Emedastine Difumarate(레미코트)의 통년성 알레르기 비염환자에 대한 임상 : 이중맹검 군간 비교시험

권삼현 中央醫學社 1997 中央醫學 Vol.62 No.11

Emedastine difumarate has anti allergic effect and stabilizing effect on mast cell in animal experiment. A double-blind placebo-controlled study was carried out in 52 patients with perennial allergic rhinitis to assess the effectiveness, safety and usefulness of emedastine difumarate. Emedastine difumarate(2 mg per single dose, twice a day) was given for two weeks. Patients were randomly allocated into two groups, one active ingredient(E group, 34 patients) and the other placebo(P group, 18 patients). Most symptoms and physical findings were more improved in the second week compared with the first week. The subjective symptomatic improvement was statistically significant(P<0.05) in sneezing and rhino rhea. With respect to the global safety rate, 93.4 % of the E group was assessed as <safe>, and there was no significant differences between E and P group. The clinical usefulness (excluding no change) was 88.3 % for the E group, significant differences being noted between the two groups(p<0.01) In conclusion, Emedastine difumarate is an effective drug for management of perennial allergic rhinitis.

柔道試合에서의 體級別 使用 技術 頻度에 關한 比較硏究

崔鍾三,金官鉉 龍仁大學校 1990 용인대학교 논문집 Vol.6 No.-

The frequency of technical application by weight class towards 370 athletes participated in the 1st Selection Match of the National Representatiues in 1989, Concurrenthy the 28th National Judo Championships by weght class, the frequency of technical application by weight class towards 265 athletes participated in the 1st Selection Match of the National Representation in 1990 and the National judo Champion for the 27th Presidential cup are studiet and avalyzed. The Hand Technique was mush used in the light weight, while the foot technique was mairly applied in the heawy weight auording to the presious srudy. As noted above this diferent from the previous research, both the Hand and Foot Technique were applied in the heavey and light weight in all the compplied in the heavey and light weight in all the competitions of 1989 and 1990. In the case of the application of the Foot Technique showed constauihy a high propation in all heavy weights, while in the heavy weight was much depended on GATAME in the defeat. 1) Extra Light Class Prior to the 1989s athletic match, it was applied in sequence of the Hand Technique (SEOI-NAGE), the Foot Technique (UCHI-MATA) and CATAME (KAMI-SHIHO-GATAME). As the result, it was turned out in the sequence of the Hand Technique, the Foot Technique, an GATAME (UDE-HISHIGI-JUJI-GATAME). 2) Half Light Class In the athletic match of 1989, the sequence was turned out to be the Foot Technique (KO-UCHI-GARI), the Hand Technique (SEOI-NAGE) and GATAME (HON-KESA-GATAME). According to the Athletic Comptition in 1990, the order was stood in sequence of the Foot Technique (O-SOTO-GARI), the Hand Technique (SEOI-NAGE) and GATAME (KAMI-SHIHO-GATAME). 3) Light Class While it showed an order of the Foot Technique (KO-UCHI-GARI), the Hand Technique (SEOI-NAGE) and GATAME in the Athletic mach in 1989. Also the Foot Technique, the Hand Technique and Nurugi were shown as its sequence in 1990. 4) Half Middle Class The sequence stood in order of the Foot Technique and the Hand Technique in terms of the Athlitic match of 1989 Also in the Athetic match was in sequence of the Foot Technique and the Hand Technique. 5) Middle Class The athletic competition has indicated its order as the Foot Technique the Hand Technique and NURUGI in 1989. Also in terms of its order the athletic meeting was the Foot Technique, the Hand Technique in 1990. 6) Half Heavy Class The sequence of the Foot Technique, the Hand Technique and the Waist Technique was applied the athletic competition in 1989. The athlitic completion in sequence was in order of the Foot Technique, the Hand Technique and the Waist Technique in 1990 7) Heavy Class It was used in the sequence of the Foot Technique, NURUGI(KOYT-NURUGI) and the Hand Technique (HOBOKTARI-KOLKI) in the athletic competition in 1990. Meanwhile, the sequence of on application in the 1990. athletic competition was in order of the Foot Technique (HOBOKTARI-KOLKI), the Hand Technique (BIT-DANGKY-O-CHIKI) and NURUGI (KYOT-NURUGI). Recommendations for Further Research There are several directions in which future research in this area could be pursued. Several proposals are conduction for on improvement of our internal Judo. 1) The contest in most cosets was determened either by the hand or the Foot Technique both in 1989 and 1990. Therefore, a variety of techniques are necessarily required to learn other than these techniques in the future. In addition, KUD-CHIKI will be able to exercise a great influence for ocitory. Further, the technique of KUD -CHIKI has to he more often applied. 2) Such technique as may be applied by other athletes shall be researched and improved, also individual player has to do its best in the development of the Korean Style Judo Technique is quite similor to KAWI -CHIKI. 3) A numver of investigators recommended in the foreyuing study, but the Judo player will be able to play more intensive style talon aim at the gaining of points. 4) It is even more desirous that the Judo players of may country have to concentrate extorts in the physical training in order to cope with the changing situation of the international Judo from the technical Judo to the Judo of strength. 5) Currently, the Juo Uniform had a narrow to take hold of during the contests, but the international Judo Federation has taken necessary measures to broaden the uniform's width in order to the athletes, therefore it is helieved argenthy necessary that Judo players are able to egage in the whole hearted devotion to an assault hased on the technique than to a struggle to take hold of its oppaonent.

일부 자동차 공장 근로자들의 職業的 特性과 社會 心理的 Stress의 相關性 硏究

김성삼,홍지우,한현정,최희석,권소희,정해경,김삼태,송용선,이기남 한국전통의학연구소 2004 한국전통의학지 Vol.14 No.1

〈Objective〉 This study were carried out to study to assess the relationship between job characteristics, general characteristics, health behaviors, and psychosocial distress and suggested the preventive oriental medicine approaches in occupational health area. 〈Methods〉 We measured job characteristics(job demand, job control, jop insecurity) by The Karasek's Job Content Questionnaire, health behaviors(smoking, drinking, exercise, coffee), general characteristics at work by a self-administered questionnaire. Psycho social distress was measured by PWI(Psychosocial Well-being Index), a 18-item self- administered instrument. 370 data for research were collected through the process of oriental health examination with questionnaire in workplace. Statistical analysis was done by t test, oneway ANOVA, and hierarchical multiple regression analysis with SPSSWIN (version 10.0) 〈Results〉 Among the 152 respondents, the prevalence of high job strain was 27%(41 persons). The Odds ratio of high job strain was 3.11(95 2.12~4.11), and those of passive group and active group were 2.01(95 0.83~2.76) and 1.80(95 0.83~2.76), respectively. Our results supported the association between psychosocial distress and job strain. 〈Conclusion〉 The odds ratio of high strain isolated group(high strain group+low social support) was 3.59(95 2.05 5.13), but the odds ratio of high strain collective group was 1.32(95 0.23 2.41). Social support at work was modifing factor of the association between psycho social distress and job strain. Therefore we reviewed the evidence that economic depression was associated with psycho social distress in this study, and that the strength of the social support was important in maintain health.

濟州産 柑橘醱酵酒 蒸溜酒의 熟成條件

高正三,吳現道,高男權,姜順善 濟州大學校 亞熱帶農業硏究所 1992 亞熱帶農業硏究 Vol.9 No.-

제주산 온주밀감을 이용하여 醱酵最適條件에서 얻어진 감귤주의 單式蒸溜하여 알콜농도를 43˚와 60˚로 조절한 다음 불란서산 참나무 술통재의 切片(1×1×3cm)을 浸漬 하여 熟成條件을 검토하였다. 알콜농도 60˚인 증류수중의 메탄올은 0.136g/100㎖, 알데히드는 4.07㎎/100㎖휴젤油는18.35㎎/100㎖, 에스테르는 27.03㎎/100㎖였다. 알콜농도가 높고 온도가 높을수록 참나무성분의 浸出이 잘 일어났으며, 단기간 熟成을 위해서는 다소 고온에서 熟成하는 것이 좋을 것으로 판단되었다. 숙성 pH는 4.1에서 색소침출효과가 좋았으며 자외선 처리효과는 없었다. 色素浸出은 온도에 많은 영향을 받고 있는 것을 알 수 있었으며, 官能檢査 결과 45˚, pH 4.1에서 6개월 熟成時에 외관 및 기호도에서 충분한 상품가치를 나타내었다. 감귤 브랜디의 경우 외국산 유명제품과 큰 차이를 보이지 않아 브랜딩기술의 확립과 熟成技術의 보완한다면 産業化에 대한 충분한 가능성이 있는 것으로 平價되었다. In order to produce citrus brandy made from Citrus unshiu produced in Cheju, aging conditions of citrus fine spirit with dipping oak chip were investigated. Citrus fine spirit prepared with simple distillation of citrus wine was adjusted to 43。 and 60。 alcohol concentration, and then three pieces of oak chip (1×1×3cm) was added to 300㎖ citrus fine spirit. The contents of methanol, aldehyde, fusel oil and ester were 0.136g/100㎖, 4.07mg/100㎖, 18.35mg/㎖ and 27.03mg/100㎖ respectively. The absorbance at 500nm of citrus fine spirit was increased with high alcohol concentration and high temperature. Color extraction from oak chip was mainly affected on temperature, and the effect of UV irradiation was not appeared. Compared with commercial Scotch whisky, citrus brandy adjusted to pH 4.1 and aged at 45℃ for 6 month was good in sensory evaluation.

사골동에서 발생한 양성골모세포종에 병발한 동맥류성 골낭종 1례

권삼현,박종권,문우성,권삼현,문우성 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.4

The Effects of Alcohol on Nasal Patency and Mucociliary Clearance

Kwon, Sam-Hyun,Seo, Su-Young Korean Rhinologic Society 1999 Journal of rhinology Vol.6 No.2

The Effect of CSR Activities of the Citizens Professional Football Club on Regional Attachment and Expansion of Fans: Focused on Seongnam Football Club, Korea

Sam Kwon JUNG,Ki Hyun KWON,Hyuk Jin LEE 한국스포츠과학회 2021 스포츠과학연구(JSAS) Vol.5 No.4

Purpose: This study aims to empirically analyze fans responses to the types of Corporate Social Responsibility (CSR) activities implemented by the citizens professional football club and seek strategic measures for the continuous growth of the club and the formation of long-term relationships with fans. The purpose of this study is to investigate the relationship between regional attachment and expansion of fans according to the type of CSR activities of the club, and to examine influencing relationships among the types of CSR activities, regional attachment, and expansion of fans. Research design, data, and methodology: To achieve the purpose of the study, the survey was conducted on 150 home spectators of Seongnam Football Club, and the analysis of the data was conducted using SPSS Window Version 21.0. Correlation analysis, simple regression analysis, and multiple regression analysis were conducted to analyze the relationship between regional attachment and expansion of fans according to the types of CSR activities performed by the Seongnam Citizens Football Club. Results: As a result of the analysis, it was found that CSR activities had a statistically significant effect on regional attachment. In addition, CSR activities were found to have a statistically significant effect on expansion of fans. Finally, it was found that regional attachment had a statistically significant effect on the expansion of fans. Conclusions: Based on these results, CSR activities of the professional football club are considered an opportunity to build regional attachment. In addition, it is thought that the expansion of fans can be achieved through CSR activities.

사람태아 기관상피에서 섬모발생에 관한 연구

권삼현(Sam Hyun Kwon),이송은(Song Eun Lee),남광일(Kwang Il Nam),안규윤(Kyu Youn Ahn),배춘상(Choon Sang Bae),박성식(Sung Sik Park) 대한해부학회 2002 Anatomy & Cell Biology Vol.35 No.4

임신 중기 태아 기관상피의 섬모세포에서 섬모의 발생과정과 축미세관의 형성을 시작하는 바닥소체의 미세구조를 전 자현미경으로 관찰하고, 또한 연속절편으로 얻은 사진에서 바닥소체의 부속구조물을 관찰하였다. 섬모발생세포는 세포질 농도가 성숙섬모세포나 점액세포에 비해 낮았고 무과립세포질세망, 유리리보소체, 미세사 등이 풍부하였으며 섬유성과립, 이차소체, 풋중심소체, 중심소체, 바닥소체와 같은 섬모 발생과 관련된 구조물들을 함유하고 있었다. 간혹 세포꼭대기에 한쌍의 중심소체 또는 하나의 중심소체를 중심으로 한쌍의 풋중심소체가 형성되고 있는 세포가 출현하였다. 바닥소체는 세포막에 근접한 내강측 세포질에 출현하였으며 간혹 바닥발, 바닥뿌리가 관찰되었다. 횡단절편에서 바닥소 체에는 원위부와 섬모 축미세관과의 이행부에 날개판이 출현하였고, 원위부 가까이에 바닥발이, 근위부 끝에 바닥뿌리가 출현하였다. 날개판은 각 주위미세관세짝 또는 두짝에서 기시한 풍차 바퀴모양의 기다란 섬유성물질로 시계방향으로 굽어 있었다. 바닥발은 가로무늬를 갖는 섬유성물질이 농과립으로 된 바닥발 뚜껑으로 모아들었다. 바닥소체의 연속 횡단절편의 삼차원적 재구축에서 날개판은 바닥소체 원위부와 축미세관의 이행부에서 관찰되었으며 판의 배열은 내강측에서 관찰했을 때 시계방향으로 굽어 있음을 확인하였다. 바닥발은 바닥소체의 원위부에서 출현하였 으며 바닥부위가 바닥소체 옆벽에 부착된 원뿔 형태를 취하고 있었다. 면역조직화학 반응 실험에서 α-tubulin은 기관상피의 바닥세포와 표층세포에서 모두 양성 반응을 보였으나 γ-tubulin은 표층 섬모세포의 세포꼭대기 쪽에서 강한 양성 반응을 나타내었다. 이상의 관찰로 임신중기 사람태아 섬모발생은 주로 비중심소체기원에 의함을 확인하였고, 이 시기의 기관상피 섬모는 발생과 운동이 매우 활성적임을 시사하였다. Ciliogenesis was investigated in the tracheal epithelium of human fetus at mid trimester of gestation (15~22 weeks), and the substructure of basal body was studied with serial, cross sections. The ciliogenic cells were long columnar cells with an electron-lucent cytoplasm, and contained rich free ribosomes and smooth endoplasmic reticulum. Apical cytoplasm of these cells contained various structures related to ciliogenesis including fibrous granules, procentrioles, centrioles and basal bodies. Basal bodies were located near apical plasma membrane and had basal foot and striated rootlets. In cross section, alar sheets appeared at transitional area between distal portion of basal body and axoneme, and basal foot at distal portion of basal body. Alar sheets arouse from each peripheral triplets of basal body and projected radially clockwise in apex to base view. Basal foot was a cone shaped structure with cross striation which base attached to two or three of the peripheral triplet sets and apex converged to basal foot cap. Three dimentional reconstruction by serial cross section of the basal body showed a structural relationship of alar sheets and basal feet with basal body. By immunohistochemistry, α-tubulin label was seen in both basal and surface ciliated cells, and γ-tubulin label was seen in the apical region of surface cilated cells. These results indicate that ciliogenesis of tracheal epithelium of human fetus is performed mainly by acentriolar ciliogenesis, and suggest the ciliogenesis and ciliary movement at mid trimester of gestation are active.

반응표면분석에 의한 생강의 분자압축탈수 방법 최적화

이현석(Hyun-Seok Lee),권기현(Ki-Hyun Kwon),김병삼(Byeong-Sam Kim),김종훈(Jong-Hoon Kim),차환수(Hwan-Soo Cha),정강현(Kang-Hyun Chung) 한국식품과학회 2010 한국식품과학회지 Vol.42 No.4

분자압축탈수 방법을 이용하여 기존의 다른 건조방법보다 우수한 탈수 및 건조된 생강을 얻고자 생강을 이용한 분자압축탈수법에 탈수제(maltodextrin) 첨가량, 탈수시간, 절단 두께를 다르게 한 후 반응표면분석법으로 최적화하여 생강의 탈수 및 건조 최적조건을 얻고자 하였다. 분자압축탈수 방법을 이용한 생강의 탈수제 첨가량을 증가시킬수록 탈수율, 복원율, 관능적 특성의 외관(external), 향기(flavor), 조직감(texture) 및 전체적인 기호도(overall acceptability) 등은 증가하였으나 색(color)의 경우 낮아졌다. 또한 탈수시간, 절단 표면을 증가시킬수록 탈수율, 복원율, 관능적 특성이 증가하는 경향을 나타내었다. 분자압축탈수를 이용한 생강의 최적조건 범위는 탈수제 첨가량이 70-82%, 탈수시간이 5.2-9.2시간 이고 절단 두께가 1.0-1.2 mm로 설정되었다. 따라서 분자압축탈수 방법을 이용한 생강의 최적 탈수 및 건조조건은 탈수제 첨가량이 76%, 탈수시간 7.2시간, 절단 두께 1.1 ㎜가 적당한 것으로 나타났다. The purpose of this study was to determine the optimal mixing ratios for three different concentrations of maltodextrin, dehydration time, and cutting thickness to prepare gingers using molecular press dehydration (MPD) through response surface methodology (RSM) based on the dehydration rate, rehydration rate, and a sensory evaluation. As maltodextrin concentration increased, dehydration rate, rehydration rate, external, flavor, texture, overall acceptability of the gingers tended to be high, and the color tended to be low. As the dehydration time and cutting thickness increased, dehydration rate, rehydration rate and the sensory evaluation of the gingers tended to be high. The maltodextrin concentrations were 70-82%, dehydration time was 5.2-9.2 hr, and cutting thickness levels were 1.0-1.2 ㎜. The optimal mixing ratios, maltodextrin concentration, dehydration time, and cutting thickness for manufacturing the best quality of gingers using molecular press dehydration were 76%, 7.2 hr, and 1.1 ㎜, respectively.

Biochemical and clinical correlation of intraplaque neovascularization using contrast-enhanced ultrasound of the carotid artery

Kim, Hyun Soo,Woo, Jong Shin,Kim, Bu Yong,Jang, Hyun Hee,Hwang, Seung Joon,Kwon, Sung Jin,Choi, Eun Young,Kim, Jin Bae,Cheng, Xianwu,Jin, Enze,Kim, Woo Shik,Kim, Kwon Sam,Kim, Weon Elsevier 2014 Atherosclerosis Vol.233 No.2

<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Several biomarkers reflecting inflammatory or proteolytic activity have been known to represent plaque vulnerability. Moreover, a recent study confirmed that contrast-enhanced ultrasound (CEUS) can visualize intraplaque neovascularization (IPN) and demonstrate plaque vulnerability. In this study, we tried to demonstrate that IPN detected by CEUS was correlated with several well-known biomarkers and clinical outcome in patients with coronary artery disease (CAD).</P> <P><B>Methods</B></P> <P>Patients with stable CAD were screened by conventional carotid ultrasound and patients with carotid plaque thickness more than 2 mm were performed by CEUS for the presence of IPN. Plasma levels of biomarkers and clinical outcomes were evaluated.</P> <P><B>Results</B></P> <P>Among consecutive 89 patients fulfilled the inclusion criteria, 30 patients without IPN (group 1) and 59 patients with IPN (group 2) were analyzed. There were no significant difference in baseline characteristics except for mean age (62.9 ± 10.1 yrs versus 68.4 ± 9.6 yrs, <I>p</I> = 0.015). On multivariate analysis, only MMP-9 (<I>p</I> = 0.021, 95% CI 1.002–1.027) showed a significant association with IPN. But patients with IPN showed only trend for a history of cardiovascular disease (CVD) (44% versus 30%, <I>p</I> = 0.19) and one-year cardiovascular events (CVE) (6.8% versus 3.3%, <I>p</I> = 0.50) compared to group 1. Maximum plaque thickness (<I>p</I> = 0.04, 95% CI 1.230–6.322) showed a significant correlation with the clinical outcome including CVD or CVE.</P> <P><B>Conclusion</B></P> <P>MMP-9 correlated with IPN on CEUS. For clinical implication, however, large prospective studies are needed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We examine intraplaque neovascularization using contrast enhanced ultrasound. </LI> <LI> We model correlation between intraplaque neovascularization with biomarkers. </LI> <LI> The factors to affect clinical outcomes would be examined including intraplaque neovascularization. </LI> <LI> Only MMP-9 showed a significant association with intraplaque neovascularization. </LI> <LI> Maximum plaque thickness showed a significant correlation with the clinical outcome. </LI> </UL> </P>