표재성 방광암에서 Bacillus Calmette-Guerin 방광 내 주입요법 : 장기적 추적결과 Long-term Follow up Results

김용웅,왕세환,육승모,한동석,노안식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

To evaluated the results of long-term follow up of superficial bladder cancer patients who were treated with transurethral resection and intravesical BCG therapy. Between April 1989 and December 1997, 65 patients with superficial bladder cancer were treated with TUR-B(Transurethral resection of bladder tumor) and intravesical BCG instillation, and follow-up was performed for 5 years longer, and the mean follow-up duration was 82 months. Of 65 patients, pathologic stage were Ta in 17 cases and T1 in 48 cases and grade were G Ⅰ in 22 cases, G Ⅱ in 35 cases and G Ⅲ in 8 cases. The tumor recurred in 22(33.8%) at the median of 21.8 months and the tumor progressed in 9(13.8%) at the median of 20.8 months. Most of the recurrences and progression were within 3 year(838 and 77%). Progression is more likely in higher grade(G Ⅱ, G Ⅲ) and higher stage(T1). The complete response rate after first and second courses of BCG therapy were 53% and 73% and the 5 and 10 year disease specific survival rates were 89.5 and 78% respectively. The complete response rate after first and second courses of BCG therapywere 53% and 73%. Most of recurrences and progressions were within 3 years of the BCG therapy, but some cases occured after 5 years. Therefore, close long-term follow up is needed.

가토에 있어서 편측 요관 폐색시 환측, 반대측 요관에 대한 변화 : 조직학적 소견을 중심으로

설종구,김용웅,육승모,노안식,김홍식,김상현,이충식 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

This study was designed to clarify histological changes in the experimental rabbit ureter after unilateral prartial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, partial obstruction followed by 4 weeks, complete obstruction followed by 2 weeks, complete obstruction followed by 4 weeks. The normal control group consisted of 5 adult white rabbits. The H & E stain. light microscopy were used. Abnormal histological fingings were showed in ipsilateral ureter of all subgroups; dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis, interstitial inflammation. These findings were most severe in the complete-obstructed ureter for 4 weeks. There were no significant changes in contralateral ureter of all subgroups. Despite of progressive histological changes in ipsilateral ureter no abnormal findings were showed in contralateral ureter. We suggest that long term experimental investigation for histological changes in ipsilateral ureter and compensatory changes in contralateral ureter should be done.

가토에서 일측 요관 부분 및 완전폐색시 신장과 요관의 조직학적 변화

김상현,김용웅,육승모,한동석,노안식,임재성,김홍식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits. The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin. Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman's space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation). These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups. The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side. We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.

전립선 비대증 진단에 있어서 전립선 이행대 용적 지수의 유용성

임재성,노안식,김용웅,육승모 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Purpose : Prostate volume has been poorly correlated to various parameters used to assess benign prostatic hyperplasia (BPH), including symptom score, peak urine flow and detrusor pressure at peak urine flow. The purpose of this study was 2-fold: 1) to determine if transrectal ultrasound measurement of the transition zone of the prostate served as a better proxy for determining prostate size and correlated better with IPSS, peak urine flow and detrusor pressure and 2) if the parameter transition zone index (the ratio between transition zone volume and prostate volume) was useful in evaluating clinical prostatism. Materials and Methods: We prospectively evaluated 30 men with symptomatic BPH (mean age 65.4 years) according to symptom sore, peak urine flow, pressure/flow study, transrectal ultrasound volume of the entire prostate and the transition zone and calculation of the transition zone index. Results : There was a week correlation between prostate volume and symptom score, peak urine flow and detrusor pressure at peak urine flow: a stronger correlation between volume of transition zone and symptom score (r=0.679 p=0.03), and peak urine flow (r=-0.672 p=0.05) and a significant correlation (p=0.001) between transition zone index and symptom score (r=0.868), and peak urine flow(r=-0.870). Conclusion : Transition zone index is a parameter that correlates siginificantly with parameters of BPH and may serve as a useful proxy for evaluating worsening obstruction. Studies are underway to determine whether transtion zone index can be used prospectively to predict and correlate response with therapies designed to ablate prostatic tissue medically or surgically.

생산자 선호도를 반영한 누에 신품종 개발을 위한 계통 선발 및 FGI분석결과

김웅 ( Woong Kim ),임주락 ( Ju-rak Lim ),이상식 ( Sang-sik Lee ),안숙자 ( Suk-ja An ),김용식 ( Yong-sik Kim ),이미란 ( Mi-ran Lee ),박문식 ( Mun-sik Park ),손홍대 ( Hong-dae Son ),김영복 ( Young-bok Kim ) 한국식품유통학회 2021 한국식품유통학회 학술대회 Vol.- No.하계

에토좀 입자크기와 멤브레인 특성 조절을 통한 약물의 경피흡수능 향상

안은정 ( Eun Jung An ),심종원 ( Jongwon Shim ),최장원 ( Jang Won Choi ),김진웅 ( Jin-woong Kim ),박원석 ( Won Seok Park ),김한곤 ( Han-kon Kim ),박기동 ( Ki-dong Park ),한성식 ( Sung-sik Han ) 대한화장품학회 2010 대한화장품학회지 Vol.36 No.2

본 연구에서는 입자 크기 뿐만 아니라 베지클 멤브레인의 변형도를 조절할 수 있는 에토좀을 통해 약물의 경피흡수능을 향상시킬 수 있는 새로운 접근을 소개한다. 이를 위해 신규 육모효능성분인 Triaminodil을 포집한 에토좀을 제조하였고 입자 제조 후 추가적인 에너지를 가함으로써 입자의 크기를 조절하였다. 광산란법, 투과전자현미경, 멤브레인변형도 측정 등을 통해 입자의 변형도가 입자 크기에 의존하는 것을 확인하였다. 또한 in vitro 피부흡수시험과 전임상성장기 유도평가를 통해 베지클 멤브레인의 변형도가 Triaminodil의 피부 전달효능에 크게 영향을 미치는 것을 확인하였다. 이러한 결과로부터 담지 된 약물의 전달효능을 극대화 시킬 수 있는 최적 크기의 전달체 영역이 존재함을 확인하였고 이는 입자의 크기와 멤브레인 특성에 큰 영향을 받기 때문에 전달체를 설계하는데 있어 이 두 가지 요인을 고려해야 한다. This study introduces a flexible approach to enhance skin permeation by using ethosomes with deformable lipid membranes as well as controllable sizes. To demonstrate this, a set of ethosomes encapsulating an anti-hair loss ingredient, Triaminodil^TM, as a model drug, were fabricated with varying their size, which was achieved by solely applying the different level of mechanical energy, while maintaining their chemical composition. After characterization of the ethosomes with dynamic light scattering, transmission electron microscopy, and deformability measurements, it was found that their membrane deformability depended on the particle size. Moreover, studies on in vitro skin permeation and murine anagen induction allowed us to figure out that the membrane deformability of ethosomes essentially affects delivery efficiency of Triaminodil^TM through the skin. It was noticeable in our study that there existed an optimum particle size that can not only maximize the delivery of the drug through the skin, but also increase its actual dermatological activity. These findings offer a useful basis for understanding how ethosomes should be designed to improve delivery efficiency of encapsulated drugs therein in the aspects of changing their length scales and membrane properties.

IT 제품의 조립 공정 맞춤형 그리퍼 개념 설계에 관한 연구

김현국(Hyeon-Guk Kim),황순웅(Soon-Woong Hwang),안보영(Bo-Young An),허준형(Jun-Hyung Heo),최윤성(Youn-Sung Choi),신규식(Kyoo-Sik Shin),한창수(Chang-Soo Han) 한국산학기술학회 2018 한국산학기술학회논문지 Vol.19 No.2

본 논문은 제품 교체 주기가 비교적 짧고 정기적인 IT 제품의 조립 공정 맞춤형 그리퍼 개념 설계에 관한 내용을 담고 있다. 제조 현장에서 쓰이는 그리퍼는 대부분 1~2 자유도로 간단하게 구성되고 한 번에 다양한 물체가 아닌 정해진것만 다룬다. 또한 가격이 중요한 비중을 차지한다. 만약 공정에 적합한 그리퍼를 빠르고 쉽게 개발 할 수 있다면 제품 및 공정의 잦은 변경에 따른 자동화의 어려움을 일부 해소할 것으로 기대한다. 연구에 필요한 조립 공정은 제조사의 기밀인 관계로 공정 분석 진행 절차와 방법을 정의하고 기술하였다. 공리적 설계를 이용해 테블릿 PC 조립을 위한 그리퍼의 기능 요구와 설계 파라미터를 도출하였다. 이러한 파라미터를 결정함으로써 그리퍼의 개념 설계가 이루어질 수 있도록 설계 방법을 제안하였다. 타당성 검토를 위해 특정 공정을 선택하고 그리퍼 설계 진행 과정을 예제로 기술하였다. 그리퍼 설계 지침에 관한 연구가 있지만 고려 사항이 너무 일반적이고 아이디어 도출의 자유도가 높은 문제가 있다. 본 논문은 제품 및 자동화 시장이 활성화 된 IT 제품의 조립 공정을 바탕으로 그리퍼의 기능을 정의하였다. 이를 통해 물체를 잡는 것에 그치지 않고 조립 과정을 반영한 설계를 목표로 하였다. This paper describes the conceptual design of a customized gripper for the assembly process of IT products, which has a relatively short and regular product replacement cycle. The grippers that are used in the manufacturing field are mostly composed of one to two degrees of freedom and they can only handle one object, not multiple ones. Cost is also an important factor. If it were possible to develop a gripper suitable for the assembly process quickly and easily, some of the difficulties involved in its automation caused by the frequent changes of product and process could be solved. The assembly process utilized for this research is defined and described as the procedure and method of the process analysis due to the confidentiality of the manufacturer. We used an axiomatic design to derive the functional requirements and design parameters of the gripper used for the tablet PC assembly process. We proposed a design method for the conceptual design of the gripper by determining these parameters. For the feasibility study, a specific process was selected and the progress of the gripper design was described as an example. Although there have been studies on the design guidelines for grippers, their considerations are too general and their degree of freedom is too high. This paper defines the function of the gripper based on the assembly process of the IT products, which allows their production to be streamlined and automated. In this research, we attempted to produce a design that reflects the assembly process, not just one that enables objects to be held.

C 형 감염 바이러스 항체 양성자 75 명 역학조사

천석배(Seog Bae Cheon),박창현(Chang Hyun Park),박찬웅(Chan Woong Park),강상구(Sang Gu Kang),최요안(Yo An Choi),김건형(Geon Hyung Kim),심승식(Seung Sik Shim),김지운(Ji Woon Kim) 대한내과학회 1995 대한내과학회지 Vol.49 No.4

N/A Objectives: To determine the transmission route of hepatitis C virus in Korea, we studied 75, anti- HCV positive patients by epidemiologic questionnaire, retrospectively. Methods: 75patients were compared with 75healthy controls on the basis of the following factors : blood transfusion, acupuncture, admission, hepatitis patient within household(spouse andother's), extramarital intercourse, ear piercing, frequent alcohol drinking, frequent raw-fish ingestion, frequent shaving at barbershop, low socio-economic status, tattooing. Results: Compared with control group, the relative ratio(anti-HCV positive case/control case) of the history of blood transfusion was 2.4(p=0.275); acupuncture was 1A2 (p=0.383); admission was 1.83(p=0.001); spouse`s hepatitis was 13(p=0.003) (6.4% in male, 28.6% in female); hepatitis patient within household except spouse was 1.75(p=0.46) (17.0% in male, 35.7% in female); extramarital intercourse was 5.44 (p< 0.001); frequent alcohol drinking was 1.42 (p=0.515); frequent shaving at barbershop in male was 2.95(p=0.043); low status of the education or economic was 1.39 or 1.71, and tattooing were 5cases in only anti-HCV positive group, respectively. Conclusion: According to the results, hepatitis C virus infection was related to the histories of admission, spouses hepatitis, extramarital intercourse, frequent shaving at barber-shop, and tattooing, closely. Although the relationship was not siginficant, the histories of blood transfusion, acupunture, hepatitis patient within household except spouse, frequent alcohol drinking and low socioeconomic status in anti-HCV positive group were more than the control group. Therefore, it is necessary to make a close inspection of these suspicious potential risk factors. And also, every risk factor calls for the serologic examination, not by questionnaire, of the intrafamilial or contracked personal transmission, for the prospective study and for the strengthened test by RIHA or PCR.

흙막이 구조물 대체공법으로서 고품질 급속지반고결공법(CQC 공법) 적용사례

김웅구(Woong-Ku Kim),신현영(hyun-young Shin),김경민(Kyoung-Min Kim),안세웅(Se-Ung An),신용식(Yong-Sik, Shin) 한국콘크리트학회 2019 콘크리트학회지 Vol.31 No.2

상부 위장관 내시경의 전처치로서 Propofol의 효과

김대식,이승현,윤지호,이진웅,박찬웅,윤태용,김영용,이동채,최요안 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.5

Background/Aims: This research was conducted in order to study the clinical usefulness and stability of the propofol used for sedation during upper gastrointestinal endoscopy. Methods: The objective of this research was to study one hundred patients, who were chosen based upon their preference to be examined through diagnostic upper gastrointestinal endoscopy accompanied with propofol from July 1998 to August 1998, and who showed normality in the pulmonary function test and ECG. The elements observed were hemodynamic variations, injection dosage, injection time, recovery time and side effects. Results: All patatints had no recollection of the procedure during gastrointestinal endoscopy. It was found that the older the patients were, the less amount of propofol sleep was indued. Systolic blood pressure, diastolic blood pressure and the mean arterial blood pressure were lowered noticeably after sleep, compared with those before the injection of propofol, while the heart rate hardly changed. Conclusions: Profopol is believed to be a useful sedative for upper gastrointestinal endoscopy. As blood pressre can be lowered however, a cautious attitude should be considered when injecting propofol in the elderly or in patients who have cardiovascular disease.