노년기 우울성 가성치매 환자군에서의 뇌 단일광자방출 전산화 단층촬영 소견

이동우,이명철,정준기,이동수,곽철은,이재성,조경형,조맹제 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.6

연구 목적 : 우울성 가성치매 환자군의 Tc-HMPAO SPECT영상 소견을 정상 대조군, 인지기능장애가 없는 우울증 환자군 및 알쯔하이머형 치매 환자군과 비교함으로써 노년기 우울성 가성치매의 병태생리의 일부를 알아 보았다. 연구 방법: 9명의 알쯔하이머형 치매 환자군, 7명의 인지기능장애가 없는 우울증 환자군, 7명의 우울성 가성치매 환자군, 4명의 정상대조군을 대상으로 하였다. 우울증 환자군은 DSM-III-R의 우울증의 진단 기준에 의해 진단되었고, 알쯔하이머형 치매 환자군은 DSM-III-R의 진단기준과 NINCDS-ADRDA의 알쯔하이머형 치매의 진단 기준에 의해 진단되었다. 모든 대상자가 해밀턴 우울증 척도 및 MMSE-K에 의해 평가되었다. 모든 대상자에 대해 99m-HMPAO SPECT를 시행하였고, 각 대상군의 영상을 Friston의 통계적 매개변수 지도 방법을 이용, 매 복셀(voxel) 단위로 비교분석하였다. 결과 : 결과는 아래와 같다. 1) 알쯔하이머형 치매 환자군은 대조군에 비해 우측 전두엽, 우측 측두엽, 양측 두정엽에서 유의한 혈류감소 소견을 보였다.(p<0.05). 2) 우울증 환자군은 대조군에 비해 좌측 전두엽에서 유의한 혈류감소 소견을 보였다.(p<0.05). 3) 우울성 가성치매 환자군은 대조군에 비해 우측 측두엽과 좌측 두정엽에서 유의한 혈류감소 소견을 보였다.(p<0.05). 4) 우울성 가성치매 환자군은 우울증 환자군에 비해 우측 측두엽과 양측 두정엽에서 유의한 혈류감소 소견을 보였다.(p<0.05). 결론 : 우울성 가성치매 환자군은 측두-두정엽의 혈류감소 소견을 보였고, 이는 알쯔하이머형 치매와 유사한 소견이었다. 이러한 결과는 우울성 가성치매가 초기의 원발성 치매 환자군을 포함한다는 가설을 지지해준다. 0bjects : Through comparison of the Tc-HMPAO SPECT image ofdepressive pseudo-dementia group with those of control group(depression group free from cognitive impairment)and DAT(Dementia of Alzheimer's type). we tried to see part of pathophysiology of she depressive pseudodementia of the elderly. Methods : The subjects consisted of 9 patients with dementia of Alzheimer type(DAT group),7 patients with depression free from cognitive impairment(depression group),7 patients with depressive pseudodementia(depressive pseudodementia group), and 4 normal controls. De-pression patients were diagnosed according to DSM 111-R DAT patients were diagnosed by DSM 111-R and N1NCDS-ADRDA criteria of DAT. All were rated with Hamilton Rating Scale for Depression and Mini Mental State Exam. All underwent 99m-HMPAO SPECT scan. The images of each group were analysed using SPM of Friston, which compares the images on voxel-by-voxel basis. Results : The results were as follows : 1) DAT group showed significant decrease in cerebral blood flow (CBF) compared with controls in the right frontal region, the right temporal region, and both temporal regions(p<0.05). 2) Depression group showed significant decrease in CBF in the left frontal region(p<0.05). 3) Depressive pseudodementia group showed significant decrease in CBF compared with controls in the right temporal region and the left parietal region(p <0.05). 4) Depressive pseudodementia group showed significant decrease in CBF compared with depression group in the right temporal region and both parietal regions(p<0.05). Conclusion : Depressive pseudodementia group showed decreased CBF in temporo-parietal region, similar to that of the DAT group. This result supports the hypothesis that depressive psuedodementia includes a subgroup of patients with early-stage primary dementia.

[18F]FDG PET을 이용한 강박증 환자에서 뇌 포도당 대사의 이상에 관한 연구

권준수,이동우,이재성,최정임,이동수,정준기,조맹제,이명철,류인균 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 강박증에 대한 기능적 뇌영상 연구들에서 강박증 환자들의 안와전두엽과 미상핵의 대사율 증가 소견이 비교적 일과되게 발표되어 왔으며, 전두-피질하 회로의 이상이라는 이론이 수립되기도 하였다. 그러나 기존의 연구들은 강박증의 유병기간에 따른 구분없이 시행된 연구였고, 영상분석 방법에 있어서도 관심영역 방법을 이용했다는 한계를 지니고 있다. 본 연구의 목적은 첫째, 강박증의 유병기간에 따라 환자군을 구분하여 PET 영상소견을 분석함으로써 유병 기간에 따른 차이가 있는지를 조사하였으며, 둘째, 강바증 환자의 포도당 양전자방출 단층촬영(18-Fluor-deoxyglucose Positron Emission Tomography : FDG-PET) 영상분석에 통계적 매개변수 지도법(Statistical Parametric Mapping : SPM)을 이용함으로써 강박증의 병인기전 및 강박증상과 뇌기능 간의 관계를 명확히 규명하고자 하였다. 방법: 구조적 면담도구(Structured clinical interview for DSM-IV : SCID-IV)를 적용하여 진단된 12명의 강박증 환자들과 10명의 정상 대조군에 대해 FDG-PET을 촬영하여 SPM으로 분석하였다. PET 촬영 전 적어도 4주 동안에는 약물복용을 하지 않은 상태였다. 결과: 1) 환자군과 대조군의 비교 : 강박증 환자군은 대조군에 비해 양측 두정 영역의 대사율이 유의하게 감소되어 있었으며(P<0.01). 대사증가를 보인 영역은 없었다. 강박증의 유병기간이 10년 이상인 만성강박증 환자 4명은 양측 안와전두엽에서 유의한 대사증가 소견을 보였으며(P<0.01), 양측 두정영역에서 유의한 대사감소 소견을 보였다 (P<0.01), 유병기간이 10년 이하인 환자에서는 전체 환자군의 분석에서와 마찬가지로 대조군에 비해 유의한 대사증가 소견을 보인 영역은 없었으며, 양측 두정엽 부위에서 유 의한 대사 감소 소견을 보였다.(P<0.01). 2) 강박증상의 심각도와의 상관관계 분석 : 우측 두정엽의 대사율은 강박장애 척도 점수와 유의한 음의 상관관계를 보였으며(p<0.01), 양측 시상 영역의 대사율은 예일-브라운 강박장애 척도의 강박장애척도 점수와 유의한 양의 상관관계(p<0.01)를 보였다. 결론: 본 연구는 결과는 기존의 연구들에서 보고된 안와전두엽의 대사 증가 소견이 강박증의 만성화로 인해 나타나는 2차적 장애이며, 두정엽의 대사 저하가 보다 1차적인 장애일 가능성을 시사한다. Baxter가 수립한 전두-피질하 회로 이론은 두정엽의 이상을 포함하는 전두-두정엽 복합체 이론으로 확장되어야 할 것이다. Objectives: Functional imaging studies on obsessive-compulsive disorder(OCD) subjects have repeatedly reported increased metabolism in orbitofrontal lobes and caudate nucleus, resulting in the "frontal-subcortical" circuit abnormality theory. Limitations of the previous studies to date include little consideration for the duration of illness, and the use of regions of interest methods, as an image analysis method. Our study objectives are 1) to include the duration of illness as an important study variable, and 2) to use Statistical Parametric Mapping(SPM) method in order to tap relations between the brain function and the psychopathology and symptoms of OCD. Methods: The [18] fluorodeoxyglucose positron emission tomography(FDG-PET) scans of OCD subjects and normal comparison subjects, as diagnosed by the Structured Clinical Interview for DSM-IV(SCID-IV), were analyzed using SPM. Results: 1) Comparison of OCD and control groups : OCD subjects had significantly decreased metabolism in both parietal lobes and didn't have any areas of increased metabolism in comparison to comparison subjects(p.<0.01). four OCD subjects with the illness duration of 10 years or longer, had significantly increased metabolism in both orbitofrontal lobes<p<0.01). OCD subjects whose illness duration is shorter than 10 years didn't have any areas of increased metabolism and had significantly decreased parietal lobe metabolism, as in the analyses of all subjects(p<0.01). 2) Correlation analysis between areas and symptom severity : Metabolism of both thalamic sreas showed significant positive correlation with Yale-Brown Obsessive-Compulsive Scale(Y-BOCS) scores(p<0.01). Metabolism of right parietal area showed significant negative corre lation with Y-BOCS scores(p<0.01). Conclusions: The current findings suggest that the increased metabolism in orbitofrontal lobe, previously rported, may be a secondary phenomenon due to the extended illness dur- ation and that decreased metabolism in the parietal lobes are primary abnormality in OCD subjects. Thus Baxter's fronto-subcortical circuit theory should be extended into "fronto-pari-etal" complex theory, which includes the parietal lobes.

Rhodotorula glutinis KCTC 1209 유래 Phenylalanine ammonia-lyase를 통한 Phenylalanine의 생산

이준우 慶北專門大學 2003 慶北專門大學 論文集 Vol.22 No.-

The aim of this study is to determine the cultural conditions for production of L-phenylalanine through the reverse reaction of L-phenylalanine ammonia-lyase(PAL, EC 4.3.1.5). Phenylalanine is an important essential amino acids and can be used as one of essential raw material for manufacture of a sweetener, such as aspartame. A variety of phenylalanine production methods including the direct fermentation of sugar and enzymatic conversion of trans-cinnamic acid using phenylalanine ammonia-lyase. Rhodotorula glutinis having a phenylalanine ammonia-lyase, and it can be to the production of phenylalanine, In this study, Rhodotorula glutinis KCTC 1209 was aerobically cultured with reciprocal shaker at 30℃ and initial pH 6.2. The formation of PAL reached its maximum at 20~22 hours in medium containing 1% NZ-amine A, 1% tryptone, 0.5% NaCl, 0.1% KH_(2)PO_(4), 0.05% K_(2)HPO_(4), 0.05% MgSO_(4)·7H_(2)O. Whole cell of Rhodotorula glutinis KCTC 1209 were immobilized with sodium alginate. And then, the conversion yield of trans-cinnamic acid to L-phenylalanine by the immobilized cells were about 62%.

강의 수소취화에 대한 국부영역에서의 수소의 거동(Ⅰ) : 지연파괴의 수소집적에 미치는 응력 및 소성변형의 영향

이영호,이진우,배명일,고준빈,이규천 충남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.16 No.1

Hydrogen embrittlement cause decrease of it's mechanical properties during hydrogen dissolved in steels. Many mechanisms of hydrogen concentration researches have done, but it is not clearly known yet. In this study the effect of plastic deformation and external stress on mechanism of hydrogen concentration by high temperature hydro-genation treatment were investigated. The main results are as follow : 1)For short time fracture process, a defect rate of chemical potential energy is an important factor on hydrogen concentration for delayed fracture of steel processed with high temperature hydrogen. 2)For long time fracture process, the important element is long range diffusion of hydrogen due to the rate of effective hydrogen density and plastic deformation. 3)hydrogen concentration as plastic deformation vary in proportion to slope of plastic deformation. 4)Hydrogen concentration due to the effect of external stress, but this effect is limited in short range. 5)External stress is an acceleration element for delayed fracture of steel.

신경회로망과 Classifier를 이용한 부분방전패턴의 인식

李峻昊,李鎭雨 湖西大學校工業技術硏究所 1999 工業技術硏究所論文集 Vol.18 No.-

In this work, two approaches were proposed for the recognition of partial discharge patterns. The first approach was neural network with backpropagation algorithm, and the second approach was angle calculation between two operator vectors. PD signals were detected using three electrode system: IEC(b), needle-plane and CIGRE method Ⅱ electrode system. Both of neural network and angle comparison method showed good recognition performance for the pattern similar to the trained patterns. And the number of operators to be used had a great influence on the recognition performance to the untrained patterns.

만성 B형 간염 환자의 급성 악화 후 발생한 피부 결절 다발동맥염과 류마티스관절염

이주현,김민,이준성,장선희,윤보영,이윤우 인제대학교 2009 仁濟醫學 Vol.30 No.-

Cutaneous polyarteritis nodosa(CPAN) is a rare vascular disorder that affects small and medium-sized arteries in the reticular dermis and subcutaneous tissue. It has been described as a distinct clinical entity with benign and a chronic prolonged course without systemic involvement. Hepatitis B virus-related polyarteritis nodosa (HBV-related PAN) is typical form of classic PAN. Its pathogenesis is not well known, but considered an immune complex-mediated disease. The patients with HBV-related PAN often present with malignant hypertension, orchitis, and vascular nephropathy. But, HBV-related CPAN has been rarely reported. Rheumatoid vasculitis is a complication of rheumatoid arthritis that can be lead to variety of clinically significant skin and systemic conditions, It has been reported before or at the time of rheumatoid arthritis diagnosis but is usually seen an average of 10 to 14 years after arthritis onset. The histological features of cutaneous vasculitis in rheumatoid arthritis overlapped both the characteristics of cutaneous necrotizing venulitis and cutaneous polyarteritis nodosa. But polyarteritis nodosa-like rheumatoid vasculitis has rarely been reported. We report a case of rheumatoid arthritis and cutaneous polyarteritis nodosa in a chronic hepatitis B with acute exacerbation.

온실에서 동양란인 심비디움 재배에 공생균의 효과에 관한 연구

이상선,이준기,이정우,박소영,백기엽 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-

The orchid symbiotic fungus (Tulsanella repens P-01; OSF) was cultured on the soil materials by solid culture and inoculated in the two varieties of GwanUm and SaGae of Cymbidium hybrids with the barks. The two varieties of the oriental orchid were measured after 12 months' cultivation under the conditions of greenhouse; fresh weight, numbers of bulb, and rate of dead bulb for an individual plant. The fresh weight of plants were measured to be different for the individual plant. The fresh weight of plants were measured to be different for the individual plants treated with the OSF or not, depending on the varieties, but the rates of dead bulb were significant, disregarding with the varieties. The roots of the plants treated were observed to be more health and heavier weight than those not treated. The bulbs of the plants not treated were measured to be dead at the rate of 20% for a year's cultivation. The roots of two varieties were also observed by naked eyes and by microscope; Several peletons were observed to be in the root cells in the individual plants treated with OSF, but not in the individual plants treated without the OSF. Further, the pathogenic fungal hyphae were observed to be in the roots under the dead bulbs of both varieties not treated; appessorium or hasutorium on the epidermal cells of root. The inoculation of OSF was speculated to stimulate the growth of plants by absorption of mineral nutrition and defense the invasions of soil pathogenic fungi for the cultivations of Cymbidium hybrids.

천식에서 관련 유전자들 사이의 상호작용과 천식에대한 영향

이준혁,박성우,장안수,박춘식 순천향대학교 의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

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전자식 안정기에 적용 가능한 형광램프의 모델링

이준호,이진우 湖西大學校 工業技術硏究所 2002 工業技術硏究所論文集 Vol.21 No.-

This paper introduces a fluorescent lamp model based on gas discharge phenomena. The fluorescent lamp discharge has been successfully modeled by employing the radial variation of particle density and considering driving circuit effects on the characteristics of discharge process. The electron energy distribution is assumed to have a Maxwellian. The electron mobility and the ambipolar diffusion coefficients are considered to vary with an electron energy rather than a simple uniform value. Energy states of mercury atom in the discharge process are regarded as six levels rather than simple 4 or 5 levels. These discharge processes have been accurately solved by numerically employing mixed the FDM and the 2nd Runge-Kutta method. We applied this model to analyzing real high frequency circuit. Simulation and experimental results were presented to verify the feasibility of the modeling. Simulation and experimental results were presented to verify the feasibility of the modeling.

두경부에서 생긴 림프종에서 EBV와 HTLV-1의 검색

박준식,정효순,권성우,이상숙 경북대학교 병원 2003 경북대학교병원의학연구소논문집 Vol.7 No.1

Background and Objectives : Extranodal non-Hodgkin's lymphoma(NHL) of the head and neck(H&N) accounts for 10-20% of all cases of NHL. Despite their frequency, the cause of these lymphomas is still poorly understood. Recently, the role of viral origin in NHLs, including Epstein-Barr virus(EBV), as the main cause of sinonasal lymphomas of T/NK cell phenotype and HTLV-1 as a cause of acute T-cell lymphoma/leukemia has been well documented. We investigated the clinicopathologic findings, immunophenotypic profile, and status of EBV and HTLV-1 DNA of patients with H&N lymphoma. Materials and Methods : Twenty-seven patients with NHL of H&N region were studied. There were 15 males and 12 females with the median age of 50 years. All patients were reclassified according to the Working formulation(WF) and REAL classification. EBV genome DNA and HTLV-1 RNA were surveyed by PCR assay using formalin-fixed and paraffin-embedded tissue blocks. Results : The tonsil was the most commonly involved site(44.4%) followed by nasal cavity(18.5%), nasopharynx(18.5%) and orbit(7.4%). Immunophenotyping revealed 19 cases of B cell lineage, 7 cases of T cell lineage and one case of null cell type. Most of B-cell lymphomas were diffuse large cell lymphomas(58%). Tonsillar lymphomas were all B-cell origin. Four of the five nasal cavity lymphomas and one nasopharyngeal lymphoma showed an angiocentric T/NK cell phenotype with strong association with EBV. EBV genome was detected in 15 of 26 H&N NHLs(57.7%). Seven of 19 B-cell lymphomas(36.8%) and all T/NK or null cell type lymphomas were positive for EBV DNA. However, there was no HTLV-1 positive cases found. Conclusions : It could be concluded that the high incidence of EBV of angiocentric T/NK-cell lymphomas of the nasal cavity may indicate a probable role of EBV in the development of these lymphomas.