가요성 알루미늄피 케이블 (MCIF CABLE)을 적용한 일체형 배선시스템

구경완(KOO Kyung Wan),전인석(CHUN In Suk),문영재(MOON Young Jae),이병용(Lee Byung Yong) 대한전기학회 2007 대한전기학회 학술대회 논문집 Vol.2007 No.4

This paper introduces the IN-FLEX system using aluminum clad flex cable, which is expected to alternate the conventional wiring method, such as, a steel pipe wiring method, and a synthetic resin pipe wiring method. The aluminum clad flex cable has a superior operation characteristics in heat dissipation property, in installation and maintenance facility, flammability, and appearance. Moreover, the IN-FLEX system adopted an easy connection mechanism which enable to reduce the time, hands and expense for the installation and maintenance of the system. Certification tests verifying the superior operation characteristics and reliability of the system using aluminum clad flex cable were carried with standard method in KOLAS certification institute.

니페디핀과 β-시클로덱스트린 유도체류와의 포접복합체 형성 및 고체분산체 함유 마이크로캅셀의 제어방출

전인구,최선애 同德女子大學校 1997 同大論叢 Vol.27 No.1

To overcome poor dissolution property of nifedipine (NFD), which is used in the treatment of ischemic heart disease and hypertension as a calcium antagonist, effects of β-cyclodextrin (β-CyD) derivatives on the solubility of NFD in aqueous buffered solutions were investigated. The aqueous solubility of NFD increased linearly with increase in the concentration of CyDs, showing an A???-type phase solubility diagram. The stability constant of NFD-CyD complexes was in the order of 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) <β-CyD ≪diemthyl-β-cyclodextrin (DM-β-CyD), and the solubilizing ability of the β-CyDs was also in the same order. The dissolution rate of NFD-DM-β-CyD (1 :2 molar ratio) or NFD-β-CyD (1 :2 molar ratio) solid dispersions was much faster than those of NFD-β-CyD physical mixtures and the drug alone. Therefore, solid dispersion system of NFD with β-CyD (1 : 2 molar ratio) was prepared by solvent evaporation and encapsulated with Eudragit RS as the coat at core to wall ratios of 1 : 0.1 and 1:0.3 (w/w) using phase separation method by non-solvent addition. All the Eudragit RS microcapsules of NFD-β-CyD solid dispersion at core to wall ratio of 1:0.1 or 1:0.3 (w/w) were small and uniform. Although dissolution of NFD from Eudragit RS microcapsules was retarded with increasing the ratio of core wall from 1:0.1 to 1:0.3 (w/w), the release rate was sustained in a much higher concentration than those of drug alone and commercial sustained release NFD tablets.

服飾에 있어서 紫色에 對한 一考察 : 古代 中國 服飾을 中心으로

具仁淑,吳春子 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.1

In this paper, we studied on symbolic conceptions and the order of value of colors in the ancient China. In the society of ancient China, there was a value system which the five primary colors being matched to the five elements, were placed at upper positions and the intermidiate colors being formed by the sum of some primary colors were placed at the lower. Purple, as it was called a secondary color, was placed at the lower position but it became to represent divinity with raising the thoughts of the Taoist and with the combination of the meanings of Purple Palace on which TAI-IL of the Taoist, that is, the highest one of gods dwelt. Accordingly, purple became a color of favor and loft in the Lu, the color of the ribbon of the seal(綬) in the era of Han, a color of the trousers and lined clothes at the matial time of the Northern and Southern Dynasties of Wui, Chin and a color of the highest minister's clothes in Su, Dang dynasty. Therefore if the five primary colors are symbolized as colors of the Confucian we can regard purple as a color of the Taoist.

테녹시캄과 β-시콜로멕스트린 간의 고체분산체 형성에 의한 용출 증가

박옥선,전인구 동덕여자대학교 종합약학연구소 2001 동덕약학연구지 Vol.5 No.-

The purpose of this study is to investigate the interaction of tenoxicam with various cyclodextrins (CDs) in the aqueous solution and in solid state, and finally to formulate a tablet with enhanced dissolution rate. CDs used in solubility studies were α-, β- and γ -CD, 2-hydroxypropyl-β-CD (HPCD), sulfobutyl ether-β-CD (SBCD), dimethyl-β-CD (DMCD) and trimethyl-β-CD (TMCD). The effect of CDs on the solubility of tenoxicam was observed. Solid dispersions were prepared with β-CD using solvent evaporation and freeze-drying process and physical mixtures were prepared by trituration in a mortar. The ratios of drug to carrier were 1:1 and 1:2 molar ratio. These solid dispersions were evaluated by differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and dissolution studies. Solid dispersions were also formulated to tablets and then dissolution rates were compared with that of a commercial product. In aqueous solution, complex formation with α- and β-CD gives rise to Bs type solubility phase diagram, and DMCD, TMCD, HPCD and SBCD showed AL type diagrams. The solubility increase of tenoxicam was in the order of SBCD>γ-CD>β-CD>HPCD>DMCD>α-CD>TMCD. The presence of water soluble polymers such as povidone and hydroxypropyl methylcellulose in β-CD solution did not increase the solubility of tenoxicam. DSC and FT-IR studies confirmed the formation of an solid complex of tenoxicam with β-CD. Dissolution of solid dispersion was about 4-fold higher than that of drug alone and about 2-fold higher than that of physical mixture within 10 min at pH 1.2. As the ratio of carrier to drug increased, dissolution rate became faster. The dissolution rate of tenoxicam from the tablets prepared using freeze-dried solid dispersion at 1:2 molar raio was fast; more than 80% was dissolved within 15 min at pH 1.2. All tenoxicam tablets prepared using tenoxicam-β-CD solid dispersions showed more rapid dissolution rates than commercial tablets. Therefore, the solid dispersion technique is an effective method for increasing the dissolution rate of poorly water soluble tenoxicam. β-CD was thought to be a candidate carrier for preparing solid dispersion with tenoxicam.

Coco Chanel의 作品世界와 그 現代的 意味

구인숙,박춘순,백민숙 충남대학교 자연과학연구소 1987 忠南科學硏究誌 Vol.14 No.1

Poiret was the first innovator of the new fashion of the twentieth century. Chanel was the second innovator. It is Chanel who saw positively the great spirit of the twentieth century and showed modern emancipated women how to dress. Chanel conveyed their headiness and independence in her clothes. She thought it would be chic to dress them lie working girls and she made the Garconne look, with its flat-bosomed silhouette bounded by straight lines. This look in fashion was closely related to the cubist movement in art popular at that time. Chanel expressed the casual simplicity, comfortness, function in her clothes and Chanel style had the smart, understated(Deluxe poor look), easy-to-wear looks. Chanel wanted to dress all women and had great understanding of the value of publicity as a fashion force. With Chanel-designed clothes, the wholesale apparel business therived. Her simplified clothes lent themselves to mass production as the elaborate creations before her could not do.

紳士服의 成立過程에 관한 歷史的 考察

朴春順,具仁淑 충남대학교 자연과학연구소 1986 忠南科學硏究誌 Vol.13 No.2

Modern gentleman garments, suits were originated in 18th century. At that time men's suits were tinged with the inclination of women's dress, and they were at the zenith of splendor in golden days of Rococo style. After that time suits had been sloughed off the inclination of women's costume, and the practical use of costume were emphasized more and more. Incidentally, they were increasingly simple and plain because of the influence of English costume. The mode of suits similar to modern jackets were appeard in the mid-nineteenth century. Suits were gradually refined and became the so-called modern jackets. The mode of modern jackets however, was not changed for nearly ten years. In other words its mode was constantly popular for nearly one hundred years, although its mode was partially changed. In this paper an attempt was made to examine the establishing process of suits from 18th century of mid-twentieth century. In addition, the process which became the formal dress was also examined.

인플렉스 시스템의 신뢰성 평가

정순원(Soon-Won Jung),김향곤(Hyang-Kon Kim),전인석(In-Suk Chun),구경완(Kyung-Wan Koo) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.9

中世 BYZANTINE의 織物

吳春子,具仁叔 충남대학교 자연과학연구소 1982 忠南科學硏究誌 Vol.9 No.2

Les tissu d'art sont represente´s les collections par des pie`ces de genres tre`s differents. On range sous cette denomination les e´toffes decore´es par le itssage, par l'impression a` la planche ou par la pienture, les broderips, les dentelles, les tapisseries et les tapis. Un des caracte´res les plus frappants de l'art byzantin, c'est qu'il s'est inspire´ de la tradition greco-romaine et de la tradition orientale. Quand le triomphe de l'eglise fut assure par la protection impe´riale, les formes exte´rieures de l'iconographie chre´tienne se rapproche´rent tressensiblement des mode´les venus de la Gre´te´ constriuite du pagnisme et celle des vieilles mythologies asiatiques. L'influence greco-romaine, celle de la Parse, de l'Egypte et de la Syrie, celle de le´gendes chre´tiennes et des dogmes religieux se retrouverant dans le de´cor des tissus fabrique´s par les ateliers byzantins.

효소 억재제에 의한 토끼의 점막 추출액중 로이신엔케팔린 및【D-알라2】-로이신엔케팔린아미드의 분해 억제

전인구,박인숙,현진 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.3

To inhibit the enzymatic degradation of leucine enkephalin (Leu-Enk) and its synthetic analog, (D-ala²]-leucine enkephalinamide (YAGFL), in the nasal, rectal and vaginal mucosal and serosal extracts of rabbits, effects of enzyme inhibitors such as amastatin (AM), puromycin (PM), thiorphan (TP), thimerosal (TM), EDTA, N-carboxymethyl-Phe-Leu (CPL), phenylethyl alcohol (PEA), phenylmercuric acetate (PMA), benzalkonium chloride (BC) and modified cyclodextrins, alone or in combination, were observed by assaying the pentapeptides staying intact during incubation. Mucosa extracts were prepared by exposing freshly-excised mucosal specimens mounted on Valia-Chien cells to isotonic phosphate buffer while stirring. The degradation of Leu-Enk and YAGFL followed the apparent first-order kinetics. The half-lives (mean) in the nasal, rectal and vaginal mucosal extracts were found to be 1.07, 0.33 and 1.14 hr for Leu-Enk, and 16.9, 6.2 and 6.8 hr for YAGFL, respectively. AM or PM, which is an aminopeptidase inhibitor, did not show a sufficient inhibition of Leu-Enk (50 ㎍/㎖) degradation in all kinds of extracts. Dimethyl-β-cyclodextrin (DM-β-CyD) decreased the degradation rate constants of Leu-Enk about 2 or 3 times, comparing with no additive. However, the use of mixed inhibitors of AM (50 μM)/TM (0.25 mM)/EDTA (5 mM) resulted in a full stabilization of Leu-Enk by decreasing the degradation rate constants 67.3, 161.3 and 113.8 times for the nasal, rectal and vaginal mucosal extracts, respectively, comparing with no inhibitor. With mixed inhibitors. Leu-Enk remained intact more than 90% after 6 hr-incubation. In the stabilization of YAGFL. AM, TP or CPL alone showed little effect, and some additives demonstrated a considerable inhibition of YAGFL degradation in the rank order of TM > BC > EDTA. However, the addition of mixed inhibitors such as TM (0.5 mM) and EDTA (5 mM) into the extracts protected YAGFL from the degradation by more than 85% even after 24 hr-incubation, suggesting almost complete inhibition of YAGFL degradation in the extract. On the other hand. DM-β-CyD or hydroxypropyl-β-cyclodextrin (10%) were also found to retard enzymatic degradation rates of YAGFL markedly, and resulted in staying intact more than 80% of YAGFL in the nasal and vaginal mucosal extracts, and more than 60% in the rectal mucosal extract after 16 hr-incubation.

Changes in the expression of DNA-binding/differentiation protein inhibitors in neurons and glial cells of the gerbil hippocampus following transient global cerebral ischemia

LEE, JAE-CHUL,CHEN, BAI HUI,CHO, JEONG-HWI,KIM, IN HYE,AHN, JI HYEON,PARK, JOON HA,TAE, HYUN-JIN,CHO, GEUM-SIL,YAN, BING CHUN,KIM, DAE WON,HWANG, IN KOO,PARK, JINSEU,LEE, YUN LYUL,CHOI, SOO YOUNG,WON, SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.11 No.4

<P>Inhibitors of DNA-binding/differentiation (ID) proteins bind to basic helix-loop-helix (bHLH) transcription factors, including those that regulate differentiation and cell-cycle progression during development, and regulate gene transcription. However, little is known about the role of ID proteins in the brain under transient cerebral ischemic conditions. In the present study, we examined the effects of ischemia-reperfusion (I-R) injury on the immunoreactivity and protein levels of IDs 1–4 in the gerbil hippocampus proper <I>Cornu Ammonis</I> regions CA1–3 following 5 min of transient cerebral ischemia. Strong ID1 immunoreactivity was detected in the nuclei of pyramidal neurons in the hippocampal CA1–3 regions; immunoreactivity was significantly changed following I-R in the CA1 region, but not in the CA2/3 region. Five days following I-R, ID1 immunoreactivity was not detected in the CA1 pyramidal neurons. ID1 immunoreactivity was detected only in GABAergic interneurons in the ischemic CA1 region. Weak ID4 immunoreactivity was detected in non-pyramidal cells, and immunoreactivity was again only changed in the ischemic CA1 region. Five days following I-R, strong ID4 immunoreactivity was detected in non-pyramidal cells, which were identified as microglia, and not astrocytes, in the ischemic CA1 region. Furthermore, changes in the protein levels of ID1 and ID4 in the ischemic CA1 region studied by western blot were consistent with patterns of immunoreactivity. In summary, these results indicate that immunoreactivity and protein levels of ID1 and ID4 are distinctively altered following transient cerebral ischemia only in the CA1 region, and that the changes in ID1 and ID4 expression may relate to the ischemia-induced delayed neuronal death.</P>