심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

중·장년층의 스트레스 완화를 위한 뇌호흡 프로그램 적용 효과

심준영,오미경,안승찬,이승헌 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

This study assigns 21 subjects randomly who had no brain respiration training and regular exercise experience to 7 subjects with brain respiration training, 7 subjects with aerobic exercise experience and 7 subjects of control group in order to examine their physiological reactions of stress when brain respiration program was applied to the middle-aged class in their thirties and forties, and the experiment was conducted for one hour per session by three times a week for 8 weeks. After eight-week experiment, it measured ACTH, Cortisol, heart rate(HR), skin conductance level(SCL) and breath rate(BR) before and after stimulus when they were exposed to auditory noise and mental arithmetic stressor and analyzed results. ACTH and Cortisol showed little change or reduction in brain respiration group before and after stimulus, compared to the increase of ACTH and Cortisol in aerobic exercise group and control group, but there was significantly significant trend in HR, SCL and BR. In particular, in ACTH density, brain respiration group showed a significant change between group and period and it is found that application of brain respiration program is effective in reducing vigorous maintenance of homeostasis of temporary stimulus and reaction against stress.

비타민K 티오에테르유도체의 세포성장 억제 연구

심정훈,마미라,함승욱 중앙대학교 기초과학연구소 2000 基礎科學硏究所 論文集 Vol.14 No.-

The early reports have indicated that menadione (vitamin K3) exerts antitumor activity by inhibiting Cdkl activity and overexpressing th c-myc gene to induce an apoptotic cell death. It was alsofound that a thioether analog of vitamin K inhibited the activity of protein tyrosine phosphatases and induced protein tyrosine phosphorylarion in a human hepatoma cell line (Hep3B). Because of the potential arylating activity of thioether analog of vitamin K, it might inhibit Cdc25 phosphatases, which comtain a cystein in the catalytic site. To test this hypothesis we examine the inhibitory activity of this compound against several phosphatases and found that this compound was a potent inhibitor of Cdc25 phosphatases.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

류마티스 관절염환자의 건강상태와 자기효능, 강인성, 가족지지 및 통증과의 관련성

백광미,심승철,김종임 대한류마티스 건강전문학회 2000 근관절건강학회지 Vol.7 No.2

This study was conducted to find out the relationship among several variables such as health status, self-efficacy, health related hardiness, family support and pain in patients with rheumatoid arthritis. The subjects were 108 patients with rheumatoid arthritis who visited the out patient department of Rheumatism at E university hospital in Teajon. Data were collected by questionnaire from November 26, 1999 to January 14, 2000. The instrument used in this study were health status developed by Bae et at(1998), self-efficacy scale developed by KRHPS, health related hardiness modified by Suh(1988), family support scale developed by Kang(1984), Pain with graphic rating scale. Data were analyzed by descriptive statistics, one-way ANOVA, Pearson Correlation Coefficient, multiple regression using the SPSS Win Program. The results were as follows; 1.There were no statistically significant differences between general characteristics and variables such as health status, self-efficacy, health related hardiness and family support respectively. 2.Statistically significant differences were not found between clinical characteristic and variables such as health status, self-efficacy, health related hardiness and family support respectively. 3.Significant correlations were found between health status and self-efficacy, self- efficacy and hardiness, hardiness and family support, health status and pain, self-efficacy and pain respectively(P<0.01), and health status and hardiness, self-efficacy and family support, hardiness and pain respectively(P<0.05). 4.Self-efficacy and pain were significant affecting factors of a health status. In these results, it is suggested that nursing intervention to increase self-efficacy and to reduce pain was very important for patients with rheumatoid arthritis.

관동맥 우회로 이식술후 우회 혈관의 개존 여부 평가에 있어 전자선 단층 촬영을 이용한 3차원 혈관조영술의 유용성

하종원,조승연,심원흠,정남식,이향미,최규옥,장양수,유경종,강면식 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

Notes : Abstracts of Presentations - The Cultural Conditions for the Favorable Mycelial Growth and Artificial Fruiting Body Production of Paecilomyces sin - clairii Lloyd

(Seung Mi Shim),(Yun Hee Oh),(Jung Eun Na),(Ji Won Lee),(Tae Hyung Kim),(Hae Young Kim),(Seung Hwan Kim),(Kyung Rim Lee),(Min Woong Lee),(U Youn Lee),(Tae Soo Lee) 한국균학회 2002 Mycobiology Vol.30 No.2

노인복지서비스 이용에 미치는 영향요인에 관한 연구

심미승 ( Mi Seung Shim ) 한국행정학회 2011 韓國行政學報 Vol.45 No.4

기존의 선행연구에서는 주로 노인의 개인적 특성에 초점을 맞추어 노인복지서비스 이용에 영향을 미치는 요인들을 분석하여 왔다. 본 연구는 노인복지서비스 이용에 가족의 특성들이 어떤 영향을 미치는지를 실증분석을 통해 알아보고자 한다. 이를 위해 2008년 서울시 복지패널 데이터를 활용하였다. 분석 결과에 따르면, 노인의 개인적 상태 변수뿐만 아니라 가구주의 성별, 연령, 교육수준, 결혼여부, 직장여부, 가족구성원의 수, 가구소득, 자기집 소유 여부 등이 노인복지서비스 유형별로 유의미하게 영향을 미치는 것으로 나타났다. 이러한 결과는 노인복지 서비스 이용에 미치는 영향 요인으로서 노인 개인뿐만 아니라, 가족 구성원의 생계를 책임지고 가구를 대표하는 가구주의 특성 또한 중요하게 고려되어야 함을 시사한다. 또한 노인복지서비스의 정책 및 실질적인 내용구성에 있어서도 가족의 영향력이 고려되어야 함을 의미한다. This paper examines the factors affecting welfare service utilization for the elderly. Most previous studies have mainly focused on the individual-level characteristics of the elderly. However, this study extensively takes into account the characteristics of households and householders as well as those of elderly individuals. For empirical estimation, this study utilizes a binary probit regression model and uses the 2008 data from the Seoul Welfare Panel Study. According to empirical findings, the characteristics of households-including the number of household members, household income, and house ownership-and the characteristics of householders-including gender, age, education attainment level, marriage status, and job-significantly influence welfare service utilization for the elderly. These findings strongly suggest that future research needs to consider the characteristics of households and householders as well as those of elderly individuals in understanding the factors affecting use of elderly welfare services.

지역사회복지관점에서 로컬거버넌스 특성 분석

심미승(Mi-Seung Shim) 한국콘텐츠학회 2016 한국콘텐츠학회논문지 Vol.16 No.9

최근 지역사회가 직면한 문제를 해결하기 위하여 지역주민의 참여, 지역사회 이해관계자들의 네트워크, 그리고 이들의 파트너십에 주목하고 있다. 이는 지역사회문제 해결기제로서 로컬거버넌스의 특성을 활용한 것이다. 이에 본 연구는 광주 푸른길 사례를 중심으로 지역사회복지 관점에서 로컬거버넌스 특성 분석을 시도하였다. 지역사회 문제해결에 있어 지역주민의 참여는 스스로 문제해결에 참여하고 지역사회 구성원과 소통을 통해 더 나은 해결방안을 찾아나감으로써 주민역량을 강화시킨다. 무엇보다 지역주민 참여의 질을 높이기 위해서는 지방정부의 복지정책 입안사항 및 지역사회복지계획 수립과정에 적극적으로 참여하는 등 지방정부와 지역주민간의 네트워킹 및 연대의 방안을 모색해 나가야 한다. 광주 푸른길은 지역사회 구성원들이 삶의 질 향상을 위해서 공동의 연대감을 갖고 사회적 상호작용을 통해 지역사회 내의 문제를 함께 해결하면서 지역사회에서의 공공선에 대한 가치를 실현한 지역사회복지의 사례라고 할 수 있다. Community recently pays attention to participation, network, and partnership of local residents and community stakeholders for the purpose of solving community problems and issues. This is the typical characteristics of local governance as an institutional setting to solve the problems which communities face with. The aim of this study is to attempt an analysis of local governance from the perspective of community welfare. To do that, it especially focuses on Gwangju Greenway as a case. Participation of and communications among local residents strengthen their communitys capabilities to deal with problems and seek better solutions. Above all, networking and cooperation between local government and local residents are required to improve the quality of local residents participation at the process of planning and policy-making in the area of community welfare. Gwangju Greenway is a good example of community welfare in that local residents actively seek to solve their own problems and realize common good within their local community through the improvement of social interaction and solidarity among local residents, thus resulting in good quality of life.

기능성 화장품 소재로써 오이풀 뿌리(Sanguisorba officinalis L. roots)의 다양한 생리활성 및 항염증 효과

박승미(Seung-Mi Park),오민정(Min-Jeong Oh),염현지(Hyeon-Ji Yeom),심미옥(Mi-Ock Shim),이진영(Jin-Young Lee) 한국생명과학회 2023 생명과학회지 Vol.33 No.5

본 연구에서는 기능성 화장품 소재로써 오이풀 뿌리 추출물의 다양한 생리활성 및 항염증 활성을 연구하였다. 오이풀 뿌리 추출물의 항산화능을 알아보기 위해 전자공여능을 측정한 결과 농도가 증가함에 따라 활성이 증가하였으며 1,000 μg/ml의 농도에서 93.8%의 우수한 항산화능을 나타내었다. 또한, ABTS+ radical scavenging activity 측정을 통해 알아본 오이풀 뿌리 추출물의 항산화력은 50 μg/ml 이상의 농도에서부터 99% 이상을 나타내었다. 미백활성 검증을 위해 tyrosinase 저해활성 측정을 시행하였으며 최고 농도인 1,000 μg/ml에서 37.7%의 저해율을 나타내었다. 오이풀 뿌리 추출물의 주름개선 활성을 알아보기 위해 elastase 및 collagenase 저해활성을 측정한 결과 농도 의존적으로 저해율이 증가하였으며 각각 1,000 μg/ml의 농도에서 84.9%, 90.3%의 저해율을 나타내었다. MTT assay에 따른 Raw 264.7 cell의 생존율을 확인한 결과 100 μg/ml 농도 이하에서 80% 이상의 세포 생존율을 보여 이하의 세포 관련 실험에서는 100 μg/ml이하의 농도에서 세포 실험을 시행하였다. 오이풀 뿌리 추출물의 항염증 활성을 알아보기 위해 NO assay를 측정한 결과 500 μg/ml의 농도에서 50.8%의 저해율을 나타내었으며 오이풀 뿌리 추출물이 염증발현 억제에 뛰어난 효능이 있음을 확인할 수 있었다. Raw 264.7 cell에 오이풀 뿌리 추출물을 처리하여 단백질 발현저해를 확인한 결과 모든 인자에서 단백질 발현이 농도 의존적으로 저해됨을 확인할 수 있었다. 따라서 오이풀 뿌리가 항산화, 미백 및 주름개선의 생리활성과 항염 활성이 있는 기능성 화장품 소재로써 활용가능이 적합하다고 판단된다. In this study, the various physiological and anti-inflammatory activities of Sanguisorba officinalis L. roots (SR) were assessed for potential use as functional cosmetic materials. As a result of measuring electron-donating abilities to determine the antioxidant ability of SR extract, activity increased as the concentration increased, showing an excellent antioxidant capacity of 93.8% at a 1,000 μg/ml concentration. Further, the antioxidant power of SR extract, which was determined using an ABTS+ assay measurement, was more than 99% at concentrations of 50 μg/ml or more, while the tyrosinase inhibition rate was 37.7% at the highest concentration of 1,000 μg/ml. Consequently, the elastase and collagenase inhibition of SR extract measured 84.9% and 90.3%, respectively, at a 1,000-μg/ml concentration. As a result of confirming the survival rate of Raw 264.7 cells, the cell survival rate was determined to be 80% or more below a 100 μg/ml concentration, and subsequent cell-related experiments were conducted at concentrations below 100 μg/ml. Furthermore, after applying a NO assay to identify anti-inflammatory activity, it was confirmed that SR extract had an inhibitory rate of 50.8% at a concentration of 500 μg/ml, and it was excellent at suppressing the inflammatory expression. As a result of verifying protein expression by treating SR extract in Raw 264.7 cells, it was confirmed that expression was inhibited concentrated in all factors. Therefore, it is judged that SR can be used as a functional cosmetic material with antioxidant, whitening, and wrinkle-improving physiological effects and anti-inflammatory activities.