인진쑥 배지에서 배양한 노루궁뎅이버섯 균사체 추출물(HEAC)의 알코올 대사촉진 활성

최원식(Choi, Won-Sik),장도연(Jang, Do-Yoen),차경민(Cha, Kyung-Min),박천규(Park, Chun-Kyu) 한국산학기술학회 2008 한국산학기술학회논문지 Vol.9 No.1

인진쑥 배지에서 배양한 노루궁뎅이버섯(HEAC), 노루궁뎅이버섯과 인진쑥 추출물들의 음주 후 체내 알코올 농도의 감소 효과를 확인하였으며, 또한 혈중 알코올 탈수소효소 및 아세트알데히드 탈수소효소의 활성을 조사하여 알코올 분해 활성을 조사하였다. 체내 알코올 농도 측정결과 HEAC의 경우 170분, 노루궁뎅이 버섯 추출물은 210 분후에 혈중 알코올이 검출되지 않았다. 또한, HEAC는 알코올 탈수소효소 활성에서 대조군 보다 시간에 따라 154%, 노루궁뎅이버섯 추출물은 148%로 비교적 높은 활성을 나타내었다. 아세트알데히드 탈수소활성에서는 HEAC와 노루궁뎅이버섯 추출붙이 대조구에 비해 104~111%이상의 효소활성이 유지되는 것을 확인하였으며 이들 추출물들은 알코올 분해 촉진작용이 매우 우수함을 알았다. Alcohol concentration in the blood was effectively decreased by extracts from Hericium erinaceum hypha cultivated with Artermisia capillaris medium(HEAC), Hericium erinaceum hypha and Artermisia capillaris after dirnking. Also, the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase in the blood was studied. As a result of testing an alcohol concentration in the blood, the alcohol in the blood was not detected after 170 min. in case of HEAC and after 210 min. in case of Hericium erinaceum. Compared to control, each activities of alcohol dehydrogenase of HEAC and Hericium erinaceum hypha was showed up to 154% and 148% respectively. The activities of the acetaldehyde dehydrogenase of both extracts from HEAC and Hericium erinaceum was maintained in the range of 104 to 110% compared to control. In conclusion, such extracts represent significant effect to facilitate decomposition of alcohol.

ABAQUS를 이용한 휨벽체의 비선형 유한요소 해석기법

한민기,박완신,한병찬,황선경,최창식,윤현도 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The finite element method(FEM) models were developed for the reinforced concrete flexural walls and analysed under constant axial and monotonic lateral load using ABAQUS. The major objective of the present study is to determine if the ABAQUS finite element program can be used to accurately model the post-cracked mode of failure in plastic regions of walls, and, if so, to develop practical failure criteria in the plastic range of the material response. The research comprises constitutive models to represent behavior of the materials that compose a wall on the basis of experimental data, development of techniques that are appropriate for analysis of reinforced concrete structures, verification, and calibration of the global model for reinforced concrete walls of increasing complexity. The proposed FEA technique is verified by Lefas's benchmark data. Results from the analyses of these FEM models offers significant insight into the flexural behavior of benchmark data.

資本自由化와 韓國證券市場의 課題

李正道,孫炳海,申敏植 慶北大學校 經濟經營硏究所 1986 經濟經營硏究 Vol.2 No.-

Korea now stands on the verge of capital liberalization in line with its open door economic policy. On January 14, 1981, the korean government announced a long-term plan concerning the liberalization of the capital market with emphasis on an open securities market. The liberalization of the securities market will be phased-in as follows; (1) allowing the establishment of international investment trusts to invest in listed korean securities and permitting the opening of branch offices of foreign securities firms in korea by 1984, (2) permitting foreign investors to directly invest in korean securities on a limited basis, around 1985, (3) permitting foreigners to invest in koran securities without any limitations and allowing the issuance of domestic securities in oversea markets by the late 1980s (4) permitting korean securities to be listed on foreign stock exchanges and allowing capital outflow by the early 1990s. In 1981, two open-end on-shore investment trusts; namely, "Korea Trust" and "Korea International Trust", were privately placed in the european market. In 1984, following these two international trusts of $50 million total, the $60 million Korea Fund, third round of three more international issues of korea-managed trusts(KGT, SIT and ST) totalling $90 million were completed. All six of these indirect vehicles have brought into korea $200 million of foreign capital. In the second stage, korean leading companies have launched oversea offerings of convertible bonds to further proceed with the market's liberalization. Sam Sung Electronics, Co., Dae Woo Heavy Ind. Co., and Yu Kong Ltd. Co., issued convertible bonds of $80 million total. The next step in the internationalization process following convertible issues or depositary receipts is limited direct access by foreign investors to the korean stock market. This is expected to occur sometime between 1987 and 1988. Our government contemplates that the last step in the market's liberalization; that is, the outflow of korean capital into foreign securities investments will take place after 1990 with the assumption that economic targets have been met, and more importantly, that the country has a current account surplus in its balance of payments. In connection with this, it is important for us to be better prepared for the upcoming internationalization of the korean capital market. First of all, the government must take measures to foster the functions of the korean capital market in both the primary and secondary markets. Secondly, the korean securities companies must be able to provide a wide range of financial services to its domestic and oversea clients.

대동맥 협착증과 동반된 출혈성 위장관 동정맥 기형에서 Estrogen-Progesterone 치료 1예

김도연,김화정,김효정,남준식,박수영,박영미,신정은,주미순,황민규,정혜경,손혜영,이선영,이한주 大韓消化器內視鏡學會 1999 Clinical Endoscopy Vol.19 No.부록2

통년성 알레르기성 비염(Perennial allergic rhinitis)에 대한 아크리바스틴(Semprair)^(�)의 임상효과

김민식,신민호,조승호,서병도 최신의학사 1992 最新醫學 Vol.35 No.2

생물학적 자극 통제 수단으로 활용하기 위한 돼지 페로몬성 냄새 물질의 탐색 I : Ⅲ. 2-(Cyclohexyloxy) Tetrahydrofurane 유도체와 Porcine Odorant Binding Protein 사이의 결합 친화력에 관한 비교 분자장 분석

성낙도,박창식,정훈성,성민규 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

생물학적 자극통제 수단으로 활용하기 위한 돼지 웅성 페르몬성 분자를 탐색하고자 일련의 냄새 분자로서 2-(cyclo-hexyloxy) tetrahydrofurane 유도체들의 정량적인 구조와 수용체인 porcine odorant binding protein (pOBP)간의 결합 친화력 상수(p(Od)_(50))에 대한 비교 분자장 분석(CoMFA)을 실행하였다. 가장 양호한 CoMFA 모델 ATV (r²_(cv.)(q²)=O.886 및 r²(ncv.)=0.984)은 기질 분자 내 입체 중심(chiral center)의 절대 배열이 C₁(R),C₂(S)인 분자를 atom based fit 방법으로 배열하였을 경우의 standard field와 indicator field가 조합된 CoMFA장의 조건에서 유도되었다. 이 CoMFA 모델은 입체장 40.8%,정전기장 14.6% 및 소수성장 44.6%가 결합 친화력 상수에 영향을 미치는 요소임을 나타내었다. 등고도의 분석 결과로부터 효과적인 결합 친화력 냄새 분자를 수식하는 데 몇 가지 가치 있는 정보를 얻을 수 있었다. To search of new porcine pheromonal odorants for biostirnulation control system technologies to improve reproductive efficiency in livestock species, the comparative molecular field analysis (CoMFA) for binding affinity constant (p(Od)_(50)) between porcine odorant binding protein (pOBP) and ligands of odorant 2-(cyclohexyloxy) tetrahydrofurane derivatives as substrate molecule was conducted and discussed. In the optimized CoMFA model AIV with chirality (C₁'(R), C₂(S)) in substrate molecule and atom based fit alignment (A) of odorants, the statistical results showed the best predictability of the binding affinities (p(Od)_(50)) based on the LOO cross-validated value r²_(cv.) (q²=O.886) and non-cross-validated conventional coefficient (r²_(ncv.)=O.984). The binding affinity constants exhibited a good correlation with steric (40.8%), electrostatic (14.6%) and hydrophobic (44.6%) factors of the substrate molecules. From the analytical results of the contour maps, which may give us some valuable informations to the modification of odorants for effective binding affinity.

Histoid Leprosy의 1例

尹在一,金鍾敏,金洪植,金道一 大韓癩學會 1976 癩學 會誌 Vol.10 No.1

가와사끼 병 환아에서 이상뇌파와 신경학적 합병증 발현과의 연관성에 대한 고찰

박준수,공도연,박경배,민용식,김영창,정순이,이혜경 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

목적 : 가와사끼 병의 뇌파 소견 및 다른 임상인자들과의 연관성을 알아보고자 하였다. 방법 : 1994년 1월부터 1995년 12월 사이에 순천향대학 천안병원 소아과에 입원한 23명의 신경학적으로 정상인 가와사끼 병 환아에게 뇌파검사를 실시하여 이를 검사시기, 성별, 연령, 혈소판, 간기능 검사치, 그리고 동맥류 유무등의 임상인자들과 비교하였다. 결과 : 이상뇌파가 23명중 52.2%인 12명에게서 관찰되었으며, 이상뇌파로는 예파 및 극파, 극·서파 복합 양상과 전반적인 배경파의 서파양상이 나타났다. 뇌파의 검사시기가 진단부터 1주 이내인 경우에 이상뇌파의 빈도가 그 후보다 의미있게 높았으나, 그 밖의 다른 임상인자와의 연관성은 별 의미가 없었다. 결론 : 가와사끼 병 초기에 이상뇌파가 나타나는 것은 비록 신경적 증상은 없지만 중추 신경계가 영향을 받는다는 간접적인 증거로 생각할 수 있어 향후 신경적 합병증 발생 여부에 대한 면밀한 관찰이 필요하다고 생각된다. Purpose : This study is to find out if there is any association between EEG abnormalities in Kawasaki disease with other clinical factors. Methods : We performed EEG in 23 Kawasaki disease patients without any neurologic sign who admitted in Soonchunhyang Chunan Hospital from 1994. 1. to 1995. 12. and compared it with sex, age, platelet count, liver function test and presence of coronary artery aneurysm. Results : Abnormal EEG findings were observed in 12 of 23 patients(52.2%) and as for abnormal EEG findings, sharp, spike, spike & slow wave complex, and generalized slow background activity were noted. When EEG was performed within a week after the diagnosis, the incidence of abnormalities of EEG increased significantly but there was no correlation with other clinical factors. Conclusion : EEG abnormalities in the early stage of Kawasaki disease indicate that although there is no abnormal neurologic signs clinically, central nervous system might be affected and there should be a close observation for the developement of neurologic complication.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

건조 재료를 사용한 콘크리트의 포장화에 관한 실험적 연구

한다희,박희곤,백민수,김성식,이영도,정상진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

Most concrete is recently made of an aggregate which is properly absorbed, and earned in it in order to do capability at every fields. We have been close to demand new capability of high flowing and enduring for specific concretes. That is difficult to cope with claiming the efficiency on deterioration from lack of a high quality aggregate. Therefore, For solving the problems we apply to a packing method for using dried materials. That is to say it is a kind of making into an instant. In this study, There is a purpose to present fundamental data, comparing and analyzing a phenomenon about aggregate's absorption following the rate of adding water, for using existing materials.