Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

노화가 인체 중간엽 줄기세포로부터 조골세포로의 증식 및 분화에 미치는 영향

백기현,태현정,오기원,이원영,조정기,권순용,강무일,차봉연,이광우,손호영,강성구,김춘추 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.3

연구배경: 일반적으로 골다공증과 연관된 위험인자로는 연령, 폐경, 약물, 불충분한 칼슘섭취, 만성질환 및 운동부족 등이 있는데, 특히 노화가 진행할수록 골밀도가 감소하는 것은 잘 알려져 있다. 노화와 관련하여 진행되는 골소실은 조골세포 및 전구조골세포의 기능적 결핍에 의한 골형성의 감소가 주요한 요인으로 여겨지고 있다. 그 동안 연령이 조골모 세포의 양과 조골모 세포로부터 성숙조골세포로의 분화 및 증식에 미치는 영향에 대한 일부 보고들이 있었으나 아직 일치된 견해는 없는 형편이다. 방법: 다양한 연령의 사람으로부터 골수를 채취, 중간엽 줄기세포가 포함된 단핵세포를 분리한 후 조골세포로 분화하기 좋은 조건하에서 배양하였다. 대상군은다시 젊은군과 노령군으로 구분하여 다양한 변수를 비교 분석하였다. 일차배양에서는 CFU-F를 계수하여 골수내 중간엽 줄기세포의 수를 추산하였고, 칼슘측정을 통하여 기질의 무기화 정도를 비교하였다. 계대배양후 이차배양에서는 시기별로 알카리성 포스파타제 활성도를 측정하고 오스테오칼신 mRNA의 발현을 관찰하여 젊은군과 노령군 사이의 증식능 차이를 비교하였다. 또한 이차배양 시기별로 MTT 측정을 하여 양군간에 증식능 차이가 있는지 알아보았다. 결과: 1. 일차배양 15일째에 평균 CFU-F의 수는 젊은군에서 유의하게 많았다(젊은군 148.3±28.9, 노령군 54.3±9.1, p=0.02). CFU-F의 평균면적은 젊은군에서 넓은 경향을 보였으나 통계적으로 유의하지는 않았다. 2. 일차배양 17일 경과 후 양군간에 기질 칼슘 침착정도는 유의한 차이를 보이지 않았다(젊은군 103.6±50.6, 노령군: 114.0±56.5, p=NS). 3. 이차배양 10일째에 젊은군에서 알카리성 포스파타제 활성도가 고령군에 비해 유의하게 높았다(젊은군: 935.5±115.0 U/mg, 노령군: 578.4±115.7U/mg,p.0.05). 고령군에서는 시간 경과에 따른 변화가 미약했으며 전반적으로 알카리성 포스파타제의 활성도가 젊은군에 비해 낮았다. 4. 이차배양도중 오스테오칼신 mRNA의 발현은 배양시기별로 젊은군에 비해 고령군에서 더 낮은 경향을 관찰할 수 있었다. 5. 이차배양 10일과 15일에 젊은군에서 노령군보다세포증식이 유의하게 증가된 양상을 보였다(10앓 젊은군 0.73±0.05, 노령군 0.58±0.04, p=0.05, 15일; 젊은군 0.80±0.05, 노령군 0.70±0.03, p=0.05).결론: 이상의 연구에서 저자들은 노령군에서 젊은군보다 골수 내 중간엽줄기세포의 수가 적고, 노령군에서 유래한 전구조골세포의 성숙조골세포로의 증식 및 분화가 젊은군 보다 감소해 있는 것을 관찰할 수 있었다. Background: Osteoblasts originate from osteoprogenitor cells in bone marrow stroma, termed mesenchymal stem cells (MSCs) or bone marrow stromal cells. Each MSC forms colonies (colony forming units-fibroblasts [CFL-Fs]) when cultured ex vivo. There are some reports about the age-related changes of the number and osteogenic potential of osteoprogenitor cells, but any relationship has not been clearly established in humans. In this study, we counted MSCs using CFU-Fs count and examined the proliferative capacity and differentiation potential of osteoprogenitor cells. Finally, we analyzed how these parameters varied with donor age. Methods: Bone marrow was obtained from the iliac crest of young (n=6, 27.2±8.6 years old) and old (n= 10, 57.4k6.7 years old) healthy donors. Mononuclear cells, including MSCs, were isolated and cultured in osteogenic medium. In primary culture, we compared the colony-forming efficiency of MSCs between the two groups and determined the matrix calcification. When primary culture showed near confluence, the cells were subcultured. Alkaline phosphatase activity, osteocalcin expression by RT-PCR and proliferative potential by MTT assay were examined by the time course of secondary culture. Results: At the 15th day of primary culture, the mean number of CFU-Fs was significantly higher in the younger donors (young: 148.3±28.9, old: 54.3±9.1, p=0.02) and the mean size of CFL-Fs was also larger in the younger donors than the older donors. However, matrix calcification was not different between the two groups (young: 103.6±50.6, old: 114.0±56.5, p=NS). In secondary culture, alkaline phosphatase activities were significantly lower in the older donors. The younger donors showed peak alkaline phosphatase activity at day 10, while the older donors didn't showed a remarkable peak (young: 935.5±115.OU/mg, old: 578.4±115.7U/mg, p<0.05). Total cell number as a proliferative index increased progressively during the secondary culture and a significantly greater cell number was noted in the younger donors. Osteocalcin expression was generally upregulated in the younger donors, but this was not statistically significant. Conclusion: Our study shows that the number of osteoprogenitor cells is decreased during aging and that the proliferative capacity and differentiation potential of osteoprogenitor cells seem to be reduced during aging (J Kor SOC Endocrinol 18:296-305, 2003).

殺鼠劑 RH-787 飮毒에 依한 糖尿病 發生機轉에 關한 硏究

李民化,李泰熙,李起榮 全南大醫大 1979 전남의대학술지 Vol.16 No.1

까치버섯을 이용한 아이라이너 제조 및 평가

이기영ㆍ김정희(Kee Young LeeㆍJeong hee Kim) 한국인체미용예술학회 2016 한국인체미용예술학회지 Vol.17 No.1

Application of natural dye will be able to further produce the development of various color products in color cosmetics, as well as reduce the pollution of heavy metals coming from the combination of a large amount of pigment. This experiment created an eyeliner product containing Polyozellus Multiplex as part of an agenda regarding natural pigments and evaluated safety, cosmetic formulation, coloration and sensory testing. The stability of eyeliners containing Polyozellus Multiplex and control eyeliner were evaluated. All eyeliner products showed no significant change in a centrifugation test and cycling test. All eyeliner products were investigated for viscosity using the DV-E Viscometer on LV30 rpm, s64, 2min at 25℃. The viscosity property of the control eyeliner is 11,139±0.82 CPS and eyeliner containing Polyozellus Multiplex 30%, 50%, 100% are 11,282±4.08 CPS, 11,222±5.40 CPS, 11,343±2.04 CPS, respectively. As a result of a patch test, erythema appeared in 1 of 10 people for the control eyeliner but there were no reactions to the eyeliners containing Polyozellus Multiplex 30%, 50% and 100%. The coloration value of the eyeliner containing Polyozellus Multiplex 30% was similar to the control eyeliner. The characteristics of spreading, color formation, persistency, texture, and application value were determined by a 5-point Likert scale. As a result of the sensory test, eyeliner containing Polyozellus Multiplex 50% is the highest satisfaction. Based on these findings, the partial replacement of Polyozellus Multiplex as part of a natural pigment is useful and it can be utilized in eyeliner products as a safe ingredient.

頭痛에 관한 精神醫學的 硏究

羅澈,李吉弘,李在光,奇柏錫,李在禹,兪英植,李永植 서울醫大 1990 精神醫學 Vol.15 No.3

유기용제 노출에 따른 신발제조업체 근무 여성근로자들에서의 후천적 색각이상

변주현,이광영,김영기,고광욱,이용환 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.3

목적 : 복합유기용제에 노출되는 신발제조업체 근무 여성근로자들에서 유기용제 누적노출량과 후천성 색각이상 발현빈도간의 상관성을 조사하기 위해 본 연구를 실시하였다. 방법 : 신발제조업체 근무 여성근로자들 가운데 유기용제에 노출되는 85명과 유기용제에 노출되지 않는 근로자 88명을 대상으로 조사하였다. 조도가 표준화된 방에서 시력검사와 색각이상 검사를 실시하였다. 작업 부서를 접착, 사상 및 선처리 부서로 나누었고 작업 부서별로 현재노출량과 누적노출량을 구하였다. 결과 : 색각이상의 유병률은 노출군이 대조군보다 통계학적으로 유의하게 높았으며 (P=0.017). 유기용제 노출군 85명 가운데 후천적 색각이상인 청황색 색각이상자가 5명(5.9 %)이었다. 안증상도 노출군이 대조군보다 발생빈도가 높았으며 통계학적으로 유의한 차이를 보였다(P=0.001). 색 혼란지수에 영향을 줄 수 있는 변수들인 연령, 교육기간, 누적노출량 등은 유의한 변수로 나타나지 않았다. 결론 : 유기용제 노출군에서 색각이상의 유병률이 대조군보다 유의하게 높았으며, 특히 유기용제 노출군에서 후천적 색각이상인 청황색 색각이상도 발견되었다. 그러나 유기용제 누적노출량과 색 혼란지수와 유의한 연관성은 발견할 수 없었는데 이는 유기용제의 노출량이 너무 낮았으며, 근로자의 이직률 또한 놓아 누적노출량 계산을 위한 추적기간이 제한되었기 때문인 것으로 생각되며 앞으로 고농도 노출 근로자를 대상으로 연구를 하면 분명한 결과를 얻을 수 있을 것으로 기대된다. Objectives : This study was undertaken to investigate the relationship between color vision defects and occupational exposure to mixed organic solvents in women workers who were engaged in the shoe manufacturing industry. Methods : A total of 173 women workers were involved in this study, 85 of whom were exposed to mixed organic solvents and were defined as the exposed group, and 88 workers comprised the non-exposed control group. The patients were questioned as to their drinking history, the year in which they were exposed and whether they had eye symptoms of blureed vision, eye fatigue, and eye irritation. The exposed workers in the shoe manufacturing factory were engaged in 3 work areas which were pasting, trimming, and cleaning. Their Color vision was assessed using the Hahn's double 15 hue test under standard illumination and their current and cumulative exposure levels were measured. Results : The prevalence of color vision defect was 21.2% in the exposed group and 8.0% in the control group, and the blue-yellow defect was found to be 5.9% in the exposed group. The logistic regression for the acquired dyschromatopsia and color confusion index showed that there were no variables that had significant relationships. Eye symptoms were more frequently developed in the exposed group. Conclusions : There is a possibility of developing color vision defects when workers are exposed to mixed organic solvents. However, the results of the color confusion index showed that there was no significant relationship to the coumulative exposure level, because of the low exposure level and high occupational turn over rate of the workers. Because the workers in the present study were exposed to low level solvents it will be necessary to study workers exposed to higher levels of organic solvents.

연령대별 요추 추간판탈출증 환자의 요근과 척추주위근 단면적에 대한 분석

공덕현 ( Deok Hyun Kong ),배광호 ( Kwang Ho Bae ),고호연 ( Ho Yeon Go ),강명진 ( Myung Jin Kang ),김준수 ( Jun Su Kim ),양기영 ( Kee Young Yang ),이재훈 ( Jae Hoon Lee ),은영준 ( Young Jun Eun ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.4

Objectives :This study was designed to evaluate the correlation of the cross-sectional areas(CSA) of paraspinalis(iliocostalis lumborum, multifidus, longissimus thoracis parts lumborum) and psoas muscle and sex, age, change of the VAS(visual analogue scale) and past history of chronic low back pain in patients suffering from HIVD(herniation of intervertebral disc). Methods :Medical records of 140 subjects with HIVD were retrospectively reviewed. The MRI(magnetic resonance imaging) findings on the patients were scanned and analyzed by PiView program to find the paraspinal and psoas muscle CSA and were evaluated by the correlation of sex, age, change of the VAS, and past history of chronic low back pain. Results :There was significant difference between groups in male and female, young-adults age and middle age, middle age and old age, young-adults age and old age. But the correlation of the paraspinal and psoas muscle CSA and past history of chronic low back pain were partially significant. On the other hand, the correlation of the paraspinal and psoas muscle CSA and change of the VAS were not significant. Conclusions :These results suggest that the cross-sectional areas(CSA) of paraspinalis and psoas muscle have relevance to sex and age.

u-캠퍼스 구축 모델에 관한 연구

이양민,한희도,구영철,이재기 東亞大學校附設情報技術硏究所 2005 情報技術硏究所論文誌 Vol.12 No.2

Together with the development of information and telecommunication technologies, the information environment of campus also has been changed. Recently uniquitous computing technology is going to introduce into various areas. In this paper we proposed new construction models for u-campus which applies to ubiquitous computing technologies. Our proposed models are included in a network model and a service system model. The network model is classified into stage 1~3 according to supported network bandwidths and services. Also the service system model is consisted of 3 levels hierarchical structure according to their functions and characteristics.

유전자 알고리즘을 이용한 에이전트 멀티캐스팅 기법

이기준,강경아,정채영 조선대학교 통계연구소 2000 統計硏究所論文誌 Vol.2 No.1

하나의 작업지점에서 그룹의 다름 멤버들에게 다중으로 데이터 전송하기 위하여 point-to-point네트워크의 multicast tree를 이용하여 구현할 수 있다. 이러한 최소화 Steiner tree를 사용한 multicast 기법은 그룹에 대하여 하나의 Steiner tree를 이용할 수 있다는 장점을 지니고 있다. 따라서 최소화된 Steiner tree를 작성하는 것은 NP-Complete 문제와 효율적인 알고리즘을 작성하는데 필수적인 문제이다. 본 논문에서는 최소화된 Steiner tree를 찾는 에이전트와 유전자 알고리즘에 대하여 기술하고자 한다. 에이전트는 노드들 사이의 가중치를 검사하고 유전자 알고리즘에 이를 전송하다. 그리고 유전자 알고리즘 이 가중치와 최적화 Steiner tree 검색작업을 시도하여 Steiner tree를 작성한다. 본 논문에서는 전형적인 유전자알고리즘에 적용된 이진 스트링(DNA)의 특징을 가진 트리기반의 genetic encoding 방법을 기술하고 이에 대한 유용성을 보이고자 한다. Multicasting transfer data from one point to the members of groups. which can be supported by using multicast tree in point-to-point network. For multicast routing a minimal steiner tree is used, and has an advantage in that only one Steiner tree is needed for a group. However, finding a minimal Steiner tree is an NP-complete problems and it is necessary to develop efficient heuristic algorithms. In this paper, we present agents and genetic algortihms for a finding minimal Steiner tree. Agents check weights among nodes and transmit these to genetic algorithms. Then, genetics algorithms build Steiner trees with these weights and try to find a optimal Steiner tree. This paper describes a tree-based genetic encoding scheme which is in sharp contrast with binary string representations usually adopted in conventional genetic algorithms, and shows the efficiency of this scheme through experiments.

一酸化炭素의 除毒에 關한 硏究 : 1. Carboxyhemoglobin의 解離에 미치는 酸素解離促進藥物의 影響 I. Effects of Hemoglobin-0₂Affinity-Reducing Agents on the Dissociation of Carboxyhemoglobin

李民化,李起榮 全南大醫大 1978 전남의대학술지 Vol.15 No.1