혈액 내 구리, 아연 및 ceruloplasmin 농도에 흡연, 음주 및 신체적 활동이 미치는 영향

홍연표,강은용,신인철,최병선,박정덕,장임원,박진완 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : To investigate the influence of smoking, alcohol ingestion, and physical activity on copper and zinc in RBC and serum and serum ceruloplasmin, this study was performed in a cross-sectional study in 113 healthy men aged 20 to 40 years who had no symptomatic liver, heart, gastrointestinal, and other chronic diseases. Methods : At the men's entry into the study, blood samples were drawn from each subject and immediately centrifuged for analysis of copper, zinc, iron, ceruloplasmin, total cholesterol, and hematocrit. Each man completed a questionnaire that provided information on smoking, amount of alcohol intake, and physical activity. Partial regression analysis was performed on confounding variables such as age, body mass index, hematocrit, serum cholesterol, and serum iron. Results : In general linear models, adjustment for confounding variables did not show statistical differences, and there was only an increasing tendency in serum copper in heavy smoker(P=0.0678). There was no difference between high physical activity with mild smokers and lower physical with heavy smokers. Conclusions : This study suggested that copper, zinc and ceruloplasmin were not good biomarker for early effect by smoking, alcohol intake and physical activity in young adult. However, selection bias should be considered in evaluation of this result, and a large prospective study will be needed in advance on usefulness of copper, zinc and ceruloplasmin as a marker for risk factors and early change of atherosclerosis.

Poster Session : PS 1510 ; Rheumatology : Postoperative Infection Rates after Surgery with Prosthesis in Patients with Ankylosing Spondylitis Treated by TNF Alpha Blockade Compared to Conventional NSAIDs

( Ki Pyo Kim ),( Joon Young Hur ),( Ji Young Choi ),( Ran Song ),( Sang Wan Chung ),( Yeon Ah Lee ),( Seung Jae Hong ),( Hyung In Yang ),( Sang Hoon Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Some patients with severely advanced ankylosing spondylitis (AS) need to replace or correct destructed joints by surgical treatment. Among these patients, some patients who don’trespond sufficiently to conventional NSAIDs have to be treated by anti-TNF alpha blockades. We reviewed these patients to assess postoperative infection rate after surgery with prosthesis. Methods: We retrospectively reviewed the medical records of the patients with AS who experienced the surgery with prosthesis in Kyung Hee university hospital at Gangdong in Seoul, South Korea from Mar 2006 to May 2014. Results: Total 307 patients underwent the surgeries such as total hip replacement (THR) or corrective osteotomy of spine. Among them, 25 patients have been treated by TNF alpha blockades after surgery. 9 patients had been treated by TNF alpha blockade before the surgery. Total follow-up period was 4.3±2.3 years per person. Their average ages for surgeries are 35.6± 10.7 years. Among them, 13 patients had THR and the others had corrective osteotomy in spine. 11 patients have been treated by adalimumab, 9 patients have been treated by etanercept and 5 patients have been treated by in. iximab. There was no wound complication associated with infection after the surgery during follow-up period in the group of patients treated by TNF alpha blockade. But in the group of patients who had been treated by conventional NSAIDs, one patient had wound infection after spine surgery. His age was 62 and he had uncontrolled DM. Conclusions: There is no increased risk of infection after the surgeries using prosthesis in patients with AS treated by TNF alpha blockade compared to the patients treated by conventional NSAIDs.

금강의 수질, 어패류, 이끼 및 토양중의 중금속의 함량 조사

한인전,홍춘표,최용규 공주대학교 사범대학 과학교육연구소 1993 과학교육연구 Vol.24 No.1

This survey is to study the corresponding degree of water pollution of the Kum river areas, covering the eight places of main stream of the river from the Daechung dam to Kangkyung county, and two trivutary streams of Kap stream, and Miho stream. Besides, the heavy metal content of the fishes, shellfish, moss, and soil in the main stream of Kum river is investigated, whose results are as follows: 1. The water quality The water quality of the area from the Daechung dam to the Sintanjin county is first grade for the standard of drinking water in terms of BOD, COD values, that of both Kap stream and Miho stream is third or fourth grade respectively, and the other areas are turned out to be second grade. The water of the Daechung dam to the Sintanjin has little NO₂-N and ??, which can be said to be possible for the drinking water. The quantity of ?? and ?? in the water of all the areas is below the standard for the available drinking water, but, that of Kap stream and Miho stream is about two or three times higher than other areas. 2. Heavy metal The content of Cd, Cu, Mn, and Zn are shown to be comparatively less than that of Co, Fe, Ni, and Pb. And the content of Cu, Mn, Zn are less than the possible standard value for the drinking water. The relationship of the heavy metal content of the fish and shellfish were in order of Co>Zn>Cu>Cd, for the moss, Zn>Pb>Co>Cu>Cd, and for the soil, Zn>Pb>Cu>Co>Cd. The most of collecting samples in the Kumnam area have lots of heavy metals, and Pb is well contained in shells than fishes. When summarize the above result, the water in the Daechung dam and Sintanjin area is comparatively favorable for the drinking water, and the water quality below the Kumnam areas appears to be wores because of influx of Kap stream and Miho stream. In short, the necessary counter measure is to be required for the good preservation of water of fine quality in Kum River.

錦江上流地域에 있어 다슬기科의 分布에 關한 硏究

金鍾煥,崔信錫,宋仁植,洪榮杓 충남대학교 자연과학연구소 1982 忠南科學硏究誌 Vol.9 No.1

The distribution and identification of Semisulcospira species were studied at the 8 stations in the upper streams of Geum River and it's tributatries, and some physicochemical analysis were obtained from all stations. The results are summerized as follows: 1. Four species of Semisulcospira were collected from the 7 stations in the 8 stations, except a station, the Buchang stream. S. coreana was found at all the 7 stations, S. ovulum at the 6 stations, S. globus at the 4 stations, and S. tegulata was found only two stations, but the density of all the snails was generally low in a m^2. 2. Identification of the snail species were based on the external morphology, radula ribbon and central teeth patterns. 3. The chromosome numbers were observed : n = 18 in S. coreana and S. ovulum ; n = 16 in S. globus, however, in S. tegulata the chromosome was not observed. 4. Physicochemical analysis in the aquatic environment were determined from all the 8 stations. The pH, Ca, Mg, SO_4, Na and Cl values in the water varied not widely, but the values of chemical oxidation demand at the 5th station and electric conductivity at the 7th station were higher than those of the another stations.

치약중 불소성분에 관한 연구(Ⅱ) : 치약중 용성불소의 안정성 Stability of Soluble Fluoride in Toothpaste

최상숙,장영경,김인규,윤미옥,손경훈,김필선,이정표,정정자,오원식 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-

치약에 치아우식증 둥을 예방하기 위하여 불소화합물이 많이 첨11되괴 있다. 치약에 주로 사용되는 불소화합물은 불화나트륨(보aF), 일불소인산나트륨(NaBPP03), 불화주석(SHf'B) 및 유기 툴소차합물이 사용되고 있다. 이들 성분은 치약중의 연마제 등 다른 성둘과 결합한 결합형 불소와 결합하지 쟈은 용성불소로 나뉘어 존재하며,생산시에는 대부분 용성불소의 상태로 존재하치만시간이 지남에 따라 결합헝 불소화함물로 바커어 활성을 잃게 되고, 그 정도는 치약중 연마제나 부형제의 종류와 양에 따라 영향을 받게 된다. 본 연구에서는 치약중 용성불소의 안정성에 미치는 연마제 및 첨가제와 포장재의 영향에 관하여 조사하여 그에 따라 simulated product의 처방플 설계하고, 불소화합물인 불화나트륨과 일뿔소인산나트륭, 연마제인 함수이산화규소, 알루미나, 인산일수소칼슘,침깡탄산칼슘 및 인산삶칼슘와 5종을 기본처방으로 한 18종의 치약을 제조하여 라미네이트 튜브와 폴리에칠렌 튜브에 각각 충진하였다. 이 검체를 가지고 제조 직후외 총불소 및 용성불소 함량을 측정하였고, 보관온도에 파른 용성불소 함량의 변화 및 실온 및 40'c서 3개월간 보환 후 파시 총불소 및 용성불쇼의 함량을 측정하여 용성불소의 안정성에 영향을 미치는 요인에 관하여 실험하였다. 정량은 전보에 수재한 이온크로마토그래피와 불소이온측정기에 의한 불화나트륨과 일불소인산나르륨좌 분석법을 이용하였다. 사험한 결과 제조 직후에는 연마제 인산삼칼슘을 사용한 3종의 치약은 모두 용성불소함량이 40%이하로 현저히 저하죄었파.또한, 연마제의 종류와 상관얼이 전반적으로 불화나트륨을 사웅한 처방이 일불소인산나트륨을 사용한 처방보다 용성불소랑이 더 낮게 나타났다. 3개월후의 검체를 시험한 결과 상온에 보관한 검체는 생산 직후의 결과와 크게 다르지 않았고 튜브의 종류에 따른 차이는 나타나지 않았다. 그러나 40'c에서 보관한 검체는용쳐불소의 양이 전반적으로 현저히 감소하였오 감소.정도는 연마제의 종류에 따라 영향을 받는 것으로 나타났으며 튜브의 종류에 따른 차이는 나타나지 않았다. 이상의 결과로 불소치약의 연마제로 인산삼칸습은 T'☞우 부작합하였고, 함수이산화규소 또는 알루미 나는 비교적 양호한 결과를 나타내었다. 튜브의 종류는 용성불소의 안정성에 별 놓향을 미치지 않았으나 40'c에서 3개월간 가속시험할 때 전반적으로 불쇼는 연마제 등 다른 성분과 더욱 강하게 결합하는 것을 알 수 있었다. In fluoride toothpaste, sodium fluoride, sodium monofluorophosBhate or stanBous flue. ride are usually used as fluoride donor. These flouride compounds may react with abrasive agents so thesoluble fluoride ion content and its acitivity are decrf:aaed. In this gtudy, we prepared fluoride toothpasteaccording to simulated formulation with fluoride compound(sodium inonofluorophosphate, sodium flufride), abrasiues(hydrated silica, alumina, dibasic calciunl phosphate, precipitated calcium carbonate,kind of the abrasives, fluoride compounds, pac]fags naaterials and variation of temperatvre. The soluble fluorde ion content was stable when using hydrated silica as abrasive. But, tricalcium phosphate wasnot suitable in fluoride toothpaste as abrasive. The soluble fluoride ion content was decreased as raisiBgtemperature and not influenced by package materials.

비선형 유한요소해석을 이용한 CANDU형 격납건물의 내압취약도 평가

함대기,최인길,이홍표,Hahm, Dae-Gi,Choi, In-Kil,Lee, Hong-Pyo 한국전산구조공학회 2010 한국전산구조공학회논문집 Vol.23 No.4

CANDU형 격납건물에 대하여 극한내압하중에 대한 확률론적 취약도 평가를 수행하였다. 격납건물 성능의 불확실성은 가동중 검사 결과를 통해 얻어진 재료 물성치 중앙값과 텐던 긴장력 중앙값을 적용하여 고려하였다. 격납건물은 개구부를 고려하여 3차원 유한요소로 모델링하였으며, 확률론적 취약도 평가를 위하여 대규모의 비선형 유한요소해석 모델을 적용하기에 적합한 효율적인 취약도 평가기법을 개발하였다. 월성 1호기 격납건물에 대한 물성치를 사용하였다. 개발된 새로운 취약도 평가기법을 도입하여 각각의 파괴모드에 대한 취약도 평가를 수행하였으며, 파괴모드 별, 신뢰도 수준별 취약도 곡선을 도출하였다. 벽체 중단부가 극한내압발생으로 인한 방사능물질 누출에 가장 취약한 것으로 나타났다. In this paper an assessment of the internal pressure fragility of the CANDU type containment buildings is performed. The uncertainties of the performance of the containment buildings, material properties and tendon characteristics are referred from the in-service reports of Wolsung Unit 1. The containment buildings are modeled as a three-dimensional finite elements with considering the major opening and penetrations. A new method to evaluate the probabilistic fragility of the massive structural system is developed. The fragility curves of the target containment building are presented with repect to the failure modes and reliability levels. The center of wall is reveled as the most weak structural component of the containment building in the sense of the rupture and catastrophic rupture failure modes.

비선형 유한요소해석을 이용한 CANDU형 격납건물의 내압취약도 평가

함대기,최인길,이홍표,Hahm, Dae-Gi,Choi, In-Kil,Lee, Hong-Pyo 한국전산구조공학회 2010 전산구조공학 Vol.23 No.4

CANDU형 격납건물에 대하여 극한내압하중에 대한 확률론적 취약도 평가를 수행하였다. 격납건물 성능의 불확실성은 가동중 검사 결과를 통해 얻어진 재료 물성치 중앙값과 텐던 긴장력 중앙값을 적용하여 고려하였다. 격납건물은 개구부를 고려하여 3차원 유한요소로 모델링하였으며, 확률론적 취약도 평가를 위하여 대규모의 비선형 유한요소해석 모델을 적용하기에 적합한 효율적인 취약도 평가기법을 개발하였다. 월성 1호기 격납건물에 대한 물성치를 사용하였다. 개발된 새로운 취약도 평가기법을 도입하여 각각의 파괴모드에 대한 취약도 평가를 수행하였으며, 파괴모드 별, 신뢰도 수준별 취약도 곡선을 도출하였다. 벽체 중단부가 극한내압발생으로 인한 방사능물질 누출에 가장 취약한 것으로 나타났다. In this paper an assessment of the internal pressure fragility of the CANDU type containment buildings is performed. The uncertainties of the performance of the containment buildings, material properties and tendon characteristics are referred from the in-service reports of Wolsung Unit 1. The containment buildings are modeled as a three-dimensional finite elements with considering the major opening and penetrations. A new method to evaluate the probabilistic fragility of the massive structural system is developed. The fragility curves of the target containment building are presented with repect to the failure modes and reliability levels. The center of wall is reveled as the most weak structural component of the containment building in the sense of the rupture and catastrophic rupture failure modes.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

羅末麗初 師子山門의 動向

崔仁杓 효성여자대학교 한국전통문화연구소 1996 韓國傳統文化硏究 Vol.11 No.-

新羅末 禪宗 政策에 대한 一考察

崔仁杓 효성여자대학교 한국전통문화연구소 1994 韓國傳統文化硏究 Vol.9 No.-