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도파민 수용체 제 2 형 Exon 8 유전자 다형성과 알코올 의존의 임상 양상
이소희(So Hee Lee),이분희(Bun-Hee Lee),이준석(Jun-Seok Lee),채영규(Young Gyu Chai),최미란(Mi Ran Choi),한달무리(Dal Mu Ri Han),지 홍(Hong Ji),장경호(Gyeong-Ho Jang),신혜은(Hye Eun Shin),최인근(Ihn Geun Choi) 한국중독정신의학회 2013 중독정신의학 Vol.17 No.1
Objectives : Various single nucleotide polymorphisms (SNPs) of dopamine D2 receptor (DRD2) genes have been reported to be involved in the susceptibility to alcohol dependence. We investigated the association of exon 8 (E8) SNP in the DRD2 gene with alcohol dependence in Korean subjects and examined their associations with severities of depression, craving, and alcohol-withdrawal symptoms. Methods : The DRD2 E8 A/G polymorphisms were genotyped in a case-control sample consisting of 245 alcohol-dependent (AD) patients and 130 healthy controls (HC). Severities of de-pression, craving, and alcohol-withdrawal symptoms were examined with BDI, PACS, and CIWA-Ar in AD patients. Results : The genotype or allele frequencies of DRD2 E8 A/G had no significant differences between AD and HC groups (χ 2 = 2.659, p=0.265; χ 2 =2.694, p=0.107). AD with A/A genotype and A allele in E8 had significantly higher BDI scores (F=3.705, p=0.029; t=2.073, p=0.040), although there were no significant differences in PACS and CIWA-Ar scores among genotypes or alleles of E8 A/G. Conclusion : The present study suggests the possibility that DRD2 E8 polymorphisms have an impact on the AD phenotype, such as an increased depressiveness in Korean patients with alcohol dependence.
Lingans from Korean Red Ginseng
Huh, Bong-Hee,Lee, Ihn-Ran,Han, Byung-Hoon The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.3
Two lingans were isolated from hexane-soluble fraction of Korean red ginseng. Their chemical structures were elucidated as gomisin N and gomisin A by spectrometric analysis.
Lignan Components from Panax ginseng C.A. Meyer
Han, Byung Hoon,Huh, Bong Hee,Lee, Ihn Ran 梨花女子大學校 藥學硏究所 1991 藥學硏究論文集 Vol.- No.1
Two lignanes, Comp.-Ⅰ, mp 108-10℃ and Comp.-Ⅱ, mp 50-52℃ were isolated from Korean ginseng extract by repeated column chromatographic purification. Comp.-Ⅰ was identified as gomisin-N and Comp.-Ⅱ as gomisin A by spectrometric analysis, both of which have already been described as the anti-hepatotoxic lignan components of Schizandra chinensis Bail.
A Novel Cycloartane Glycoside from Thalictrum uchiyamai
Choi, Young-Hee,Kim, Nan Gyeong,Lee, Ihn Ran 梨花女子大學校 藥學硏究所 1997 藥學硏究論文集 Vol.- No.6
A new cycloartane glycoside (1) was isolated from the aerial part of Thalictrum uchiyamai Nakai (Ranunculaceae). On the basis of chemical and physicochemical evidence, the aglycone structure of this compound was characterized as 16,25-dihydroxy-3,24-diacetoxy-9,19-cycloartane-29-oic acid, a new derivative of cycloartane triterpene. Also, the oli-gosaccharide moiety of this glycoside were determined as 29-O-α-L-rhanmnopyranosyl-(1→2)-[β-D-xylofuranosyl-(1→6)]-β-D-glucopyranose by application of HMBC technique. Consequently, the structure of compound 1 was elucidated as 29-O-α-L-rhanmnopyranosyl-(1→2)-[β-D-xylofuranosyl-(1→6)]-β-D-glucopyranosyl-16,25-dihydroxy-3,24-diacetoxy-9,19-cycloartane-29-oic acid ester.
A Novel Cycloartane Glycoside from Thalictrum uchiyamai
Choi, Young-Hee,Kim, Nan-Gyeong,Lee, Ihn-Ran The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.5
A new cycloartane glycoside (1) was isolated from the aerial part of Thalictrum uchiyamai Nakai (Ranunculaceae). On the basis of chemical and physicochemical evidence, the aglycone structure of this compound was characterized as 116, 25-dihydroxy-3, 24-diacetoxy-9, 19-cycloartane-29-oic acid, a new derivative of cycloartane triterpene. Also the oli-gosaccharide moiety of this glycoside were determined as 29-O-${alpha}$-L-rhanmnopyranosyl- ($1rightarrow2$)-[${beta}$-D-xylofuranosyl-($1rightarrow6$)-${beta}$-D-glucopyranose by application of HMBC technoque. Consequently, the structure of compound 1 was elucidated as 29-O-${alpha}$-L-rhanmnopyranosy-($1rightarrow2$)-[${beta}$-D-xylofuranosyl-($1rightarrow6$)-${beta}$-D-glucopyranosyl-16, 25-dihydroxy-3, 24-diacetoxy-9, 19-cycloartane-29-oic acid ester.
Lignan Components from Panax ginseng C.A. Meyer
Han, Byung-Hoon,Huh, Bong-Hee,Lee, Ihn-Ran The Korean Society of Ginseng 1990 Journal of Ginseng Research Vol.14 No.2
Two lignanes, Comp.-I, mp 108-1$0^{\circ}C$ and Comp.-II 50-52$^{\circ}$were isolated from Korea ginseng extract by repeated column chromatographic purification. Comp.-I was identified as gomisin-N and Comp.-II as gomisin-A by spectrometric analysis, both of which have already been described as the anti-hepatotoxic lignan components of Schizandra chinesis Bail.
한정미,이인란,신국현,Han, Jung-Mee,Lee, Ihn-Ran,Shin, Kuk-Hyun 한국생약학회 1996 생약학회지 Vol.27 No.4
The ether soluble fraction of the roots of Angelicae gigantis Radix caused a significant prolongation of hexobarbital(HB) induced sleeping time in mice. Through systematic fractionation of the ether fraction monitored by bioassays, two pyranocoumarins, decursinol angelate and decursin were isolated as active principles. Decursin, as a main component, exhibited significant prolongation of HB-induced hypnosis as well as significant inhibition of hepatic microsomal drug metabolizing enzyme(DME) activities at relatively high dose which indicated that it is a weak DME inhibitor.
흰쥐 C6 신경교종 세포에서 Venlafaxine 그리고 Dexamethasone 처리가 열충격 단백질 70의 발현에 미치는 영향
유재학,이준석,양병환,최미란,채영규,김석현,노성원,오동열,최인근,Yu, Jae-Hak,Lee, Jun-Seok,Yang, Byung-Hwan,Choi, Mi-Ran,Chai, Young-Gyu,Kim, Seok-Hyeon,Roh, Sung-Won,Oh, Dong-Yul,Choi, Ihn-Geun 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2
Object:The intracellular action of the antidepressant, venlafaxine, was studied in C6-gliomas using heat shock protein 70(HSP70) immunocytochemistry and HSP70 Western blots because HSP70 is associated with stress and depression. Methods:To examine how the glucocorticoid affects the expression of HSP70 in nerve cells, the rat C6 glioma cell was treated with dexamethasone for 6 hours. In addition, venlafaxine was administered to the experimental groups of C6 glioma cells for 1, 6, 24, and 72 hours each, after which the expression of HSP70 was investigated. Finally, venlafaxine and dexamethasone were simultaneously administered to the experimental groups for 1, 6, 24, and 72 hours, followed by an investigation of the expression of HSP70. Results:The short term(1 hour) venlafaxine treatment significantly increased the level of HSP70 expression. The short term treatment of venlafaxine with dexamethasone also increased the level of HSP70 expression but this reduction was not statistically significant. The long term(72 hours) venlafaxine with dexamethasone treatment significantly reduced the level of HSP70 expression. The long term treatment of venlafaxine also reduced the level of HSP70 expression but this reduction was not statistically significant. Dexamethasone(10uM, 6hours) did not affect the level of HSP70 expression compared with controls. Conclusion:Venlafaxine increases the expression of HSP70 at short term treatment, but prolonged treatment with dexamethasone suppresses the expression of HSP70.