무증상 갑상선기능저하증 환자에서 Thyroxine 치료에 따른 혈청 지질 및 아포지단백의 변화

조보연,신찬수,김원배,고창순,김성연,박혜영,박건상,이홍규,박형규,김숙경 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.1

Background: Subclinical hypothyroidism(SCH) is a common biochemical abnormality which can be found in routine screening tests of thyroid function. We are increasingly faced with the question of whether its an indication for thyroxine replacement therapy. The effect of thyroxine replacement on lipid profile in SCH has aroused a great interest because of an association of overt hypothyroidism(OVH) with hyperlipidemia and increased risk of coronary artery disease. Method: We prospectively evaluated the changes in lipids and apoproteins before and after thyroxine replacement therapy in 23 patients with SCH and in 37 patients with OVH. We measured serum total cholesterol and triglyceride using autoanalyzer, high density lipoprotein(HDL) chole-sterol by dextran sulfate method, Apo A1 and Apo B by immunonephelometric assay. Results: Thyroxine replacement therapy significantly decreased total cholesterol, low density lipoprotein(LDL) cholesterol and apo B levels, but did not affect the level of triglyceride, HDL cholesterol or apo AI in patients with OVH. In SCH, thyroxine replacement therapy with the doses to normalize serum TSH concentrations also decreased significantly the level of cholesterol and LDL cholesterol albeit apo B levels did not change. Moreover, in most of patients with OVH (11 of 12) and in all of patients with SCH(5 of 5) who had had hyperchlesterolemia before treatment, thyroxine replament normalized their cholesterol and LDL cholesterol levels. Conclusion: In regard to the beneficial changes in blood lipid levels, patients with SCH should be treated, especially in cases who have other risk factors for the development of atherosclerosis. If thyroxine replacement only will reduce the incidence of coronary artery disease in SCH remains to be elucidated by long-term prospective studies(J Kor Soc Endocrinol 11:41-51, 1996).

과학 실험·실습의 지도평가를 위한 모형과 도구개발

고재걸,민경덕,최종락,오대섭,권병규,변창진,여환진,정원우 경북대학교 과학교육연구소 1988 科學敎育硏究誌 Vol.12 No.-

The purpose of this study is to develop models and instruments for teaching and assessing scientific experiments and practices. General objectives for teaching and evaluating scientific experiments and practices in secondary schools were analyzed and categorized into three domains:they were inquiry skill, scientific thinking skill, and scientific attitude. The sub-categories for each domain were constructed, and specific objectives for each general objective were also stated in terms of behavioral objectives according to Mager's suggestion. The tables of specification (content×behavior) were developed in order to assist secondary school teachers to teach and evaluate scientific experiments in class. In addition, we introduced some useful assessment techniques which can be adopted to evaluating learning outcomes of each specific objective. The sample test items corresponding to each objective were listed for practical usage in class.

共産主義體制의 內在的 危機要因에 關한 硏究 : 蘇聯 및 東歐를 中心으로

高性俊,韓昌榮,金恒元 제주대학교 1983 논문집 Vol.16 No.2

This year is 100th since Marx died. There have been so many reports that the 100th anniversary of Marx's death was being marked in unforgettable ways. If Marx were to come back, what does he discover? Maybe he discovers that things aren't what he has expected. What is the significance of polish crisis in early 1980s? It has taught the world a lesson that is both stark and undeniable: as a means of organizing an economy and providing for the well-being of a citizenry, Communism is a failure. It is related to the dark future of communism. The causes of polish crisis are two: one is the fall of social status and the consciousness of frustration. The other is the continuous failure of Economic policy and the bankrupty of national Economic life. If we interpretate the two causes on the thread of connection in communist system, the former implies the "equality" idea of communism is falseconsciousness. The latter means the practical limit of communist economic system. Nowaday in Communist Societies, the dream of classless society is not practical. Rather as Millovan Djilas said, new class came in view. He sees the party as the incumbent institution of class rule: The new ownership is not the same as the political government, but is created and aided by that government. The use, enjoyment, and distribution of property is the privilege of the party and the party's top men. We call them Nomenklatura. The alienation of the worker from his work is at least as great today at the plants in communist countries as it was in the Manchester textile mills that Engels studied in the mid-l9th century. The command economy, too is slowing down if not breaking down. No communist country has met the proclaimed goals of its Five-Year plan: The desired results that the economies were organized to achieve have simply failed to materialize. And the projections for the next ten years are even gloomier. So U.S.S.R and Eastern Europe try to reform the economic policy, But those reforms challenge the very essence of the system, which is totalitarianism. It is the dilemma of the communist countries hold. What is the result of Soviet Communist System? The result is a tension and a paradox. On the one hand, inefficiency, stagnation and alienation are theinevitable accompaniments of the centralization, elitism and repression that are necessary to carry out the first order of businss: the preservation of power. On the other hand, the political system is well designed to be impervious to the consequences of the economic failure and social demoralization that are built into it.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

난소의 호산성 투명세포암종 - 1예의 보고 -

하창원,고재수,명나혜,조경자,박상윤,김미경,장자준 대한병리학회 1992 Journal of Pathology and Translational Medicine Vol.26 No.5

복강경 검사로 진단한 결핵성 복막염 1례

박민경,서원석,박재옥,김창휘,고은석,임철완 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Tuberculous peritonitis is discovered from sixty to ninty percent of pulmonary tuberculosis patients. Clinical symptoms are nonspecific such as mild fever, weakness and malaise but show tenderness in right lower abdomen and abdominal distension. Diagnosis is confirmed by laparoscopic and pathologic findings. We report a case of tuberculous peritonitis in an 11-year-old boy who was hospitalized because of abdominal distension with pain on right lower abdomen which had developed one day before he came to hospital. Chest X-ray showed pleural effusion on both sides. We did laparoscopic examination and observed diffuse nodular infiltration. In biopsy specimen we observed osseous granuloma and acid-fast bacilli in AFB stain.

구속된 비행 청소년들의 석방 후 6개월 이내 재범의 예측요인

서동혁,정선주,손창호,김원식,고승희,함봉진,조성진,김영기,이중재 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 본 연구는 범법행위로 인해 검참에 구속된 청소년들의 6개월 이내 재범여부를 예측할 수 있는 요인을 분석함으로써 재범의 가능성이 높은 청소년들을 조기에 선별하여 적절한 중재를 시행하기 위한 목적으로 시행되었다. 방 법 : 검찰에 구속된 후 교도소나 소년원에 수감되지 않고 석박된 남자 청소년 125명을 대상으로 하였다. 범죄기록 검토를 통해 사회인구학적, 범죄관련 변인들에 대해 조사하였고, 가족환경 및 부모양육태도, 정신병리, 성격장애, 도덕발달수준 등과 연관된 변인을 알아보기 위해, 부모-이동 갈등해결척도(CTSPC), 한국판 가정환경척도(FES), 한국형 부모양육행동척도, 간이정신진단검사(SCL-90-R), Beck 우울증척도, Beck 불안 척도, 한국판 청소년용 도덕발달수준 평가도구와 한국판 성격장애검사(PDQ-R)를 시행하였다. 결 과 : 전체 연구대상 125명 중 55명 (44%)이 석방 후 6개월 이내에 1회 이상의 재범을 행하였다. 재범군은 비재범군에 비해 구속당시 나이가 어리고, 신체적 학대력이 높았으며, 도덕발달수준이 낮고, SCL-90-R의 적대감척도점수가 높으며 PDQ-R의 반사회적 인격장애에 해당되는 경우가 많았다. 두 집단간 가족환경이나 부모양육태도에는 유의한 차이가 나타나지 않았다. 재범군은 폭력범죄로 구속된 경우가 비재범군에 비해 적었고 첫 범죄시 연령이 어리고 전과가 있는 경우가 많았다. 로지스틱 회귀분석 결과, 재범에 대한 예측요인으로 첫 범죄당시 연령(오즈비=2.91), 반사회적 성격장애(오즈비=2.85), 신체적 학대력(오즈비=2.65)의 세 변인이 포함되었으며, 재범여부에 대한 판별력은 72.8%로 나타났다. 결 론 : 본 연구결과 구속된 청소년들의 재범률이 매우 높다는 사실과 범죄행위에 가담한 연령이 어릴수록, 반사회적 성격장애가 있고 성장과정 중 부모로부터 학대를 받은 경험이 있을수록 반복적인 범죄를 저지를 위험도가 높다는 것을 알 수 있었다. 향후 비행 청소년들의 재범을 예방하기 위해서는 이러한 특성을 가진 고위험군에 대한 조기개입 및 적응을 돕기 위한 프로그램의 개발이 중요할 것으로 사료된다. Objectives : This study was performed to investigate the factors predicting recidivism within 6months after release in arrested juvenile delinquents for proper screening and intervention of high-risk-subjects. Methods : The subjects consisted of 125 arrested male adolescents who were released after legal procedure in prosecutor office and court. The socio-demographic and crime-related characteristics. Were evaluated by police records, and the familial, psychopathology and personality characteristics, and the level of moral development measured by the Conflict Tactics Scale(CTS), Family Environment Scale(FES), Parental Behavioral Inventory, Symptom Checklist-90-Revised(SCL-90-R), Beck Depression Inventory, Beck Anxiety Inventory, Korean form of Moral Developmental Inventory for adolescents, and Personality Disorder Questionnaire-Revised(PDQ-R). Results : The recidivism rate within 6 months after release was 44% of the initial sample, Recidivists were younger and had higher scores on Anger-hostility scale of SCL-90-R and lower principle morality score than nonrecidivists. More recidivists had history of physical abuse and antisocial personality disorder on PDQ-R than nonrecidivists. They also showed the crime-related characteristics of lower percent of violence crime, higher incidence of previous conviction, younger age of the first crime. Among those variables, logistic regression showed that age of first crime, antisocial personality disorder, and history of physical abuse best predicted the recidivism within 6months after release. Conclusion : These results of present study suggest that the recidivism rate of arrested male adolescents is very high, and the age of first crime, antisocial personality disorder and history of physical abuse were key factors predicting recidivism. To prevent repeated crime of delinquent adolescents, the development of programs for those high-risk groups to help rehabilitation and adaptation in community would be essentil.

한국형출혈열에서의 혈장 Renin 활성에 관한 연구

이문호,조보연,이정상,김성권,고창순,김원동,윤홍진 대한핵의학회 1976 핵의학 분자영상 Vol.10 No.1

서울대학교 의과대학 부속병원 내과에 1975년 10월부터 1976년 1월사이에 건강진단을 위하여 입원한 정상인 15명과, 1974년 8월부터 1976년 1월사이에 서울대학교 의과대학 부속병원 내과에 입원한 20명 및 국군수도통합병원에 입원한 22명에서 병력 임상상 이학적소견 및 검사소견상 한국형출혈열로 확진된 환자 총 42명을 대상으로 Radioimmunoassay를 사용하여 기저혈장 Renin 활성치 및 Lasixⓡ 자극부하검사를 실시하여 다음과 같은 결과를 얻었다. 1) 기저혈장 Renin 활성치는 정상대조군에서는 2.9±2.16ng/ml/hr, 한국형출혈열의 핍뇨기환자에서는 4.7±2.13ng/ml/hr로 정상대조군과 비교하여 통계학적으로 유의한 차이를 보였다(p$lt;0.01). 이뇨기의 Renin 활성치는 3.4±2.09ng/ml/hr이었으며 핍뇨기와 비교하여 통계학적으로 유의한 차이를 보였다(p$lt;0.05). 2) 정상대조군에서 Lasixⓡ 자극부하검사를 실시하여 2.9±2.16ng/ml/hr인 기저치에서 Lasixⓡ 40mg 정맥주사후 1시간 혈장 Renin 활성치는 5.3±20.20ng/ml/hr로 통계학적으로 유의한 증가를 보였다(p$lt;0.01). 3) 핍뇨기환자에서 Lasixⓡ 자극부하검사를 실시하여 기저치는 4.6±2.01ng/ml/hr이었으며, Lasixⓡ 40mg 주사후 1시간치는 4.4±2.34ng/ml/hr로 유의한 차이를 나타내지 않았다. 4) 이뇨기환자에서 Lasixⓡ 자극부하검사를 실시하여 기저치는 3.3±1.8ng/ml/hr로 통계학적으로 유의한 차이를 나타내었다(p$lt;0.01). 5) 기저혈장 Renin 활성치 및 Lasixⓡ 자극부하검사에 대한 반응과 혈청 creatinine치, BUN치, 1일뇨량 및 복막투석과의 상관관계는 없었다. 이상과 같은 결과를 종합해 보면 핍뇨기에는 기저혈장 Renin 활성치가 증가하고, Lasixⓡ 자극부하검사에 반응을 보이지 않다가, 이뇨기에서 혈장 Renin 활성치가 감소하며, Lasixⓡ 자극부하검사에 반응을 나타내어 한국형출혈열때의 급성신부전에서는 Renin이 그 발생기전에 어떤 주요한 역할 즉 신내혈류의 변화의 초래 등을 할 것으로 추정할 수 있다. To evaluate the possible pathophysiologic role of renin in acute renal failure observed in Korean hemorrhagic fever (KHF), the author measured the basal plasma renin activity (PRA) and the stimulated PRA by radioimmunoassay for angiotensin I in 15 normal controls and 42 KHF patients who are admitted in Seoul National University Hospital and Nation Army Hospital from Jan. 1975 to Jan. 1976. The results obtained were as follows: The mean basal PRA in normal control group was 2.9±2.16 ng/ml/hr in the patients during the oliguric phase of KHF, the mean basal PRA was 4.7±2.13ng/ml/hr, and there was statistically significant increase compared to the normal control. In the patients during the diuretic phase of KHF, tke mean basal PRA was 3.4±2.09ng/ml/hr, and there was statistically significant decrease compared to the olipuric phase of KHF. In normal controI group, the mean basal PRA was 2.9±2.16ng/ml/hr. And the PRA 1 hour after the administration of Lasixⓡ 40mg intravenously(stmulated PRA) was 5.3±2.20ng/ml/ there was statistically significant increasec compared to basal level. In oliguric phase of KHF, the mean basal PRA was 4.6±2.01ng/ml/hr. And stimulated PRA was 4.4±2.34ng/ml/hr and there was no significant changes. In diuretic phase of KHF, the mean basal PR was 3.3±1.86ng/ml/hr. And stimulated PRA was 5.2±2.58ng/ml/hr and there was statistically significant increase compared to basal level. There were statistically no significant correlations between basal PRA and stimulated PRA and serum creatinine. BUN, urine volume and peritonial dialysis. $quot;

말단비대증 환자에서의 수술전 Octreotide 투여 효과

박경수,김현규,조보연,이홍규,고창순,민헌기,김성연,고경수,이석인,한대희,최길수,정희원,김현집 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.1

Seven patients with previously untreated acromegaly and invasive pituitary macroadenomas were treated with the long-acting somatostatin analog, octreotide (San- dostatin*, Sandoz) for 3~6 months, before transsphenoidal pituitary adenomectomy. Preoperatively, treatment with octreotide for 3 months reduced the pituitary tumor size by 55~60% in 2 patients, 20~39% in 3 patients and little in the remaining 2 patients. Six patients were treated for another 3 monts, but the size of the pituiary tumor showed no further remarkable changes. Mean basal serum GH concentration fell from 251.6(53.0~470.0) ng/ml to 80.1(9.5~308.0) ng/ml after 3~6months treatment with octreotide. Postopercentrationn of one patient whose pituitary tumor size decreased 65% fell into the normal range. Thus, preoperative administration of octreotide induced shrinkage of GH-producing pituitary rumors in some patients and might have favorable effects on the remission rate in the treated patients. (J Kor Endocrinol 8:35~41, 1993)

Characteristics of cosmetic medical tourism in Korea

Chang-Won Koh 대한미용의학회 2017 대한미용의학회지 Vol.1 No.1

This review explores strategies to promote medical tourism in Korea through assessing the characteristics of cosmetic medical tourism selection by nationality, visiting clinics, and consumption tendency. It also discusses several issues regarding the medical tourism market in Korea, such as patient safety, patient satisfaction, medical visas, tax refunds, and legal aspects. The author reviewed articles that involved the cosmetic medical tourism in korea and summarized their findings. In 2015, the number of foreign pathients was 296,889, registering an increase of 11.1% compared to that of the previous year. This increasing trend has been registered since 2009, with an overall increase of 30.5% between 2009 and 2015. The number of registered medical institutions was 3,013 and that of medical tourism agencies 1,666 in 2016. In 2015, cosmetic surgery reported the highest total amount of medical costs from foreign patients, followed by internal medicine, general surgery, and medical checkups in this order. The government of South Korea supports medical tourism policies through programs that include the accreditation of medical institutions, issuance of medical visas, tax refunds, and assistance for medical dispute resolution. Recently, in an effort to support medical tourism through a systematic approach, the institution of MEDICAL KOREA was established in 2016. Various measures taken by the government are expected to help activate and promote medical tourism by ensuring quality medical services to be provided to medical tourists.