풍력발전기 축소 구조 모델의 진동특성 연구

박무열,은성용,김석현 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B

A reduced structure model of a wind turbine generator is designed and manufactured. Mode data are obtained by modal testing and analytical method. Vibration response is measured and investigated under various speed condition by using a waterfall plot. Possibility of severe resonance is observed and the mechanism is explained by using the mode data. Simplified theoretical model gives the 1st resonance frequency of wind turbine structure model. The theoretical model can be applied in the design stage of the wind turbine structure to avoid the severe resonance problem.

병원과 그 외부환경에서 분리된 포도상구균의 항균제 감수성과 카드뮴 저항성비교

김은숙,문상은,김강주,유용욱,정수진,김신무,문영희 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

It has been reported that Stratococcus aures(S. aureus) causes outbreaks of infection. To investigate the nosocomial infection, one hundred strains of S. aureus were isolated from the nasal cavity of the personnel and the environment in the dental clinic at Chonbuk province in Korea, the nasal cavity of personnel in healthy students, and the disease site from the patients at the Wonkwang medical center and Jesus presbyterian medical center. S. aureus was identified by Gram stain, catalase test, mannitol fermentation test and coagulase test. After isolation, the strains were characterized by antibiotic resistance. The antibiotic susceptibility tests were performed according to the National Committee of Clinical Laboratory Standards. Cadmium-resistance testing was assayed by broth dilution using Mueller-Hinton containing 125 μM of cadmium. Plasmid DNA was isolated by boiling method. All isolate of S. aureus in this study showed the resistance to ampicillin and penicillin, and the susceptibility to vancomycin. The resistance ratio of cadmium in the disease site was higher than that of the healthy site. These results suggest that S. aureus in the hospital might show the resistance to ampicillin and penicillin, and vancomycin be a drug of choice in the nosocomial infection.

조혈모세포이식 후 골성장인자의 변화 및 골대사에 미치는 영향 : Impact on Bone Mineral Metabolism

백기현,오은숙,오기원,이원영,김혜수,권순용,한제호,강무일,차봉연,이광우,손호영,강성구,김춘추 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 각종 장기이식의 시행이 많아지고 이식 후 생존율이 증가함에 따라 이식 후 합병증에 대한 관심 또한 높아지고 있다. 조혈모세포이식 후에도 다양한 내분비적 합병증이 발생할 수 있으며 골격에 대한 합병증도 문제점으로 대두되고 있다. 조혈모세포 이식 후 발생하는 골소실에는 이식 후 초기의 골형성 저하와 골흡수 증가가 중요한 역할을 담당하리라고 추측되는데 이러한 골재형성불일치(biochemical uncoupling)에 골 성장인자들이 미치는 영향에 대해서는 알려진 바가 없다. 본 연구에서는 조혈모세포이식 전, 후로 말초 혈액에서 IGF-I, FGF-2, M-CSF같은 성장인자의 변화를 알아보고, 이들 성장인자의 변화가 조혈모세포이식 후의 골형과 골흡수에 미치는 영향 및 이식 후 발생되는 골량 소실과의 연관성을 확인해 보고자 하였다. 방법: 여러 가지 혈액질환으로 인해 동종 골수이식을 시행 받은 환자들을 전향적으로 관찰하였으며 이식 전 및 이식 후 1주, 2주, 3주, 4주 및 3개월, 6개월 1년에 말초 혈액에서 골교체표지자를 측정하였다. 이식 전 및 이식1년 후에 요추골 및 대퇴골 골밀도를 측정할 수 있었던 36명의 환자들을 대상으로 냉동 보관되어 있던 혈청을 이용하여 IGF-I, FGF-2 및 M-CSF를 시기별로 측정하였으며 이들 성장인자와 골교체표지자의 변화 및 골밀도 변화 사이의 상관관계를 확인하였다. 결과: 골흡수 표지자인 혈청 ICTP는 이식 전에 비해 이식 후 4주까지 점차 의의 있게 증가하다가 이후 6개월까지 더욱 증가한 후 감소하였다. 골형성 표지자인 osteocalcin은 이식 후 3주까지는 점차 감소하다가 이후 증가하여 이식 후 3개월 및 6개월에 기저치보다 통계적으로 유의하게 증가한 후 감소하였다. 혈청 IGF-I과 FGF-2는 각각 이식 후 3주 및 1주까지 의미있게 감소하다가 이후 증가하였으며 혈청 M-CSF는 이식 후 1주째에 기저치에 비해 의미 있게 증가하였다가 이후 기저치로 회복되었다. 이식 1년 후 평균 요추부 골밀도는 5.2% 감소하였고 평균 근위대퇴골 골밀도는 11.6% 감소하였다. 이식 전 및 이식 후 3주에 측정한 IGF-I과 같은 시기에 측정한 오스테오칼신 사이에 유의한 상관관계가 관찰되었으며 이식 후 3주째의 M-CSF와 골흡수표지자인 M-CSF 사이에서 의미 있는 양의 상관관계를 관찰할 수 있었다. 이식 후 3주 및 3개월에 IGF-I이 낮은 환자일수록 이식 1년 후 근위대퇴골에서의 골소실이 많은 것으로 분석되었다. 결론: 조혈모세포이식 후 발생하는 골소실에는 기존에 알려진 기저질환의 영향, 성호르몬의 감소, 면역억제의 투여, 골수기질세포와 조골세포의 손상 및 이식초기 사이토카인의 변화이외에도 골성장인자가 관련이 있음을 확인하였고, 이는 이식 후 발생되는 골량소실에 중요한 역할을 할 것이라고 사료된다. Background: A loss of bone mass is usually detected after a bone marrow transplantation (BMT), especially during the early post-transplant period. We recently reported that enhanced bone resorption following a BMT was related to both the steroid dose and the increase in IL-6. We also suggested damage to the marrow stromal microenvironment, by myoablation, partly explains the impaired bone formation following a BMT. It is well known that some growth factor play important role in bone growth and osteogenesis. However, the pathogenetic role of bone growth factors in post-BMT bone loss is unknown and data on the changes in the growth factors, in accordance with bone turnover markers and bone mineral density (BMD) changes are scarce. We investigated changes in bone growth factors such as IGF-I (Insulin-like growth factor-I), fibroblast growth factor-2 (FGF-2) and Macrophage colony stimulating factor (M-CSF), during the post-BMT period, and assessed whether the growth factor changes influenced the bone turnover and post-BMT bone loss. The present study is the first prospective study to describe the changes in bone growth factors following a BMT. Methods: We prospectively investigated 110 patients undergoing a BMT, and analyzed 36 patients (32.4±1.3 years, 17 men and 19 women) whose BMDs were measured before, and 1 year after, the BMT. The serum biochemical markers of bone turnover were measured before, 1, 2, 3 and 4 weeks, 3 and 6 months, and 1 year, after the BMT. The serum, FGF-2, IGF-I and M-CSF levels were measured before and 1 and 3 weeks, and 3 months after the BMT. The correlation between the changes of growth factors and various bone parameters was analyzed. Results: The mean bone losses in the lumbar spine and total proximal femur, calculated as the percentage change from the baseline to the level at 1 year, were 5.2(p<0.05) and 11.6%(p<0.01), respectively. the serum type I carboxyterminal telopeptide(ICTP), a bone resorption marker, increased progressively until 6 months after the BMT, but thereafter decreased, to the base value after 1 year. Serum osteocalcin, a bone formation marker, decreased progressively, until 3 weeks after the BMT but then increased transiently, and finally returned to the base level at 1 year. The serum IGF-I and FGF-2 also decreased progressively until 3 weeks 1 week after the BMT, respectively, then increased to the base values at 3 months. The serum M-CSF increased briskly at 1 week post-BMT, then decreased to the base level. There were positive correlations between the percentage changes from the baseline proximal femur BMD and the IGF-I levels 3 weeks and 3 months (r=0.52, p<0.01, r=0.41, p<0.05) post BMT. A significant correlation was found between the IGF-I and osteocalcin levels pre-BMT, and 3 weeks after the BMT. Another positive correlation was found between the M-CSF and the ICTP levels at 3 weeks post BMT (r=0.54, p<0.05). Conclusion: In conclusion, there were significant changes in the serum IGF-I, FGF-2 and M-CSF levels in the immediate post-BMT period, which were related to a decrease in bone formation and loss in the proximal femoral BMD during the year following the BMT (J Kor Soc Endocrinol 17:664∼674, 2002).

노인정신장애 평가척도(Psychogeriatric Assessment Scale)의 한국판 표준화 연구

조맹제,박임순,신영민,김무진,정희연,정은기,최용성,조성진,서국희,함봉진 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

연구목적 : 본 연구는 치매와 우울증을 다차원적으로 평가할 수 있는 도구인 Psychogeriatric Assessment Scale(PAS)의 한국판(PAS-K)을 개발하기 위한 것이다. 방 법 : 번역, 역번역, 그리고 세차례의 예비조사를 통하여 PAS-K를 제작하였다. 60세 이상의 노인 291명(임상환자군 : 58명, 지역사회노인군 : 168명, 수용시설 거주자 : 67명)과 그들의 정보제공자들을 대상으로 PAS-K, Geriatric Depression Scale(GDS), Korean version of Mini-Mental State Examination(MMSE-K), Hamilton Rating Scale for Depression(HRSD), 그리고 Hachinski Ischemic Score 를 적용하고, Diagnostic Interview chedule(DIS-Ⅲ-R)을 사용하여 치매와 우울증을 진단하였다. PAS-K의 신뢰도와 타당도를 평가하고, 예민도와 특이도, Kappa값, 그리고 ROC커브 분석법을 이용하여 PAS-K의 6개의 소척도들(피검자면접 : 인지기능 장애척도, 우울척도, 뇌졸중척도, 정보제공자면접 : 인지기능 저하척도, 행동변화척도, 뇌졸중척도)의 최적 절단점을 구하였다. 결 과 : PAS-K는 높은 내적 일관성을 보였고, 검사자간 신뢰도도 만족할 만한 수준이었다. PAS-K의 소척도들을 다른 표준화된 검사도구들과 비교하였을 때 인지기능 장애척도와 인지기능 저하척도는 MMSE-K와, 우울척도는 GDS 및 HRSD와 유의한 상관관계를 보였으며, 뇌졸중척도는 Hachinski Ischemic Score와 통계적으로 의미있는 상관관계를 보였다. 최적절단점은 인지기능 장애척도 10점, 인지기능 저하척도 3점, 우울척도 5점, 피검자면접과 정보제공자 뇌졸중척도 모두 1점, 그리고 행동변화척도 2점으로 추정하였다. 결 론 : 본 연구를 통해 PAS-K의 신뢰도와 타당도가 검증되었고, 노인정신의학 역학연구나 보건분야에서 치매와 우울증의 임상경과관찰 및 일차 선별도구로서 유용하게 사용될 수 있게 되었다. Objectives : This study was designed to develop the Korean version of the Psychogeriatric Assessment Scale(PAS-K), a multidimensional screening tool for the dementia and depression. Methods : Through three times preliminary trials, the authors translated PAS into Korean. The PAS-K, Geriatric Depression Scale, Hamilton Depression Rating Scale, Hachinski Ischemic Scale and Mini-Mental State Examination-Korean version were administered to 291 subjects over the age of 60 and the same number of their informants(67 subjects were institutionalized, 168 subjects were in community, 58 subjects were psychiatric hospital patients). And the Diagnostic Interview Schedule(DSM-Ⅲ-R) was independently administered to exactly diagnose dementia and depression. The reliability and validity test, optimal cut-off point estimation for six each scale and ROC curve analyses were done to investigate the diagnostic validity of PAS-K. Results : Internal consistency and interrater reliability of the PAS-K were high. Concurrent validity of each scales of PAS-K was good in being measured with other standardized scales. The optimal cut-off points of each scale of the PAS-K were estimated as follows : 1) Stroke Scale of subject interview : 1, 2) Cognitive Impairment Scale of subject interview: 10, 3) Depression Scale of subject interview : 5, 4) Stroke Scale of informant interview : 1, 5) Cognitive Decline Scale of informant interview : 3, and 6) Behavioral Change Scale of informant : 2. conclusions : The PAS-K was valid and reliable screening tools for detecting dementia and depression. Therefore the PAS-K could be widely and extensively used in psychogeriatric epidemiological research or clinical setting of primary screening for dementia and depression.

等電點 電氣泳動法에 의한 벼 種子內 esterase 同位酵素 遺傳子 分析

Moo Young Eun(殷茂永),Yong Kwon Kim(金容權),Yong Gu Cho(趙龍九),Tae Young Chung(鄭泰英) 한국육종학회 1990 한국육종학회지 Vol.22 No.3

The inheritance of esterase isozvmes in rice was identified by controlled crosses and segregation analysis with esterase phenotypes classified. Using the method of isoelectric focusing(IEF), four esterase loci and their allozymes were identified and named as Est Ⅰ-1, Est Ⅰ-2, Est Ⅰ-3, and Est Ⅰ-4. There allozymes at each locus were found. Est Ⅰ-1 locus was controlled by two active dimeric alleles and a null allele. Two monomeric alleles and a null allele were found at both Est Ⅰ-2 and Est Ⅰ-3 locus. Two dimeric alleles and one weak allele were recognized at Est Ⅰ-4 locus. Linkage tests showed that four esterase loci were independent each other.

S-624 The Case of Severe Fever with Thrombycotopenia Syndrome related Encephalitis

( Moo Hyun Kim ),( Woo Yong Jeong ),( In Young Jung ),( Dong Hyun Oh ),( Yong Chan Kim ),( Mi Young Ahn ),( Yong Duk Jeon ),( Je Eun Song ),( Eun Jin Kim ),( Hea Won Ann ),( Su Jin Jeong ),( Nam Su Ku 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever caused by a novel bunyavirus, first reported in the year 2009 by Chinese researchers. Fever, myalgia, nausea and vomiting are common symptoms, and central nervous system manifestations, such as seizure and confusion, could be presented in about 6% of SFTS patients. However in South Korea, only a few data on SFTS related encephalitis has been reported. Here we introduce the case of a male patient diagnosed and treated with reversible encephalitis despite normal initial CSF findings. A 20-year old soilder, who had experienced three days of fever, headache, nausea and vomiting visited our medical center via the military hospital. He had no underlying disease but had a history of receiving military training in the wilderness. Physical examination showed no meningeal irrigation signs. The laboratory studies revealed thrombocytopenia, leukopenia and elevated liver enzymes; alanine aminotransferase and aspartate aminotransferase. Initial CSF analysis showed normal results. The serum SFTSV result was positive by RT-PCR. On day 5, the patient suddenly presented generalized tonic-clonic seizure and myoclonus in the right side limbs. On brain MRI, focal high signals at the cerebral cortex were detected and follow up CSF analysis showed pleocytosis (WBC : 34/uL [normal range : 0~5/uL]) (Table1). The patient was treated using corticosteroid. In about one month, symptoms and abnormal laboratory findings, such as liver enzyme and hematologic abnormalities, were normalized. This case reveals that fatal disease of SFTS could manifest as late-onset encephalitis. In cases where initial CSF findings are normal, we should not exclude the possibility of SFTS related encephalitis.

A new analytical method of β-phenyl ethyl amines in foods and dietary supplements

Moo Song Lim,Eun Jeong Kim,Hye Soon Kang,Eun Jung Jang,Yong Woo Shin,Miok Kim,Ki Mi No,Yu kyung Lee,Ji-Yong Yang,Joong Hoon Cho,Chul-Joo Lim,Sun-Ok Choi 한국분석과학회 2017 학술대회논문집 Vol.2017 No.11

Identification of an Isozyme Marker , Est Ⅰ-2 , Linked Tightly with Semidwarf ( sd -1 ) Character in Rice

Moo Young Eun,Yong Kwon Kim,Yong Gu Choi,Tae Young Chung 한국식물생명공학회 ( 구 한국식물조직배양학회 ) 1991 한국식물생명공학회 춘계학술연구발표회 Vol.1991 No.-

Effects of The Home Physical Therapy on Recovery of Muscle Strength and Gait for Discharged Patients Who Underwent Total Knee Replacement

Yong Su Jang,Moo Ki Kim,Ji Sung Kim,Ja Pung Koo,Si Eun Park,Wan Suk Choi,Bo Kyoung Kim,Yong Youn Kim,Soon Hee Kim 국제물리치료학회 2014 Journal of International Academy of Physical Ther Vol.5 No.2

This study aims to identify the effect of home physical therapy on patients who left the hospital after total knee arthroplasty, compared to the Daily living group, when it was applied to them, under the guidance of physical therapists. As research subjects, 20 patients that were scheduled to leave the hospital after unilateral total knee arthroplasty, were chosen, and they were randomly divided into a home physical therapy group(10 patients) and an Daily living group(10 patients) in order to conduct an experiment. During the 4-week research, home physical therapy was offered for 40 mins once for 5 days a week, and muscular strength, gait components were measured. For muscular strength, quadriceps muscle strength, hamstring muscle strength were measured, and as gait components, endurance, speed, step time, single-limb support were analysed. For this experiment, pre- and post-measurement were performed, and collected data were analyzed using SPSS ver. 18.0 statistical program. From the analysis of data, the following study results were obtained. Home physical therapy group and Daily living group both showed significant improvements in quadriceps muscle strength, hamstring muscle strength, and quadriceps muscle strength, hamstring muscle strength of home physical therapy group more significantly improved than Daily living group's. In relation to gait components, gait endurance, gait speed, step time significantly improved in both of home physical therapy group and Daily living group, whereas home physical therapy group only showed significant improvements in single-limp support. According to the comparison between two groups, gait speed, single-limp support and step time improved more significantly in the home physical therapy group than in the Daily living group. In conclusion, positive results were revealed in both home physical therapy group and Daily living group, with regard to muscular recovery of lower limbs of patients discharged from the hospital after total knee arthroplasty and walking, but considering the comparison results between two groups, it seems that applying home physical therapy is more effective than maintaining a daily life.

韓國 벼 在來種의 同位酵素 形態特性에 의한 品種區分

Moo Young Eun(殷茂永),Yong Kwon Kim(金容權),Yong Gu Cho(趙龍九),Young Woo Kim(金永雨),Tae Young Chung(鄭泰英),Hae Chune Choi(崔海椿) 한국육종학회 1989 한국육종학회지 Vol.21 No.4

Using the method of isoelectric focusing in polyacrylamide horizontal slab gels, Korean native rice cultivars, which were collected from Gene Bank of the Rural Development Administration, were analyzed for their five isozyme patterns and classified into the enzymatic groups. Among 259 Korean native rice cultivars screened, 5 esterase(EST), 4 phosphoglucose isomerase(PGI), 4 malic enzyme(ME), 2 hexokinase(HK) and 5 β-amylase(β-AMY) isozyme phenotypes were distinguished. Total 15 enzymatic groups could be classified by combining five enzyme phenotypes. The eleventh enzymatic group 〔EST-ⅡC:ME-Ⅲ:PGI-Ⅱ:HK-Ⅱ:β-AMY-Ⅰ〕 was most frequent (111 cultivars), but only one to three cultivars were found in the 1st-6th, 9th and 13th groups. Over 96% of Korean native rice cultivars were showed the isozyme phenotypes of 〔EST-ⅡC:ME-Ⅲ:PGI-Ⅱ〕.