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( Seoung Wan Nam ),( Soo-kyung Cho ),( Dam Kim ),( Kyung-eun Lee ),( Dong-jin Park ),( Shin-seok Lee ),( Yoon-kyoung Sung ) 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.4
Objective. To identify the prevalence of antiphospholipid antibodies (aPL) in systemic lupus erythematosus (SLE) patients and determine the relationship between aPL and the clinical outcomes. Methods. SLE patients with aPL test results within 2 years of enrollment were selected from Korean lupus network study. They were classified into two groups: aPL (+) group, patients positive for at least one aPL, and aPL (-) group, patients without an aPL. The clinical characteristics of the two groups were compared and the role of aPL in the risk of chronic kidney disease (CKD) in SLE patients was examined. Results. Among the 469 SLE patients, 69 (14.7%) had at least one aPL. The prevalence of cerebrovascular disease and CKD was higher in the aPL (+) group than in the aPL (-) group (10.1% vs. 1.8% and 13.8% vs. 5.1%, p<0.05). Multivariable regression analysis showed that the aPL positivity (odds ratio=3.93, 95% confidence interval=1.48∼10.47) was associated with the risk of CKD after adjusting for age, disease duration, and lupus nephritis history. Conclusion. The prevalence of aPL in Korean SLE patients is 14.7%, and it is associated with a higher prevalence of cerebrovascular disease and CKD in SLE patients. The aPL positivity is independently associated with the risk of CKD in SLE patients. (J Rheum Dis 2018;25:239-247)
Yoon, Mi Young,Kim, Jin Hong,Choi, Doo Seoung,Shin, Ueon Sang,Lee, Jin Yong,Song, Choong Eui WILEY-VCH 2007 Advanced Synthesis & Catalysis Vol.349 No.10
<P>In the metal triflate-catalyzed hydroarylation of alkynes, employing an ionic liquid dramatically enhanced the catalytic activities, resulting in broadening the scope of substrates (arenes and alkynes). In some cases, even reactions that were not possible in conventional organic solvents proceeded smoothly in ionic liquids. Moreover, the ionic liquid phase containing catalyst could be readily recovered by simple decantation of the organic layer after reaction and reused for the following runs without any significant loss of activity. Mechanistic studies including <SUP>13</SUP>C NMR analysis of reaction intermediates and isotope experiments confirmed for the first time that this type of reaction proceeds via vinyl cationic intermediates.</P> <B>Graphic Abstract</B> <P> <img src='wiley_img/16154150-2007-349-10-ADSC200700039-content.gif' alt='wiley_img/16154150-2007-349-10-ADSC200700039-content'> </P>
윤종구,신제현,강문원,신완식,이상학,권혁상,유진홍,김양리,이현승,최영진 대한내과학회 1996 대한내과학회지 Vol.51 No.5
We experienced a rare case of amyloidosis associated with tuberculosis. A 34-year-old man in was admitted because of multiple lymphadenopathy, intermittent fever, and generalized weakness. He showed massive proteinuria, metabolic acidosis, low creatinine clearance and hematmesis. The cervical lymph node biopsy revealed chronic granuloma with multinucleated giant cell and caseous necrosis consistent with tuberculous lymphadenopathy, and also showed diffuse deposition of homogenous amorphous eosinophilic material. The percutaneous needle biopsy of kidney showed massive infiltration of pale pinkish amorphous material in the glomerular mesangium. Gastric mucosal biopsy revealed infiltration of amorphous material in the lamina propria. Polarizing illumination after Congored staining on all the three tissue biopsy showed typical green birefringence. A computerized tomographic (CT) scan of the abdomen showed hepatosplenomegaly and both renal vein thrombosis. He was managed with peritoneal dialysis, anti-TBc medication, steroids and other supportive measures. Despite aggressive treatment, his condition deteriorated day by day. He was discharged with hopeless condition. This case indicated that we should not exclude a possibility of the secondary amyloidosis in case of tuberculosis and massive proteinuria. To our knowledge, we think that this case is the first case of amyloidosis associated with tuberculosis in Korea.
Shin, Hyun Woo,Suk, Sangwoo,Chae, Seoung Wan,Yoon, Kun Chul,Kim, Junekyu Korean Society of Plastic and Reconstructive Surge 2021 Archives of Plastic Surgery Vol.48 No.4
Background Mastectomy leaves unsightly scarring, which can be distressing to patients. Laser therapy for scar prevention has been consistently emphasized in recent studies showing that several types of lasers, including fractional ablation lasers, are effective for reducing scar formation. Nonetheless, there are few studies evaluating the therapeutic efficacy of ablative CO<sub>2</sub> fractional lasers (ACFLs). Methods This study had a randomized, comparative, prospective, split-scar design with blinded evaluation of mastectomy scars. Fifteen patients with mastectomy scars were treated using an ACFL. Half of each scar was randomized to "A," while the other side was allocated to group "B." Laser treatment was conducted randomly. Scars were assessed using digital photographs of the scar and Vancouver scar scale (VSS) scores. Histological assessments were also done. Results The mean VSS scores were 2.20±1.28 for the treatment side and 2.96±1.40 for the control side. There was a significant difference in the VSS score between the treatment side and the control side (P=0.002). The mean visual analog scale (VAS) scores were 4.13±1.36 for the treatment side and 4.67±1.53 for the control side. There was a significant difference in VAS score between the treatment side and the control side (P=0.02). Conclusions This study demonstrated that early scar treatment using an ACFL significantly improved the clinical results of the treatment compared to the untreated scar, and this difference was associated with patient satisfaction.
배성훈(Seoung Hun Bae),임정선(Jung Sun Lim),신광민(Kwang Min Shin),윤진선(Jin Seon Yoon),강상규(Sang Kyu Kang),이솔희(Sol Hee Lee),김민관(Min Kwan Kim),이정우(Jung Woo Lee),김준현(Jun Hyun Kim),신민수(Min Soo Shin),한창희(Chang Hee H 한국산업경영시스템학회 2015 한국산업경영시스템학회지 Vol.38 No.1
It is difficult to make an accurate estimate of the economic value and effects on societal economy of Nano-technologies. This research measures an economic value of Nano-technologies quantitatively and analyzes its influences on societal economy. This paper chooses some major industries as analysis targets and adapts the DEFRA comparative methodology model which has been developed in the UK and recommended by OECD. For this reason, some industries which are in range of economic value assessment were investigated and related data were collected. Also, the economic value and societal influences of Nano-technologies were calculated, through the procedure of the model. In addition, this study conducts a questionnaire to experts for the validity of measurement results and procedures. This paper suggests a guideline for economic value and effects on societal economy of Nano-technologies assessments through quantitative Defra comparative methodologies.