Here, the flows of energy, matter and information between the systems and their surroundings play a key role. We introduce a conceptual framework for such continually morphing dynamical systems, i.e. self-organizing hierarchical open systems (SOHOs). To understand the structure and functionality of SOHOs, we revisit the two fundamental laws of physics. Re-interpretation of these principles helps understand the destiny and better path toward sustainability, and how to reconcile ecosystem integrity with societal vision and value. We then integrate the so-called visioneering (V) framework with that of SOHOs as feedback/feedforward loops so that 'a nudged self-organization' may guide systems' agents to work together toward sustainable ESS. Finally, example is given with newly endorsed Sustainable Development Goals (SDG) Lab (i.e., 'Rural systems visioneering') by Future Earth, which is now underway in rural villages in Tanzania.