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급성 췌장염의 원인 감별 및 병의 중증도 평가에서 Lipase / Amylase비의 유용성
이상우,이성준,이홍식,김승주,김창덕,진윤태,최재현,엄순호,류호상,전훈재,송치욱,김광희,현진해,박흥진 대한소화기학회 1998 대한소화기학회지 Vol.31 No.3
Background/Aims: The usefulness of serum pancreatic enzyme deterrninations in the diagnosis of acute pancreatitis is well established. There are differences between clinical course and outcome due to the underlying etiological factors in acute pancreatitis. In this study we assess the ability of the serurn lipase/amylase ratio to differentiate the etiologies and to predict the severity of it. Methods: We evaluated retrospectively the records of 104 patients (M:64, F:40) with acute pancreatitis. The diagnosis of acute pancreatitis was based on the typical symptoms, signs, pancreatic enzyme elevation and radiological findings. Ranson, Glasgow and APACHE II at admission were used for grading of clinical severity. The patients were classified into four etiologic groups: alcohol, gallstone, idiopathic and others. Results: The ratio of underlying cause of acute pancreatitis were as follows: alcohol, 35.6%; gallstone, 27.9%; idiopathic, 22.1%; others, 14.4%. There were no differences in the serum amylase, lipase and lipase/amylase ratio among the etiological groups. The clinical severities of pancreatitis according to the Ranson, Glasgow and APACHE II were not related with the lipase/amylase ratio in pancreatitis. Conclusions: Evaluation of serum lipase/amylase ratio is not useful for assessing etiology and severity of acute pancreatitis.
이상우,이성준,이홍식,김창덕,진윤태,최재현,엄순호,류호상,전훈재,송치욱,현진해,김광희,박흥진 대한소화기학회 1998 대한소화기학회지 Vol.31 No.4
Background/Aims: The clinical severity of gallstone pancreatitis is known to be more intense than that of alcoholic pancreatitis. However, it is still controversial whether the etiology is risk factors for the pronosis of acute pancreatitis (AP). This study was designed to elucidate the role of etiological factors on the prognosis and severity in AP. Methods: We have retrospectively evaluated 216 patients (M:137, F:79) with AP during recent 6 years. The diagnosis of AP was based on the typical symptoms and signs, enzyme elevation and radiologic findings. Acute physiology and chronic health evaluation (APACHE II) and Ranson score at admission were used for grading the severity. Etiological groups were subdivided into alcohol, gallstone, idiopathic and others. Results: The causes of AP were alcohol (32.4%), gallstone (26.9%), idiopathic (23.1%) and others (17.6%). The clinical severity was not different between alcohol and gallstone pancreatitis. The mortality rate was 10% in patients with alcoholic pancreatitis, but no death was seen in patients with gallstone pancreatitis. Conclusions: The alcoholic pancreatitis was not severe than the gallstone pancreatitis in clinical severity, but the complication and mortality of the alcoholic pancreatitis were higher than those of the gallstone pancreatitis. The prognosis and mortality were influenced by etiological factors in AP.
Cardiac Sarcoidosis Presenting as a Sudden Complete Atrioventricular Block
( Soo Han Woo ),( Yong Chul Lee ),( So Ri Kim ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Sarcoidosis is a multisystem granulomatous disorder with unknown etiology that can affect any organ system. A cardiac involvement is one of the least common manifestations among them. Myocardial sarcoidosis can lead to death. Clinical signs of cardiac involvement can be the first presentation of systemic sarcoidosis. In young or middle-aged patients presenting with conduction abnormalities cardiac sarcoidosis should always be included in the differential diagnosis. In our present case, the cardiac symptom such as arrhythmia was preceded before diagnosing the involvement of the lung or other organs. The other symptoms such as weakness, uveitis, or anemia were not observed except arrhythmia. Here, we report a 51-year old male patient with complete atrioventricular block and pacemaker implantation due to cardiac sarcoidosis, which was unsuccessfully diagnosed.
Recurrent thrombosis after endovascular treatment for malignant superior vena cava syndrome
( Sang Ho Lee ),( Sun Young Kim ),( Heung Tae Kim ),( Chang Woo Shim ),( Ho Seok Chi ),( Hye In Lee ),( Do Il Choi ),( Hyun Bum Kim ),( In Jun Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Endovascular treatment (EVT) including angioplasty and stenting is an effective treatment for superior vena cava (SVC) syndrome. Recurrence of SVC syndrome is mainly caused by tumor progression and occurs in around 20% after EVT, but sometimes venous thrombosis within stent accounts for recurrence of SVC syndrome. Anticoagulation after EVT is still a controversial issue. In our case, a 73 year-old man with SVC syndrome caused by mediastinal lymph node metastasis from non-small cell lung cancer underwent EVT followed by anticoagulation with low molecular weight heparin (LMWH), but symptomatic progression due to in-stent thrombosis necessitated the second procedure after two weeks. A total of 4 sessions of EVT and anticoagulation with LMWH, warfarin and rivaroxaban did not induce durable resolution of in-stent thrombosis. The 4th EVT was done with stent -graft, but computed tomography after the last procedure revealed remained thrombus in SVC and newly developed pulmonary thromboembolism during warfarinization. Our case suggests refractory in-stent thrombosis could develop despite of anticoagulation after EVT for SVC syndrome.
금 나노입자를 처리한 홍삼의 산화스트레스 완화 및 PC-12 신경세포 보호
김지원(Ji Won Kim),조치흥(Chi Heung Cho),황윤구(Yun-Gu Hwang),박우정(Woo Jung Park),강희(Hee Kang),김대옥(Dae-Ok Kim) 한국식품과학회 2017 한국식품과학회지 Vol.49 No.2
본 연구에서는 금 나노입자 용액을 생장하는 6년근 인삼에 직접 시비해서 금 나노입자가 전이된 황금인삼을 열수 추출하여 총 페놀 함량, 총플라보노이드 함량, 산화방지능 및 신경세포 보호능을 평가하였다. 1°Bx의 황금홍삼 추출물은 총페놀과 총플라보노이드 함량이 각각 212.2 mg GAE와 3.5 mg CE였다. ABTS, DPPH 및 ORAC 법으로 측정시, 황금홍삼 추출물의 산화방지능은 각각 272.3, 141.2, 868.4 mg VCE/°Bx였다. 황금홍삼 추출물은 과산화수소로부터 유래한 세포 내 산화스트레스를 감소시켜 PC-12 신경세포의 생존율을 농도 의존적으로 증가시켰다. 또한, 황금홍삼 추출물은 신경전달물질인 아세틸콜린을 가수분해하는 AChE 및 BChE 활성을 억제하였다. 이러한 결과는 금 나노입자를 처리한 홍삼을 이용한 산화방지 및 신경손상억제 소재로 활용할 가능성을 제시하였다. Red ginseng prepared from fresh 6-year-old ginseng treated with colloidal gold nanoparticles was extracted using hot water to evaluate its total phenolic and flavonoid contents, antioxidant capacity, and neuroprotective effects. Water extract of red ginseng treated with gold nanoparticles (WERGGN) had total phenolic and total flavonoid contents of 212.2 mg gallic acid equivalents/°Bx and 3.5 mg catechin equivalents/°Bx, respectively. The antioxidant capacities of WERGGN measured using ABTS, DPPH, and ORAC assays were 272.3, 141.2, and 868.4 mg vitamin C equivalents/°Bx, respectively. The WERGGN showed protective effects on the viability of neuron-like PC-12 cells against oxidative stress induced by hydrogen peroxide in a dose-dependent manner, partly because of a reduction in intracellular oxidative stress. Acetylcholinesterase and butyrylcholinesterase, which degrade the neurotransmitter acetylcholine to terminate neurotransmission, were inhibited by treatment with WERGGN. These results suggest that WERGGN is useful as a functional material to decrease oxidative stress and neuronal damage.
증례(症例) : 후천성 면역 결핍증 (AIDS) 연관형 Kaposi 육종 1예
이선화 ( Sun Hwa Lee ),이민희 ( Min Hee Lee ),김상균 ( Sang Kyoon Kim ),유창우 ( Chang Woo Rheu ),백경현 ( Kyung Hyun Paeck ),정치량 ( Chi Ryang Chung ),이석 ( Seok Lee ),이흥범 ( Heung Bum Lee ) 전북대학교 의과학연구소 2004 全北醫大論文集 Vol.28 No.2
Kaposi 육종은 후천성 면역 결핍증 환자에서 가장 흔하게 발생하는 신생물이지만그 치료에 대해서는 최근까지도 명확한 기준이 정립되어 었지 않았다. 근래에는 AIDS 연관형 Kaposi 육종의 병인에 있어서 HHV-8의 감염이나 숙주의 면역 상태가 중요한 역할을 한다는 것이 밝혀지면서 nucleoside analogues reverse transcriptase inhibitor와 protease inhibitor를 병합 사용하는 적극적인 항 retrovirus 치료 (HAART)를 시도하는 경향이며, 그 외에도 다양한 방법들을 사용한 성공적인 치료 예들이 보고 되고 있다. 본 저자들은 국내에 흔하게 보고되지 않은 AIDS 연관형 Kaposi 육종의 증례를 진단하고 HAART와 foscarnet 그리고 고식적 방사선 치료를 병행하여 적극 적인 내과적 치료를 시도한 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. AIDS-related Kaposi`s sarcoma is one of the most common neoplasms in patients with acquired immunodeficiency syndrome. Recently, human herpesvirus-8 (HHV-8) and the immune status of the host have known to be closely related to the pathogenesis of AIDS-related Kaposi`s sarcoma. Therefore, highly active antiretroviral therapy (HAART) which includes nucleoside analogues reverse transcriptase inhibitor and protease inhibitor has been widely attempted in AIDS-related Kaposi`s sarcoma. Other successful treatment regimens including cytotoxic agents, interferon-α, thalidomide and so on have been reported. However, standard treatment option. has not been established yet. Hereby, we report a case of patient with AIDS-related Kaposi`s sarcoma who was treated by zidovudine, lamivudine and indinavir for underlying HIV infection, and intravenous foscarnet and palliative radiotherapy for local control of oropharyngeal Kaposi`s sarcoma with literature review.