身體的 律動이 肺 機能에 미치는 影響

廉哲鎬,尹坪晉 조선의대 1984 The Medical Journal of Chosun University Vol.9 No.1

吸煙이 肺機能에 미치는 影響(1)

廉哲鎬,尹坪晋 朝鮮大學校 附設 醫學硏究所 1986 The Medical Journal of Chosun University Vol.11 No.1

To examine the effect of cigarette smoking on pulmonary function, we undertook a analysis of 44 smokers and 41 nona dickers whose ages were from 20 to 34 years and who were living' in kwang-ju city. FVC(forced vital capacity), FEV₁ (forced expiratory volume for 1 second), FEF 200~1200, FEF 25~75%, and FEV_(1)/FVC% were calculated by determining the distance from the point of maximum inspiration to the point of maximum expiration. The results obtained were summarized as follows : 1) FVC and FEF 200~1200 showed no significant difference between smoking group and nonsmoking group. 2) In age group 30 to 34 years, FEV₁, FEF 25~75% and FEV₁/FVC% in smoking group were significantly diminished compared with nonsmoking group. 3) It seemed that diminution of forced expiratory volume for 1 second in smoking group is ascribed to diminution of FEF 25~75% of the first expiratory rate. In conclusion, the results of the present study suggested that it may be lead to small airway obstruction by long term cigarette smoking.

흰쥐에서 중추 고장성식염 주입에 의한 승압효과에 미치는 ANP의 영향

오승호,양민준,염철호 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

The present study was designed to examine the effects of intracerbroventricular (ICV) administration of atrial natriuretic peptide (ANP) on the pressor response induced by ICV hypertonic NaCl in rats. Rats (male. Sprague-Dawley) weighing 220-300g were anesthetized with pentobarbital sodium (50mg/kg. IP) and their right lateral cerebral ventricle were cannulated. Both isotonic and hypertonic NaCl (0.15 M, 0.6 M and 1.2 M) were ICV (3μl/min) applied and arterial blood pressure and heart rate (HR) responses registered. Central administration of hypertonic NaCl solution caused an elevation in mean arterial pressure (MAP) and HR, while the response magnitude was comparable correlated to the NaCl concentration. The ANP (3pmol/min, ICV) alone did not cause recognizable changes in MAP. When ANP was administered with 0.6 M NaCl, however, hypertonic NaCl-induced changes in MAP were interrupted. These results indicate that ANP may have the role in central cardiovascular regulation. It is also suggested that in some conditions. ANP may act as an antipressor substance in the brain.

신성고혈압 흰쥐에서 측뇌실내 Captopril이 Bradykinin의 중추승압효과에 미치는 영향

정태호,양민준,오승호,전제열,염철호,윤평진 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Effects of intracerebroventricular captopril on the central pressor response to bradykinin were examined in normotensive and 2-kidney, 1 clip (2KIC) Goldblatt hypertensive rats. The experiment was done under pentobarbital (50 ㎎/㎏. IP) anesthesia. Captopril (1 ㎎)and bradykinin (5 nmol) were administered into the right lateral cerebral ventricle, while arterial blood perssure and heart rate were continuously monitored throughout the experiment. Intracerebroventricular captopril did not affect the blood pressure within 10 minutes in both normotensive and 2KIC hypertensive rats, while it significantly augmented the central pressor response to bradykinin in the hypertensive rats. These observations suggest that an elevation in endogenous kinin levels is without effect on arterial pressure in normotensive and 2KIC hypertensive rats. However, the kallikreinkinin system in the central nervous system plays a role in the regulation of blood pressure, possibly maintaining the hypertension, in 2KIC hypertensive rats.

靑少年運動選手의 肺機能에 關한 硏究

尹坪晋,廉哲鎬 朝鮮大學校 附設 醫學硏究所 1983 The Medical Journal of Chosun University Vol.8 No.1

Despite the theoretical problems of the water spirometer and its poor frequency response, the water spirometer is adequate for the physiological function tests even in healthy people. We must encourage the use of the spirometer as part of routine examination of nearly all adult patients. Recently, Pulmonary function studies are widely used in evaluation of various physical condition. The aim of this study was to report the pulmonary function studies of young athletes. Subjects were 221 young athletes from 11 to 17 years of age. They were elementary school boys and girls, middle school boys and girls, high school boys and girls. The following were mainly observed for the study; frequency of breath, vital capacity, tidal volume, and breath holding time. The results obtained were summarized as follow; 1. Frequency of breath; (cycle/min. M±SD) Elementary school boys show 18±5.5, elementary school girls 19±5.0, middle school boys 17±2.3, middle school girls 17±3.0, high school boys 15±6.5, high school girls 15±5.7. 2. Vital capacity; (ℓ, M±SD) Elementary school boys show 1.63±0.138, elementary school girls 1.60±0.241, middle school boys 3.08±0.650, middle school girls 2.79±0.562, high school boys 4.24±0.545, high school girls 2.90±0.792. 3. Tidal volume; (㎖, M±SD) Elementary school boys show 393±40.7, elementary school girls 439±108, middle school boys 590±103, middle school girls 508±78.6, high school boys 727±113, high school girls 618±84. 4. Breath holding time; (sec, M±SD) Elementary school boys show 43±15.5, elementary school girls 45±15.4, middle school boys 53±9.7, middle school girls 46±9.4, high school boys 57±12.9, high school. girls 45±10.1.

실혈성쇼크의 회복에 미치는 고장성욕액의 영향

南基鏞,廉哲鎬 朝鮮大學校 附設 醫學硏究所 1984 The Medical Journal of Chosun University Vol.9 No.1

This study was to investigate the effects of hypertonic saline solution on the recovery of hemorrhagic shock in rabbits, Infusions of hyperosmotic NaCl (2,400 mOsm/L) solution were given to the anesthetized rabbits in severe hemorrhagic hypotension by intravenous injection. Arterial pressure, heart rate, plasma osmolarity, plasma electrolyte, hematocrit and plasma volume were measured in rabbits during experiments. The results obtained were as follows : 1) Increase of arterial pressure and diminution of heart rate were observed after infusions of hypertonic saline solution in hemorrhagic shock as compared with physiological saline solution infusion. 2) Plasma osmolarity and plasma sodium concentration increased slightly after infusions of hypertonic saline solution in hemorrhagic shock as compared with physiological saline solution infusion, and hematocrit diminished slightly in both groups. 3) Increase of plasma volume was observed after infusions of hypertonic saline solution in hemorrhagic shock. 4) Infusions of hypertonic NaCl showed almost no influence on hemodynamic factors in nonhemorrhagic state. 5) The effects of hypertonic NaCl infusions on hemorrhagic shock in rabbits were transient.

흰쥐에서 측뇌실내 Bradykinin의 승압효과

김장만,염철호 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

Central hemodynamic actions of bradykinin were studied in anesthetized rats in order to investigate its mode of action in the central nervous system. Bradykinin(0.5~10 nmoℓ) was administered into the right lateral ventricle, while blood pressure and heart rate were monitored continuously. Effects of various drugs including phentolamine(2 ㎎/㎏), hexamethonium(2.5 ㎎/㎏/min), reserpine (2 ㎎/㎏/day), indomethacin(10 ㎎/㎏) and sara1asin(20 ㎍/㎏/min) on the hemodynamic effects of bradykinin were also examined. The results obtained were as follows: 1. Administration of bradykinin into the lateral ventricle, elicited an increase in mean arterial pressure without significant changes in heart rate. 2. Bradykinin, doses ranging from 0.5 to 10 nmoℓ, produced a dose-dependent increase in mean arterial pressure. The maximum increase in blood pressure was noted at 5 nmoℓ, 3. Central pressor responses to bradykinin were attenuated by pretreatment with phentolamine or hexamethonium. Reserpine, indomethacin and saralasin did not affect the pressor response to bradykinin. 4. These results suggest that the central pressor effect of bradykinin is, at least in part, due to excitation of the autonomic nervous activity. Mechanisms other than the enhanced sympathetic nervous activity cannot be ruled out completely in the central action of bradykinin.

大學生 肺容積 및 最大換氣能에 關한 硏究

尹坪晋,廉哲鎬 中央醫學社 1983 中央醫學 Vol.45 No.6

The aim of this study was to report the lung volume and the maximal voluntary ventilation of the students in the courses of physical and medical education at Chosun university. Subjects were 165 physical students and 74 medical students. The results are as follows: 1) Frequency of breath: (cycle/min, M±SD) Physical male students show 13+3.28, physical female students 17±4.88, medical male students 17+3.51, medical female students 16±4.22. The values of physical male students are represented lower than those of medical male students. There are almost no differences between the two female groups. 2) Vital capacity: (1, M±SD) Physical male students show 4.35±0.610, physical female students 3.45±0.683, medical male students 3.88±0.487, medical female students 2.64±0.318. The values of physical male and female students in common are represented significantly higher than those of medical male and female students. 3) Tidal volume: (ml, M±SD) Physical male students show 684±119, physical female students 677±198, medical male students 482±114, medical female students 468±151. The values of physical male and female students are represented considerably higher than those of medical male and female students. 4) Maximal voluntary ventilation: (1 /min, M±SD) Physical male students show 152.6+12.75, physical female students 117.4±10.24, medical male students 129.7±13.83, medical female students 93.9±11.94. The values of physical male and female students are represented significantly higher than those of medical male and female students.

鬪技種目選手의 肺機能에 關한 硏究

尹坪晉,廉哲鎬 조선의대 1985 The Medical Journal of Chosun University Vol.10 No.1

신성고혈압 흰쥐 대동맥 평활근에서 세포외 칼륨에 의한 혈관이완반응의 변이

전제열,염철호,윤평진,이정회,최형호,박유환,김진호 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8