Predicting postoperative total calcium requirements after parathyroidectomy in secondary hyperparathyroidism

( Byung Heon Kang ),( Soon Young Hwang ),( Jeong Yeop Kim ),( Yu Ah Hong ),( Mi Yeon Jung ),( Eun Ah Lee ),( Ji Eun Lee3 ),( Jae Bok Lee ),( Gang Jee Ko ),( Heui Jung Pyo ),( Young Joo Kwon ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Background/Aims: To prevent hypocalcemia after parathyroidectomy (PTX), parenteral calcium is required in addition to oral calcitriol and calcium. After switching to oral calcium, patients can be discharged from the hospital. The aim of this study was to analyze the clinical characteristics and outcomes of PTX performed at a single Korean center and to investigate the associated laboratory factors used to analyze the total amount of postoperative calcium required. Methods: We enrolled 91 hemodialysis patients undergoing PTX from November 2003 to December 2011. We collected clinical and laboratory data preoperatively, 12 and 48 hours postoperatively, at discharge, and 3 and 6 months postoperatively. Results: In total, 59 patients underwent PTX with autotransplantation (AT), 6 underwent total PTX without AT, 11 underwent subtotal PTX, and 15 underwent limited PTX. Total PTX without AT showed the lowest recurrence rate. At all postoperative time points, the mean levels of serum calcium, phosphorus, and intact parathyroid hormone (iPTH) decreased significantly, compared with preoperative levels; however, alkaline phosphatase (ALP) increased significantly from 48 hours postoperatively to discharge (p < 0.001). On multiple linear regression analysis, the total amount of injected calcium during hospitalization showed a significant correlation with preoperative ALP (p < 0.001), preoperative iPTH (p = 0.037), and Δphosphorus at 48 hours (p < 0.001). We developed an equation for estimating the total calcium requirement after PTX. Conclusions: Preoperative ALP, preoperative iPTH, and Δphosphorus at 48 hours may be significant factors in estimating the postoperative calcium requirement. The formula for postoperative calcium requirement after PTX may help to predict the duration of postoperative hospitalization.

顎矯正 手術 後 顎關節 障碍의 發現頻度에 關한 臨床的 硏究

백은호,이국엽,신효근,김정기 全北大學校 齒醫學硏究所 1992 전북치대논문집 Vol.10 No.1

The main purpose of the demanding surgical corrections aimed to improve esthetic appearance and masticatory function. But there are presumable etiologic factors in the development of T M symptoms after orthognathic surgery, that is, potential joint pathology due to different morphology of TMJ, hypombility after surgery, changes in condylar position, and changes in neuromuscular adaptation. These factors can influence on TMJ function. It is very important to find the etiological factors of TMD after surgery. Consequently, this survey was performed to evaluate TMJ function in 65 patients by questionaires, physical examination, radiogram after maxillofacial surgical corrections of the deformity patient. All patients were received pre- and post-operative orthodontic treatment. An acylic splint(wafer) was constructed prior to surgery with occlusal contacts in the anterior and posterior. The study group was consisted of 26 males and 39 females. The patients were evaluated at an average fellow-up period of 17.2 months with a range of 15 to 27 months. The results obtained were as follows: 1. The 65 patients were found to present preoperatively TMJ dysfunction symptom with an incidence of 18.5%(12 cases). 2. The patients with no TMJ dysfunction symptoms preoperatively, presented such symptom with an indicence of 26.4%(14 cases) postoperatively. 3. The main symptoms of TMJ dysfunction were 17 joints(15 clicking), TMJ pain(5 cases). 4. The mean preoperative MIO(maximal interincisal opening) of 49.7㎜ was reduced to 43.9㎜ postoperatively after sagittal split ramus osteotomy(n=38) with wire osteosynthesis(p<0.05).

양식장 배출물 발효물의 어류 사료 첨가에 따른 넙치, Paralichthys olivaceus의 혈액학적 변동에 미치는 영향

강주찬,지정훈,송승엽,문상욱,강지웅,이영돈,김세재 한국어병학회 2004 한국어병학회지 Vol.17 No.1

본 연구는 우리나라 주요 양식어류인 넙치, Paralichthys olivaceus를 대상으로 육상수조식양식장 배출물 발효물의 어류 사료 첨가에 따른 혈액학적 변동에 미치는 영향을 검토하였다. 젖산균 및 효모를 사용하여 발효한 양식장 배출물의 이화학적 분석을 실시하였고, 발효물을 0.1, 0.5, 1.0 및 5.0% 농도로 8주간 투여하였다. 투여 4주째 및 8주째에 각 투여 구간별로 혈액학적 항목을 중심으로 그 차이를 확인하였다. 배출물 발효농도별 유의한 차이는 나타나지 않았지만, 분석시기에 따른 적혈구수, 혈색소 농도 및 혈색소 지수가 증가하는 경향을 나타내었으나, 주요 혈청 무기 및 유기성분은 배출 발효물 농도별로 유의한 차이는 나타나지 않았다. 또한 혈청 효소학적 조사에서는 조사시기별로 변동은 나타났지만, 동일 조시시기에서 각 구간별 유의한 차이는 나타나지 않았다. 따라서 이러한 육상 약식장 유래의 배출물 발효산물에 대한 다양한 방면의 연구가 진행되어야겠다. Effects of oral administration with fermented product from sewage in land-based seawater fish farm on haematological disturbance in the olive flounder, Paralichthys olivaceus was investigated. After 4 weeks of conditioning with a basal diet, fish were divided into 4 groups and provided experimental diet (0.1,0.5, 1.0 and 2.0%) supplement of fermented sewage for 80 days. Proximal analysis was performed for the product of sewage which was fermented by lactic acid and yeast. RBC count, hemoglobin concentration and hematocrit value were increased according to the treated periods, however, no statistical difference was observed between control and treatment groups. There were no significant difference in serum organic, inorganic compounds and enzyme activities between control and treatment groups. This study hypothesized that the supplement of fermented product from sewage in land-based seawater fish farm might be an additive sup plement for source of fish diet in view of haematological examination. Recycling of the sewage may be an economic artificial sources of diet for fish aquaculture practices.

일제식민지 치하 경성부민의 도시적 감수성 형성과정 연구 : 1930년대 한국소설에 나타난 도시적 소비문화의 성립을 중심으로 Focusing on the Establishment of Urban Consuming Culture in the 1930's Korean novels

강심호,전우형,배주영,이정엽 서울시립대학교 부설 서울학연구소 2003 서울학연구 Vol.- No.21

In 1930's, capitalism gradually became established in Chosun. As Chosun's economy was incorporated into the global capitalistic system, the domestic economy became dependent on the international market. During this time, Kyeong-Seong was transformed into a capitalistic city. Various forms of modern facilities appeared, while urban consumerism constituted the city life. Thus, the everyday life in Kyeong-Seong demanded the acceptance of modern culture in order to adapt to the changing environment. Inside the city, people experienced modern civilization and urban consuming life, and came to adjust their form of living and their viewpoint of the world. This thesis examines the advertisement and text that appears in the newspapers, magazines, and other journalistic material of the thirties in order to determine how the commercials, romance, hobby or entertainment, and the newly discovered "pastoral" influenced the contemporary life and mind. Also, we intend to reveal how these factors took form in the contemporary literature. The contemporary Korean writers were inevitably surrounded by the popular and urban sensibility mentioned above. Even though unconsciously, or sometimes through negative criticism, this sensibility was included in their text. Even the nature that was considered to be a replacement of the desolate and inhuman city life was in fact a filtered form of nature - an image constructed by the popular culture and advertisements. Also, the romance described by the sensitive authors often took the form of a consumer love. Meanwhile, judging from the penetration of commercial statements which appears in several works, there was a growing desire to consume the image. Along with the newly adapted hobbies and leisure culture, the Korean life style went through a significant change, and so did the content of the contemporary novels. The urban sensibility formed in Kyeong-seong during the nineteen thirties can be defined as the common popular sensibility attained by people living in a capitalistic consuming culture. It is attitude of setting the commercial image as a model of life, and is the search of individual life in the standardized and uniform life style of the popular culture. Whether they chose to criticize it or saturate themselves in it, the contemporary writers were unavoidably related to this sensibility and life style.

Murray’s law and the bifurcation angle in the arterial micro-circulation system and their application to the design of microfluidics

Lee, Jung Yeop,Lee, Sang Joon Springer-Verlag 2010 MICROFLUIDICS AND NANOFLUIDICS Vol.8 No.1

Numerical Identification of Streptomyces fIaveus Producing Antibiotic Substances Inhibitory to Plant Pathogenic Fungi

Lee, Jung-Yeop,Kim, Beom-Seok,Hwang, Byung-Kook The Korean Society for Microbiology and Biotechnol 1995 Journal of microbiology and biotechnology Vol.5 No.6

The actinomycete strain A 11 was antagonistic to plant pathogenic fungi Phytophthora capsid and Magnaporthe grisea. Based on the diaminopimelic acid (DAP) type and morphological characteristics examined by scanning electron microscopy, the strain A 11 was confirmed to belong to the genus Streptomyces. Based on Willcox probability and similarity level, the strain A 11 was numerically identified as Streptomyces flaveus using TAXON program of Ward and Goodfellow. Antibiotic production of S. flaveus strain A 11 was most favorable when cultured on glycerol yeast extract peptone (GYP) agar for 20 days at $28^{\circ}C$. The crude antibiotics from solid GYP agar cultures of the strain A 11 were most effective against Phytophthora capsici and Sclerotinia sclerotiorum among the fungi tested. Antifungal activity of the antibiotics against Alternaria solani, Botryosphaeria dothidea, Cercospora capsici, Magnaporthe grisea, and Rhizoctonia solani was somewhat high, whereas Colletotrichum gloeosporioides and Fusarium oxysporum f. sp. cucumerinum were rarely inhibited even at high concentrations.

Field Control of Phytophthora Blight of Pepper Plants with Antagonistic Rhizobacteria and DL-β-Amino-n-Butyric Acid

Jung Yeop Lee,Beom Seok Kim,Song Won Lim,Byung Kook Lee,Choong Hoe Kim,Byung Kook Hwang 한국식물병리학회 1999 Plant Pathology Journal Vol.15 No.4

Isolation and antifungal activity of kakuol, a propiophenone derivative from Asarum sieboldii rhizome

Lee, Jung Yeop,Moon, Surk Sik,Hwang, Byung Kook John Wiley Sons, Ltd. 2005 Pest management science Vol.61 No.8

<P>An antifungal substance active against Colletotrichum orbiculare (Berk & Mont) Arx was isolated from the methanol extracts of Asarum sieboldii (Miq) Maek rhizomes. High-resolution MS, NMR and UV spectral data confirmed that the antifungal substance is kakuol, 2-hydroxy-4,5-methylenedioxypropiophenone. Colletotrichum orbiculare was most sensitive to kakuol, with MIC of 10 µg ml<SUP>−1</SUP>. Kakuol also completely inhibited the mycelial growth of Botrytis cinerea Pers ex Fr and Cladosporium cucumerinum Ellis & Arthur at 50 µg ml<SUP>−1</SUP> and 30 µg ml<SUP>−1</SUP>, respectively. However, no antimicrobial activity was found against yeast and bacteria even at 100 µg ml<SUP>−1</SUP>. Kakuol exhibited a protective activity against the development of anthracnose disease on cucumber plants. The control efficacy of kakuol against the anthracnose disease was in general somewhat less than that of the commercial fungicide chlorothalonil. This is the first report to demonstrate in vitro and in vivo antifungal activity of kakuol against C orbiculare infection. Copyright © 2005 Society of Chemical Industry</P>

사립체 DNA의 11778 점돌연변이가 확인된 Leber씨 유전성 시신경병증 1례

이준,이세진,박미영,박승권,하정상,이승엽,정윤석 영남대학교 의과대학 1999 Yeungnam University Journal of Medicine Vol.16 No.1

LHON은 사립체 DNA의 점돌연변이에 의해서 유발되며 11778, 3460, 14484의 세 부위가 주된 사립체 DNA 점돌연변이의 위치로 알려져 있다. 이에 저자들은 점진적인 시력 저하를 호소하면서 사립체 DNA 분석 결과 11778 점돌연변이가 확인된 LHON환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Leber's hereditary optic neuropathy(LHON) is an optic nerve disease that causes blindness and is associated with maternally inherited mitochondrial DNA(mt DNA) mutations. The most common mitochondrial DNA mutation among LHON patients is a point mutation at the nucleotide 11778 in the subunit 4 of complex I. In one 45-year old male LHON patient with bilateral optic neuropathy, we investigated the presence of a point mutation of mitochondrial DNA and identified a single guanine to adenine transition mutation in the mitochondrial DNA at nucleotide point 11778.

Clinical Usefulness of Serial Neutrophil Geletinase-Associated Lipocalin as a Predictor for Aki

( Jung Yeop Lee ),( Seung Yong Park ),( Yeong Hun Choe ),( So Ri Kim ),( Seoung Ju Park ),( Heung Bum Lee ),( Yong Chul Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Background: Plasma neutrophil geletinase-associated lipocalin (NGAL) has been regarded as one of the valuable markers of development of acute kidney injury (AKI) in ICU admitted patients. However, clinical significance of short-term change of plasma NGAL was not clearly investigated. Methods: 50 patients who admitted intensive care unit (ICU) was included by prospective manner. We analyzed plasma NGAL level by Triage immunoassay on ICU admitted time and 12 hours after. Change of estimated glomerular filtration rate (by MDRD equation) and need of renal replacement therapy was investigated. Patients with chronic kidney disease were excluded. Results: Persistent elevation of plasma NGAL above 1,000 ng/mL on 0 and 12 hours was significantly associated with need for early renal replacement therapy. Patient with increased level of NGAL at 12 hours showed unfavorable outcome which is related to renal replacement therapy or progressive renal impairment (13/25; 48% of patients). Conversely, 2/17 (11.8%) of patients had poor renal outcome when NGAL decrease more than 20% from baseline at 12 hours after ICU admission. On multivariate analysis, baseline NGAL and ΔNGAL0-12 hr was independent predictors of unfavorable renal outcome. However, ΔNGAL0-12 hr did not significantly correlated with the change of glomerular filtration rate between day 1 and day3. Conclusions: Our data suggest that measurement of early serum NGAL change may be useful marker in predicting the renal impairment and need for renal replacement therapy in intensive care unit.