조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

동강의 어류상과 생태학적 군집분석

최준길 ( Jun Kil Choi ),오사무미타무라 ( Osamu Mitamura ),이동준 ( Dong Jun Lee ),신현선 ( Hyun Seon Shin ) 한국환경생태학회 2008 한국환경생태학회지 Vol.22 No.6

2006년 5월부터 2007년 5월까지 동강의 어류상과 생태학적 군집분석을 조사한 결과는 다음과 같다. 조사된 어종은 총 10과 31종이었다. 총 31종의 어종 중 일차담수어가 26종, 주연성 담수어가 5종으로 나타나 일차담수어의 구성비가 매우 높았다. 우점종은 참갈겨니(Zacco koreanus) 55.73%, 아우점종은 쉬리(Coreoleuciscus splendidus) 7.15%였으며, 우세종은 배가시리(Microphysogobio longidorsalis) 6.12%, 어름치(Hemibarbus mylodon) 4.87%, 참종개(Iksookimia koreensis) 4.49% 등이었다. 한국고유종은 묵납자루(Acheilognathus signifer), 줄납자루(A. yamatsutae), 가는돌고기(Pseudopungtungia tenuicorpus), 쉬리(C. splendidus), 긴몰개(Squalidus gracilis majimae) 그리고 어름치(H. mylodon) 등 19종(61.29%)으로 고유종의 빈도가 매우 높았으며, 천연기념물이 1종, 환경부지정 멸종위기 야생동물 II급 종이 5종으로 각각 확인되었다. 예상되는 종수(기대종)의 분석 결과, 동강의 전 조사지점에서는 18(지점 4, 5)∼22종(지점 3)이 서식하고 있을 것으로 나타났으며, 유사도 분석은 62.28%(지점 1과 2)∼84.13%(지점 1과 5)의 범위로 나타났다. 따라서 동강유역은 어류가 서식하기에 매우 적합한 수환경을 유지하고 있으며, 각 조사지점별 수환경도 매우 유사한 것으로 판단된다. The ichthyofauna and ecological community analysis in the Dong River, Korea, were investigated from May, 2006 to May, 2007. During the surveyed period, 31 species belonging 9 families were collected. Total of 31 species(primary freshwater: 26 species, peripheral freshwater: 5 species) were found with the primary freshwater fishes being highest. Dominant species was Zacco koreanus(55.73%), and subdominant species was Coreoleuciscus splendidus(7.15%). Also, Microphysogobio longidorsalis (6.12%), Hemibarbus mylodon(4.87%), Iksookimia koreensis(4.49%) were numerous. There were 19 Korean endemic species(61.29%), including Acheilognathus signifer, A. yamatsutae, Pseudopungtungia tenuicorpus, C. splendidus, Squalidus gracilis majimae, H. mylodon. Among them, 1 species was identified as qualifying for possible desigantion as a natural monument catergory, and 5 species were identified for designation required to protect under a wildlife category. As result of expected number of species according to rarefaction curve, the expected species of the Dong-river ranged from 19(St. 4, 5) to 22(St. 3) and result of similarity analysis ranged from 62.28%(St. 1 and 2) to 84.13%(St. 1 and 5). In conclusions, we could define that the Dong-river has a very good water conditions as habitat of fish, and habitat conditions also are very similar in every survey sites.

韓國河川의 流出率과 流出指標로서의 洪水直前 流量

金熙鍾,柳又秀,金佳鉉,申東守,韓健模,全裕燦 東亞大學校 大學院 1984 大學院論文集 Vol.9 No.-

This paper is a study on relation between run-off ratio and antecedent discharge, run-off ratio and antecedent discharge per unit area, antecedent discharge and antecedent precipitation, by the data from the five major river basins in Korea and the small river basins in Pusan. The Nak-Dong rivers(An-Dong upper stream) f=0.4780+0.0124 ln qA r=0.99 qA=0.3368e0.1101R r=0.99 f=0.5793+0.0146 ln(qA/A) r=0.99 The Nak-Dong rivers except Ga-song station f=0.2017-0.0840 ln qA r=0.75 f=0.7012+0.0750 ln(aA/A) r=0.71 The Han rivers f=-0.0035+01267 on qA r=0.75 f=1.1311+0.1263 ln(qA/A) r=0.71 L=302.9064-43.8490 ln qA r=0.84 The Geun rivers(Mu-sin Cheon) f=0.295+0.1823 ln qA r=0.93 f=0.8417+0.1823 ln(qA/A) r=0.93 L=40.0456+62.0346 ln qA r=0.94 The Yeong-san rivers f=0.3766+0.0598 ln qA r=0.79 f=0.8084+0.0599 ln(qA/A) r=0.79 The Seom-jin rivers f=-1.3875+0.6505 ln qA r=0.92 f=2.1633+0.3465 ln(qA/A) r=0.76 Small river basin in Pusan f=0.3635+0.1120 ln qA r=0.87

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

하수 방류수 살균소독을 위한 무전극 UV Lamp의 개발

신동호,이규현,이용택 한국공업화학회 2003 응용화학 Vol.7 No.2

하수방류수 살균소독에 이용되는 UV 램프를 기존의 전극용보다 효율을 높이고 수명이 긴 무전극 UV 램프를 제작하고 그 성능을 알아보았다. 우선 활성물질을 변화시키면서 제조한 램프의 UV강도 및 온도의 변화를 살펴보았다. 그 결과 활성물질이 Hg/Ind의 무게비 95/5로 만든 램프를 250분간 운전한 결과 UV 강도 300 mW/㎤ 및 표면온도 200-250 ℃로 가장 안정적인 결과를 가져왔다. 그러나 무전극 램프를 장시간 발광시켰을 경우 램프의 표면온도가 상승하기 때문에 실제 하수처리공정에 사용하기 위하여 냉각이 가능한 이중관 형태로 제작하여 UV강도와 온도 변화특성도 알아보았다. 또한 제작된 무전극 UV lamp를 하수 방류수의 살균소독을 위하여 대장균(E-coli.)으로 실험한 결과 99.9% 이상의 살균효율을 보였다.

용매추출에 의한 2-propanol회수에 관한 연구

신현심,정상훈,박동원 東亞大學校 海洋資源硏究所 1994 硏究論文集 Vol.7 No.2

The experimental binodal curve and tie line data were determined for ternary systems of 2-propanol-water with isoamylacetate and 1-butanol as solvents at 25℃. Consistency of the experimental data for several correlations was investigated, the experimental tie line data were correlated with NRTL model and the parameters in NRTL model were estimated and the calculated values of tie lines were predicted.

콘택트렌즈 소독제 및 PHMB의 3종 가시아메바 포낭에 대한 살충능력 평가

신종원,유학선,공현희,정동일 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 국내에 시판되고 있는 콘택트렌즈 보존 및 소독액, 그리고 아메바성 각막염의 치료제로서 인정받고 있는 polyhexamethylene biguanide (PHMB)의 가시아메바 포낭에 대한 살충효과를 평가하고자 한다. 대상 및 방법 : 카스텔라니가시아메바 Ma주, 대식가시아메바 Nagington주 및 담수가시아메바 KA/LI주에 대한 소독액의 살충효과의 평가는 한천 plate위에서 수행하였고, 최저살충농도(minimal cysticidal concentration : MCC)의 결정은 microplate를 이용하였다. 7일간 관찰 후, 탈낭하지 않는 가시아메바 포낭은 사멸한 것으로 판정하였다. Chlorhexidine 및 PHMB의 MCC를 결정하기 위해 8시간 및 48시간 처리 실험을 분리하여 시행하였다. 결과 : 시판 소독액 중 chlorhexidine과 thimerosal를 함유하는 용액 C만이 가시아메바 포낭에 대한 살충효과가 있었고, 나머지 3종의 소독액은 살충효과가 없었다. 0.02% PHMB로 4시간 이상 처리한 가시아메바 포낭은 충주에 관계없이 사멸되었다. Chlorhexidine 과 PHMB, 두 약제 모두 8시간 처리 MCC가 48시간 처리 MCC보다 다소 높았다. PHMB에 대한 감수성은 가시아메바 충주에 따라 차이가 격심하였다. 결론 : 3종 가시아메바 포낭에 대한 PHMB의 MCC (0.29∼9.38㎍/㎖)가 chlorhexidine의 그것(2.73∼18.75㎍/㎖)보다 낮아 PHMB는 아메바성 각막염의 치료제 및 콘택트렌즈 소독제로 사용 될 수 있을 것으로 사료되며 화학소독액에 PHMB를 10㎍/㎖ 첨가하는 것이 요망된다. In order to evaluate the cysticidal effects of contact lens disinfectants and polyhexamethylene biguanide(PHMB) against 3 clinical isolates of Acanthamoeba. in vitro cysticidal assay was performed on agar plates covered with heat-inactivated Escherichia coli. Three clinical isolates of Acanthamoeba were A. castellanii Ma strain. A. polyphaga Nagington strain, and A. lugdunensis KA/LI strain. After treatment of Acanthamoeba cysts with the disinfectants or PHMB, the cysts were cultivated for 7 or more days. Cysts which were not excysted in 7 days after treatment were recognized killed. Among commercial disinfectants, the solution C. which contains chlorhexidine and thimerosal. was the only one with cysticidal effects on Acanthamoeba cysts. PHMB of 0.02% concentration was also cysticidal. Sensitivity to PHMB varied profoundly from isolate to isolate. Minimal cysticidal concentration (MCC) of chorhexidine and PHMB were determined by cultivation of cysts treated for 8 or 48 hours with serially diluted chlorhexidine and PHMB in wells of a 96-well microplate containing axenic culture media for amoebae. MCC of 48-hour treatment with both chemicals was lower than that of 8-hour treatment. MCC of PHMB against amoebic cysts was lower than that of chlorhexidine. In the light of these results. PHMB could be a contact lens disinfectant as well as a chemotherapeutic agent of amoebic keratitis.

순열 및 구개열 환자의 외과적 치료방법에 관한 임상적 연구

신병철,이동근,성길현 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

In order to find the distribution, causes and treatments of cleft lip and/or palate, I analyzed 113 patients of cleft lip and/or palate who were treated in the Department of Oral and Maxillofacial Surgery, School of Dentistry, Wonkwang University, Iksan, Chunbuk, KOREA from September 1984 to August 1995. The obtained results were as follows. 1. In total 113 patients of cleft lip and/or palate, male patients were 63 cases (56%) and female patients were 50 cases(44%). 2. In distribution of cleft lip and/or palate, cleft lip patients were 30 cases (27%), cleft palate patient were 23 cases(20%) and cleft lip and palate patients were 60 cases(53%). 3. Unilateral cleft lip patients (78 cases: 87%) were larger than bilateral cleft lip. In unilateral cleft lip patients, lip side cleft lip patients (54 cases: 50%) were larger than right side cleft lip patients (33 cases: 37%). 4. Possible causes of cleft lip and/or palate were related with familial tendency, drug intoxication, malnutrition, old maternal age, stress and hypoxia during 4-8 weeks of pregnancy period. 5. The favorite treated method of cleft lip was Millard rotation-advancement method. probably the most popular operated period was 3 months. 6. The useful operating technique of cleft palate was Wardill V-Y flap method. The most popular period has been 18 to 24 months. 7. In 11 patients with velopharyngeal insufficiency, hypernasality decreased by superior based pharyngeal flap pharyngoplasty. 8. Cleft alveolus was treated with autogenous and allogeneic bone graft. The most appropriate operation period was 9 to 11 years.

하수방류수의 자외선 살균을 위한 설계인자 최적화에 관한 연구

신동호,김진현,김정민,고승민,모효원,이용택 한국공업화학회 2004 응용화학 Vol.8 No.2

로봇 매니퓰레이터의 시각구동제어

신행봉,정동연,한성현 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-

The equipment of industrial robot in manufacturing and assembly lines has rapidly increased. In order to achieve high productivity and flexibility, it becomes very important to develop the visual feedback control system with Off-Line Programming System(OLPS). We can save much efforts and time in adjusting robots to newly defined workcells by using OLPS. A proposed visual calibration scheme is based on position-based visual feedback. The calibration program firstly generates predicted images of objects in an assumed end-effector position. The process to generate predicted images consists of projection to screen-coordinates, visible range test, and construction of simple silhouette figures. Then, camera images acquired are compared with predicted ones for updating position and orientation data. Computation of error is very simple because the scheme is based on perspective projection, which can be also expanded to experimental results. Computation time can be extremely reduced because the proposed method does not require the precise calculation of tree-dimensional object data and image Jacobian.