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처음 발견된 고혈압 환자들의 관리의도와 실천에 영향을 미치는 요인
전소연,주성민,이석구 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2
This study will provide early effective intervention strategy through a predicting behavioral intention or behaviors of hypertension patients, and improve the compliance via early removal of barriers. Study subjects are new case of hypertension with above stage 2 by JNC-Ⅵ from first community survey including blood pressure measurement, sociodemographic questionnaires and physical examination in study region. Second survey was applied to the new case of hypertension(541 persons) for estimation of behavioral intention. Subject of this survey was 383 persons. Follow-up survey performed about 5 months later after regular telephone visiting by trained nurse previously. Final study subjects were 222 persons with above stage 2 hypertension by JNC-Ⅵ criteria. This results were as follows ; 1. State of hypertension management 18.9% of subjects managed with drug medication, 19.7% with exercise, 29.8% with quitting or reducing of smoking, 37.0% with quitting or reducing of alcohol. 2. Sociodemographic factors Drug medication was higher in old age, lower education level, and rural residents. Its difference is statistically significant. In gender difference, female was higher than male. In aspect of life style modification management, exercise rate was higher in male, high educational level, 5th and 4th decade age group, but it was not statistically significant. Reducing or quitting of smoking was higher in male, rural area residents, above high school educational level, but was not significant with the exception of habitation area. 3. Life style modification It was revealed statistically significant that male and rural area residents were higher in life style modification. In education level, contrary to the intention for life style modification, the lower education level is, the higher life style modification occurs. 4. Factors associated with intention The former or abstinence smoker and alcohol drinker revealed higher intention score than current in intention for life style modification. And the other variables were not statistically significant.
림프절외 NK/T세포 림프종에서 Epstein-Barr Virus에 대한 연구
조민선,우소연 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.2
목적 : NK/T 세포 림프종의 발생은 EBV와 연관되어 있으며, EBV 아형과 LMP-1유전자의 30염기쌍 결손 돌연변이가 EBV의 종양유발성과 관련 있다는 연구 결과가 있는 바, 본원에서 NK/T 세포 림프종으로 진단된 예를 대상으로 이에 대해 알아보고자 하였다. 대상과 방법 : 본원에서 진단된 NK/T세포 림프종 16예를 대상으로 EBER-1 in situ hybridization으로 EBV 양성율을 검사하고, PCR방법을 통해 EBV아형과 결손 돌연변이 유무를 관찰하였다. 결과 : 16예 모두 EBER-1 in situ hybridization에서 양성반응을 보였다. EBV는 모두 A 아형이었고 LMP-1의 30염기쌍 결손은 전체 16예 중 10예(62.5%)에서 있었고 나머지 6예는 wild type이었다. 결론 : 본원에서 진단된 NK/T세포 림프종 모든 예어서 EBV를 발견할 수 있었으며, EBV는 모두 A아형이었다. LMP-1 결손 돌연변이는 62.5%에서 관찰되었으며 예후와의 연관성은 보다 많은 예에 대한 연구를 통해 밝혀져야 할 것이다. Objectives: Epstein-Barr virus(EBV) is associated with development of various types of lymphoma, especially NK/T cell lymphoma. Recently, its subtypes and LMP-1, major oncoprotein of EBV, have been studied. We investigated the frequency of EBV, its subtypes, and LMP-1 status on the cases diagnosed at Ewha university hospital between 1993 and 2002. Material and Methods: Sixteen cases of NK/T cell lymphomas were studied. In situ hybridization for EBER-1 mRNA and PCR for EBV subtypes and 30 base pair deletion of LMP-1 were done. Results: All cases showed EBV positivity by EBER in situ hybridization. All cases contained Type A viruses and 10 cases(62.5%) revealed LMP-1 30bp deletion. Conclusion: EBV act as a causative role in the development of NK/T cell lymphoma. The exact role of LMP-1 30bp deletion variant in the lymphomatogenesis should be studied with larger number of cases.
차용준,박지영,장성민,김훈,김소정 창원대학교 생활과학연구소 1998 생활과학연구 Vol.- No.2
Volatile flavor components in salt-fermented anchovy sauce were analyzed by simultaneous steam distillation-solvent extraction/gas chromatography/mass spectormetry. Ninety-eight compounds were detected in sample. These compounds were composed mainly of aldehydes(13). ketones(6), alcohols(16), aromatic compounds(21), N-containing compounds(7), esters(5), S-containing compounds(5) and miscellaneous compounds(25). Among these, 3-(methythio)propanal, 2-ethyl-3.5-dimethylpyrazine, dimethyl disulfide and dimethyl trisulfide having high odor values were supposed to be playing to be a major role in the overall aroma of salt-fermented anchovy sauce.
상부요로계감염 환자에서 Gallium-67 Citrate 스캔 및 Tc-99m Dimercaptosuccinic Acid(DMSA)스캔의 임상적 의의
이강욱,강민규,장윤경,양종오,이상주,박기현,소영,신영태 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2
It is often not certain whether the focal defect of renal cortex of Tc-99m Dimercaptosuccinic acid(DMSA) renal scan in patients with acute pyelonephritis means the cortical scar by previous inflammation or recent active inflammatory lesion. Gallium-67 citrate(Ga-67) also has been known to be accumulated at the active inflammatory lesion. In order to evaluate the usefulness of the Ga67 and Tc-99m DMSA renal scan in patients with acute pyelonephritis, we reviewed the results of both study and clinical findings. Nintecn patients with typical clinical findings of acute pyelonephritis and admitted to our institute from Jan. 1998 to Nov. 1998 were included in this study. Tc-99m DMSA and Ga-67 scan were performed mean 3.3 and 7.3 days after admission. Eleven of 19 patients (57.9%) showed abnormally increased focal renal uptake on the Gallium-67 citrate scan and 14 of 19 patients(73.7%) had a cortical defect on the kidneys in Tc-99m DMSA scan. Seven(36.8%) patients had an abnormality in both study. Seven(36.8%) patients had an abnormality only in Tc-99m DMSA scan and 4 (21.1%) patients had an abnormality only in Ga-67 scan. Of 7 patients who had an abnormality on both scan, 5 patients had. an abnormality at same region in both scan and 2 patients had an abnormality at the different sites on the kidneys. With the above results, we speculate that Ga-67 scan and Tc-99m DMSA scan play a complementary role in the patients with upper urinary tract infection.
Min, So-Youn,Park, Kyung-Su,Cho, Mi-La,Kang, Jung-Won,Cho, Young-Gyu,Hwang, Sue-Yun,Park, Min-Jung,Yoon, Chong-Hyeon,Min, Jun-Ki,Lee, Sang-Heon,Park, Sung-Hwan,Kim, Ho-Youn Wiley Subscription Services, Inc., A Wiley Company 2006 Vol.54 No.3
<B>Objective</B><P>Although oral tolerance is a well-known phenomenon, the role of dendritic cells (DCs) is not well characterized. This study was conducted to better understand the differential role played by each Peyer's patch DC subset in the induction of oral tolerance to type II collagen (CII) in murine collagen-induced arthritis (CIA).</P><B>Methods</B><P>CII was fed 6 times to DBA/1 mice beginning 2 weeks before immunization, and the effect on arthritis was assessed. We compared the proportion of CD11c+,CD11b+ DCs and CD11c+,CD8α+ DCs in the Peyer's patches of CII-fed tolerized and phosphate buffered saline–fed nontolerized mice after the induction of CIA. The immunosuppressive properties of each DC subset were determined using fluorescence-activated cell sorter analysis for intracellular interleukin-10 (IL-10) and IL-12 and mixed lymphocyte culture. The ability of each DC subset to induce CD4+,CD25+ T regulatory cells was also examined. Mice were injected with CII-pulsed CD11c+,CD11b+ DCs isolated from Peyer's patches of tolerized mice, and the effect on CIA was examined.</P><B>Results</B><P>The severity of arthritis was significantly lower in tolerized mice. The proportion of CD11c+,CD11b+ DCs was increased in the Peyer's patches of tolerized mice and those DCs exhibited immunosuppressive characteristics, such as increased IL-10 production, inhibition of T cell proliferative responses to CII, and CD4+,CD25+ regulatory T cell induction. Furthermore, the CD11c+,CD11b+ DCs suppressed the severity of arthritis upon adoptive transfer.</P><B>Conclusion</B><P>Our observations demonstrate that CD11c+,CD11b+ DCs, which are abundant in Peyer's patches during the induction of oral tolerance to CII, are crucial for the suppression of CIA and could be exploited for immunotherapy of autoimmune diseases.</P>