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혈전용해치료와 혈관 내 스텐트삽입술로 치료한 상장간막동맥 혈전폐쇄 1예
김경식,김명환,송건훈,전재윤,한광협,문영명,이도연,조덕규 대한소화기학회 2001 대한소화기학회지 Vol.37 No.2
Superior mesenteric artery thrombosis usually occurs in an area of severe atherosclerotic narrowing, most often at the origin of the superior mesenteric artery. On angiography, the absence of collateral vessels or the presence of collaterals with inadequate filling of the superior mesenteric artery indicates an acute occlusion and demands prompt intervention. A 44-year-old man presented with epigastric and right upper quadrant pain after eating. Computed tomography and angiography showed superior mesenteric artery thrombosis. After treating with intra-arterial infusion of urokinase and intraluminal stent insertion, the patient showed clinical improvement and near complete resolution of superior mesenteric artery thrombosis. Thus, direct infusion of urokinase into the superior mesenteric artery and angioplasty with stenting for treatment of superior mesenteric artery thrombosis can be the alternative to surgery in selected patients with superior mesenteric artery thrombosis.
Kinase Suppressor of Ras 1 Promotes YAP/TAZ-Mediated Tumorigenesis in the Liver
( Hyuk Moon ),( Kyungjoo Cho ),( Soonyoung Shin ),( Simon W. Ro ),( Beom Kyung Kim ),( Seung Up Kim ),( Jun Yong Park ),( Sang Hoon Ahn ),( Do Young Kim ),( Kwang-hyub Han ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Liver cancer is the second most common cause of cancer-related deaths worldwide. The Hippo signaling pathway is tumor suppressive, as its inactivation leads to tissue overgrowth and tumor formation via YAP- or TAZ-mediated transcriptional activation. YAP is overexpressed in 62% of patients with hepatocellular carcinoma (HCC) and in almost 90% of human cholangiocarcinoma (CCC). Kinase Suppressor of Ras 1 (KSR1) is a scaffold protein for the Ras/Raf/MEK/ERK signaling pathway, promoting activation of MEK and ERK. Pro-tumorigenic roles of KSR1 in Ras-activated cancers have been verified in murine models for lung, skin, and pancreatic cancers. In this study, we have investigated the role of KSR1 in YAP/TAZ-mediated hepatocarcinogenesis. Methods: Transposons were constructed encoding KSR1 and an activated from of TAZ (TAZ<sup>S89A</sup>). Transposons were hydrodynamically delivered to livers of 6-week-old C57BL/6 mice. Mice were monitored at least twice per week and sacrificed when moribund. Tumor-bearing livers were formalin fixed for hematoxylin-eosin staining and immunohistochemistry. Results: Analysis of gene expression levels in human HCC and CCC samples deposited in The Cancer Genome Atlas (TCGA) revealed that KSR1 was significantly upregulated both in human HCC and CCC, compared with non-tumoral surrounding livers (P<0.0001 in HCC and P=0.0063 in CCC). Co-expression of KSR1 and an activated form of TAZ (TAZ<sup>S89A</sup>) led to the development of both HCC and CCC in the murine livers, while expression of TAZ<sup>S89A</sup> alone failed to induce hepatic tumors. Conclusions: KSR1 promotes hepatocarcinogenesis, both in HCC and CCC. Suppression of KSR1 might be an attractive therapeutic option for both types of hepatic malignancies.
간세포암 환자에서 Bleomycin에 대한 염색체 감수성의 의의
김경철(Kyung Chul Kim),한광협(Kwang Hyub Han),성진실(Jin Sil Sung),박효진(Hyo Jin Park),정준표(Jun Pyo Chung),이관식(Kwan Sik Lee),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),박인서(In Suh Park) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.3
N/A Backgrounds/Aims: There are interindividual differences, genetically determined, in susceptibility to .ancer and such variable susceptibility may reflect individual variation in DNA repair capability. A cytogenetic assay, so-called mutagen sensitivity assay, has been developed in which in vitro bleomycin-induced chromosome breaks provide indirect measure of such repair. By assessing muta- gen sensitivity in patients with chronic liver disease(CLD) and hepatocellular carcinoma(HCC), we explored the possibility of interindividual differences in chrornosomal susceptibility to mutagen and evaluated the significance of mutagen sensitivity in patients with HCC. Methods: Lymphocytes from 14 patients with CLD and 21 patients with HCC were cultured in vitro and challenged with bleornycin. Chrornosomal damage was quantified by scoring chromatid breaks of 100 metaphase cells. Results: Chromosomal sensitivity to bleomycin varied interindividua]ly in both patients with CLD and HCC, the number of bleomycin-induced chromatid breaks per cell(b/c) ranging from 0.2 to 0.6. The mean b/c value showed no significant difference between the two groups(0.37+0.06 in CLD vs 0.43+0.07 in HCC). However, the distributional profiles of b/c differed significantly between the two groups, the frequency of subjects with a b/c value of >0.4 being significantly higher in HCC patients than CLD patients(61.8% vs 28.5%, p0.05). Bleomycin sensitivity in HCC patients was influenced by patients age an<I family history of the disease(p0.05), but not by alcohol or smoking history and sex. The patients of HCC with young age onset or with a positive family history responded with a relatively higher degree of b/c value. Conclusions: We could observe interindividual differences in sensitivity to bleomycin-induced chromosomal damage and that bleomycin-sensitive subjects were more common in HCC patients than CLD patients, especially in those with young age or who had a family history of HCC. These findings suggest that bleomycin-induced chromosomal sensitivity may serve as an indicator of genetic susceptibility to the development of HCC. (Korean J Gastroenterol 1996; 28:382 - 390)
춘계학술대회 발표 : 구연 ; 간암 : 간문맥 혈전을 동반한 국한된 간세포암(4a기) 환자에서 병합치료가 단일치료에 비하여 과연 우월한가?
( Ja Kyung Kim ),( Kwang Hyub Han ),( Sang Hoon Ahn ),( Jong Tae Lee ),( Do Yun Lee ),( Jong Yoon Won ),( Jin Sil Seong ),( Chae Yoon Chon ),( Young Myoung Moon ) 대한간학회 2006 Clinical and Molecular Hepatology(대한간학회지) Vol.12 No.3(S)
접촉피부염 환자의 조직 병변에서 보인 Incidental Acantholysis
이상협 ( Sang Hyub Lee ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3
Incidental acantholysis is a rare histologic findings, and reported in basal cell carcinoma, keratoacanthoma, psoriasis, tinea corporis, etc. We describe a case of contact dermatitis in a 64-year-old female who suffered from recurrent itchy, erythematous patches on face, neck, and shoulder. She presented with recently aggravated itchy skin lesions after using perfume and Tiger balm. Patch test showed strong positive reaction to balsam of Peru, fragrance anix, and Tiger balm. A biopsy specimen showed lichenoid dermatitis and incidental focal acantholysis which was not previously reported in literatures. (Kor J Dermatol 1996;34(3): 422-425)
원발성 간암환자의 간염 바이러스 감염유형에 따른 임상양상 및 예후
한광협(Kwang Hyub Han),문희용(Hee Yong Moon),김범수(Bum Soo Kim),백용한(Yong Han Paik),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park) 대한내과학회 2001 대한내과학회지 Vol.60 No.1
N/A Background : Hepatocellular carcinoma(HCC) is one of the important causes of cancer-related mortality and morbidity in East Asia, including Korea. Most of the hepatocellular carcinoma in Korea are associated with hepatitis B and C virus infection. The clinical characteristics and prognosis of the patients with HCC were evaluated in relation to the type of hepatitis virus. Methods : A retrospective analysis of the clinical data and survival rate was done in 603 patients(M:F=4.9:1, mean age; 54.2 years) who were admitted to Yonsei medical center from April, 1991 through April, 1994. Results : Among 603 patients, tests for HBsAg and anti-HCV was done simultaneously in 455 patients. Out of the 455 HCC patients, 303 patients (66.6%) were classified as Group B(HBsAg+ve, anti-HCV-ve), 102 patients (22.4%) were classified as Group C (HBsAg-ve, anti-HCV+ve), 45 patients (9.9%) were classified as Group non-BC (HBsAg-ve, anti-HCV-ve), and 5 patients (1.1%) were classified as Group BC (HBsAg+ve, anti-HCV+ve). The mean age of the patients in Group C was older than that of Group B (64.9 vs. 51.3 yr) (p<0.05). Liver cirrhosis was frequently noticed in Group C than Group B (84.3 vs. 68.0%) (p<0.05). The number of the patients whose serum FP level was elevated (>400 ng/mL) was significantly higher in Group B than in Group C (70.0 vs. 52.0%)(p<0.05). According to the gross type, nodular type was more common in Group C than in Group B(72.0 vs. 38.1%) (p<0.01). The incidence of portal vein thrombosis was significantly lower in Group C compared with that in Group B (16.7 vs. 31.4%)(p<0.05). The number of the patients whose tumor size of less than 5 cm was significantly higher in Group C than in Group B (35.3 vs. 17.8%) (p<0.05). Using multivariant analysis, independent prognostic factors were found to be Child grading, FP level, size of the tumor, gross type, and the type of hepatitis virus. The cumulative survival rate of 1, 2, and 3 year in each Group was 31.5%, 17.5%, and 10.8%, respectively in Group B, and 55.7%, 30.2%, and 21.6%, respectively in Group C. The median duration of survival of Group B was significantly shorter than that of Group C(5.0 vs. 13 months)(p<0.05). Conclusion : About 90 % of HCC was associated with hepatitis B or C viral infection in Korea. Hepatitis B virus associated HCC had poorer prognosis compared with hepatitis C virus associated HCC in Korea.(Korean J Med 60:22-31, 2001)