사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

성인에서 Haemophilus influenzae 감염증의 임상양상과 미생물학적 특성

이종섭,황병연,정희진,김우주,박승철,이도현,이창규,신종희,황규잠,이영희 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.2

목적 : H. influenzae는 성인에서 흔히 호흡기 감염을 일으키는 균주로, 최근 ampicillin 내성 β-lactamase 생성 균주들이 지속적인 증가를 보이고 있어, 이에 국내 성인에서 H. influenzae에 의한 감염의 임상양상과 분리된 균주들의 미생물학적 특성을 조사하고자 하였다. 방법 : 1998년 3월부터 1999년 9월까지 고려대 구로병원에 내원한 환자중에서 H. influenzae가 분리된 68명을 대상으로 임상양상을 조사하고 항균제 감수성 검사를 시행하였다. 분리된 33주에 대해서 혈청형, 생물형, 세포외막 단백분석을 시행하였고, β-lactamase 생성여부에 따른 감염 환자군간 임상상 및 예후의 차이를 비교하였다. 결과 : 환자의 평균연령은 68세였고, 지역사회 획득감염이 전체의 85%를 차지하였다. 폐렴과 기관지염과 같은 하기도 감염이 전체환자의 75%를 차지하였고 분리 검체 역시 객담이 84%로 가장 많았다. 환자의 71%가 기저질환을 가지고 있었으며, 그 중에 만성 폐쇄성 폐질환, 심혈관 질환, 악성종양, 당뇨병이 대부분이었다. 혈청형으로는 nontypeable 형이 68%로 가장 많았고 b형은 한 예도 없었다. β-lactamase 생성율은 63.2%였고, β-lactamase 양성균주의 항균제 내성율이 음성균주에 비하여 높았으나 β-lactamase 생성 여부에 관계없이 cefotaxime, azithromycin, ciprofloxacin에 대하여 100%의 감수성을 나타내었고 cefaclor, cefuroxime에 대해서는 10% 이하의 낮은 내성율을 보여 이들 항균제들이 치료에 효과적일 것으로 사료된다. 세포외막 단백분석에서는 C형과 D형이 전체의 64%로 가장 많았으며, 혈청형과의 유의한 연관성은 보이지 않았다. 결론 : 성인에서 H. influenzae는 주로 만성 기저질환자에서 급성 호흡기감염 또는 만성 폐쇄성 폐질환의 급성 악화를 유발한다. 기존의 보고에 비해 β-lactamase 양성율이 증가하였고, 이에 따른 항균제 내성율도 증가하여 항균제의 선택에 유의하여야 할 것으로 생각된다. 세포외막 단백분석상 특정한 유형의 균주에 의해 감염이 집중적으로 발생하고 있어 향후 역학 조사의 도구로 이용할 수 있겠다. Purpose : H. influenzae is one of the common causative microorganisms of respiratory tract infections in adults. Recently. β-lactamase producing, ampicillin-resistant H. infiuenzae has become worldwide problem as well as in Korea. We studied to investigate the clinical features and microbiologic characteristics of H. infiuenzae infections in adults. Materials & Methods : From March 1998 to September 1999, 68 patients were enrolled in this study. Clinical features of H. infiuenzae infections were investigated, 68 isolates were subjected to the β-lactamase test, and 33 isolates were used for serotyping. biotyping, antibiotic susceptibility and outer membrane protein (OMP) analysis. Results : Mean age of study patients was 68 years-old and the acquisition rate in community was 85%. Pneumonia and bronchitis were the most common type of infection such as 80%, sputum was the most common clinical specimen for H. mQuenzae isolation. 70% of patients had chronic underlying diseases. Non-typeable strains were 68% and β-lactamase producing rate was 63%. There was no difference in the clinical features and prognosis of H. influenzae infection between the β-lactamase positivie and -negative groups. The susceptibility of cefotaxime, azithromycin, and ciprofloxacin was 100% and that of cefaclor, cefuroxime was under 10% in spite of β-lactamase positivity. In OMP analysis, C and D types were dominant (64%). Conclusion : H. influenzae caused acute respiratory infections in adults with chronic underlying disorders. This study shows higher β-lactamase producing rate and antibiotic-resistance rate than that were reported previously. OMP analysis shows that two major types of strains cause clinical infections intensively.

심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

Korean Dictionaries and Some Model Dictionaries of the World : Critical Essays toward the Plan for a New Korean Dictionary

Lee, Sang Sup,Nam, Ki Shim,Ahn, Sam Huan,Choi, Young Ai,Hong, Chai Song 연세대학교 언어정보개발원 1988 사전편찬학 연구 Vol.1 No.1

After briefly reviewing the history of lexcoigraphy in modem Korea, Nam Kishim tackles many problems created by the general deficiency of current Korean monolingual dictionaries in phonological morphological and semantic points. For example, most Korean dictionaries do not treat such phonological changes as the shortening of the stem vowel ㅓ in 더운, the prenominal form of the adjective 덥다, whose stem vowel ㅓ is pronounced long. He also takes issue with the practice of Korean dictionaries of including all kinds of proper names on little reliable principles : a typical dictionary enters a 600m-high hill while excluding better-known mountains higher than that. Hong Chai-song concentrates on the often misguiding information on transitive / intransitive verbs in current dictionaries. For example, a representative dictionary designates the verb 뛰다 simply as intransitive. But it is quite often used as an transitive also. In the sentence, 철수는 운동장을 뛰었다, 운동장 is the object of the transitive verb 뛰다. How could the compilers miss such an obvious fact? Hong suggests that they may have not been interested in being grammatically informative. A historical survey of the Oxford English Dictionary(OED) is given by Lee Sang-sup, with special emphasis on the vast amount of quotations from real sources contributed by thousands of volunteer readers through several decades and on its unwavering historical principle. A comparison between the OED's definition of Kimchi and a Korean dictionary's 김치 is given, showing the difference of principle in treating the same lexical item. Ahn Sam-huan presents a detailed account of Grimm's Deutsches Wo¨rterbuch which took generations of German lexicographers 133 years from its inception to its completion in 1971. On the basis of his study, Ahn suggests that future dictionary makers should cooperate as a group on a long-range comprehensive project. A moltivolume dictionary is an all-important cultural event for the whole nation, not to be influenced by private commercial interests. Choi Young-ai's survey of Chinese lexicography highlights the now on-going publication of 漢語字典 and 漢語詞典, admirable results of the cooperative effort of hundreds of Chinese scholars, a modus operandi for the Yonsei University graze to adopt in planning a new dictionary of the Korean language.

진행성 위암과 동반된 후복막 섬유화증 7예의 임상적 고찰

장재영,천영국,최우봉,김진오,조주영,이준성,이문성,심찬섭 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background/Aims: Retroperitoneal fibrosis is a fibrosing disease process which frequently develops ureteral obstruction. Malignant retroperitoneal fibrosis has been reported that various types of cancer including cancer of the breast, stomach, prostate, lung, cervix, uteri, colon, pancreas, ovary, and even Hodgkin's disease. While the pathogenesis remains obscure, small foci of metastatic neoplasm in the retroperitoneal space can elicit a desmoplastic reaction in secondary form to malignancy. Methods: Recently we experienced 7 cases of retroperitoneal fibrosis with advanced gastric cancer. So, we report 7 cases of retroperitoneal fibrosis with clinical and radiologic characteristics. Results: The most common signs and symptoms were related irreversible renal dysfunction. The urologic finding noted medial deviation of the involved ureters and hydronephrosis Conclusions: Clinical manifestations are abdominal pain, back pain, hydronephrosis, and uremia. When sudden back pain and hydronephrosis develop in advanced malignancy, physicians should be considerd for retroperitoneal fibrosis.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

위염 환자에서 변현된 Urea agar로 Helicobacter pylori 검사에 관한 연구

이건섭,방용준 대구보건대학 2000 대구보건대학 論文集 Vol.20 No.-

Helicobacter pylori, a gram negative spiral bacilli, is known to be the cause of chronic gastritis and peptic ulcer disease and is strangly associated with gastric cancer. The authors have tried to make a new urea test more convenient for routine H. pylori laboratory study than CLO-test. Two piece of biopsy speciments were investigated with the urease test and histopathologic examination. The results urea summurized as follows : The urease positive reaction of CLO-test and modifyed urea agar from biopsy material were 70% and 70% in gastritis, 25% and 25% in gastric ulcer. Among the total 36 cases, 20 cases showed positive urease reaction from CLO-test and 19 cases were ureas positive from modified urea agar. 16 cases were urea negative specimen.

장애인의 성 향유에 영향을 미치는 요인연구 : 20대 미혼 장애인을 중심으로

이익섭,이영미 연세대학교 사회복지연구소 2003 연세사회복지연구 Vol.9 No.-

본 연구는 장애인의 성 문제에 관한 최초의 전국 조사로서 성을 보다 다차원적이고 포괄적인 개념으로 보아 장애인의 성이 타인과의 상호작용이자 자신의 존재의미와 자아존중감과도 연결되는 근원적인 힘으로 작용한다고 보고 결혼한 장애인들이 아닌 미혼의 청장년 장애인들을 연구대상으로 하여 이들이 포괄적인 의미에서의 성을 얼마만큼 향유하고 있는지 그리고 성향유에 영향을 주는 요인들은 무엇인지를 밝힘으로서 통합적이고 전인적인 기능을 하는 성을 향유하도록 돕고자 하였다. 그리고 이 연구를 통해 향후 장애인의 성 향유를 촉진할 수 있는 정책의 방향설정에 토대가 될 수 있는 함의를 도출하고자 하였다. 조사 결과 우리나라 장애인은 비교적 긍정적인 성에 대한 태도를 보이고 있음에도 불구하고 성과 관련된 사생활이 보장되지 않고 성문제를 상담할 수 있는 기회가 제한되어 있으며 이성과의 접촉이 어려움으로 인해 성을 향유하지 못하고 있었다. 성의 향유에는 이성과의 접촉정도, 사생활 보장, 성에 대한 대화정도가 영향을 미치며 그 외에 장애유형이나 교육수준, 성별도 영향을 미치고 있음을 알 수 있었다. 장애인의 성문제를 해결하기 위해 성 상담프로그램이나 이동권 보장, 체계적인 성교육강화 등의 정책적 접근이 이루어져야 하며 장애인의 성에 대한 부정적 선입견을 해소하기 위한 다양한 방법이 모색되어야 할 것이다. The Purpose of Study is to examine degree of sexuality enjoyment of the disabled in holistic perspective and to find factors affecting sexuality of the disabled in Korea. Reasearch was conducted on the people with visual disabilities and physical disabilities. Telephone survey was used for the persons with visual disabilities whereas mailing survey was used for persons with physical disabilities. The final sample was consisted of 353 respondents. The major findings of this study were as follows: First, although persons with disabilities have positive attitudes about their sexuality, they don't have the privacy nor the opportunity to talk openly about their sexuality. Second, the factors affecting sexuality of the disabled were the opportunity to meet the opposit sex, the degree of privacy and the extent of open discussion. The current findings suggest that intervention and policy aimed at improving sexuality enjoyment of the people with disabilities such as enhanced availability, sexuality education, sexuality counselling, and inclusive education.

Bio-sensor 개발을 위한 Langmuir-Blodgett(LB)법의 연구

이경섭,강용철 東新大學校 工業技術硏究所 2000 工業技術硏究 Vol.6 No.-

In this paper generation form of displacement current was compared and measured with light stimulus induce mono layers which 8A5H with azobenzene and arac.acid mixed. In the view point of photo device applications 8A5H organic monolayer with the characteristic of photoisomerization is spread on the surface of water by displacement current and surface pressure changes of organic monolayer by pressure stimulus and generation forms of displacement current were measured. Light response of two mono layers which dynamics behavior are different was compared and measured though they are the same isomer The experimental results are as following; In the case of light stimulus mixed mono layers reacted less than 8A5H about 4[fA]. This is the reason molecule dynamic behave our in cis and trans was not activated due to its very long chain length.

Si₃N₄/SiO₂/Si₃N₄열차단막을 이용한 유속센서 제작

이형주,김도훈,김진섭,박세일,최용문,권대혁,이정희 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1