Al_(0.3)Ga_(0.7)As/GaAs HEMT 구조에서의 Photoreflectance에 관한 연구

이정열,김기홍,배인호,박성배,신영남 대구대학교 기초과학연구소 2000 基礎科學硏究 Vol.16 No.2

The optical characteristics of Al_(0.3)Ga_(0.7)As/GaAs HEMT structure were investigated by using the photoreflectance method. From the PR measurement, 2DEG transition energy related signal were obtained by between GaAs buffer and Al_(0.3)Ga_(0.7)As/GaAs spacer layer at the temperature of below about 150 K. And the transition energy is shift to low energy about 21 meV. We obtained that 2DEG transition energy, interface field and carrier concentration are 1.455 eV, 5.26 × 10⁴ V/cm and 7.18 × 10⁴cm^(-3), respectively.

十全大補湯의 免疫增强 및 抗癌 效果

崔承勳,吳旼錫,宋泰元,남기열 대전대학교 한의학연구소 2002 혜화의학회지 Vol.11 No.1

Objectives : Sipjundaebo-tang is prepared by ten medical herbs that tone the blood and vital energy, and strengthen health. This prescription has long been used traditionally against anemia, anorexia, extreme exhausion and fatigue. The purpose of this thesis was to review the effects of Sipjundaebo-tang that are about immunopotentiation effects, antitumor activities and potentiation, detoxification of antitumor drugs Methods : We studied the research methods and results of experiments which were selected from Korean, Japaness and American theses were on the topic of immunopotentiation effects, antitumor activities and potetiation, detoxification of antitumor drugs from Sipjundaebo-tang Results and conclusions : Sipjundaebo-tang not only potentiates the effects of the combined use of chemotherapy, but also reduces and elimimate the immunotoxicity of antitumor drugs and radiotherapy. And it strengthen immunity and improve QOL, S/OH of cancer patients.

고려인삼의 주요 효능과 그 임상적 응용

남기열(Nam Ki Yeul) 고려인삼학회 2002 Journal of Ginseng Research Vol.26 No.3

본총설은 1980년대부터 최근까지 국내외 학술잡지나 심포지움 등에 발표된 인삼의 주요 임상효능 연구결과를 요약 고찰하고, 그 임상 적응증과 안전성 등에 대한 검토를 통해 금후 인삼의 임상적 활용성 제고와 인삼의 진정한 약용가치 평가를 위한 임상연구의 발전에 도움을 주고자 하였다. 당뇨병을 비롯한 동맥경화성 질환, 고혈압, 악성질환, 성기능 장애 등의 만성질환에 대한 그 동안의 연구결과는 인삼의치료효과보다는 예방 및 회복제로서의 효용성을 보여 주었다. 특히 이들 질환의 각종 자각적 장해증상과 장기 약물치료의 부작용으로 인한 QOL의 악화에 에 대한 개선효과가 관찰되<br/> 었다. 그러나 인삼의 효과는 일반적으로 mild 하여 일차적 치료보다는 관행적 약물요법과 병용할 때 보조요법제로서 또는 부작용을 보다 적게 하는 효과가 기대된다. 또한 주요 강장효능과 관련하여 작업수행능력에 미치는 임상연구 결과는 인삼복용이 각종 스트레스 상태하의 신체적 조건에 대한 적응능력을 개선시켜 육체적 정신적 기능저하를 회복시키는 효과를 보였다. 이러한 임상시험에서 얻어진 결과가 그대로 인삼의 적응증(indication)이라고 단정할 수는 없으며, 그 효능의 과학적 증거들에 대해서는 아직도 논란이 많고, 임상실험의 유효성 평가와 관련된 방법론적 문제점도 많이 지적되고 있다. 보다 확실한 적응증 제시를 위해서는 표준화된 인삼시료를 이용하여보다 체계적인 시험설계에 의한 객관적 효능평가가 필요하다. 한편 인삼(제품) 복용에 의한 부작용(adverse effects)의발생 가능성에 대한 사례보고들도 대부분 인삼의 과량복용이나 품질관리 미흡에서 기인되는 것으로 여겨지고 있다. 최근 해외 시장에서 유통되는 인삼제품 품질검사에서 사포닌 성분의 불검출 또는 함량 미달과 유해성분의 오염가능성 등 부정적 견해들이 다수 보고되었다. 그러나 표준화된 인삼제품의 추천복용량을 사용한 대부분의 임상실험에서는 거의 유의할만한 부작용은 인정되지 않았다. 금후 연구와 관련하여, 품질표준의 지표성분으로 간주되는 진세노사이드의 절대함량과 그 성분조성 차이에 따른 임상효<br/> 과의 차별성이 있는지에 대한 검토와, 특히 최근 실험적으로 밝혀지고 있는 사포닌 성분의 장내 세균에 의한 생물전환체의 인체 실험을 통한 효과 검정이 필요하다. 나아가서는 적정복용량의 설정과 이와 관련되는 생체내 동태 및 생체이용율(bioavilability)에 관한 정보가 거의 없으므로 이것도 금후 검<br/> 토해야 할 과제로 사료된다. 인삼은 전통약물로서 오랜 역사성과 그 동안의 연구결과에 의한 과학성을 가지고 있으므로 건강유지와 병의 예방 및 회복촉진을 위한 보조요법제 또는 기능성 식품으로써의 유용성이 있는 것으로 판단된다. 앞으로 인삼의 활용성 증대를 위해서는 보다 과학적인 임상평가에 의한 안전성 및 유효성 입증과 제품의 엄격한 품질관리의 필요성이 더욱 강조되어야 할것이다. Korean ginseng (Panax ginseng C.A. Meyer) received a great deal of attention from the Orient and West as a tonic agent, health food and/or alternative herbal therapeutic agent. However, controversy with respect to scientific evidence on pharmacological effects especially, evaluation of clinical efficacy and the methodological approach still remains to be solved. Author reviewed those articles published since 1980 when pharmacodynamic studies on ginseng have intensively started. Special concern was paid on metabolic disorders including diabetes mellitus, circulatory disorders, malignant tumor, sexual dysfunction, and physical and mental performance to give clear information to those who are interested in pharmacological study of ginseng and to promote its clinical use. With respect to chronic diseases such as diabetes mellitus, atherosclerosis, high blood pressure, malignant disorders, and sexual disorders, it seems that ginseng plays preventive and restorative role rather than therapeutics. Particularly, ginseng plays a significant role in ameliorating subjective symptoms and preventing quality of life from deteriorating by long term exposure of chemical therapeutic agents. Also it seems that the potency of ginseng is mild, therefore it could be more effective when used concomitantly with conventional therapy. Clinical studies on the tonic effect of ginseng on work performance demonstrated that physical and mental dysfunction induced by various stresses are improved by increasing adaptability of physical condition. However, the results obtained from clinical studies cannot be mentioned in the indication, which are variable upon the scientist who performed those studies. In this respect, standardized ginseng product and providing planning of the systematic clinical research in double-blind randomized controlled trials are needed to assess the real efficacy for proposing ginseng indication. Pharmacological mode of action of ginseng has not yet been fully elucidated. Pharmacodynamic and pharmacokinetic researches reveal that the role of ginseng not seem to be confined to a given single organ. It has been known that ginseng plays a beneficial role in such general organs as central nervous, endocrine, metabolic, immune systems, which means<br/> ginseng improves general physical and mental conditions. Such multivalent effect of ginseng can be attributed to the main active component of ginseng, ginsenosides or non-saponin compounds which are also recently suggested to be another active ingredients. As is generally the similar case with other herbal medicines, effect of ginseng cannot be attributed as a given single compound or group of components. Diversified ingredients play synergistic or antagonistic role each other and act in harmonized manner. A few cases of adverse effect in clinical uses are reported, however, it is not observed when standardized ginseng products are used and recommended dose was administered. Unfavorable interaction with other drugs has also been suggested, which the information on the products and administered dosage are not available. However, efficacy, safety, interaction or contraindication with other medicines has to be more intensively investigated in order to promote clinical application of ginseng. For example, daily recommended doses per day are not agreement as 1-2 g in the West and 3-6 g in the Orient. Duration of administration also seems variable according to the purpose. Two to three months are generally recommended to feel the benefit but time- and dose-dependent effects of ginseng still need to be solved from now on. Furthermore, the effect of ginsenosides transformed by the intestinal microflora, and differential effect associated with ginsenosides content and its composition also should be clinically evaluated in the future. In conclusion, the more wide-spread use of ginseng as a herbal medicine or nutraceutical supplement warrants the more rigorous investigations to assess its effacy and sa

土壌水分이 人蔘生育에 미치는 影響

南基烈(Ki-Yeul Nam),朴薰(Hoon Park),李壹鎬(Il-Ho Lee) 한국토양비료학회 1980 한국토양비료학회지 Vol.13 No.2

A case of Pseudomembranous Tracheobronchitis complicated by Coinfection of Novel Influenza A (H1N1) and Staphylococcus Aureus (초)

( Ki Ho Nam ),( Hong Yeul Lee ),( Jong Sam Hong ),( Jae Min Lim ),( Mi Hye Kim ),( Bock Hyun Jung ),( Eun Hee Song ),( Dae Sick Ryu ) 대한내과학회 2010 대한내과학회 추계학술대회 Vol.2010 No.-

인삼의 임간재배가 생육 및 품질에 미치는 영향

남기열 충북대학 대학원 1980 大學院論文集 Vol.6 No.-

본문참고

Apoptotic Damage during Co-culture of Lung Epithelial Cells and Macrophages in the Presence of Metal Nanoparticles Is Modulated by TNF-α from Macrophages

( Ki Heon Kim ),( Seung Yeul Kim ),( Bok Hwan Chun ),( Yong Kwon Lee ),( Nam Hyun Chung ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.1

Metal nanoparticles have attracted strong interest, because they open up a new field in fundamental science and have potential technological applications. The mechanisms of cytotoxic action as well as cellular target for metal nanoparticles remain to be elucidated. In the present study, the differences in the toxicity and cytokine production between mono-and co-culture with murine alveolar macrophages (RAW264.7) and alveolar epithelial cells (MLE12) in the presence of metal nanoparticles were elucidated. Among eight nanoparticles tested, n-Co, n-Cu, and n-Zn had higher degrees of cytotoxicity toward both cells than the other particles. These three metal nanoparticles induced a high degree of apoptotic damages, which, in turn, was correlated with extent of cytotoxicity at a lower concentration tested. In most cases, extent of apoptotic damage was higher with co-culture than with mono-culture for both cells due to a communication through TNF-α and other unknown factors between epithelial cells and macrophages. These results may be crucial in understanding the nanoparticle-induced apoptotic responses in the lung.

The importance of multi-omics approaches for the health assessment of freshwater ecosystems

Nam Sang-Eun,Bae Dae-Yeul,Ki Jang-Seu,AHN, CHI-YONG,Rhee Jae-Sung 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.1

Background The major goals of monitoring aquatic animals are to understand ecosystem health status and to identify signals of environmental change and pollution. Over the past few decades, advances in individual omics technology have been expanded to aquatic ecotoxicology and health assessment. The single-omics approach has produced one type of result, but recently, the combined multi-omics approach has enabled depiction of multidimensional datasets for holistic interpretation regarding the molecular responses of biological systems. Objective In this mini review, the power of the multi-omics approach for monitoring the health of freshwater animals is described, along with a discussion on challenges and the current limitations in the complexity of integrating multidimensional datasets. Results Recent studies have suggested that the aquatic ecotoxicology field can benefit significantly using multi-omics platforms; however, the examples of multi-omics applications remain limited. The complex metabolism underlying the sensitivity, health status, response, tolerance, and adaptation of certain aquatic organisms can be uncovered through comprehensively integrated omics results and advanced bioinformatics. Conclusion Multi-omics approaches can provide crucial datasets for developing multidimensional biomarkers and deciphering novel biological insights into aquatic ecotoxicology and health assessments. This platform provides a novel opportunity for environmental scientists to connect the biological responses and chemical data in aquatic organisms exposed to environmental challenges.

한국의 하계기단의 출현특성

남기열 서울대학교 지리교육과 1984 지리학과 지리교육 Vol.14 No.1

This study aims to clarify the occurrence characteristics of air masses which influence the Korean peninsula in summer. Equivalent potential temperatures of the East Asia region (forty-seven aerological stations of 850mb height surface were selected) were acquired. The air masses are classified by the method of Saito classification (1966). The patterns of the equivalent potential temperature maps were classified into five types according to the air masses which influence Korean peninsula. The results of the study summarize as follows: 1) Type I: Type I is the case of the Ohotsk Air Mass (mP) covering the Korean peninsula. The occurrence frequency of this type of airmass is very high during the periods from June 1-July 5, and after that it is reduced. The occurrence frequency during Changma Periods the so called $quot;summer rainy seasons$quot;, is very high, up to 16.9%. When this type appears the weather is wet and cold. 2) Type II: Type II is the case of the Continental Air Mass (cP) covering the Korean peninsula. The occurrence frequency of this type of airmass is high during the periods of early of June, July 6 through July 15, and after August 19. The occurrence frequency during Changma Periods is 3.0%. 3) Type III: Type III is the case of the Polar Air Mass covering the Korean peninsula. But there was difficulty in identifying the air mass, This type is same as type I, and type II. From June 1 to June 30 a high frequency is noted. 4) Type IV: Type IV is the case of the Tropical Air Mass (T) or Monsoon Air Mass (M) covering the Korean peninsula. Because study deals with summer, type IV has the most frequently occurs. The occurrence frequency increases sharply during the period from June 26 to 30 and this high frequency continues to August 14. The maximum frequency is during the period from July 26 to August 4. By this classification Ohotsk High influences the formation of Changma Front. In June the Ohotsk High blocks the northward shifting of Changma Front so that the arrival of Changma Front upon the Korean peninsula is delayed. In July it again blocks the northward shifting of Changma Front so that it delays the departure of the Changma Front from the Korean peninsula. During East Asia's summer rainy period, the air mass which is located at the nothern side of Changma Front is usually the Ohotsk Air Mass and which is then followed by a Continental Air Mass.

Clinical and Epidemiological Features of Hepatitis C Virus Infection in South Korea from 2007 to 2017: A Prospec-tive, Multicenter Cohort Study

( Joon Yeul Nam ),( Eun Sun Jang ),( Young Seok Kim ),( Youn Jae Lee ),( In Hee Kim ),( Sung Bum Cho ),( Han Chu Lee ),( Si Hyun Bae ),( Mo-ran Ki ),( Eun Young Lee ),( Sook-hyang Jeong ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: This study aimed to investigate the clinical and epidemiological features of chronic hepatitis C patients in South Korea from 2007 to 2017. Methods: The Korea hepatitis C virus (HCV) cohort is a prospective, multicenter cohort which enrolled 2,910 adult patients with anti-HCV positivity at 7 tertiary centers. A standardized questionnaire survey on the risk factor for HCV infection, and clinical data collection with patient follow-up were prospectively performed. Among them, clinical profiles of 2,758 patients with HCV RNA viremia were described. Results: The HCV cohort showed a mean age of 57.3 years with 50.7% men, current or past alcohol intake in 52.8%, obesity in 27.4%, and diabetes mellitus in 18.6%. Past history of transfusion before 1995 was in 14.4%, intravenous drug use (IVDU) in 5.6%, piercing in 33.4%, and tattooing in 37.4%. The diagnostic category consisted of chronic hepatitis (69.5%, n=1918), liver cirrhosis (18.9%, n=522), and hepatocellular carcinoma (HCC) (11.5%, n=318). The mean level of platelet count was 235K, ALT level over upper normal limit (UNL) in 50.1%, and HCV RNA level>600,000 IU/mL in 48.1%. The major HCV genotypes were genotype 1b (48.2%), genotype 2 (46.4%), genotype 3, 4, and 6 in 0.6%, 0.2%, and 0.5%, respectively. Liver biopsy was performed in 227 patients (8.2%), while FibroScan^® was performed in 289 patients. Antiviral treatment including interferon-based therapy and direct acting antivirals was undergone in 32.8%. Comparison of clinical profiles between the first half period (2007-2011) and second half (2012-2017) will be discussed. Conclusions: The current clinical profile of Korean chronic hepatitis C patients showed a mean age of 57 years with male to female ratio of 1, past history of transfusion and IVDU in less than 25%, genotype 1 and 2 in 95%, liver cirrhosis and HCC in 30%, and one third of the patients underwent antiviral therapy.