고환수염전과 동반된 고환미석증 1예

양상국,신현준,김홍섭,정상원,노용수,김상윤 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

Testicular microlithiasis is a rare disease characterized by calcifications within the seminiferous tubules. Testicular microlithiasis has been found with a wide variety of testicular pathology, but to our knowledge its association with torsion of appendix testis has been reported only one case. Therefore, we report on an 13-year-old boy with torsion of testis appendix and bilaterally diffusely echogenic testes on sonography.

숯 처리에 의한 녹차 추출액 중 질산태질소 제거 효과

김진우,고영옥,신동국,이 협,전현식,이종옥 진주산업대학교 산업과학기술연구소 2005 산업과학기술연구소보 Vol.- No.12

This experiment was carried out to measure the elimination effect of nitrate nitrogen from green tea extracts through the column system filled with charcoal activated and bamboo charcoal powder compare to that of an nitrate nitrogen standard solution prepared with KNO3 chemicals. The change patterns of pH, and the amount of removed nitrate nitrogen from green tea and nitrate nitrogen standard solution were analyzed according to time course and the amount of charcoal treatments. The results were summarized as follow: 1. pH The pH of Green tea extractions treated with charcoal was high up to 8.17(after 30min treated with 0.4% charcoal) and 8.36(after 60min with 0.4% charcoal) which pH of non-treated green tea (control) was 5.8 The results indicated that the pH values were variable to the treated amount of charcoal and the teated time course. 2. Nitrate nitrogen From the nitrate nitrogen standard solution, the least rate 69.1% and the highest rate 74.5% of nitrate nitrogen were observed to be absorbed through the column treatment (60 min), which with green tea extract solution 21.3% (the least) and 43.8% (the highest) were detected to be absorbed through column treatment (after 60min with 0.4% charcoal). In the case of bamboo treatments with nitrate nitrogen solution samples were showed the least rate 62.8% (30min with 0.1% bamboo) and the highest rate 68.9% (60min with 0.4% bamboo), and with green tea extract solution were observed the least 13.6 (30min with 0.1% bamboo) the highest rate 29.4% (60min with 0.4% bamboo). In general, the elimination activity of nitrate nitrogen was higher by the charcoal activated powder treatment than bamboo charcoal.

신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예

이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4

저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.

분말녹용의 약물활성 연구(I)

Shin Kuk Hyun,Lee Eun Bang,Kim Jea Hyun,Chung Myoun Sook,Cho Sung Ik 한국양록협회 1989 양록회보 Vol.8 No.-

Systematic pharmacological studies on powdered whole part of unossified antler obtained from Cervus nippon var. mantchuricus have been carried out in mice and rats. Powdered antler, with a single oral administration, showed a very weak acute and subacute

Pharmacologically Active Principle of Piper retrofractum

Kuk Hyun Shin(신국현),Hye Sook Yun Choi(윤혜숙),Won Sick Woo(우원식),Chung Kyu Lee(이정규) 한국생약학회 1979 생약학회지 Vol.10 No.2

A pharmacologically active constituent was separated from the methanol extract of the seeds of Piper retrofractum and identified as piperline.

Immuno-stimulating , Anti-stress and Anti-thrombotic Effects of Unossified Velvet Antlers

Kuk Hyun Shin,Hye Sook Yun Choi,Soon Sung Lim,Do Hee Won,Jae Kun Kim 한국생약학회 1999 Natural Product Sciences Vol.5 No.1

Both ethanol and water extracts of unossified velvet antler were found to exhibit a significant immuno-stimulating activity as measured by carbon clearance test in mice, a remarkable antifatigue effect in weight-loaded forced swimming performance in mice. a significant anti-stress effect on immobilization in rats. The antler extracts also showed a weak but significant anti-thrombotic activity. These findings are indicative of adaptogenic properties of antlers and their normalizing effects during stressful condition.

Inhibition of hepatic microsomal drug-metabolizing enzymes by imperatorin

Shin, Kuk-Hyun,Woo, Won-Sick The Pharmaceutical Society of Korea 1986 Archives of Pharmacal Research Vol.9 No.2

The effect of imperatorin on hepatic microsomal mixed function oxidases (MF0) was investigated. On acute treatment, imperatorin (30 mg/kg, i.p) caused a significant reduction in activities of hepatic aminopyrine N-demethylase, hexobarbital hydroxylase and aniline hydroxylase as well as cytochrome p0450 content in rats and mice. Kinetic studies on rat liver enzymes revealed that imperatorin appeared to be a competitive inhibitor of aminopyrine N-demethylase (Ki,0.007 mM), whereas a non-competitive inhibitor of hexobarbital hydroxylase (Ki, 0.0148 mM). Imperatorin also inhibited non-competitively aniline metabolism (Ki 0.2 mM). Imperatorin binds to phenobarbital-induced cytochrome p-450 to give a typical type 1 binding sepctrum (max. 388nm, min 422 nm). Multiple administrations of imperatorin (30 mg/kg. i. p. daily for 7 days) to mice shortended markedly the duration of hexobarbital narcosis and increased activities of hepatic aminopyrine N-demethylase and hexobarbital hydroxylase and the level of cytochrome p-450 where as aniline hydroxylase activity was unaffected.

Effects of Psoralen and Angelicin on Hepatic Drug-Metabolizing Enzyme Activities

Shin, Kuk-Hyun,Woo, Won-Sick The Pharmaceutical Society of Korea 1988 Archives of Pharmacal Research Vol.11 No.2

The effects of psoralen and angelicin on hepatic microsomal drug-metabolizing enzyme (DME) activities were investigated to elucidate the mode of the interaction of furanocoumarins with DME system. A single administration (30 mg/kg,i. p.) of both coumarins to mice cased a significant prolonagation of hexobarbital-induced hypnosis as well as an increase in strychnine toxicity. The inhibitory potencies of both coumarins as measured by rat hepatic microsomal aminopyrine N-demethylase and hexobarbital hydroxylase activities in vitro were considerably weaker than those of other furanocoumarins which possess a side chain moiety. Both coumarins were found to have significant inducing effects of DME system, with repeated treatments of them. The activities of an angular coumarin were stronger than those of a linear coumarin.

Effects of Lignans on Hepatic Drug-Methabolizing Enzymes

Shin, Kuk-Hyun,Woo, Won-Sick,Lee, Jung-Yun,Han, Yong-Bong The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.3

The effects of lignans, related to macelignan, on hepatic microsomal drug-metabolizing enzyme (DME) activity were evaluated to elucidate the structure-activity relationship in mice and rats. The compounds carrying the methylenedioxyphenyl nucleus were found to be the msot potent among compounds tested; which not only produced a marked inhibition of DME with a single dose but a significant induction with repeated treatments. Lack of the methylenedioxy group caused marked decrease in the activity, implying that a methylenedioxy group is essential and of major importance eliciting DME modifying activity.

Effect of Naturally Occurring Coumarins on Drug Metabolism

Shin, Kuk Hyun,Woo, Won Sick,Lee, Chung Kyu 생화학분자생물학회 1987 BMB Reports Vol.14 No.4

In the course of continued search for medicinal plants affecting drug metabolizing function in the liver, it has been found that Angelica plants exhibited the most potent activity. Systematic fractionation of these plants monitoring animal experiments led to principles which were identified as coumarins. This finding provoked us to investigate the effect of various natural coumarins on the activity of drug metabolizing emzymes. The potency of the natural coumarins such as furano, pyrano and simple coumarins on drug metabolism was tested and compared by evaluating hexobarbital induced hypnosis, strychnine mortality, serum level of hexobarbital as well as barbiturate metabolism in vitro. Among coumarins tested, only furanocoumarins such as imperatorin, isoimperatorin, bergapten, oxypeucedanin and isooxypeucedanin were found to be active but, other coumarins with acyclic substituents pyranocoumarins and dihydrofuranocoumarins were inactive at the dosage used. The mode of action of furanocoumarins were very similar to those of SKF-525A, indicating that these compounds may belong to an enzyme inhibitor rather than an enzyme inducer. A double bond in furan ring seems to be essential for the manifestation of the activity, as the activity could not be observed in nodakenin and nodakenetin in which the furan ring is saturated.